Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....
9bact-q1m315   	----------MLLIRIRL---------AAVYSPSMLGCTTA-----PNTLAVNTTQKIIQYERSKSDLEVKSLTLASGDKMVYAENDN-----VTGEPILLIHGLGGNKDNFTRIADKL--EGYHLIIPDLLGFGNSSKPMTADYRADAQATRLHELMQAKGLAS-NTHVGGNSMGGAISVAYAAKYPKEIKSLWLVDTAGFWSAGVPKSLEGAT-------LENNPLLI-NSKEDFYKMY-DFVMYKPPYIPKSVKAVFAQERINNKALDTKILEQIVTDN------VGER----AKIIAKFNIPTLVVWGDKDQVIKPETTELITEIIPQALV-MMMNDVAHVPMVEAVQDTASDYQAYGDAPKE-------------     =====>
9bact-q5i686   	--------MELLVGSIGLVFLTILIVLLCIAVAFYLIA------------PGLLLDSFLALGRWHAGLKRRESTLDM-VNWVWLDSGGE------GDVIVLIHGFAAHKYGWLQVASRLRGRGYRLIIPDLPGFGENQVSADISYSVLEQAQRLQTFLASLGIN--RFHAVGHSMGGYVAGACAFIDSDMLLSLYLVAPAGITVEGEPIDLSEKG--------KKNNLFIIETVEQFQEVM-AIAMANPPKLPRRIVESMVARELTMRKLREKQNEVW---------DSPSL----QRLLSNCSIPLRMLWGERDRMLSVDRAALIVEAVPMASI-RYLPDIAHVIPQEAPSVMVRDYLISLLLSH--------------     =====>
9brad-q35a75   	-----------MLIVVFVAAVA---GILLAIAFLNFIVP------------EFTARQLLALRLRIMGFADKRLSIRG-INIAYWE--AGS-----GEPLVLLHGMGVDRGTLLDVAGKLT-GHYRVILPDLPGFGDSDKPERADYGISAQVDNLREIIKALGLH--RVHLGGHSMGGWISAGFAASSPEMVESLWLISAAGTSELDHSLPMEAFR-------RGEYVLCC-RSPSELRGVM-HLAMFKLPRLPYCVWQALGRRAAANYALHTRIFARIMQDI-----SGYNL----EERLPKITAPTLIVFGDSDRLVPPSVLRTFKRLIPNSRS-ILLKNVGHVPQMEAVDRCASDYLAFRQSQEATGR----------     =====>
9delt-q0ym59   	----------MFIKRVV---GG---LLALVVMMGLGGCD-----------KRSLFQSIMNRERESAKLTVKMENLPY-GKVVYLTN-GPA--AGSEPPIVMLHGFGGEKDNWNRFSKELT-DEYRVIIPDLPGHGESVQDSGLNYGIDEQAKRLKQFLDALGVK--KAHLVGNSMGGAIALRYAYLYPQSVASLGLFAAAGVEQT-VADFHTAMKA------TGKNPLLEIQNAKDFEDVMSRYVFVDPPYIPGFIVDILVEEKLKRRALEKKMFVELMADM--------DQ----TSILSSINSPTLILWGSQDKILHVDNAELFRTKLAGSRK-EIIDGVGHCPMIEKPEVAREAYRKFLQETAPQGKRAGI------     =====>
9gamm-q1n052   	------------MKIL----IK---TAAIISLSLLTACA---------SIENSIFDLAISVERSFANLQEKRIKLEE-HEWVYLE--ANA--DEGKETVLLLHGFAAEKDNWTRMADSL--EDYHVIAPDLPGHGESSFDSDLFYGFDVQSLRLARFVDALGLK--QFHIVGNSMGGGIAALYAYRHPHRILSLGLIDAVGFYGNEPSDLEIVLEK------NLDNPLIV-ESKDDFDRLI-EYAMHQPPFMPWPAKSVLTRKAMNRTEANKHIFEHIHKEA-----EAAKFAGGFVHVFEQLDMPTLVLWGEKDRVLDVSSVDKFFQHTPNVEV-NVLLDIGHAPMLEVPQQTALILQDFWQRHTDSKAKLASNTNE--     =====>
9gamm-q2ktb4   	----------MLLKRLCL---------AAVFSLSMVGCTTA-----PNQLAVNTTQKIIQYERNKSDLDIKALTLASGDKMVYADNGN-----VAGEPLLLIHGFGGNKDNFTRIARQL--EGYHLIIPDLLGFGESSKPMSADYRSEAQATRLHELLQAKGLAS-NIHISGNSMGGAISVAYAAKYLKDVKSLWLGDSAGFWSAGIPKSLEGAT-------LENNPLLI-KSNEDFYKMY-DFVMYKPPYLPKSVKAVFAQERIKNKELDAKILEQIVTDN------VEER----AKIIAQYNIPTLVVWGDKDQIIKPETVNLIKKIIPQAQV-IRMPEIGHVPMIEAVEQTADDYKAFRRILEAQR-----------     =====>
