Gene_locus Report for: trycr-q4e4t5 Trypanosoma cruzi bem46-like serine peptidase, putative
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Euglenozoa: N E > Kinetoplastida: N E > Trypanosomatidae: N E > Trypanosoma: N E > Schizotrypanum: N E > Trypanosoma cruzi: N E 6_AlphaBeta_hydrolase :
trycr-q4cq94 Trypanosoma cruzi hydrolase-like protein (fragment) ,
trycr-q4cq96 Trypanosoma cruzi hypothetical protein ,
trycr-q4d8h8 Trypanosoma cruzi hydrolase-like protein, putative ,
trycr-q4dhv2 Trypanosoma cruzi Putative uncharacterized protein .
ABHD17-depalmitoylase :
trycr-q4dbn1 Trypanosoma cruzi serine peptidase, putative ,
trycr-q4dzp6 Trypanosoma cruzi serine peptidase, putative .
abh_upf0017 :
trycr-q4dpt2 Trypanosoma cruzi Putative uncharacterized protein ,
trycr-q4dpy4 Trypanosoma cruzi Putative uncharacterized protein ,
trycr-q4e3m8 Trypanosoma cruzi hypothetical protein .
Aclacinomycin-methylesterase_RdmC :
trycr-q4cq95 Trypanosoma cruzi hydrolase, alpha/beta fold family, putative ,
trycr-q4d8h9 Trypanosoma cruzi hydrolase, alpha/beta fold family, putative ,
trycr-q4d8i0 Trypanosoma cruzi hydrolase-like protein, putative .
AlphaBeta_hydrolase :
trycr-q4dhn8 Trypanosoma cruzi hypothetical protein .
Carboxypeptidase_S10 :
trycr-q6y3z8 Trypanosoma cruzi serine carboxypeptidase precursor (EC 3.4.16.5) .
Cocaine_esterase :
trycr-q4de42 Trypanosoma cruzi dipeptidyl-peptidase, putative .
DPP4N_Peptidase_S9 :
trycr-q4cx66 Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase, putative .
Duf_676 :
trycr-q4cxr6 Trypanosoma cruzi hypothetical protein ,
trycr-q4cyf6 Trypanosoma cruzi hypothetical protein ,
trycr-q4d1s2 Trypanosoma cruzi hypothetical protein ,
trycr-q4dbm2 Trypanosoma cruzi hypothetical protein .
Duf_726 :
trycr-q4czy3 Trypanosoma cruzi Putative uncharacterized protein .
FSH1 :
trycr-q4dab1 Trypanosoma cruzi hypothetical protein (fragment) .
Fusarinine_C_esterase_sidJ :
trycr-q4dry8 Trypanosoma cruzi. hypothetical protein .
LIDHydrolase :
trycr-q4dp03 Trypanosoma cruzi Putative uncharacterized protein ,
trycr-q4dvl8 Trypanosoma cruzi Putative uncharacterized protein .
Lipase_3 :
trycr-q4cq28 Trypanosoma cruzi lipase, putative ,
trycr-q4cqq5 Trypanosoma cruzi lipase, putative ,
trycr-q4cwv3 Trypanosoma cruzi hypothetical protein ,
trycr-q4cyc3 Trypanosoma cruzi lipase, putative ,
trycr-q4cyc5 Trypanosoma cruzi lipase, putative ,
trycr-q4d2n1 Trypanosoma cruzi hypothetical protein ,
trycr-q4d3a2 Trypanosoma cruzi class 3 lipase, putative (fragment) ,
trycr-q4d3y4 Trypanosoma cruzi class 3 lipase, putative ,
trycr-q4dap6 Trypanosoma cruzi lipase, putative ,
trycr-q4dap7 Trypanosoma cruzi lipase, putative ,
trycr-q4ddw7 Trypanosoma cruzi lipase, putative ,
trycr-q4dkk8 Trypanosoma cruzi lipase domain protein, putative ,
trycr-q4dkk9 Trypanosoma cruzi lipase domain protein, putative ,
trycr-q4dwm3 Trypanosoma cruzi hypothetical protein ,
trycr-q4e5d1 Trypanosoma cruzi hypothetical protein .
