ESTHER Database

Home
Search
Tools
Families
Biological
data
Basics on AChE
ESTHER definition
What is up?
Acknowledgments
& disclaimer


MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....900..5....910..5....920..5....930..5....940..5....950..5....960..5....970..5....980..5....990..5....1000.5....1010.5....1020.5....1030.5....1040.5....1050.5....1060.5....1070.5....1080.5....1090.5....1100.5....1110.5....1120.5....1130.5....1140.5....1150.5....1160.5....1170.5....1180.5....1190.5....1200.5....1210.5....1220.5....1230.5....1240.5....1250.5....1260.5....1270.5....1280.5....1290.5....1300.5....1310.5....1320.5....1330.5....1340.5....1350.5....1360.5....1370.5....1380.5....1390.5....1400.5....1410.5....1420.5....1430.5....1440.5....1450.5....1460.5....1470.5....1480.5....1490.5....1500.5....1510.5....1520.5....1530.5....1540.5....1550.5....1560.5....1570.5....1580.5....1590.5....1600.5....1610.5....1620.5....1630.5....1640.5....1650.5....1660.5....1670.5....1680.5....1690.5....1700.5....1710.5....1720.5....1730.5....1740.5....1750.5....1760.5....1770.5....1780.5....1790.5....1800.5....1810.5....1820.5....1830.5....1840.5....1850.5....1860.5....1870.5....1880.5....1890.5....1900.5....1910.5....1920.5....1930.5....1940.5....1950.5....1960.5....1970.5....1980.5....1990.5....2000.5....
9baci-q2auk6   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKM---------------------------------------NEKTYLSIEEIISLPTLSGTNIS------D-----------DGKNV--AFVKKTA---------NWED----------NTYRN--YVWIYE-KDKEQ-S---------------------------------------------------------Y----------------------PLT--DGDIDSTHP----LWSPDSK--------------------------TIAYLSPGGDG------------------------------------------------------------------------ANTNQIFVK-S---I---------------------------------------------------------DGGSKVQ----------I--------TDE-------------------------------------------------------------------------KEGVNTFKREPTGKG----------FYYVAQSKECEEIKK-RKERY--G-----------------------DFHHVG--KEHR--------------------------------------------------------------------------------------------------------------------------------------NNCLYYVEIEK--GIQ----------------------------NDKGERKVSSVY-QLTNGKDFYIHNFDISNDG--------TKVVFMATPSL-------------ND-HMNGDLYILDVEA----------------------------------------E---ELQ-KMNVDKL-----LGGSVCFS-------------------PEGSKICYSASIREKE-------YYRNHIQ---ESTL---------------------------EIY-DMNT--G----------------------------EVIQPLTNFDSTV--MPLQW-----TDKGILIR--WQD----------------KTNYLI--GLLCE-----------------------------------------------------------------------------DGTV--EMLSD--KV--DGF-IMD-----A-SITRDG--RHISYSKAITNETFEIYL----------------------------------------DDKKITDEN--------------SFFK-------GKLKS-------------------------------NREIISW-QSSDGF-EIKGVLSTPVDFDAN-----KKYPLLVVIH---------------GGPAWASFPIFSDCFN--EKYP-IEQFIEKGFIVLEPNYRGSSGYGN--------E--FLKANYRKQGI-ADYDDVISGV-DKLVEQ--GI-ADKDRVGVMGWSNGGYISVFCSTF--------------S-N-----RFKAI-----SVGGGITNWSTHYVNT-DIP---------YFIRMY-------------------LGNTPWND-------------------------PEIYTKTS-P--MTYIKSACTPTLIQHGEKDARIP-TSNAYELYQGLRD-ME--V-D-TELIIFKGMAYSSDQPGVH----VAIMKQNLMWFSHYILGESMKGFRVL--------------------------------     =====>
9baci-q2b4h3   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEMIIDRQRYP-----------------------------------------------------------SPNP--AI----------------------------------------ELSLIT-YTAGGL-KIKGLLAEPKDGE-------IYDGF-LYLR---------------GGIKNVGKVR---------PGR-IVQFASEGFIVFAPFYRGNQGGEG------NED--FAGEDRE---------DAFS-GFRLLQNH--PR-V--DKVHIFGFSRGGVMALLAAIH--------------H-P-----EAASV-----VTWGGVSDMALTYVERKDLR---------RMMKR-------------------VIGGTPVKY-------------------------PERYESRT-P--LYHLEDMGPPVLIIHGAKDHNVS-VEHAYRLEKRLKA-LG--K-P-VESWYFNEYTHYFPP---A-VNRRV-VSDLTAWMKKQAEYC--TIRVD---------------------------------     =====>
9baci-q2b998   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIIMAKNTIASKDLHHLKSAADPQLA------P-----------NGKDC--VYTETVIL---------EEK----------DAYSS--NLYYINTEDQSA-P---------------------------------------------------------V----------------------QWT--FGTWRNHSP----RWSHDGR--------------------------QVAFVSNRS--------------------------------------------------------------------G-K------NQIHILSAA-------------------------------------------------------------GGEARQLT-------------------------------------------------------------------------------------------YCKNGAGNPVWSPDGSR----------IAFTVSLGEGESVNDRE--G---------------------GE----EK---DEKP-------------------------------------------------------------------------------------------------------------------APLEVNKMRYKSDAQGFW-NGKFTHIAIADTDT-----------------------------------------GNIE-QVTEGENDY-SLQSWSPDG--------KHLAVTADLSGD-----------KDFSY-GSDAYLINLETK-------------------------------------------EQEKITQG-T---GYF--GNITWS-------------------PDSRYLGLIGHEREF--E--------NATLSKAWVYDREQ-RE----------------LRCLTADT-DL-----------------LIGDY-----AIG---DFQ-----QGA--VSPGLLW-----SNDNRSFYFIATD---------------NGSTA---VYYG-T---VEG----ELFPA-----------L------------------------------------------------------------L--DR-------QH---VYGLSTGGNN--DRAVVAISKPDHPGDLFLLEITTG----------------------------------KLEQLTAVN-------------SEFLE-------KTGLS-------------------------------AAEPIEFTSA-DGW-GLHGWLMKPAGFEEG-----KKYPLVLEIH---------------GGPHAMYANSY--------FHE-FQVLAAKGYAVLYINPRGSHGYGQ--------K--FVDAVRGDYGG-RDYEDLMDAV-DYVLKE-YSF-IDQDRLGVTGGSYGGFMTNWIIGH---------------TD-----RFKAA-----VTQRSISNWISFYGVS-DIG----YYFTDWQIQA--------------------GL----DD-------------------------IEKLWKHS-P--LAYVDQMNTPLLILHGEKDFRCP-IEQAEQLFISLKH-RK--K-E-TSFVRFPESNHELSRSGKP-SLRISRLDYISGWFDKYL-------------------------------------------     =====>