9sphn-q3v9n8   	------------MKILLFLIV----APLIALALLYFLFP------------EQLVRMMRALMRKRARVVRRSITVDG-RNWPYLE--GGD--PSK-PTLVMVHGFGADKDHWIFYAPWMT-RDYHLIAPDLPGFGENDRDGALPFDVASQAARLKAFLDALGVD--RPHLGGNSMGGWIALRFAIDYPDRLRTLTLMNNAGVVGENESELQKLAAT------RDYNPLVL-ANLDDADRLI-AFVVRKPTYVPARLKPVIYADALRHRELLDRIFWIIADEM-----EQAPL----NGELDKVTVPTLILWGRHDKLIDVSCVAVLEKGIANSRA-HIFEHVAHVPMIEDPKATAEVQRAFLADHP--------------     =====>
aciad-q6fd56   	------------MKRIFA-------NLYLSCSLLLPITTTIIYSPAISAASGIDIQNVLQQERAWAGLQTKHLKVGD-IEWVYSE--SGN---SSKPTIILIHGLAGSRDNWNRVAYNLT-PYYHVIIPDLPAHGDTKIPNDFDLSIPNLTEKLRRFAEAGHFEK-NVHIAGHSMGGAIALLYTAQYPLETKSLLLVDSAGVFKTANTPYLKDPN--------LLNNLVV-KKTGDFDKLF-KLATASPPFIPVELKTEQEKLMIAQSKNTQKMVDQLVAMS------KIYTPDTFAIATKSIDVPTYIIWGDQDKIINVEAAQELKSLLKNAETPYILKGVGHMPILEADQLVSQQYLIFLNKQP--------------     =====>
bovin-q1lz86   	--M------DLDVVNMFVIAGGTLALPILAFVASFLLWP------------SALIRIYYWYWRRTLGMQVRYVRHED-YQFCYSFRGRP----GHKPSILMLHGFSAHKDMWLSMVKFLP-KNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGHVAGVYAAHYPSDVCSLSLVCPAGLQYSTDNKFVQRLKELQESAAVEKIPLIP-TTPKEMSEML-QLCSYVRFKVPQQILQGLVDVRIPHNTFYRKLFLEIVSEK-----SRYSL----HQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANSQV-ELLENCGHSVVMERPRKTAKLLVDFLASVHSTDNSKKLD-----     =====>
hahch-q2sq02   	--------MRMSHSAQFFRAG-----FLVAALTLLSACS---------EIKYGLYELAMDFERSQAGVTPKSLETQG-RHFAYLQ--NQA--APDAETILLLHGFGASKENWLRFIRHLP-ARYHIVAVDLLGHGDSSKDPSIPYDIDDQVGYVRAFTEAAGLT--RFHLMGNSMGGAISSMYAAEYPDTVASLVLIDPAGVYEF-SSELETRLQ-------KGENPLIV-RKPEDFGVLM-DFAMEDKPFIPWPITSVLTEKAIANTAIYDHIFAELVRDR-----HDYDF----KQVLQNVKCPTLVLWGKEDRVINYRNAEVFTRLITNSRK-MIIDGVGHAPMIEAPEKTAEITQIFMRLLEAEKG----------     =====>
human-ABHD6    	--M------DLDVVNMFVIAGGTLAIPILAFVASFLLWP------------SALIRIYYWYWRRTLGMQVRYVHHED-YQFCYSFRGRP----GHKPSILMLHGFSAHKDMWLSVVKFLP-KNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIP-STPEEMSEML-QLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEK-----SRYSL----HQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQV-ELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD-----     =====>
