Gene_locus Report for: tetng-4neur Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment)
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Actinopterygii: N E > Actinopteri: N E > Neopterygii: N E > Teleostei: N E > Osteoglossocephalai: N E > Clupeocephala: N E > Euteleosteomorpha: N E > Neoteleostei: N E > Eurypterygia: N E > Ctenosquamata: N E > Acanthomorphata: N E > Euacanthomorphacea: N E > Percomorphaceae: N E > Eupercaria: N E > Tetraodontiformes: N E > Tetraodontoidei: N E > Tetradontoidea: N E > Tetraodontidae: N E > Tetraodon: N E > Tetraodon nigroviridis: N E A85-EsteraseD-FGH :
tetng-q4t3m9 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4tbe2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf7138, whole genome shotgun sequence .
ABHD6-Lip :
tetng-q4rjy3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4rli3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
ABHD8 :
tetng-q4sbp0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4t7r6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
ABHD10 :
tetng-q4s578 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 6 scaf14737, whole genome shotgun sequence .
ABHD11-Acetyl_transferase :
tetng-h3dfb4 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Abhydrolase domain containing 11 .
ABHD12-PHARC :
tetng-q4ref8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 10 scaf15123, whole genome shotgun sequence .
ABHD13-BEM46 :
tetng-q4s0h8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
ABHD16 :
tetng-h3cre8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Abhydrolase domain containing 16A .
ABHD17-depalmitoylase :
tetng-q4sd49 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
ABHD18 :
tetng-h3cjy0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). ABHD18 Uncharacterized protein .
abh_upf0017 :
tetng-q4rr22 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4shl7 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4t4a1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome 15 SCAF9766, whole genome shotgun sequence ,
tetng-h3clj8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Abhydrolase domain containing 15a .
ACHE :
tetng-ACHE Tetraodon nigroviridis acetylcholinesterase precursor (AChE) mRNA, complete cds .
Acidic_Lipase :
tetng-q4tb62 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
ACPH_Peptidase_S9 :
tetng-q4rwa0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4t173 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Acyl-CoA_Thioesterase :
tetng-q4rqz6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Arylacetamide_deacetylase :
tetng-q4sku6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf14565, whole genome shotgun sequence ,
tetng-q4spq0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4sty0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-h3ctg6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Uncharacterized protein .
BCHE :
tetng-BCHE Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) acetylcholinesterase chromosome undetermined SCAF14294, whole ,
tetng-h3cl30 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein ,
tetng-h3dbr5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein .
Carboxypeptidase_S10 :
tetng-q4s091 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4tab8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Carb_B_Chordata :
tetng-h3cfz4 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodo Uncharacterized protein ,
tetng-q4s7e3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
CGI-58_ABHD5_ABHD4 :
tetng-q4snq3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4suu2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Cholesterol_esterase :
tetng-q4syn6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf12000, whole genome shotgun sequence .
CIB-CCG1-interacting-factor-B :
tetng-q4rx90 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodo nigroviridis) Chromosome 11 SCAF14979, whole genome shotgun sequence .
CMBL :
tetng-q4smy3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 6 scaf14544, whole genome shotgun sequence .
DPP4N_Peptidase_S9 :
tetng-q4rk63 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4rk66 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4rqj4 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4rvf8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4s5x0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4s309 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4sbm6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Duf_676 :
tetng-q4s050 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 21 scaf14785, whole genome shotgun sequence .
Duf_829 :
tetng-q4rjp3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome 13 SCAF15035, whole genome shotgun sequence ,
tetng-q4sbu0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome 19 SCAF14664, whole genome shotgun sequence ,
tetng-q4snp0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome 15 SCAF14542, whole genome shotgun sequence .
Epoxide_hydrolase :
tetng-q4s144 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4ser6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
FSH1 :
tetng-q4rru9 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Hepatic_Lipase :
tetng-q4sie5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Lipase, hepatic a .
Hormone-sensitive_lipase_like :
tetng-q4smu0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Kynurenine-formamidase :
tetng-h3d961 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). N-formylkynurenine formamidase .
LIDHydrolase :
tetng-q4t826 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome undetermined SCAF7912, whole genome shotgun sequence .
Lipase_3 :
tetng-q4s9w9 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4si60 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Lipoprotein_Lipase :
tetng-h3dde8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Lipoprotein lipase ,
tetng-h3dde9 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Lipoprotein Lipase ,
tetng-h3det9 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Lipase G, endothelial type .
LYsophospholipase_carboxylesterase :
tetng-q4rn09 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4sal4 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Maspardin-ACP33-SPG21_like :
tetng-h3ci57 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein .
