Gene_Locus Report

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Gene_locus Report for: strco-TAP

Streptomyces coelicolor, Streptomyces lividans, putative secreted tripeptidylaminopeptidase

Comment
Other strains: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145), Streptomyces lividans (TK24)


Relationship
Family|Tiancimycin-TnmK-Tripeptidase-HIP
Block| X
Position in NCBI Life Tree|Streptomyces coelicolor
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Streptomycetales: N E > Streptomycetaceae: N E > Streptomyces: N E > Streptomyces albidoflavus group: N E > Streptomyces coelicolor: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





1 substrate:
Gly-Pro-Leu-beta-NA
No inhibitor
2 Genbank : AL391014, L27466
3 UniProt : Q54410, D6ESC6, Q9FCD7
3 UniProt : Q9FCD7, Q54410, D6ESC6
3 Interpro : Q9FCD7, Q54410, D6ESC6
3 Prodom : Q9FCD7, Q54410, D6ESC6
3 Pfam : Q9FCD7, Q54410, D6ESC6
3 PIRSF : Q9FCD7, Q54410, D6ESC6
3 SUPERFAM : Q9FCD7, Q54410, D6ESC6
Sequence
Graphical view for this peptide sequence: strco-TAP
Colored MSA for Tiancimycin-TnmK-Tripeptidase-HIP (raw)
MRKSSIRRRATAFGTAGALVTATLIAGAVSAPAASAAPADGHGHGHGHGR
SWDREARGAAIAAARAARAGIDWEDCAADWNLPKPIQCGYVTVPMDYAKP
YGKQIRLAVDRIGNTGTRSERQGALIYNPGGPGGSGLRFPARVTSKSAVW
ANTAKAYDFVGFDPRGVGHSAPISCVDPQEFVKAPKADPVPGSEADKRAQ
RKLAREYAEGCFERSGEMLPHMTTPNTARDLDVIRAALGEKKLNYLGVSY
GTYLGAVYGTLFPDHVRRMVVDSVVNPSRDKIWYQANLDQDVAFEGRWKD
WQDWVAANDAAYHLGDTRAEVQDQWLKLRAAAAKKPLGGVVGPAELISFF
QSAPYYDSAWAPTAEIFSKYVAGDTQALVDAAAPDLSDTAGNASAENGNA
VYTAVECTDAKWPANWRTWDRDNTRLHRDHPFMTWANAWMNLPCATWPVK
QQTPLNVKTGKGLPPVLIVQSERDAATPYEGAVELHQRFRGSRLITERDA
GSHGVTGLVNPCINDRVDTYLLTGGTDARDVTCAPHATPRP
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MRKSSIRRRATAFGTAGALVTATLIAGAVSAPAASAAPADGHGHGHGHGR
SWDREARGAAIAAARAARAGIDWEDCAADWNLPKPIQCGYVTVPMDYAKP
YGKQIRLAVDRIGNTGTRSERQGALIYNPGGPGGSGLRFPARVTSKSAVW
ANTAKAYDFVGFDPRGVGHSAPISCVDPQEFVKAPKADPVPGSEADKRAQ
RKLAREYAEGCFERSGEMLPHMTTPNTARDLDVIRAALGEKKLNYLGVSY
GTYLGAVYGTLFPDHVRRMVVDSVVNPSRDKIWYQANLDQDVAFEGRWKD
WQDWVAANDAAYHLGDTRAEVQDQWLKLRAAAAKKPLGGVVGPAELISFF
QSAPYYDSAWAPTAEIFSKYVAGDTQALVDAAAPDLSDTAGNASAENGNA
VYTAVECTDAKWPANWRTWDRDNTRLHRDHPFMTWANAWMNLPCATWPVK
QQTPLNVKTGKGLPPVLIVQSERDAATPYEGAVELHQRFRGSRLITERDA
GSHGVTGLVNPCINDRVDTYLLTGGTDARDVTCAPHATPRP


References
    Title: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H and Hopwood DA <33 more author(s)>
    Ref: Nature, 417:141, 2002 : PubMed

            

    Title: A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome
    Redenbach M, Kieser HM, Denapaite D, Eichner A, Cullum J, Kinashi H, Hopwood DA
    Ref: Molecular Microbiology, 21:77, 1996 : PubMed

            

    Title: Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66
    Butler MJ, Binnie C, DiZonno MA, Krygsman P, Soltes GA, Soostmeyer G, Walczyk E, Malek LT
    Ref: Applied Environmental Microbiology, 61:3145, 1995 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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