Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....900..5....910..5....920..5....930..5....940..5....950..5....960..5....970..5....980..5....990..5....1000.5....1010.5....1020.5....1030.5....1040.5....1050.5....1060.5....1070.5....1080.5....1090.5....1100.5....1110.5....1120.5....1130.5....1140.5....1150.5....1160.5....1170.5....1180.5....1190.5....1200.5....1210.5....1220.5....1230.5....1240.5....1250.5....1260.5....1270.5....1280.5....1290.5....1300.5....1310.5....1320.5....1330.5....1340.5....1350.5....1360.5....1370.5....1380.5....1390.5....1400.5....1410.5....1420.5....1430.5....1440.5....1450.5....1460.5....1470.5....1480.5....1490.5....1500.5....1510.5....1520.5....1530.5....1540.5....1550.5....1560.5....1570.5....1580.5....1590.5....1600.5....1610.5....1620.5....1630.5....1640.5....1650.5....1660.5....1670.5....1680.5....1690.5....1700.5....1710.5....1720.5....1730.5....1740.5....1750.5....1760.5....1770.5....1780.5....1790.5....1800.5....1810.5....1820.5....1830.5....1840.5....1850.5....1860.5....1870.5....1880.5....1890.5....1900.5....1910.5....1920.5....1930.5....1940.5....1950.5....1960.5....1970.5....1980.5....1990.5....2000.5....2010.5....2020.5....2030.5....2040.5....2050.5....2060.5....2070.5....2080.5....2090.5....2100.5....2110.5....2120.5....2130.5....2140.5....2150.5....2160.5....2170.5....2180.5....2190.5....2200.5....2210.5....2220.5....2230.5....2240.5....2250.5....2260.5....
9acto-d3d9f1   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDR------------------------------------------------------------------------------------------------------------------------QI-------PLFTLEGVPGADVSIHPFSTADGLGLSMLRFTRG------G---------------------------------------------------------------------------------------------------------------------------------------VD---VREGDSVLVL--HGLTTSSDMFI---MPEHQ---------NL----------------------------VRF-----LLA--------------------------N-D--FGDVW-----LLDYRMS------N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFPY---------------------------------------------------------------------------NRAMHR-FNLDD-------VALYDHPAAVRKL-RE-----V-A-----------------------------------------------------------------------------------G------SRR-L-H---VISHCLGSMSFLMSLFGGV--VDG--ISSVVANS---------------------------------V----A-LTPRVA------TWSRL----KLAVAPNL---------CEWVLGFPYL-DPAWADRPRLSREWLFAK---ATD----------------------------ALHR--ECDV----------------------SACHMLS---------------------------------------------------------------------------------------------------------------------LMWGTGRPALWQ----------------------------------HD---N----------LLPV-THERSRDL-FGATGLNY----YRHIRAMV-S-----------------------------AG-HAV--------KYRPG--------------------------------------------------------------------------DPEY-----------------------------ARLPDDYLA-D-AGRI-S---TP-M-LL-VAGD-R-----NHV-FTN--------------SNIECWRRL-EAV-AP----------------------------GRHE--L---D-V-IP-GYGH--QDVFMGKN-------VDRDVFPRML-DFIKRRALEPVAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9burk-b5wel9   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGSGVSSRIFS---TDLTPT--------NL----------------------------VEY-----LYA--------------------------S-G--YD-VW-----LVDLRVS------I-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPT---------------------------------------------------------------------------V--LVP-TNVDK-------VAREDIPAAVAKI-RE-----V-T-----------------------------------------------------------------------------------G----V--PQ-I-Q---VLGHCLGGLALSMSLLNG---LDG--VRSAVISQ---------------------------------V----S-AHPVPG------TLQRI----KAGLHIPD---------LMQHLRVRDL-TAYTQ--EDSWPANLFDE---ALR-------LY----------------PLD-HGE--GCGN----------------------PICHRAT---------------------------------------------------------------------------------------------------------------------FLYG----LLYE----------------------------------HD---K----------LNET-LHENLQEL-FGIHDMAV----FQHLATMV-R-----------------------------AG-KVV--------DADGK--------------------------------------------------------------------------DVYL-----------------------------TG-ANGM---KGLEGM-R---MP-I-GF-IHGE-K-----NET-YLP-------------VSTALTYALL-REHFPE----------------------------QPYE--R---H-L-IP-GYGH--IDCIFGKN-------AAVDVYPVIV-DYLNAH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9burk-c9y8q9   