marhy-q36qn4   	------------MPRNTLNLV-----LLLATTLLISACS-----------KQGIYDSAIGWERSSAGLEPEQVTVGE-LEIAYLR--SKE--AVDGDTVVLVHGFGANKDNWTRLAKEFK-GEFNIYAFDLPGHGDSSKPLNIGYRFEDQVGYLNQALAKLGVE--RFHMMGNSMGGAITALYSATHPDQVQTAVLFDPAGIFEY-ESELVDLVL-------EGDNPLIP-KQEGDFDKLL-DFALEKRPFVPWPIFDVMEEKAIANREVNEVIFAAIRDTG-----FEPDF----RNAITNIQAPVLVVWGKLDRVIDYRNADVFVEAIPNARK-AILDDIGHAPMVEAPEESAALFRDFLADRQP-------------     =====>
morsp-3lipa    	----------MLLKRLGL---------AALFSLSMVGCTTA-----PNTLAVNTTQKIIQYERSKSDLEVKSLTLASGDKMVYAENDN-----VTGEPLLLIHGFGGNKDNFTRIADKL--EGYHLIIPDLLGFGNSSKPMTADYRADAQATRLHELMQAKGLAS-NTHVGGNSMGGAISVAYAAKYPKEIKSLWLVDTAGFWSAGVPKSLEGAT-------LENNPLLI-NSKEDFYKMY-DFVMYKPPYIPKSVKAVFAQERINNKALDTKILEQIVTDN------VEER----AKIIAKYNIPTLVVWGDKDQVIKPETTELIKEIIPQAQV-IMMNDVGHVPMVEAVKDTANDYKAFRDGLKK-------------     =====>
mouse-ABHD6    	--M------DLDVVNMFVIAGGTLAIPILAFVASFLLWP------------SALIRIYYWYWRRTLGMQVRYAHHED-YQFCYSFRGRP----GHKPSILMLHGFSAHKGMWLSVVKFLP-KNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCAAGLQYSTDNPFVQRLKELEESAAIQKIPLIP-STPEEMSEML-QLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEK-----SRYSL----HENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQV-EVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN------     =====>
olean-q6a2s8   	MKNTLKSSSRFSLKQL----GT---GALIISSLFFGGCT--------TTQQDNLYTGVMSLARDSAGLEVKTASAGD-VNLTYMERQGSD--KDNAESVILLHGFSADKDNWILFTKEFD-EKYHVIAVDLAGHGDSEQLLTTDYGLIKQAERLDIFLSGLGVN--SFHIAGNSMGGAISAIYSLSHPEKVKSLTLIDAAGVDGDTESEYYKVLA-------EGKNPLIA-TDEASFEYRM-GFTMTQPPFLPWPLRPSLLRKTLARAEINNKIFSDMLKTKERLG--MTNFQQKIEVKMAQHPLPTLIMWGKEDRVLDVSAAAAFKKIIPQATV-HIFPEVGHLPMVEIPSESAKVYEEFLSSIK--------------     =====>
pseae-PA2949   	------------MKRFLLGLVL---LLAVAAGVLYF-------------VPATLLASVRTVERGLAGLSEHSVQVDN-LEIAYLE--GGS--EKN-PTLLLIHGFGADKDNWLRFARPLT-ERYHVVALDLPGFGDSSKPQQASYDVGTQAERVANFAAAIGVR--RLHLAGNSMGGHIAALYAARHPEQVLSLALIDNAGVMPARKSELFEDLE-------RGENPLVV-RQPEDFQKLL-DFVFVQQPPLPAPLKRYLGERAVAASAFNAQIFEQLRQR-------YIPL----EPELPKIEAPTLLLWGDRDRVLDVSSIEVMRPLLKRPSV-VIMENCGHVPMVERPEETAQHYQAFLDGVRNAQVAGR-------     =====>
psef5-q4kej0   	---------------MLVILV----LLLLAALWCYRTYP---------RIGHLLYDASVALEARLYRLQKVPVQIGE-ETLMTYQ--GGP--AQAP-VILLLHGLSADKSIWLRFARHFN-RDYRLLIPDLGGHGETAYAAHQDYRVPAQAQRLLRLLDACGIQ--RVQVIGNSMGGYIAAWLAAHAPQRISGLALFDPAGVEAPETSDLQHLLE-------QGKNPFLV-RSRADFQHFY-SLTMAAPPWVPEAVLAAIAERYQARRGQLARIFAELQ-A-------SPPM----EPELAKIQAPTLLLWGREDRLLHPSSAQVWAKGLPQAQV-QLWEGIGHMPMVERPVRSARLYQQFLERQRH-------------     =====>