9deio-q4h703   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHSNPAMPGPESLLALAFPSDPQVS------P-----------DGQRV--VFVLSRIE---------EEDPQRPDPAFARPRYKS--QLWLSGG---GE-A---------------------------------------------------------Q----------------------PLTRGEG--RDSSP----RWSPDGQ--------------------------TLAFVREEG--------------------------------------------------------------------GQK------GQLFLLPLT-------------------------------------------------------------GGEAKRIT-------------------------------------------------------------------------------------------RFRGAVQDVQWSPDGRF----------LTFLSTADDEDRRDERG----------------------------------------------------------------------------------------------------------------------------------------------------------EARVITRPRYRFNGRDWL-PERPARLWRYDVAAEE-----------------------------------------LH-EWLTPDVEV-TGYAWWPDS--------RGVLLVSSRSEE-----------DAAHW-RQEANTLHLDG--------------------------------------------ERTHLTRW-N---SAI--DAVIPH-------------------PDGQRFALVGRPEGK--G--------SPEDHHLFLV--GPDGA----------------WQRLDEGW-DR-----------------PIGNL-----VGG---DCH-----VGA--FPSRPVW-----LD-AETLLVSSTV---------------GGACG---LFRVR----LDG----TVTAQ-----------DH-----------------------------------------------------------D--PQ-------AV---IAAFTARGDG--V--ALIRERADRFPEVE---L-NG------------------------------------LQVTALH-------------RRLP---------FPTR-------------------------------TPRRVTFTNE-LG--EGEGWVLLP---EGE-----GRAPALLSIH---------------GGPHTAYGHAF--------MHE-FQLFAARGYGVCYGNPRGSAGYGQ--------A--WTSAIHGRWGT-VDMADLLAFF-DACLAA-EHR-LDPRRTAVMGGSYGGYMTNWITGH---------------TD-----RFQAA-----ITDRSICNLISFGGTS-DIG----MRFWDDELGL--------------------NFHR-SEG-------------------------ALRLWDMS-P--LKYVENVRTPTLIIHSVLDHRCP-IEQAEQWYTALKL-HG--V-P-VRFVRFPGEDHELSRSGRP-DRRLRRLEEYLEWLEEWVPGAAQQEQRTADTRA----------------------------     =====>
9eury-b7r0h7   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLDFGRN-------AKL---------LYEKSRFT---SVVFI-----ARGLSVKDLGKFKLVGNLDA-------------------FRRKV--VFQVTEIS---------VEK----------DDYFS--KLYLYDG---RR-V---------------------------------------------------------R----------------------PFT--SGKKDS-NP----RFSPDGR--------------------------LIAFTSKRDKEG-------------------------------------------K---------------------E--------AELYVIPTD-------------------------------------------------------------GGEARLLA-------------------------------------------------------------------------------------------KFKYGIKNLRFTEDGKS----------IAV------------ITP---------------------------IDIEKKP--KD-------------------------------------------------------------------------------------------------------------------DVHLIKEIPFWFNGVGWV-YGKRSVVYLVDVET-----------------------------------------GKKR-RVTPKNLDV-SQVRFH--K--------GKLYFIAQEDRE-------------RKPMVSDLYLLE--GR-------------------------------------------KAKRLTPG-K---WSV--SD-FIP-------------------LDDGTFILKANTRER--G--------IPTNTHIYHYNPETGEM-----------------RKLTAEL-DR-----------------SAYNS-----LNS---DVR-----GSQ---RAE-LV-----FRDG-WVYYVATD---------------GPRAN---LFRVN----LGG----EIERV-----------I------------------------------------------------------------G--GD-------RS---IESFA--IG---DYIAFTAQDAVTPLELYVLRDG------------------------------------REKKITDFN-------------GWIR--------EYRLS-------------------------------RPEHFTVKAS-DGV-EIDAWIMKPVDFEPG-----KKYPAVLEIH---------------GGPKTAYGYAF--------MHE-FHVLTAKGFVVIFSNPRGSDGYGE--------E--FA-DIRGHYGE-RDYQDLMEVV-DEALRR-FDF-IDGERLGVTGGSYGGFMTNWIVGH---------------TK-----RFKSA-----VTQRSISNWVSFFGTT-DIG----YFFAPDQIGG--------------------DP---WSN-------------------------ADGYWEKS-P--LKYAPNVETPLLVIHSMEDYRCW-LPEALQFYTALKY-LG--K-T-VELALFPGENHDLSRSGKP-KHRVKRLELIVEWMERWLKD-----------------------------------------     =====>
9eury-b7r3h6   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGIEWNEKTFSRFAYVNDPRIE-------------------GSKV--AYTLTKVN---------MKD----------NRYEST--VVV-EDL-ETG-S---------------------------------------------------------K----------------------RFI-----ENASMP----RLSPDGR--------------------------KLAFTRPNEE-------------------------------------------------------------------KKE------TEVWVAELE-------------------------------------------------------------TLSAKKVL-------------------------------------------------------------------------------------------SA-KNIRSLQWNDDSRR----------LLVVGFKRHDDDDF---------------------------------------------------------------------------------------------------------------------------------------------------------------VFDDDVPFWFDSMGFL-DGEKTTFWVLDTEAEEVIEE-----------------------------------FEKP-RFSSG--------LWHGDG--------IL-INVPHREDG-----------KPALFKFYDIYLWKDGN--------------------------------------------EEKLFERV-S---L------RAVD-------------------SDGKAILLSGKREKKFMS--------E----HDWLY-IYDGEL----------------KPVY--EG-PL-----------------DVWGA-----K------------------------------LT-EGKVYFLTPD---------------AGSVH---LWLWD----G------KAERV-----------V------------------------------------------------------------V--GD-------HW---IYGLDAS-NG--K-ALLLIMTATRIGELY---LYDG----------------------------------ELKQVTDYN-------------GPIFR-------KLKTF-------------------------------EPRHFRFGSK-D-L-EIDGWYLKP-ELKED-----EKAPVIVSVH---------------GGPKGMYGHRFV-----Y---E-MQLMANKGYYVVYVNPRGSDGYSE--------D--FALRVLQRTGL-EDFEDIMAGI-EEFFKL-EPQ-ADRERVGITGISYGGFMTNWALTQ---------------SD-----LFKAG-----ISENGISYWLTSYAFS-DIG----LWFDVEVIGP--------------------NP---LEN-------------------------ENY-RKLS-P--LFYAKNVKAPILLIHSLEDYRCP-LDQSLMFYNVLKD-LG--K-E-AYIAVFKRGPHGHSIRGSP-KHRSKRYKLFIEFFERKLRKYEEGFDVEKILKSGKE-------------------------     =====>
9eury-c1vb62   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDPVPTETFYDLTSLSAVALS------P-----------TGDRA--AFVASES---------DPDE----------DERLA--SLFVVP-TDGSREP---------------------------------------------------------H----------------------RLT--RV-STAASP----TWSPDGD--------------------------RLAFVAARTEDTARRVGRSRDEE----TADDDIEATSGDRDEADIEADELDGTSEDGESD--------GAS--EDEHQSAGDDEPKPQVWVFDL---A---------------------------------------------------------LGGDARQ----------V--------TDF-------------------------------------------------------------------------DDGVKAFDWSPDGDR----------MVVSARDPTEEEREY-LDERR--E-----------------------GGPIET--ER------------------------------------------------------------------------------LQH-------------------------------------------KFDGAGYL-DTVTTYLFVVDAES----G-----------------------------DTGRLDDARGG-GAS--DDQFGMMPTWGPND--------R-IAYTAYEGE-----------R-SDDTFIRDVYSIRPDG----------------------------------------S---EKRRHTDGER------VTLLPQWS-------------------PDGSRLAFNGGD---------------------------------------------------------------AENWHLP--DQLYVTDA---DAADDAY-ESVSASLDRTLSF--SEPNW-----VDNETLYALIGDE----------------GKTRPV-RFAADE----------------------------------------------------------------------------DA-------PER--TF--TAQ--GDD--RACRALETAN--GTALVHLSHPSEGSDLYAFDLD-----------------------------SI-DATPDLTRLTDLN-------------AELRE-------TYELP-------------------------------KVRRVTY-E-SDGE-EIEGIVYAPPSFDFDD---PDPHPLVVAIH---------------GGPVNYDEPVF--------RFT-HAVFTSRDYLVFRPNYRGGSSYGR--------E--FAEALRGQWGT-VEVTDIAAGV-RELVSR--GW-AAEDRIFGHGFSYGGIAQGFLVTQ--------------EPD-----LFTAA-----APEHGIYDLRSAYGTD-DSH----------IWTDN-------------------EFGVPWEN-------------------------PERFEASS-S--ITDIGNVRTPLLVIAGGEDWRCP-PSQSEQLYVSAKK-QG--V-E-ARLVIYPDEHHNVGDPDRA----IHRLDEITSWYERHDPAVETDDKAENETHE----------------------------     =====>
9flao-q1vuy0   	--------------------------------------------------------------------------------------------------------------------MQNSLSK-----IPTIGYPLK--------------------------------NIPTKSIP------------MTILRLS------SYIL---------AF-----FLMA-TAQLKAQVPEDFFDYMDLFDLQMVGNPEIS------P-----------DGETI--IYERHQFD---------VMT----------DSRLV--NLWQISFD-GET-H---------------------------------------------------------Y----------------------PIT--SGTKYHGNV----NWSPQGD--------------------------KFAFTSNQD--------------------------------------------------------------------G-S------NQLYVYWVE-------------------------------------------------------------SKTTAALT-------------------------------------------------------------------------------------------NFTESPSNISWSPDGTQ----------LLFSKFVPESSKAI---QPKIPSPPNG---------A---------------EWEK-------------------------------------------------------------------------------------------------------------------EADVIDKAVYRRDGGGYV-QDGYSHIFVISAEG-----------------------------------------GTAR-QLTSGSHQF-GSSSWTPDG--------KHILYTVNKSED-----------AEVDPNNEQIFEQHIETG-------------------------------------------VSKQLTST-R---GPF--YSPKVS-------------------PDGKHIAYTGFDDKF--V--------GYQLTKLYLMSRDG-AE----------------LEILSKGF-AQ-----------------DI-----------------------------SSITW-----AKDAKSIYFRFDE---------------EGNSK---VGQIN----LKG----EVSTV-----------AE------------------------------------------------NLGSPS---I-G--RP-------YG---GGTYSVSDKG--K-LAFSYVTTSTPAELAVVSQKST---------------------------------RETKRLTNLN-------------ANLLK-------SKKTG-------------------------------KVEEFWVESSVDDF-KVQGWILTPPSFDPS-----KTYPMILEIH---------------GGPYTNYGSRF--------SPE-LQFMASRGYVVVYTNPRGSTSYGE--------D--FAAYINHNYPS-EDYNDLMDAT-DYVVD--QGY-INTDQLYITGGSGGGILTAWSIGK---------------TD-----RFKAS-----VVAKPVINWYSFVLTA-DGS----PFFAKYWFKN--------------------KP---WEN-------------------------PEEYLKFS-P--ISLVGNVKTPTMLLTGQQDYRTP-MSETEQYYAALKL-QG--I-E-AVMVRIAGSGHG--IARKP-SNLFRKVGYITSWFDKHKE------------------------------------------     =====>