Monoglyceridelipase_lysophospholip :
tetng-q4s7x6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Ndr_family :
tetng-q4sh74 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4sqr3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4suz1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-h3dbw2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein ,
tetng-h3cpc8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein .
Neuroligin :
tetng-3neur Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) preliminary entry ,
tetng-nlgn2b Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Neuroligin 2b ,
tetng-nlgn2a Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Neuroligin 2a ,
tetng-nlgn3b Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
NLS3-Tex30 :
tetng-h3cnh2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein ,
tetng-h3czr1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein .
PAF-Acetylhydrolase :
tetng-q4sgv2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Palmitoyl-protein_thioesterase :
tetng-q4szk0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
PC-sterol_acyltransferase :
tetng-q4t6m1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Pectinacetylesterase-Notum :
tetng-q4sgm5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome 3 SCAF14593, whole genome shotgun sequence ,
tetng-h3d966 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Uncharacterized protein ,
tetng-h3d3e3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Uncharacterized protein .
PGAP1 :
tetng-q4rk53 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Phospholipase :
tetng-q4rtq6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 2 scaf14997, Phospholipase A1 member A ,
tetng-q4sfm7 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4szy0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf11458, whole genome shotgun sequence .
PPase_methylesterase_euk :
tetng-q4s8t5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 7 scaf14703, whole genome shotgun sequence ,
tetng-q4spa7 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Prolylcarboxypeptidase :
tetng-q4ryv8 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4ryz3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 16 scaf14974, whole genome shotgun sequence ,
tetng-q4t920 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf7657, whole genome shotgun sequence ,
tetng-q4ta33 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
S9N_PPCE_Peptidase_S9 :
tetng-q4rkk3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) ,
tetng-q4s6t6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Thioesterase :
tetng-q4sxh3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) .
Valacyclovir-hydrolase :
tetng-q4s6r1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: tetng-4neur Colored MSA for Neuroligin (raw)
MKPRRSPSALPPLPSVLSLLPSLLLSCLSLISCPASSSAQQSVPVISTVQ
GRIRGILTPLPSDLLGPVVQYLGVPYARPPTGDRRFQPPEPPLPWPGIRN
VTQFAPVCPQSLDERNILGDMMPSWLTANLDIAATYLTHQSEDCLYLNIY
VPTEEAAVSSFQDIHEEGGQRPVMVFVHGGSYTEGTGNMMDGSVLASYGN
VIVITLNYRLGVLGFLSTGDQSAKGNYGLLDQIQALRWVKENIAAFGGDP
SRVTVFGSGAGASCVSLLTLSHYSEDLFHRAIIQSGSALASWAVNYQPSK
YARQLGERVGCGIDDSSQLVTCLKGRSYRELVEQSITPAKYHTAFAPVID
GDVIPDDPQILMEQGEFLNYDVMLGVNQGEGVKFVEGIVDSEDGVTAEDF
DFAVSDFVDSLYGYPEGRDTLRESIRFMYTDWADRDNAETRRKTLVALFT
DHQWVAPAIATADLHAQYGSPTYFYSFYHHCQSDATPPWADSAHGDEVPY
VFGVPMVGPTDLFNCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTK
FIHTKPNRFEEVAWSKYTPKEQLYLHIGLKPRVRDHYRATKISFWLQLVP
HLHHVNELLQSVSSFTHSPSPQDDTPYSYTKRLAKGWPPSSTRHPGSQGG
TPQPPESALGQGGGESGTRVPNEDYSTELSVTIAVGASLLFLNILAFAAL
LYKKDKRRLEHRRSRPLPPPRRDITAADVAAHLQGEGLMSLQVKQLECDA
ASADERNNAHHHHTLDTLDALDGLDTQDIYSTLDTVRLTCPPDYTLTLRR
SPDDVPLMTSLTPGSLPVT