LYsophospholipase_carboxylesterase :
trycr-q4da08 Trypanosoma cruzi lysophospholipase, putative ,
trycr-q4dy82 Trypanosoma cruzi lysophospholipase, putative .
Monoglyceridelipase_lysophospholip :
trycr-q4csm0 Trypanosoma cruzi monoglyceride lipase, putative .
PAF-Acetylhydrolase :
trycr-q4dvp1 Trypanosoma cruzi phospholipase a2-like protein, putative ,
trycr-q4dvp2 Trypanosoma cruzi phospholipase a2-like protein, putative .
PC-sterol_acyltransferase :
trycr-q4dqa6 Trypanosoma cruzi (EC 2.3.1.158) .
PGAP1 :
trycr-q4d3x3 Trypanosoma cruzi hypothetical protein ,
trycr-q4d975 Trypanosoma cruzi hypothetical protein ,
trycr-q4dt91 Trypanosoma cruzi hypothetical protein ,
trycr-q4e5z2 Trypanosoma cruzi hypothetical protein .
PPase_methylesterase_euk :
trycr-q4dy49 Trypanosoma cruzi hypothetical protein .
Prolylcarboxypeptidase :
trycr-q4dm56 Trypanosoma cruzi serine carboxypeptidase s28, putative ,
trycr-q4dw34 Trypanosoma cruzi serine carboxypeptidase s28, putative .
S9N_PPCE_Peptidase_S9 :
trycr-TCPO Trypanosoma cruzi Trypanosoma cruzi 80 kDa prolyl oligopeptidase (TCPO) mRNA, (EC 3.4.21.26) .
S9N_PREPL_Peptidase_S9 :
trycr-q4d6h1 Trypanosoma cruzi oligopeptidase b, putative (EC 3.4.21.83) ,
trycr-q4d786 Trypanosoma cruzi oligopeptidase b-like protein, putative ,
trycr-Q94795 Trypanosoma cruzi peptidase A, oligopeptidase b, putative (EC 3.4.21.83) Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Trypanosoma cruzi marinkellei:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: trycr-q4e4t5 Colored MSA for ABHD13-BEM46 (raw)
MSVVETLVACGFWFCIFVVLFSLLLIVVSYQLREKQNRLLYHPGIPAEST
LICENPMDRGFANAENVHIRTADGVTLRGFIMWPWPGQHAAQQGATTGAF
RSQGSGMNVGIPLSSSSTTLRDSLFPSPLYAVIYFHGNSGNAGHRIPIAE
LLTSKNPCAVLMVDYRGFGLSDAVPPTEEGLKLDAQACLEYLWNHPRIPQ
GRIFVMGTSLGGAVAIDLASRRMNMKRIAGVIIENTFTSISDMASVLVRT
ILRQFLTSYTEILFSVFDYYMKPLCLRIGWRNIDLVKRIRVPLLFLSGKS
DELVPPSQMQRLYAATSKSNVMRKFVEFAEGTHNTLPLMGGYSEVIDLFV
QEVLRLEAELV
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M S V V E T L V A C G F W F C I F V V L F S L L L I V V S Y Q L R E K Q N R L L Y H P G I P A E S T L I C E N P M D R G F A N A E N V H I R T A D G V T L R G F I M W P W P G Q H A A Q Q G A T T G A F R S Q G S G M N V G I P L S S S S T T L R D S L F P S P L Y A V I Y F H G N S G N A G H R I P I A E L L T S K N P C A V L M V D Y R G F G L S D A V P P T E E G L K L D A Q A C L E Y L W N H P R I P Q G R I F V M G T S L G G A V A I D L A S R R M N M K R I A G V I I E N T F T S I S D M A S V L V R T I L R Q F L T S Y T E I L F S V F D Y Y M K P L C L R I G W R N I D L V K R I R V P L L F L S G K S D E L V P P S Q M Q R L Y A A T S K S N V M R K F V E F A E G T H N T L P L M G G Y S E V I D L F V Q E V L R L E A E L V
References