9gamm-q2x537   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKL-LP--ITSL-VLLSL---------------GALSAVQAETRTKPLTLTDIMHFESLGKPVIA------D-----------NGRVF--AVESAPDRG------------------------DS--HTIIKNVHTG-Q----DYNIAGGSEPMIS-----------------------HNGRYVAMVVKPSLLTVETSDAK-------TKKQLKADMVLLDTQ--TGTQTRFERVKEFAFSHAGNH-------------------------LAIWFEADEETP--KDPKEAIET---AEIL--------T----------------G-GPV--------------KAEKSKVDKFDQGRRFSLINLENQAQRIDAEHV-TAYVFDKDSRRLALAI---------------NDIANQRHQLRLVDLTSQQQSTVFESNSQQIGALAL-AKNGRWLAFTQGKDSELP-YGRSYQLSLVDLQSGKLSKIPES---------------------------------PEWK--LNRYTSLSFSLDSER----------LFFGRVPEVSQQLSL-KK---------------------------------ITEEKDL------------------------------------------------------------------------------------------YDKEIVTGLRGLKVWHGDDPRIK-----PN---EIKQYE-K-EQQRTYLAVLHLGS---N--------------N-----------V------------VQ-LG----DQTVPDVTISQH----------KRFML------ASSDLPYRKMTTWA-GFYQDYYLVDINT----------------------------------------G---RKVLFLTQ-Q----PS-DAEPTLS-------------------GKGKYVAYYQQG--HV-----YLYDIAEGRR-----------------------------TNLTQSL-KV-----------S------FADE----DHDYPS-SAP--------GY--GFGPW-----LKDDAGFLVYDKY-DV-------------------WQFNTES---K------AGFVL-TAGQGRAQKIQYRIEGLVDN-PDE-------PTELSHNATVLLHGYSDKTKADGFYQAT--LGTAGVNTLMQ--GE--Y---KLS-----VLGRSKDA--DTLLFSKERFDLFPDLYTASYNA----------------------------P-----QNAVKQTELD--------------KQRQ--AFNWSQ------------------------------------SELVHW-TNGDGK-PLDGVLIKPTHYQQG-----KRYPVLVYYY---------------QVMTDRLHAFPSMHIN--HRPN-FAWYADNGYAIFLPDIRFDIGYPG-------------ASSVQ---------ALTSGVQK-LIDI--GI-ADPNAIGLQGHSWSGYQTVFAITQ--------------T-K-----MFKAA-----VAGAPVANMISGYSGIRHG-TGLARQFQYETGQS-------------------RIGASLFAA-------------------------PQKYIENS-P--VFYADRIQTPLMIMFGDKDDAVP-WEQGIEMYLAMRR-AG--K-E-VVFLQYEDEPHHLKK---Y-PNKLDYSIRMMEYFDHYLKGRPAPEWLSKVTV-----------------------------     =====>
9gamm-q33yi4   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRGYQLT---A--------LAAICA---------------GAMGLSSGVL-AAERTHQITTDDFFTIGNMGNVQLS------P-----------DGKHA--LWLESRW---------DKEL----------DKAQK--DLWLID-TKSRK-T---------------------------------------------------------N----------------------RLT--FTNESESSP----QWSPDGS--------------------------AIYYLVKQSRED------------------------------------------------------------------NKAPYNGKAQVFRI-N---L---------------------------------------------------------GSTEAVP----------V--------TKE-------------------------------------------------------------------------AEGVKQFQLSQDGKS----------LYFLTNKTTTDKDIWAKVRAK--H-----------------------GAPKYG--HGKVTTNPLYKLDLDH-----------------------------YQQSLVLDD---------------D--K-VVWNFSVNQ-------------------------------------------DASQIARI-TTQDNELVNLEGWS--NIEVFNT----QSQQNK-----------VLEDSAWREQAPSPY--------GWLLGLAWHEDN--------QRLAFRIDFDG-----------------HPGKLFVVKPKD----------------------------------------D---KAK-LIQVKTEGDVTFNSSDIHWR-------------------PGSDELCYRGYDHARV-------KLFCS----------------------------------------EI-------------------------------------------------------------------------------------------------DNQ----------------------------------------------------------------------------GQGDT--RTVLA--GD--LVM--GS-----Y-SFTHNG--KKLAFSHNGLDHFSDLFIADAA-----------------------------SK-KA--KYKRLTNIN--------------PQVD-------SWILP-------------------------------EISIVKW-TAPDGS-QVEGILDLPAGYKKS----DGPLPLIVQIH---------------GGPTSATPYAL---QH--RSYG-RSTFTANGWALLSPNYRGSTGYGD--------K--FLTDLVGQEHE-IEVADIMAGV-DHLIKQ--GI-ADGDKMAVMGWSNGGYLTNALIST--------------T-N-----RFKAA-----SSGAGVFDQRLQWMLE-DTP---------GHVINF-------------------MQGLPWEK-------------------------PEAYTHGS-S--LTHADKIKTPTLIHIGENDQRVP-LGHAQGLYRALKHYLN--V-P-VELVVYPGEGHGLSKYQHR----QAKMDWDKLWFEHYVLGKQMDEAK----------------------------------     =====>
9gamm-q3nza8   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRLYISH---KARLL----SLLLFL---------------PLVAMSLSAH-SAQRDHQITIDDFFGLSTLTQSQLS------Q-----------DGKQA--VWVESRW---------DKAL----------DRTQT--ELWHID-TNSRK-T---------------------------------------------------------T----------------------RLT--FSDENESNP----AWSPDGR--------------------------YVYFIAKIGEKD------------------------------------------------------------------PLHPYQGIAQIYRI-A---A---------------------------------------------------------TGGQPQM----------I--------TKS-------------------------------------------------------------------------ITGINAFELNKSGDS----------IYFSTNKEVTDKDHFASLRAD--H-----------------------SKVNYA--QGKKTTNPIYRLNLQH-----------------------------FSQELLLDD---------------D--K-VVWQFSVND-------------------------------------------NETKIARI-TTTDNELIFLEGRS--NIEVFDI----KQANNI-----------LLADDKWREKAPSAY--------GWLLGLDWHHDN--------QRLAFRIDFDG-----------------FPGQLFVANTAA----------------------------------------K---QAV-INRVTPPSQVTFFGDDLLWR-------------------GNSNDICYRGAYKARV-------KLYCT----------------------------------------EM-------------------------------------------------------------------------------------------------KAM----------------------------------------------------------------------------TQGKS--RAVIE--GD--LVI--GN-----Y-SFTASG--KQVGVSHDGLDHVSDLFIADAD-----------------------------SP-RA--QLKRLTNIN--------------PQID-------SWKLP-------------------------------QISIVKW-QATDGT-QVEGILELPFGYNKA----QGKLPLVVQLH---------------GGPTAATPYAL---QH--RSYG-RSTFSAQGWALFSPNYRGSIGYGD--------K--FLTDLIGREHD-IEVQDILSGV-DKLISD--GL-VDADKLAVMGWSNGGYLTNALISS--------------S-E-----RFKAA-----SSGAGVFDQRLEWMLE-DTP---------GHVINF-------------------MQGLPWEQ-------------------------AEAYTKAS-S--LTHANKITTPTLIHIGENDERVP-LGHAQGLYRALNHYLN--V-P-VELIVYPGEGHGLNQYQHR----KTKMEWDRRWFDYYVLGKD---------------------------------------     =====>