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGDGLGISLLRFQRA------P---------------------------------------------------------------------------------------------------------------------------------------C-------KDVVLLV--PGLTASSDMFI---MPEHR---------NL----------------------------TQV-----LLD--------------------------E-G--FTDVW-----TLDGRIS------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQPY---------------------------------------------------------------------------NHTRHR-FTVDD-------VALYDNPAALDVV-RR-----A-V-----------------------------------------------------------------------------------G----P-EAR-I-H---IISHCLGALSVAMSLFGKA--IQG--VRSVIVNG---------------------------------V----A-LTPKVG------TFAKA----KLAVGPFL---------AESVLGVDYL-NPEWNQQAGISPGKLLAK---GVS----------------------------FMHR--ECDV----------------------PECHMTS---------------------------------------------------------------------------------------------------------------------FMWGYGYPVLFR----------------------------------HE---N----------LHEI-THRRTGDL-FGGSGVHY----YRHIRKMV-G-----------------------------ADNSAV--------KFDPK--------------------------------------------------------------------------DVRY-----------------------------RHLPDNYLQ-D-AADI-T---TP-M-LL-VAGQ-E-----NAL-FLD--------------SNVLCHERL-EQV-AP----------------------------GRHQ--L---A-V-IP-GYGH--ADVIIGKN-------AAQDVFPRFV-EFLKQNAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9delt-a6gcp2   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGLGVSSGIFT---VDTIGT--------NL----------------------------VEY-----LFA--------------------------H-G--YD-LW-----LLDFRAS------I-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELAS---------------------------------------------------------------------------A--EVP-ASCDL-------MATVDLPEGIAEV-RR-----L-S-----------------------------------------------------------------------------------G----A--DS-V-Q---VIAHCIGATLFYMSALAGK--LEG--VRAALTSQ---------------------------------A----T-PHIDGS------RDHRI----KSGLRLPA---------VLESLGFTSL-TAYTDK-HDGWLDRLYDR---ALE-------LY----------------PVAREEE--RGAS----------------------ATARRIT---------------------------------------------------------------------------------------------------------------------FLYS----QLYE----------------------------------HD---Q----------LNVA-THDTLHEL-FGVANLSC----FDQLGAII-R-----------------------------AE-HIV--------DAEGG--------------------------------------------------------------------------DVYL-----------------------------PQ----------VGRL-A---LP-L-RM-IHGA-E-----NAC-YLP-------------SGSERSYAWL-RQHNDP----------------------------ALYS--R---V-V-IP-DYGH--IDCIFGKD-------AAEHVYPHIL-EHLEANL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9dipt-q0zst6   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MY------VA--QKV--------------LFAL-----------------VL-F----------------ISGD-KLQS-LA--SE--NE--VHVKQKSS--I-------LHSKND-------FVDL-SKSHG-YAAEEHTVKTDDGYLLTLHRIPRGVK---A--------------------------------------------------------------------------------------------------------------------------------------------QKNSKGVVFLL--HGLLCSSVDWI---IL----GP---Q-SAL----------------------------AFL-----LAE--------------------------E-G--YD-VW-----LGNARGNTFSR---------------------------------------------RHVSRG---------------------------------------------------------------------------------------V--KS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----AFWK-FSWHE-------IGIYDLPAMIDYA-LN-----A-T-----------------------------------------------------------------------------------R----Q--TS-L-H---YIGYSQGSTAFL-VMASMR---R---------------------------E-YMKKV--SMFQA-L------G-PAVYLS------NTR--SFVVRTLAPFTS-----------------------------Q-FQMLNSI-LGTTE-------FLPRGT----LL--D-SAS-----K-LFCHL-----HSP-----------I-KILCSNIL--------------------------------------------------------------------------------------------------------------------FLMAGF--------D-------S--EQIDM--------KLL-PTILAHS---PA-------------------G------ASVNQ----IVHYLQCV-K-----------T----------------GK---FSLFDYGS----S--------------EN--------------------------------------M---------------------VKY--------------------------N---ATTPPEYPI---E-QM-T---VP-T-VI-HYGL-N-----DVF-CSV-------------TDVQK-LIQK------------L-PN-VV-----G-------------N--YS--V-P-FA-KFNH--LDFIYAKR-------ARELVYDRVI-ENLTNNLENNIES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9dipt-q5qbg7   