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M K P R R S P S A L P P L P S V L S L L P S L L L S C L S L I S C P A S S S A Q Q S V P V I S T V Q G R I R G I L T P L P S D L L G P V V Q Y L G V P Y A R P P T G D R R F Q P P E P P L P W P G I R N V T Q F A P V C P Q S L D E R N I L G D M M P S W L T A N L D I A A T Y L T H Q S E D C L Y L N I Y V P T E E A A V S S F Q D I H E E G G Q R P V M V F V H G G S Y T E G T G N M M D G S V L A S Y G N V I V I T L N Y R L G V L G F L S T G D Q S A K G N Y G L L D Q I Q A L R W V K E N I A A F G G D P S R V T V F G S G A G A S C V S L L T L S H Y S E D L F H R A I I Q S G S A L A S W A V N Y Q P S K Y A R Q L G E R V G C G I D D S S Q L V T C L K G R S Y R E L V E Q S I T P A K Y H T A F A P V I D G D V I P D D P Q I L M E Q G E F L N Y D V M L G V N Q G E G V K F V E G I V D S E D G V T A E D F D F A V S D F V D S L Y G Y P E G R D T L R E S I R F M Y T D W A D R D N A E T R R K T L V A L F T D H Q W V A P A I A T A D L H A Q Y G S P T Y F Y S F Y H H C Q S D A T P P W A D S A H G D E V P Y V F G V P M V G P T D L F N C N F S K N D V M L S A V V M T Y W T N F A K T G D P N Q P V P Q D T K F I H T K P N R F E E V A W S K Y T P K E Q L Y L H I G L K P R V R D H Y R A T K I S F W L Q L V P H L H H V N E L L Q S V S S F T H S P S P Q D D T P Y S Y T K R L A K G W P P S S T R H P G S Q G G T P Q P P E S A L G Q G G G E S G T R V P N E D Y S T E L S V T I A V G A S L L F L N I L A F A A L L Y K K D K R R L E H R R S R P L P P P R R D I T A A D V A A H L Q G E G L M S L Q V K Q L E C D A A S A D E R N N A H H H H T L D T L D A L D G L D T Q D I Y S T L D T V R L T C P P D Y T L T L R R S P D D V P L M T S L T P G S L P V T
References
Title: Characterization of the neuroligin gene family expression and evolution in zebrafishRissone A , Sangiorgio L , Monopoli M , Beltrame M , Zucchi I , Bussolino F , Arese M , Cotelli F Ref: Developmental Dynamics, 239 :688, 2010 : PubMed Abstract ESTHER: Rissone_2010_Dev.Dyn_239_688 PubMedSearch: Rissone 2010 Dev.Dyn 239 688 PubMedID: 20034102 Gene_locus related to this paper: anoca-d2x2h9 ,
anoca-nlgn2 ,
anoca-nlgn4 ,
chick-d3wgl5 ,
chick-nlgn1 ,
chick-NLGN3 ,
ciosa-d2x2f8 ,
danre-1neur ,
danre-32neur ,
danre-d2x2g1 ,
danre-d2x2g3 ,
danre-d2x2g5 ,
danre-nlgn2a ,
danre-nlgn4a ,
gasac-d2x2j3 ,
gasac-d2x2j4 ,
gasac-nlgn2a ,
gasac-nlgn2b ,
gasac-nlgn4 ,
human-NLGN1 ,
human-NLGN3 ,
mondo-d2x2i6 ,
mondo-d2x2i8 ,
mondo-d2x2i9 ,
oryla-d2x2i4 ,
oryla-d2x2i5 ,
oryla-nlgn2 ,
takru-1neur ,
takru-2bneur ,
takru-3bneur ,
takru-nlgn2a ,
takru-nlgn3a ,
takru-nlgn4a ,
tetng-3neur ,
tetng-4neur ,
tetng-nlgn2b ,
tetng-nlgn2a ,
tetng-nlgn3b ,
xentr-d2x2k4 ,
xentr-d2x2k6 ,
xentr-d2x2k7 Abstract
Neuroligins constitute a family of transmembrane proteins localized at the postsynaptic side of both excitatory and inhibitory synapses of the central nervous system. They are involved in synaptic function and maturation and recent studies have linked mutations in specific human Neuroligins to mental retardation and autism. We isolated the human Neuroligin homologs in Danio rerio. Next, we studied their gene structures and we reconstructed the evolution of the Neuroligin genes across vertebrate phyla. Using reverse-transcriptase polymerase chain reaction, we analyzed the expression and alternative splicing pattern of each gene during zebrafish embryonic development and in different adult organs. By in situ hybridization, we analyzed the temporal and spatial expression pattern during embryonic development and larval stages and we found that zebrafish Neuroligins are expressed throughout the nervous system. Globally, our results indicate that, during evolution, specific subfunctionalization events occurred within paralogous members of this gene family in zebrafish.