9gamm-q3p4r9   	-----------------------------------------------------------------------------------------------------------------------------------------------------MNR---------------------YSIL------------RPHWSK-LL--LLGLFACASG----LAQPSVSLVGAETVNAQGLQGSTRPLTLEDIMHYQTLKLPQLS------D-----------NGQLL--AVEAKPDRG------------------------ES--QVLIKPLGHG-E----PKRV-KGSKPQVN-----------------------ADGSFVLISQEPSLLERETL----------EKAQLTTRAVLLDSQ--TGTEQVFEHVKQARFSPDGAY-------------------------ALIWFEEDKTKT--EHKIDNDIH---NEPDGSI--APNAKPSSKLSAKSK----AA-TSA--------------NTKTAKADKELAESELLLIRLTDNK-QHRFSQV-SVFAMGENAKGLLLAQGLTDCKDGKDSASETLAAKCNGQQLLFVDFASFKITPLFNSNTHRFGALAL-ADDLSYGAFTLGNSLELR-SVREYQLHRIDIASGQKTAAPKD---------------------------------TTWL--YNQYSSLVFSQDNQR----------LFVGRVPNIRALAQK-PK---------------------------------LDTQAKL------------------------------------------------------------------------------------------FDKALIQANSQGNVWHGDDRKIK-----PH---EIHDYE-K-SLKKTYLGVWHMSS---E--------------R-----------L------------LQ-IA----NEQLPEVKAGQQ----------SRFLL------ASSDIPYQKMITWA-GFFRDWSVVNLNT----------------------------------------G---KATEVLVQ-H----PS-DSPMSLS-------------------PDGKQLIYFKQG--QI-----WLYSLMSQRH-----------------------------TNLSAKI-AT-----------P------FSDE----DHDYPS-AAP--------GY--GFGPW-----LADSSAVLVYDKY-DI-------------------WQFSSQG---S------KAINL-TNAQGRKQQLQLRVKALVND-KSR-------QAVVNKGDTLLLQGYNERTKADGFYQAK--VGKTGLSVVVE--GD--H---KLT-----VLARSKNT--GQFLFSKERFDLYPDLYSADINA----------------------------P-----ATWTQQTFLA--------------KQQA--PFTWGN------------------------------------AELVQW-TNDSGK-RSDGVLIKPTHYQAG-----KAYPVIVYFY---------------RFMSDRLHDYPDMAIN--HRPN-FAWYADNGYAIFLPDIRFEEQYPG-------------LSAVK---------ALTSGVQH-LIDM--GI-AKADAIGLHGHSWGGYQTAFAVTQ--------------T-P-----LFKAA-----VAGAPVANMTSAYSGIRHG-SGLARQFQYETGQS-------------------RMGQSLMDI-------------------------PLRYMENS-P--VFYVKRVTTPLMIMFGDKDDAVP-WEQGVELYLAMRR-AG--K-A-VVFLQYEDEPHHLKK---Y-PNKLDYSIKMMQYFDHYLKGLPAPDWLKQGQAYQEYRD-----------------------     =====>
9gamm-q3qjk5   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKP-SA--L--FCALASA---------------ASLSLPALAAPSGNMQVQDIMKFESLKKPVIA------D-----------NGSLV--AVEVAPDRG------------------------DS--RTLVHSTTGK-R----QLSVAGASKPVVS-----------------------ADGRYVAMVLEPSLLEKETSDAK-------ARKKLKDGMVLVEVA--TGKEQRFSRVKEFTFNDAGTV-------------------------LAVWFEAEEDKK--DKADDKAPD---NASVA------E-------------AKPQT-AED--------------NLKKPKVDKADKGSPLTLIALNSGK-QLELQDI-TAYAFDKKGKSAAVLV---------------NDVAQAKHQLLSVTLSDLSQQQKYSSESEQLGALAI-NHDGSHIAFSAGVAADKV-DERQYRLGLVNDKG-DVRFAMHP---------------------------------DAWV--LNQYSQLSFSEDGER----------LYFGTVPEVSKVLSL-QK---------------------------------FSDEASL------------------------------------------------------------------------------------------YDTATIRDSRGLKLWHGDDPRIK-----PH---EIKTYD-K-LKKQTLLAVWHLAG---N--------------Q-----------V------------VQ-LA----TPEVPEAKPIEY----------GRFVL------GSSSEPYLKEITWA-GFYSDFYLIDTLS----------------------------------------G---ERTAVALR-Q----PS-NSEPNIS-------------------PYGRYAAYFREG--QV-----QLLNVASKQL-----------------------------RVLNANL-DV-----------P------FADE----DHDYPS-DAP--------GY--GFGPW-----LADESGLLVYDKY-DI-------------------WQFAAAD---A------KALKL-TS--GRDKGISYRVEGLYQDKNQA-------PATVNTSQSLLVKGYNERTKADGFYRVT--LGKDGLKTLHA--KE--E---KLS-----VLGRAKHA--DTLVFSRERYDRFPDLYSADVLE----------------------------V-----DDARRLTELD--------------AQRS--KFGWGK------------------------------------AELVHW-TNTDGK-PLDGVLIKPAGYEAG-----KRYPVLVYFY---------------RFMSDRLHAFPSMNIN--HRPN-FAWYANQGYAIFLPDIRFEVGYPG-------------NSSVQ---------ALTSGVQK-LIEM--GI-AEPTAVGIQGHSWGGYQTAFAVTQ--------------T-H-----IFAAA-----VTGAPVGNMTSAYSGIRHG-TGLARQFQYETGQS-------------------RIGESLMQA-------------------------PLKYVENS-P--VFYADRIKTPMMIMFGDKDDAVP-WEQGVELYLAMRR-AG--K-D-VVLLQYEGEPHHLKQ---Y-GNKLDYSIRMKEYFDHYLKGAKAPAWLEQGEPYREYAKED---------------------     =====>
9gamm-q3ql94   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPLYPRL---F--------LASL---------------------LAAPAA-MAAPSHQITLDDFFDIANMGTVKLS------P-----------NGNHA--LWLEGRW---------NKEL----------DKSQN--DLWQID-IKSRQ-P---------------------------------------------------------T----------------------RLT--FTDESESSP----VWSPDGQ--------------------------FIYFIGKEKRND------------------------------------------------------------------AKAPFNGKAQVFRI-P---V---------------------------------------------------------TGGEAVP----------M--------TRE-------------------------------------------------------------------------AEGVSAFELAPNGAS----------LYFLTHKDTKDKDRWAGMRSG--H-----------------------SAPQYG--HGKRDTNPLYKLDLVN-----------------------------FRQELVLDD---------------D--K-VVWDFSVSP-------------------------------------------DGNHIARI-TTEDNELVYLEGWS--QVEVFDT----ANKQNR-----------VLEDSAWRQQAASPY--------GWLEGLAWHGDS--------KRLAFRIDFDG-----------------HPGRLFVVDTDG----------------