(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Proteobacteria: NE > Gammaproteobacteria: NE > Enterobacterales: NE > Yersiniaceae: NE > Yersinia: NE > Yersinia enterocolitica: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Yersinia enterocolitica subsp. enterocolitica 8081: N, E.
Yersinia enterocolitica LC20: N, E.
Yersinia enterocolitica subsp. palearctica Y11: N, E.
Yersinia enterocolitica subsp. palearctica PhRBD_Ye1: N, E.
Yersinia enterocolitica subsp. palearctica 105.5R(r): N, E.
Yersinia enterocolitica W22703: N, E.
Yersinia enterocolitica (type O:9) str. YE56/03: N, E.
Yersinia enterocolitica subsp. palearctica YE-149: N, E.
Yersinia enterocolitica (type O:5) str. YE53/03: N, E.
Yersinia enterocolitica subsp. palearctica YE-P1: N, E.
Yersinia enterocolitica IP 10393: N, E.
Yersinia enterocolitica (type O:5,27) str. YE149/02: N, E.
Yersinia enterocolitica subsp. palearctica YE-P4: N, E.
Yersinia enterocolitica (type O:3) str. YE12/03: N, E.
Yersinia enterocolitica (type O:9) str. YE212/02: N, E.
Yersinia enterocolitica (type O:2) str. YE3094/96: N, E.
Yersinia enterocolitica subsp. palearctica YE-150: N, E.
Yersinia enterocolitica subsp. enterocolitica WA-314: N, E.
Yersinia intermedia ATCC 29909: N, E.
Yersinia intermedia: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MNAGLLVYTAITAILATTLTCTAVQASPVTYQKAAITESNLPVFYPQLKK QMTYQSSWLAGKYTDFALWKSDTRKILRQALLTPDSTIAFSAEKIDQQER GSYIAEKIVFNITDESRVQGLLLTPKSKGPHPAIVLLHDHGSKFDIGKEK MIRPWGDSVQLASAQAWSDKFFSGKFIGDELAKRGYVVLSIDAIGWGDRG PISYEQQQAVASNFFNLGRSLAGTMAYEDMRTVDFLATLPSVDPQRIGIV GFSMGAYRAWQLAALSDKVAATAAISWFGNYQGLMTLGNNVLRGQSAFYM LHPGIANKLDFPDIASLAAPKPMLLFNGGKDKLFPSDAVQEAYNKVHAIW RSQNAESRLVTRNWPALGHVFYQEQQDVVFPWLDRWLKP
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is a key step in our understanding of the genetic basis for this pathogenicity spectrum. Here we report the genome of Y. enterocolitica strain 8081 (serotype 0:8; biotype 1B) and extensive microarray data relating to the genetic diversity of the Y. enterocolitica species. Our analysis reveals that the genome of Y. enterocolitica strain 8081 is a patchwork of horizontally acquired genetic loci, including a plasticity zone of 199 kb containing an extraordinarily high density of virulence genes. Microarray analysis has provided insights into species-specific Y. enterocolitica gene functions and the intraspecies differences between the high, low, and nonpathogenic Y. enterocolitica biotypes. Through comparative genome sequence analysis we provide new information on the evolution of the Yersinia. We identify numerous loci that represent ancestral clusters of genes potentially important in enteric survival and pathogenesis, which have been lost or are in the process of being lost, in the other sequenced Yersinia lineages. Our analysis also highlights large metabolic operons in Y. enterocolitica that are absent in the related enteropathogen, Yersinia pseudotuberculosis, indicating major differences in niche and nutrients used within the mammalian gut. These include clusters directing, the production of hydrogenases, tetrathionate respiration, cobalamin synthesis, and propanediol utilisation. Along with ancestral gene clusters, the genome of Y. enterocolitica has revealed species-specific and enteropathogen-specific loci. This has provided important insights into the pathology of this bacterium and, more broadly, into the evolution of the genus. Moreover, wider investigations looking at the patterns of gene loss and gain in the Yersinia have highlighted common themes in the genome evolution of other human enteropathogens.