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI--NFKL-LTF--------YF--TFI--------------ALIS-----------------SS-L----------------IIAE-EIEE-I-------DHSEDDRFDGVN--IHDALSRDAGVQNF-------TSQI-ITKHG-YPWEEYEVTTADGYLLTLFRIPGSKI---S-----------------------------------------------------------------------------------------------------------------------------------------P--PKEGKSVVFLQ--HGLLSSSADWV---VT----GP---N-QGL----------------------------AFI-----LAD--------------------------A-G--YD-VW-----MGNARGNTHSR---------------------------------------------KHLYLS---------------------------------------------------------------------------------------P--KK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----QFWQ-FSWHE-------IGQIDLPAMINFV-LQ-----K-T-----------------------------------------------------------------------------------W----Q--QK-L-H---YIGHSQGTTAFF-VMGALD---NK-------------------------GT-MMSKI--KSMQA-L------A-PVAFMS------NLK--SPFVRAFSPFVN-----------------------------S-LDWILSM-LGMHE-------FFPSNK----MM--K-KGG-----Y-FLCRD-----ESP-----------F-QNVCANVI--------------------------------------------------------------------------------------------------------------------FLICGY--------N-------S--EQLNR--------TML-PG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9eugl-b6dt69   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIRLRKK-RIRFAKSTDIQSQKKEKVT--------KPQRE--------HLPH---QRMRV---Q-H------QDR-SCVLV--STI-VVL-LVC-Q--VN----------------------------------------------------------------------------------------AFTEFYP-------VCDQ-VTLLG-FPCQTHIVTTADGFQLSVNRIPPK---------------------------------------------------------------------------------------------------------------------------------------------------MEGAYPVYLQ--HGLLDTSVTWV---AN----AY---ANQNL----------------------------ATI-----LHN--------------------------A-G--YD-VW-----MSNARGNHYSM---------------------------------------------GNTQYS---------------------------------------------------------------------------------------Q-S--------D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYWLRIDMDW-------MAKYDLPAVIDYILAN-----V-TN---------------------------------------------------------------------------------------H--TK-L-S---YVGHSQGGMMGF-AGFSTW--NP---------------------------E-YAKKV--DVFVA-L------A-PACRVG------QTT--SFLIK-------------------LLA------------D-LDVDAIFEI-FGLKE-------FLA-ND----WLLR--QI------A-SFCGD-------------------L-GGICPDIL----DII---------------------------------------------------------------------------------------------------------------VGDG--------N-------P--ANIN--------QSQI-DTILRYD---PG-------------------G------TSVNN----MVHWAQEV-R-----------S----------------GE---FQAHDYGS----V---------------QN-------------------------------------Q---------------------VFY--------------------------N---STTAPKYNL---S-AM-Q--GPP-T-FI-FSGS-N-----DAL-ADP-------------QDVEW-IVAS------------LP-AS------------------VMKG--S---T-V-IN-GFAH--MDFVWGLD-------AYSLLYPQIL-QL-IEQYRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9gamm-q1ug55   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIHQTLNLVTTADHQQIAVWKITDNEAIKNPL---------------------------------------------------------------------------------------------------------------------------------------NPSIGNHKRQNLLLL--HGAFSDKGVCL-----------------GI----------------------------ASY-----FAS--------------------------L-G--YP-CF-----IMEWRGHGSSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------------------------------------------------------------------------P--KTP-YHLED-------IAFYDVRATLDYL-VN-----E-L-----------------------------------------------------------------------------------N----L--DN-L-H---CITHSGGGICLTMLLTRHT--EYVDKISSITLFAC---------------------------QA-FAA----A-TTPV----------SYA----KLLLSKAATRQMGIVRGKRLKLGTMNE-SY---YLLSQWMDWNLNQNFSSYS------------------------------------PT----------------------PIRHQLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---A----------FNQR-MHRLIDKR----SGQG-----------FQ-R-----------------------------RH-TAV--------IPQQP--------------------------------------------------------------------------FDYR-----------------------------TV----------MPYI-T---TP-T-YA-ICAA-G-----DSV-APP-------------QGCLKFLQAF-NNANNHFR-------------------------EFGIA--S---G-D-LE-NYNH--TRIFLSRN-------AAAEVWPTVL-NWIEKHSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9leca-f0uxr7   