Title: The genome of the African trypanosome Trypanosoma bruceiBerriman M , Ghedin E , Hertz-Fowler C , Blandin G , Renauld H , Bartholomeu DC , Lennard NJ , Caler E , Hamlin NE and El-Sayed NM <92 more author(s)> Berriman M , Ghedin E , Hertz-Fowler C , Blandin G , Renauld H , Bartholomeu DC , Lennard NJ , Caler E , Hamlin NE , Haas B , Bohme U , Hannick L , Aslett MA , Shallom J , Marcello L , Hou L , Wickstead B , Alsmark UC , Arrowsmith C , Atkin RJ , Barron AJ , Bringaud F , Brooks K , Carrington M , Cherevach I , Chillingworth TJ , Churcher C , Clark LN , Corton CH , Cronin A , Davies RM , Doggett J , Djikeng A , Feldblyum T , Field MC , Fraser A , Goodhead I , Hance Z , Harper D , Harris BR , Hauser H , Hostetler J , Ivens A , Jagels K , Johnson D , Johnson J , Jones K , Kerhornou AX , Koo H , Larke N , Landfear S , Larkin C , Leech V , Line A , Lord A , MacLeod A , Mooney PJ , Moule S , Martin DM , Morgan GW , Mungall K , Norbertczak H , Ormond D , Pai G , Peacock CS , Peterson J , Quail MA , Rabbinowitsch E , Rajandream MA , Reitter C , Salzberg SL , Sanders M , Schobel S , Sharp S , Simmonds M , Simpson AJ , Tallon L , Turner CM , Tait A , Tivey AR , Van Aken S , Walker D , Wanless D , Wang S , White B , White O , Whitehead S , Woodward J , Wortman J , Adams MD , Embley TM , Gull K , Ullu E , Barry JD , Fairlamb AH , Opperdoes F , Barrell BG , Donelson JE , Hall N , Fraser CM , Melville SE , El-Sayed NM (- 92) Ref: Science, 309 :416, 2005 : PubMed Abstract ESTHER: Berriman_2005_Science_309_416 PubMedSearch: Berriman 2005 Science 309 416 PubMedID: 16020726 Gene_locus related to this paper: tryb2-q6h9e3 ,
tryb2-q6ha27 ,
tryb2-q38cd5 ,
tryb2-q38cd6 ,
tryb2-q38cd7 ,
tryb2-q38dc1 ,
tryb2-q38de4 ,
tryb2-q38ds6 ,
tryb2-q38dx1 ,
tryb2-q380z6 ,
tryb2-q382c1 ,
tryb2-q382l4 ,
tryb2-q383a9 ,
tryb2-q386e3 ,
tryb2-q387r7 ,
tryb2-q388n1 ,
tryb2-q389w3 ,
trybr-PEPTB ,
trycr-q4cq28 ,
trycr-q4cq94 ,
trycr-q4cq95 ,
trycr-q4cq96 ,
trycr-q4csm0 ,
trycr-q4cwv3 ,
trycr-q4cx66 ,
trycr-q4cxr6 ,
trycr-q4cyc5 ,
trycr-q4cyf6 ,
trycr-q4d3a2 ,
trycr-q4d3x3 ,
trycr-q4d3y4 ,
trycr-q4d6h1 ,
trycr-q4d8h8 ,
trycr-q4d8h9 ,
trycr-q4d8i0 ,
trycr-q4d786 ,
trycr-q4d975 ,
trycr-q4da08 ,
trycr-q4dap6 ,
trycr-q4dbm2 ,
trycr-q4dbn1 ,
trycr-q4ddw7 ,
trycr-q4de42 ,
trycr-q4dhn8 ,
trycr-q4dkk8 ,
trycr-q4dkk9 ,
trycr-q4dm56 ,
trycr-q4dqa6 ,
trycr-q4dt91 ,
trycr-q4dvp2 ,
trycr-q4dw34 ,
trycr-q4dwm3 ,
trycr-q4dy49 ,
trycr-q4dy82 ,
trycr-q4dzp6 ,
trycr-q4e3m8 ,
trycr-q4e4t5 ,
trycr-q4e5d1 ,
trycr-q4e5z2 Abstract
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei. The 26-megabase genome contains 9068 predicted genes, including approximately 900 pseudogenes and approximately 1700 T. brucei-specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination. Comparisons of the cytoskeleton and endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences. A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.