------------------------K-----G-QMELSRSGKVTLNGADIQWR-------------------PGSDEICYRVADAARV-------KLQCT----------------------------------------EI-------------------------------------------------------------------------------------------------DGL----------------------------------------------------------------------------QQDDT--RTLIE--GD--TVI--GS-----Y-SFNSRG--SQVAFSHNGLDHFTDLFVADAN-----------------------------SK-RA--SANRLTDIN--------------PQSA-------DWQLP-------------------------------QISIYKW-QAPDGS-DVEGILELPYGWDKS----KGKLPLVVQIH---------------GGPTAATPYSL---QH--RSYG-RASFPAQGWALLSPNYRGSTGYGD--------K--FLTDLVGREHD-IEVKDILSGV-DKLIAD--GI-VDGDKLAVMGWSNGGYLTNALIST--------------T-D-----RFKAA-----SSGAGVFDQRLQWMLE-DTP---------GHVVNF-------------------MEGLPWEK-------------------------PDAYTHGS-S--LTHADKIKTPTLIHIGEKDARVP-LGHAQGLYRALHNYLG--V-P-VELVVYPGEGHGLSKYQHR----KAKMEWDLKWFNYYVLGIEP--------------------------------------     =====>
9micc-q4nah7   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSYFTGHARAVRLTIVKPEHLPLLKSVSAPAVH------P-----------DGSRA--VVSVIRPD---------FDA----------DTYVG--QLWTVPLDPEKL-P---------------------------------------------------------R----------------------RLT---RGFRDTAP----AFSPDGL--------------------------VLAFLRATA--------------------------------------------------------------------DGK------PQLYVVEAA-------------------------------------------------------------GGEPQVLT-------------------------------------------------------------------------------------------NAKLGVSSFAWSPDSHS----------IVFGARTPDDGRYGTLD--------------------------------GVSAGAE-------------------------------------------------------------------------------------------------------------------DARLITDFKYRMNGVGYT-ADKPLQLYVVEVPELDDEPPVAPAGRALRAQKTVAEGTGREAGPAREADTAEALLPPAR-QLTFAAADH-SGESFSTDG--------HSVYFVAALHEG-----------SDHDL-ETGVYRVPVVGG-------------------------------------------EPEPVRAA-N--SGRQTVGAARQS-------------------RNGQWLFYTAQELGESGQ------DFVARNTALYVMPA-GGGD----------------ASVLSDVE-TM-----------------DLAGS-----AGG---LE-----------------------LRGPDSVLLLNNA---------------QGTVE---LLEFG----ATG----NHALL-----------V------------------------------------------------------------H--GD-------RV---VTGAAAAAGS--V--FVSFADPATAGDVA--ALEEG----------------------------------QLRLLTDFS-------------AELRR-------QAEII-------------------------------EPREVTFEAA-DGY-PVHGWLVLPPGK--------GPHPVLLNIH---------------GGPFSQYTVAL--------FDE-AQVYAAAGYAVLMCNPRGSAGYGQ--------A--HGRTIKEKMGT-VDMQDVLSFL-DGALAK-FQE-LDGGALGIMGGSYGGYLTAWTISQ---------------DH-----RFKAA-----IVERGFLDPVSFIGSS-DIG----WFFGGEYTGT--------------------SP--------------------------------EQMAAQS-P--MATVGNVRTPSLVIHSEEDLRCP-VEQGQRYFTALKQ-QG--V-D-AAFLVFPGENHELSRSGTP-HHRKQRFEEVLRWWSRYLPTAANS-------------------------------------     =====>
9sphn-Q2N8C6   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTL----RTALL--------------------TATLLFPAPALARPMTAEDVAKLESVGSIAVS------P-----------DGSRV--AYTTASLPDILAGE-DNGST----------T---Q--QLKIAY-ARDNL-----------------------------------------------------------R----------------------EFL--PDDMNVSGI----QFSPDGR--------------------------WITFLWT-KD-------------------------------------------------------------------------DEKRAVWGI-P---V---------------------------------------------------------DGGAHRK----------L--------AAVE------------------------------------------------------------------------GAGVRSYSWAPDSSH----------MHLLVGAAEDKDREA-ESKDG--F-----------------------NARIYE--EEQQ--------------------------------------------------------------------------------------------------------------------------------------LNRLFR-------------------------------------AIIGAELD-PEPQ-EVT--VPGYVTSFQIAKNA--------RTGVIETAPTTL----------I-DDSYTQKKVNLLDMPT----------------------------------------G---NVRMVIETTGK------IDDVEIS-------------------PDASQLALIAAVDMND------------PA---ATTI---------------------------HFV-DTAT--G----------------------------TIRAHNAGAPEAV--VDVEY-----MPDGR-LVAAVHV----------------GAQSVL--RI-HN----------------------------------------------------------------------------RDGSL--QREVD--PG--ALI-ITD-----V-E--IGG--DQIFVEANAPQHPGELFKLDGD------------------------------------SFTRWTSHN--------------PWLA-------DIDFG-------------------------------EQRTFRF-NASDGQ-EVEGVLVLPVGGVPR-----GGAPLIMDVH---------------GGPEAHDSNGWT--TN--YSGP-GQVAAGKGYAVFQPNYRGSTGYGT--------A--FSKQHQGNYTD-PEFTDLVDAK-RALVAE--GI-ADADRVGVTGGSYGGYATAWSSTR--------------WSE-----EFAAG-----VMFVGISNQISKFGTG-DIP----YEMYNV----H-------------------SRKWPWDD-------------------------WQAMLEVS-P--IFHVDKAETPLLIMHGEEDTRVD-PGQSLEIYRAIKI-RKPDT-P-VRLVFYPGEGHGNSKAAAR----YDYNLRMLRWFDTYLMTGDRDAPLPGPRPDLEIEGDDNSE------------------     =====>