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAEEHVVQTGDGYLLGLHRLCWRKGEESLRV-------------------------------------------------------------------------N-------------------------------------------------------------AGHGSVQKEVVYLH--HGLLMNSEVWV---CM----TE--KE-RCL----------------------------PFM-----LVE--------------------------R-G--YD-VW-----LGNNRGNKYSK---------------------------------------------KSTRFS---------------------------------------------------------------------------------------P--SS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDFWN-FSMDQ-------FAFHDIPDSIDYI-LA-----T-T-----------------------------------------------------------------------------------S----Q--PS-L-S---YIGFSQGTAQAF-ATLSIH------------------------------PT-LNDKI--DVFIA-L------A-PAMSPA------GLR--NGIVDSLVK---------------------------------ASPEVLFLAFGRRS-------ILSSAT----MW--Q-SIL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9maxi-c1bq94   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI----LF-WTFVL------SL--SSA-----NP--------------------------------------------------GE-AFIDTLR--NS--YDGIFNILHPSL--FY--PQEDIPNDLP-------VPEM-VKQYG-YTVETHKVTTSDGYINSLHRLITHQ-------------------------------------------------------------------------------------------------------------------------------------------------KNATLRPILVQ--HGLFGTSADFI---MG----RP---D-KSI----------------------------GYI-----LAD--------------------------L-G--YD-VW-----LGNCRGNKYSR---------------------------------------------EHTNLS---------------------------------------------------------------------------------------V--HD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-----EYWK-FSFDE-------MGRYDIPAAILHI-KN-----V------------------------------------------------------------------------------------SN----S--DQ-I-Y---YLGHSMGTVMFW-IALEEN---P---------------------------S-LNREI--KLMMA-M------G-PVAKVT------HVR--SP-IRYLAPFSK-----------------------------D-LKLLFHF-LGINE-------IQPTNS----LL--N-FFD-----K-WICDL-----TTI-----------Q-KEICENIL--------------------------------------------------------------------------------------------------------------------FLMAGY--------D-------Y--KQMNM--------TLL-PIIFGHE---PG-------------------G------TSTRT----LIHFAQEI-N-----------D----------------DR---FQKFDHGR----E--------------EN--------------------------------------L---------------------KLY--------------------------N---QTTPPAYNI---RDNV-Q---VP-I-AL-LWSE-N-----DWL-ADP-------------LDVQW-LQDE------------LKTV-LV-----Q-------------S--YR--V-P-YK-QFNH--IDFLWGLN-------ANAMVYEFIK-TLLKNHA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9perc-d2clz8   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-MLCVVV------CV------LVL--------SGL---------VH---------------------------------------TGPTDAHSS-----VVHR--------RS--YTPQQRLDPEVHMNI-------TEI-IRHWG-YPAEEHEVLTEDGYILTVNRIPQGLKHT----------------------------------------------------------------------------------------------------------------------------------------------P-GPRPAVLLQ--HGLLAAGSNWI---TN----LP---N-CSL----------------------------GYV-----LAD--------------------------A-G--YD-VW-----MGNSRGNTWSR---------------------------------------------KHQTLT---------------------------------------------------------------------------------------P--DQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDFWR-FSYDE-------MALKDLPAVVNHI-LK-----V-T-----------------------------------------------------------------------------------G----Q--EQ-I-Y---YIGHSQGTTIAF-IAFSTL---P---------------------------E-LASKI--RMFFG-L------A-PVATVA------FTS--SPMTKLSVLPD------------------------------F---LIWDL-FGRRD-------FLPQSH----MI--K-WFA-----E-HVCSK-----QLL-------------SELCGNVF--------------------------------------------------------------------------------------------------------------------FLLCGF--------D-------E--RNLNM--------TRT-PVYTTHC---PA-------------------G------TSVQN----MVHWAQAV-H-----------G----------------GK---LMAFDFGP----V---------------GN-------------------------------------M---------------------KHY--------------------------N---QSTPPQYRV---Q-DM-K---VP-T-AL-FWGG-Q-----DTL-ADP-------------KDVAV-LLTQ------------VS-NL-V-----F----------------HQ----H-IE-HWEH--LDFIWGLD-------APEQMFPSIL-KLLQEQEDH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16e91   