psepf-q3kel6   	---------------MLLLFV----ALAVFVAWSWLSYP---------AVGHWLYDLSAALEARLYRLHKIEVPIAE-MTVSTWQ--GGP--YEASSSILMLHGYSAEKNLWLRFARHFV-GQYRVIIPDLAGHGETGFKAGGGYDIPVQAKRMIQLLDVCGVE--KVHVIGNSMGGYIAAWLAATYPDRIASVALIDPAGVTAPEPSDMERHLA-------RGHNPFLI-NSREEFRRFY-AMTMASPPWVPGLVLDAIAQRYEQCRDELEEIFRDFR-A-------SPPM----EPKLPDIKCPALLLWGRKDRLIDVSSVPVWSKGISNLRV-DVWDGVGHMPMVEQPSNTARLYREFLGEHSRQDR----------     =====>
psyck-q1qeu6   	----------MLLKRLGL---------ATLLSFSVVGCTTA-----PNTLAINTTQKIIQYERSKSDLTTQSFTLSSGDKIVYAENGN-----VAGEPLLLVHGFGGNKDNFTRIARQL--ENYNLIIPDLLGFGDSSKPMAADYHSEAQATRLHELLQAKGLAS-SIHVGGNSMGGAISVAYAAKYPKEVKSLWLIDSAGFWSAGVPKSLESAT-------LENNPLLV-DKKEDFYAMY-DFVMSKPPYIPKSVKAVFAQERIANKALESKILAQIVEDN------VEQR----AKVITEYNIPTLVVWGEEDKVIKPETVTLIKEIIPQSQV-ITMPKIGHVPMIEAVKDTANDYKAFREGLKN-------------     =====>
psyim-1lip     	----------MLLKRLCF---------AALFSLSMVGCTNA-----PNALAVNTTQKIIQYERNKSDLEIKSLTLASGDKMVYAENGN-----VAGEPLLLIHGFGGNKDNFTRIARQL--EGYHLIIPDLLGFGESSKPMSADYRSEAQRTRLHELLQAKGLAS-NIHVGGNSMGGAISVAYAAKYPKDVKSLWLVDSAGFWSAGIPKSLEGAT-------LENNPLLI-KSNEDFYKMY-DFVMYKPPYLPKSVKAVFAQERIKNKELDAKILEQIVTDN------VEER----AKIIAQYKIPTLVVWGDKDQIIKPETVNLIKKIIPQAQV-IMMEDVGHVPMVEALDETADNYKAFRSILEAQR-----------     =====>
ratno-q5xi64   	--M------DLDVVNMFVIAGGTLAIPILAFVASFLLWP------------SALIRIYYWYWRRTLGMQVRYVHHED-YQFCYSFRGRP----GHKPSVLMLHGFSAHKDMWLSVVKFLP-KNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGNVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNRFVQRLKELEDSAATQKIPLIP-STPEEMSEML-QLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVSEK-----SRYSL----HENMDKIKVPTQIIWGKQDQVLDVSGADILAKSITNSQV-EVLENCGHSVVMERPRKTAKLVVDFLASVHNPDNNKKLN-----     =====>
sheha-a0zsg8   	-------MVSFFISAF----I----LVLLISLILIYFTP------------LYLYQLLTHTTRYLSGLSRKEITLLE-KRYVYLDNANEHYQINSKPILLMLHGFTANKDNWLQMSLFLK-KKYRIIALDLLGHGESDAPLDADYCIEAQVKRVHLFVSEQKLA--PFHILGSSMGGQIAATYAALFPEEILSVTLFDNAGIDSPIKSDMFQDLAS------NRPNPLIDCTNPIEY---F-NYTFYKSGLIPKSLKQTHLALQAHKKQLHHKIFADFHNN---------DL----LPYLDKIQVPVLIVWGEEDRILDKSALDKICPLLSNVQV-VLLKNIGHLPMVEVPKKSAALFNKFVKQLDVNNEKPLG------     =====>