9sphn-q3vd53   	------------------------------------------------------------------------------------------------------------------------MRK-----LALFGTALIALTAQPLWAQQEEAP----------------AQQPPAS-------------------ET-------P-----------AATPTPMPAAAVG--SARTGPERRFTGADLFDLAIAADPQIS------P-----------DGRHI--AYVRRAND---------IMT----------DRAVS--SIWLIDTA-TGR-E---------------------------------------------------------T----------------------PLA--GQDGPAFSP----RWSPDGS--------------------------RLAYVSAAG--------------------------------------------------------------------G-S------AQLWVRWMD-------------------------------------------------------------GGEAVRLT-------------------------------------------------------------------------------------------GLPTSPSSLTWAPDGRS----------IAYTMLVKDEGARL---GSAPANKPEG---------A---------------KWAE-------------------------------------------------------------------------------------------------------------------PLDVRTLLTYRADGQGYV-EPGFEKIFLIPATG-----------------------------------------GAPR-QLTFGPYHDGGPLSWSRDG--------RTLYFSANRQAE-----------WETDPLESEIHALDVASG-------------------------------------------AIATLTDR-N---GPD--ANPLVS-------------------PDGRLIAYLGFDDAL--R--------AYEQTELYVMNRDG-SG----------------RRRIAANW-DY-----------------SV-----------------------------DAVQW-----GADSRSLYVQYDD---------------HGETK---VARVT----LDG----SVRDV-----------AK------------------------------------------------GLSGGG---L-D--RP-------YT---GGSFTVAGNG--A-IAFTGGTATRPAEVQLARGG-G---------------------------------EA-RMLTDLN-------------RTLRE-------VKSLA-------------------------------QVRKITVASSHDGL-PIEGWLTLPPGYVEG-----QRVPLILEIH---------------GGPFTAYGPHF--------STD-NQLYAAAGYAVLSANPRGSTSYGE--------A--FAQQIDKAYPG-NDYFDLISIV-DQAIA--LGI-ADPDALFVTGGSGGGVLTSWIVGK---------------TN-----RFKAA-----ATQKPVINWQTQALTA-DGP----AFFGPYWLGA--------------------QP---WED-------------------------PERYWARS-P--LSLVGNVETPTLVVVGGEDYRTP-VSESEQYYTALRL-RG--V-P-TALVKVPGASHG-GIAARP-SQSAAKAAAILAWFDKYRKGWTRPAASD---------------------------------     =====>
acib4-b5iaf1   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METKVLSLVYACKN-----MQNVKLSDMYRIKLVGDVQVS------K-----------DGTKI--AYVVARMD---------KKK----------NDYLS--KIYLYDG---KS-K--------------------------------------------------------------------------------AFT--SGPKDT-MP----RFA--GD--------------------------KIVYVRKGEKK---------------------------------------------------------------------------SEIRVISLV-------------------------------------------------------------GGESRKIA-------------------------------------------------------------------------------------------EVEKGVINMKIDGDYVY----------FLSP---------------------------------------------VVNKEND-------------------------------------------------------------------------------------------------------------------DVKRITSIPFYFNGKGFI-YNASMQIFRVPLKG-----------------------------------------GKVE-KLSNVDEKI-SSFDVK--N--------GRIIYS-ASEDE-------------REPFMENLYILK--EG-------------------------------------------KGERISGR-K---ASI--SSFRIS-------------------PDGKKIAAFLSFHDK--G--------FAEHKRLYMLSMEGGD------------------YELACGD-KF-----------------SFGKS-----LNS---DTR-----FGG---GSVMQW-----INEN-EILFIATD---------------RGKQP---VFIYS-----HG----KCWKI-----------L------------------------------------------------------------N--GN-------RS---VESFA--YAE--GTLAFIAQEMNHPADVFIKRD-------------------------------------RERRITNLN-------------RFLK-----------LP-------------------------------KGEHFTVKVS-DGE-EVEGWLLLPEGKGPH--------PAILEIH---------------GGPKTSYGHAF--------MFE-FYYFLSQGFAVIFTNPRGSSGYSE--------E--FALKIRGDFGN-RDYKDLMEAL-DFVLEN-YS--IDKKKVFVTGGSYGGFMTNWIVGH---------------TD-----RFRAA-----ATQRSISNQLSFWGTS-DIG----PWFNKDYIGAG------------------KDL---WEG-------------------------FENYWSMS-P--LKYAKNIKTPLLIIHSEEDYRCP-ISEAYQLFYALKM-QG--V-D-TKMVLFPHENHDLSRSGKP-KHREIRLKEIVDWFKEHME------------------------------------------     =====>
acib4-b5iex9   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METKVLSLVYACKN-----MQNVKLSDMYRIKLVGDVQVS------K-----------DGTKI--AYVVARMD---------KKK----------NDYLS--KIYLYDG---KS-K--------------------------------------------------------------------------------AFT--SGPKDT-MP----RFA--GD--------------------------KIVYVRKGEKK---------------------------------------------------------------------------SEIRVISLV-------------------------------------------------------------GGESRKIA-------------------------------------------------------------------------------------------EVEKGVINMKIDGDYVY----------FLSP---------------------------------------------VVNKEND-------------------------------------------------------------------------------------------------------------------DVKRITSIPFYFNGKGFI-YNASMQIFRVPLKG-----------------------------------------GKIE-KLSNVDEKI-SSFDVK--N--------GRIIYS-ASDDE-------------REPFMENLYILK--DG-------------------------------------------KGERISKK-K---ASI--SAFRIS-------------------PDGKKIAAFLSFHDK--G--------FAEHKRLYMLSMEGGD------------------YELACGD-KF-----------------SFGKS-----LNS---DTR-----FGG---GSVMQW-----INEN-EILFIATE---------------KGRQP---IFTYS-----YG----KCWKI-----------L------------------------------------------------------------N--GN-------RS---VESFA--YAE--GTLAFIAQEMNHPADVFIKRD-------------------------------------REKRITNLN-------------RFLK-----------LP-------------------------------KGEHFTVKVS-DGE-EVEGWLLLPEGKGPH--------PAILEIH---------------GGPKTSYGHAF--------MFE-FYYLLSQGFAVIFTNPRGSSGYSE--------E--FALKIRGDFGN-RDYKDLMESL-DFVLEN-YP--IDKKKVFVTGGSYGGFMTNWIVGH---------------TD-----RFRAA-----ATQRSISNQLSFWGTS-DIG----PWFNKDYIGAG------------------KDL---WEG-------------------------FENYWSMS-P--LKYAKNIKTPLLIIHSEEDYRCP-ISEAYQLFYALKM-QG--V-D-TKMVLFPKENHDLSRSGKP-KHREIRLKEIVEWFKEYME------------------------------------------     =====>