Title: The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas diseaseEl-Sayed NM , Myler PJ , Bartholomeu DC , Nilsson D , Aggarwal G , Tran AN , Ghedin E , Worthey EA , Delcher AL and Andersson B <72 more author(s)> El-Sayed NM , Myler PJ , Bartholomeu DC , Nilsson D , Aggarwal G , Tran AN , Ghedin E , Worthey EA , Delcher AL , Blandin G , Westenberger SJ , Caler E , Cerqueira GC , Branche C , Haas B , Anupama A , Arner E , Aslund L , Attipoe P , Bontempi E , Bringaud F , Burton P , Cadag E , Campbell DA , Carrington M , Crabtree J , Darban H , da Silveira JF , de Jong P , Edwards K , Englund PT , Fazelina G , Feldblyum T , Ferella M , Frasch AC , Gull K , Horn D , Hou L , Huang Y , Kindlund E , Klingbeil M , Kluge S , Koo H , Lacerda D , Levin MJ , Lorenzi H , Louie T , Machado CR , McCulloch R , McKenna A , Mizuno Y , Mottram JC , Nelson S , Ochaya S , Osoegawa K , Pai G , Parsons M , Pentony M , Pettersson U , Pop M , Ramirez JL , Rinta J , Robertson L , Salzberg SL , Sanchez DO , Seyler A , Sharma R , Shetty J , Simpson AJ , Sisk E , Tammi MT , Tarleton R , Teixeira S , Van Aken S , Vogt C , Ward PN , Wickstead B , Wortman J , White O , Fraser CM , Stuart KD , Andersson B (- 72) Ref: Science, 309 :409, 2005 : PubMed Abstract ESTHER: El-Sayed_2005_Science_309_409 PubMedSearch: El-Sayed 2005 Science 309 409 PubMedID: 16020725 Gene_locus related to this paper: tryb2-q6h9e3 ,
tryb2-q6ha27 ,
tryb2-q38cd5 ,
tryb2-q38cd6 ,
tryb2-q38cd7 ,
tryb2-q38dc1 ,
tryb2-q38de4 ,
tryb2-q38ds6 ,
tryb2-q38dx1 ,
tryb2-q380z6 ,
tryb2-q382l4 ,
tryb2-q383a9 ,
tryb2-q386e3 ,
tryb2-q387r7 ,
tryb2-q388n1 ,
tryb2-q389w3 ,
trybr-PEPTB ,
trycr-q4cq28 ,
trycr-q4cq94 ,
trycr-q4cq95 ,
trycr-q4cq96 ,
trycr-q4cqq5 ,
trycr-q4csm0 ,
trycr-q4cwv3 ,
trycr-q4cx66 ,
trycr-q4cxr6 ,
trycr-q4cyc3 ,
trycr-q4cyc5 ,
trycr-q4cyf6 ,
trycr-q4czy3 ,
trycr-q4d1s2 ,
trycr-q4d2n1 ,
trycr-q4d3a2 ,
trycr-q4d3x3 ,
trycr-q4d3y4 ,
trycr-q4d6h1 ,
trycr-q4d8h8 ,
trycr-q4d8h9 ,
trycr-q4d8i0 ,
trycr-q4d786 ,
trycr-q4d975 ,
trycr-q4da08 ,
trycr-q4dab1 ,
trycr-q4dap6 ,
trycr-q4dap7 ,
trycr-q4dbm2 ,
trycr-q4dbn1 ,
trycr-q4ddw7 ,
trycr-q4de42 ,
trycr-q4dhn8 ,
trycr-q4dkk8 ,
trycr-q4dkk9 ,
trycr-q4dm56 ,
trycr-q4dp03 ,
trycr-q4dqa6 ,
trycr-q4dry8 ,
trycr-q4dt91 ,
trycr-q4dvl8 ,
trycr-q4dvp1 ,
trycr-q4dvp2 ,
trycr-q4dw34 ,
trycr-q4dwm3 ,
trycr-q4dy49 ,
trycr-q4dy82 ,
trycr-q4dzp6 ,
trycr-q4e3m8 ,
trycr-q4e4t5 ,
trycr-q4e5d1 ,
trycr-q4e5z2 ,
trycr-q6y3z8 ,
trycr-Q94795 ,
trycr-TCPO Abstract
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Other Papers