strsp-Q93MV2   	MMM----RSKSILKQSLK-------AGLFALALSFPFASHAVEN--TIIKDKLSLQSYLLQERVTAGLKTKTLKVDD-IVWSYNE--GGA---VDKPTILLIHGFAGNRDNWNRVAQFLT-PYYHVVIPDLPTNGDTKVPDDFDLSMPNVTERLRRFVEAIHIQD-KLNVAGHSIGGSIATLYAAQYPFDTQSLFLLNSAGIYKNANTNYAKDPQ--------YLKHLIV-SKPGDLDDVM-QRVMQTPIKMPYYLKRAQEKQLITQAEKNSKVIDQLVTLN------RIYTTDSFARVTRNIEAPTLILWGKQDKIINVEVANELKSLLKRAEAPVILNNVGHMPLLEAEQAVAQHYLPFLAKTQKLKNPLADKLIPLN     =====>
tetng-q4rjy3   	MAA------DLEVLNLLVIAGATLAVPILAFVASVLLWP------------SVLVKVYYWYWRRTLGLQVRFADCGG-YRFCYASRGKP----GTRPSILMLHGFSAHKDTWLTVVKYLP-KHLHIVCVDMPGHEGTTRTNTEDYSIHGQVRRIRQFVENVHLNRKPFHLVGTSMGGNVAGVYAACYPADVCSMTLICPDGIRHPQETKFDNHLQDLKQSDYTLNIPLIP-TTVEEMEDMF-RLCSHVRFKIPQQILQGLVDVRQPHNTFYQEVFMEIIEEK-----SRYAL----QEHLHLISAPLQVIWGKQDQVVDISGATVIKEVLPQCKV-DVLENCGHSVVMERPRRTARLILEFII-----------------     =====>
tetng-q4rli3   	-------------MELLMLSGGVLLVLVLALFLAYWLWP------------GVLLKAYNWFWRRRLGLVVRYSYSGG-YRFCYSSRGTPA---GTTPSLLLLHGFSANKDMWLPLVMFLP-RNQHVVCVDMPGHEGTSRTGAEDYSIQGQVSRIHQFVQSIGLDKRPFHLAGGSMGGNVAGVYAATYPQHLSSVTLICPAGLVYPKETEFISRLRNMEPSQQQERIALIP-STLQELEDML-ELCCYNRPRLPRQVMKGLLNNRMSHNSFYKELFREIAGEK-----SRQSL----QDSLHRITAPAQVIWGKEDQVLHVSGATVLQEALANCQV-DLLENCGHSVTLERPRKVANLIADFLSAQNVSGDNTKK------     =====>
vibma-LIP      	-----------MIKKMSFVLV----SIALLLTLLYVITP-----------ISTLFQYMINAERSISGLRLHNLKTDG-LEIEYLR--GGS--G---TPLILLHGFGADKDNWNRASGYLT-ESFDVVAIDLPGFGNSTDNINLDYDVFSQVSRLKKILDILQIK--EFNLAGSSMGGYIAGNFSARYPERVKNLWLISPFGVVGSEKSEMFSAIK-------NGHNPMVLPRTELEFIQLL-DFLFVERPFIPEPIVKHLATKAEKRRELNTKIYEQIHRMKNREAHPESPL----DEVLKNYKGPVLVSWGHKDRVLHVSGAKVLKKIIPQAQI-NIMASVGHLPMIENPKGTANSFLTFALKP---------------     =====>
xenla-Q7SY73   	--M------DIDVLNMFLVAGGTLLVPLLAFMTSFLLWP------------AALIRIYYWYWRRALGMQVKYSSYGN-YKFCYTARGKP----GNKPSVLMLHGFSAHKDMWLGMVKFLP-KNLHLVCVDMPGHEGTSRSALDYYSICGQVKRIHQFVESIGLNKKPFHLVGTSMGGNVAGVYAAQHPTHISSLTLICPAGLMYPIESKFLKQLKVLEKSGDNQRIPLIP-STAGEMEDML-RLCSFVRFKIPQQVLQGLIDERIPHNEFYRKLFLALVDEK-----SRHSL----HENMNKIMAPTQIIWGKQDQVLDVSGAEVLAGSLRGCQV-EILENCGHSVVMERPRKSAKLMTDFLSSLQSTDNHKKHD-----     =====>
xenla-q6gll2   	--M------DLDVLNMFLVAGGTLLVPILAFVTSFLLWP------------AALIKIYYWYWRRALGMQVKFSSYGN-YKFCYTSRGKP----GNKASVLMLHGFSAHKDMWLSVVKFLP-KNLHLVCVDMPGHEGTTRSALDDYSICGQVKRIHQFVESIGLNKRTFHLVGTSMGGNVAGVYAAQHPTDISSLTLICPAGLMYPTESKFLKHLKGLEKSGDDQRILLIP-STAGEMEDML-RLCSFVRFKIPQQVLQGLVDVRIPHNEFYRQLFMALVNEK-----SRHSL----QENMNKIVAPTQIIWGKQDQVLDVSGAEVLAGSIRGCQV-EILENCGHSVVMERPRKSAKLMTDFLSSLQSTENNKKHE-----     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....