acib4-b5ifi0   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAIKMRWKEDTFAKFSYLQDVDIT------S-----------SGSLV--AYVLRKVN---------MKE----------NKYENT--MVI-EDL-ESG-K---------------------------------------------------------R----------------------RYV-----EDASMP----KFSPDGK--------------------------KMLYLRVDED-------------------------------------------------------------------KKR------SDLYLLELD-------------------------------------------------------------TMTSKRLI-------------------------------------------------------------------------------------------EA-KNIIGMDWHNDSRK----------ILILYSKKLDDEDL---------------------------------------------------------------------------------------------------------------------------------------------------------------YYDDSVPVWFNGKGFR-DCEKNIIQIYDTEGEVVVDE-----------------------------------FEDK-YVENA--------LWHGDE--------II-YTIARREN---------------PFKSFDIFAYK-GK--------------------------------------------KRKMFENV-P---F------YPVD-------------------SNNKILLMLGKREMQYIS--------E----HRYLM-IYDGKD----------------LKEISASY-GL-----------------ENFEG-----K------------------------------LDAEGNVYAITAD---------------AGSVV---LEKFEG---N------NKIRI-----------A------------------------------------------------------------G--ND-------AY---VYSFAVSSTG--K-IAFLMMSDTFLGELY---IFDG----------------------------------ELKKLTSYN-------------SEILK-------KLKPR-------------------------------KHIHFKYKSF-DGK-ELDGWYIKP-RGAGK-----RKLPAILFVH---------------GGPKGMYGHYFH-----Y---T-AQLIADMGFYVIFTNPRGSTGYSE--------E--FALAVLNRTGL-EDFQDILAGL-EWVIE--NEN-VDKDKLGITGISYGGYMTNWAITQ---------------TD-----KFKAA-----ISENGISYWLTSYAFS-DIG----LWFDREVIGD--------------------NP---LEN-------------------------ENY-KKLS-P--LFYAEAVKTPVLFIHSLEDYRCP-LDQSLMFYHVLKS-LG--K-E-TYIVIFKQGEHGYSIRGKP-RHRSKRYKLFAEFFIKKLKE-EKEFKIEDVLKK----------------------------     =====>
aerpe-APE1547  	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRIIMPVEFSRIV--------------------------RDV-------------ERLI-------------------AV--------------------------------------------------EKY-S------------------------------------------LQGVV--D--GD--------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLVVGFSEGSVNAYLYDGGETVKLNREPINSVL----------------------------------DPH---YGVGRV----ILVRDVS----------------------------------------------------------------------------------------------------------------------K-GAEQHALFKVNTSRPGEEQ-------------R-----------L------EA-VKPMR-------ILSGVDTG-------------EAVVFTGAT------------------EDRVALYALDG------------------------------------------G---GLREL--A----R--LPGFGFVSD-------------------IRGDLIAGLGFF----GGG-R-VSLF-------TSNLSSGGLR---------------VFDSGEGS-------------------------------------------------F--SSASI-----SPGMKVTA----------------G--LETARE-ARLVTVDP---RDG----SVEDL-------------------------E--LPSKDFSSYRPTAITWLGYLPDG---RLAVVARREGRSA--VFID--G-ERVEAPQGNH-----GRVVLWR--GKLVTSHTSLSTPPRIVSLPSG-----------------------------EP-LL---EGGLPEDL--------------------RRSIAGSRLV--WVE--------------------------------SFD-GSRV-PTYVLESGR-----A----PTPGPTVVLVH---------------GGPFAEDSDSWD--------TF-AASLAAAGFHVVMPNYRGSTGYGE--------E--WRLKIIGDPCG-GELEDVSAAA-RWARES--GL-A--SELYIMGYSYGGYMTLCALTM--------------KPG-----LFKAG-----VAGASVVDWEEMYELS-DAA----FRNFIEQLTG-------------------------GS--------------------------REIMRSRS-P--INHVDRIKEPLALIHPQNDSRTP-LKPLLRLMGELLA-RG--K-T-FEAHIIPDAGHAINT---M-EDAVKILLPAVFFLATQRERR----------------------------------------     =====>
aerpe-APE1832  	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPGP-----KKPVTPEDIIRLTFVSNPSVS------P-----------EGDKV--AYLATKAD---------EKE----------NTYRS--GIWLAEE---DS-Y---------------------------------------------------------R----------------------PLT--GGPYDR-CP----AWSPDGE--------------------------IIAFSRTVNSNQ-------------------------------------------R---------------------K--------RHYIAIVSP------------------------------------------------------------KGGEPQVLH-------------------------------------------------------------------------------------------ESVSPATSIKWSSQGSM----------IGYLSRKPT-------------------------------------GREWKPYSER-------------------------------------------------------------------------------------------------------------------DVLEIDRIPVWFDSEGWV-FDRYWGLTVISYPG-----------------------------------------GEVLLEKGGVNYNI-VDFDFAPDD--------NTIVY-AVSTDM-------------KKPFIHKLVLWDLASG-------------------------------------------REKTLIEG-L---TIA--AV-AFD-------------------PRGRYIAVKANDRKR--G--------LFSHYKIFVYDLNSEEF-----------------VCLTCDL-DL-----------------NTLNT-----VNS---DAR-----GPS---CLRGMY-----WDDNGHLYYGVHN---------------AGRMV---VMKSR----PLG----EAEAV-----------L------------------------------------------------------------D--PS------SAT---VDDFSISRGG--DTIAYVKMGPTSPPDIYIYRDD------------------------------------NEYRLTDHN-------------AWFAE-------SRSLA-------------------------------EPVRLQVQSP-LGG-SIDAWILLPPDAGEC----SGCLPWILYIH---------------GGPKTSYGYAF--------IHE-FQMLASQGFAVIYSNPRGSDGYSE--------E--FA-DLRGRYG