Title: Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotypeJaillon O , Aury JM , Brunet F , Petit JL , Stange-Thomann N , Mauceli E , Bouneau L , Fischer C , Ozouf-Costaz C and Roest Crollius H <51 more author(s)> Jaillon O , Aury JM , Brunet F , Petit JL , Stange-Thomann N , Mauceli E , Bouneau L , Fischer C , Ozouf-Costaz C , Bernot A , Nicaud S , Jaffe D , Fisher S , Lutfalla G , Dossat C , Segurens B , Dasilva C , Salanoubat M , Levy M , Boudet N , Castellano S , Anthouard V , Jubin C , Castelli V , Katinka M , Vacherie B , Biemont C , Skalli Z , Cattolico L , Poulain J , de Berardinis V , Cruaud C , Duprat S , Brottier P , Coutanceau JP , Gouzy J , Parra G , Lardier G , Chapple C , McKernan KJ , McEwan P , Bosak S , Kellis M , Volff JN , Guigo R , Zody MC , Mesirov J , Lindblad-Toh K , Birren B , Nusbaum C , Kahn D , Robinson-Rechavi M , Laudet V , Schachter V , Quetier F , Saurin W , Scarpelli C , Wincker P , Lander ES , Weissenbach J , Roest Crollius H (- 51) Ref: Nature, 431 :946, 2004 : PubMed Abstract ESTHER: Jaillon_2004_Nature_431_946 PubMedSearch: Jaillon 2004 Nature 431 946 PubMedID: 15496914 Gene_locus related to this paper: tetng-3neur ,
tetng-4neur ,
tetng-ACHE ,
tetng-BCHE ,
tetng-h3cfz4 ,
tetng-h3ci57 ,
tetng-h3cl30 ,
tetng-h3cnh2 ,
tetng-nlgn2b ,
tetng-h3czr1 ,
tetng-h3dbr5 ,
tetng-nlgn2a ,
tetng-nlgn3b ,
tetng-q4ref8 ,
tetng-q4rjp3 ,
tetng-q4rjy3 ,
tetng-q4rk53 ,
tetng-q4rk63 ,
tetng-q4rk66 ,
tetng-q4rkk3 ,
tetng-q4rli3 ,
tetng-q4rn09 ,
tetng-q4rqj4 ,
tetng-q4rqz6 ,
tetng-q4rr22 ,
tetng-q4rru9 ,
tetng-q4rtq6 ,
tetng-q4rvf8 ,
tetng-q4rwa0 ,
tetng-q4rx90 ,
tetng-q4ryv8 ,
tetng-q4ryz3 ,
tetng-q4s0h8 ,
tetng-q4s5x0 ,
tetng-q4s6r1 ,
tetng-q4s6t6 ,
tetng-q4s7e3 ,
tetng-q4s7x6 ,
tetng-q4s8t5 ,
tetng-q4s9w9 ,
tetng-q4s050 ,
tetng-q4s091 ,
tetng-q4s144 ,
tetng-q4s309 ,
tetng-q4s578 ,
tetng-q4sal4 ,
tetng-q4sbm6 ,
tetng-q4sbp0 ,
tetng-q4sbu0 ,
tetng-q4sd49 ,
tetng-q4ser6 ,
tetng-q4sfm7 ,
tetng-q4sgm5 ,
tetng-q4sgv2 ,
tetng-q4sh74 ,
tetng-q4shl7 ,
tetng-q4si60 ,
tetng-q4sie5 ,
tetng-q4sku6 ,
tetng-q4smu0 ,
tetng-q4smy3 ,
tetng-q4snp0 ,
tetng-q4snq3 ,
tetng-q4spa7 ,
tetng-q4spq0 ,
tetng-q4sqr3 ,
tetng-q4sty0 ,
tetng-q4suu2 ,
tetng-q4suz1 ,
tetng-q4sxh3 ,
tetng-q4syn6 ,
tetng-q4szk0 ,
tetng-q4szy0 ,
tetng-q4t3m9 ,
tetng-q4t4a1 ,
tetng-q4t6m1 ,
tetng-q4t7r6 ,
tetng-q4t173 ,
tetng-q4t826 ,
tetng-q4t920 ,
tetng-q4ta33 ,
tetng-q4tab8 ,
tetng-q4tb62 ,
tetng-q4tbe2 ,
tetng-h3dbw2 ,
tetng-h3cpc8 ,
tetng-h3cjy0 ,
tetng-h3d966 ,
tetng-h3d3e3 ,
tetng-h3d961 ,
tetng-h3ctg6 ,
tetng-h3dde8 ,
tetng-h3dde9 ,
tetng-h3det9 ,
tetng-h3cre8 ,
tetng-h3dfb4 ,
tetng-h3clj8 Abstract
Tetraodon nigroviridis is a freshwater puffer fish with the smallest known vertebrate genome. Here, we report a draft genome sequence with long-range linkage and substantial anchoring to the 21 Tetraodon chromosomes. Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish. Comparison with other vertebrates and a urochordate indicates that fish proteins have diverged markedly faster than their mammalian homologues. Comparison with the human genome suggests approximately 900 previously unannotated human genes. Analysis of the Tetraodon and human genomes shows that whole-genome duplication occurred in the teleost fish lineage, subsequent to its divergence from mammals. The analysis also makes it possible to infer the basic structure of the ancestral bony vertebrate genome, which was composed of 12 chromosomes, and to reconstruct much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype.
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