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-EL--LNGR-III--------VI--TLL-----IA-------AV-------------------------------------------------------------YGKKSSV-----PFQFEEEDAGLT-------VPQL-IRKYG-YNLEKHQVLTEDGYLLALFRIPPRRGP-------------------------------------------------------------------------------------------------------------------------------------------------STKRPVLMM--HSLMSSCSDFI---LI----GP---K-HAL----------------------------GYL-----LAD--------------------------R-D--YD-IW-----LGNARGNRYSR---------------------------------------------RHKRLH---------------------------------------------------------------------------------------V--KS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-----KFWN-FTFHE-------IGYYDVPALIDYV-LD-----K-T-----------------------------------------------------------------------------------N----S--AK-L-H---YVGFSQGTLVSF-VAMSTR---P---------------------------E-YNAKI--VQMQE-I------S-PAAYLG------EPP--SFFIRILSEL-----------------------------APS-LGIGFNI-SGSSE-------FLPYWK----GQ--Y-DFY-----N-TVCPA-----P-------------A-QLLCRLLL--------------------------------------------------------------------------------------------------------------------NDVVGA--------N-------P--RQLHP--------KTL-RIFLGHF---PA-------------------G------AGVLQ----MQHYGQVF-K---------------------------DGI---FRRYDYGD----D--------------EKN-------------------------------------R---------------------AAY--------------------------G---STQVPEYDL---S-QV-T---AP-V-RI-YYSY-N-----DNV-IPY-------------RNVRR-LMRD------------L-PN-VV-----G-------------S--YL--V-P-DE-RFTH--ADFILANQ-------VKELLYDEIV-RNLEAAERED------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16f25   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGS-FRCWC------LL--LLA-----GA-------LFGSG----------AL-AYPD--E-------------------D-DFWKKEND-I--QT----V-REDN-----WFQIDAEDGDMT-------LQEL-IEKYG-YKVEIHSATTEDGYMLTLFRIMPRKISE------------------------------------------------------------------------------------------------------------------------------------------------TKKLPVFVM--HGLLGSAADFV---IS----GP---N-NSL----------------------------AYY-----LAD--------------------------D-G--YE-VW-----LGNARGTRYSR---------------------------------------------RHQELP---------------------------------------------------------------------------------------L--HS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----EYWD-FSWHE-------IGYYDLPAMIDYV-LN-----K-T-----------------------------------------------------------------------------------G----S--DQ-L-Q---YIGHSQGTTTYF-VMSSSR---P---------------------------E-YNQKI--ALMTA-L------S-PAVVLK------RIR--SPILRVLLKL-----------------------------SDT-IKEVLDS-LHVFE-------FFPYND----NN--H-KVM-----E-SLCPA-----N-A-----------R-DTICEELL--------------------------------------------------------------------------------------------------------------------GQLTGP--------H-------P--ESYSP--------KLA-AAYMGHA---PA-------------------G------ASTKQ----LMHFVQVV-R---------------------------TGL---FRQYDNGR----K--------------ENL-----------------------------------------------------------QTY--------------------------S---NWKPPTYNL---T-AS-S---AP-V-LI-FYGR-N-----DWM-VHP-------------KDVQE-FYKM------------L-PR-VV-----A-------------A--NL--V-S-DR-KFNH--LDFILAKN-------ARSEVYDKMR-PVLEQYNTINNPPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16f26   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK--QL--------------L-----------------------------LV--------------------------------F-AA----LV-FAV----DA-----QIHPDIIEDAHLD-------ALGL-LRKYG-YPAEEHIVETDDGYLLGVHRCPGSPMSPPA----------------------------------------------------------------------------------------------------------------------------------------------PGKPVVLLQ--HGMLSSSADYI---LM----GP---Q-TSL----------------------------VYM-----LAD--------------------------A-G--YD-VW-----LGNGRGNRYSN---------------------------------------------RHRTRN---------------------------------------------------------------------------------------NS--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-----QFWD-FSWHE-------VGSIDIPNMIDYI-LA-----R-T-----------------------------------------------------------------------------------G----Q--QG-L-Q---YVGHSQGTTAFW-VMMSQH---P---------------------------Y-YNRRV--KSAHL-L------A-PAAYMH------HTR--SPYVIFLATFLH-----------------------------T-TELMMQM-MGTWY-------FAPTNE----MD--I-QGG-----L-DNCHD-----GAP-----------F-QQMCTINT--------------------------------------------------------------------------------------------------------------------FLIAGF--------N-------T--QEVNY--------TML-PVIHAHS---PA-------------------G------ASAMQ----MIHHAQTI-R-----------S----------------RI---FRQYDHGP----T---------------LN-------------------------------------M---------------------VRY--------------------------G---SMVPPRYNF---A-NV-Q---AP-T-LL-YHST-N-----DWL-AAP-------------EDVEL-LRRE------------L-PN-IH-----K-------------Q--YL--V-R-QP-QFNH--MDFIWAIN-------VRPLLYDELL-SDLRAYA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16f28   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-------------------E-------ICVRN----------RL-QSP---V-------------------E-AFSPVPEH-LVDARASHSDRIRSG-----SVPLQAGD--------HRRVPEL-ISKYG-YEVESHSVTTEDGYELTMFRILPQQPSE------------------------------------------------------------------------------------------------------------------------------------------------TPKLPVLMV--HGLESSAVDFI---II----GP---N-NSF----------------------------AYL-----LAD--------------------------N-G--YD-VW-----LANARGTRYSK---------------------------------------------KHSTLS---------------------------------------------------------------------------------------V--DS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----EYWS-FSWHE-------IGYYDLPAMIDYI-LN-----T-T-----------------------------------------------------------------------------------S----V--SK-L-Q---YVGFSQGCTAYF-VMATTR---P---------------------------E-YNEKI--ALMTA-L------S-PPVIVK------RVR--SPLVLLLSEV-----------------------------LKE-FRKVKAS-FKDFE-------LLPYSN----EY--R-TIA-----Q-AICTD-----D-A-----------R-GNICQKWI--------------------------------------------------------------------------------------------------------------------SLIVGP--------D-------P--DGYDQ--------KVM-TVYVGHT---PA-------------------G------ASINQ----VIHYAQIA-Q---------------------------SKT---FQQFDYGR----K--------------ENI-----------------------------------------------------------LRY--------------------------G---SKKPPVYDL---R-LA-T---AP-V-MI-YYAL-N-----DWL-VHP-------------RDVQE-LAKV------------L-PR-VV-----E-------------A--VP--V-A-DK-QFNH--LDFALAKN-------VRTLLYDQAI-QVMEKFNEK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16f29   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-ML--RIG----SLV------VL--LFV-----VD-------FG-------------------------------------------------------------LGFNHSS-----PFLVEEKDALLT-------VPQL-IRKYG-YKVEEHEVVTEDGYLLAMFRIPGRKG--------------------------------------------------------------------------------------------------------------------------------------------------TKEYPIFMM--HSLFSSCADWV---LI----GR---K-HGL----------------------------AYL-----LAD--------------------------R-G--YD-VW-----MGNARGNRYSR---------------------------------------------KHRRLS---------------------------------------------------------------------------------------T--VS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-----QFWN-FTFHE-------IGYYDVTALIDYV-LD-----R-T-----------------------------------------------------------------------------------G----A--ER-L-Q---YIGFSQGAMTSF-VALSSR---P---------------------------E-YNEKV--VQLHA-M------S-PAVYMY------RSG--SALIRVLASL-----------------------------ATP-IRDVFTS-VGKYE-------FLPFNE----QQ--Y-YLF-----R-WLCPA-----P-------------E-QKICRAII--------------------------------------------------------------------------------------------------------------------YDVVGP--------N-------P--TQLDV--------KML-RIFLGHF---PA-------------------G------ASIKQ----VTHYAQII-R---------------------------DGI---FRQLDYED----P--------------KKN-------------------------------------R---------------------QVY--------------------------G---SEQVPRYNL---S-QV-T---TP-V-RT-YYGY-N-----DNT-VVY-------------LNVLQ-LQSE------------L-PN-VV-----S-------------S--YP--V-P-DK-RFSH--VDFILANY-------VKEMLFKEII-KNVEHTERSASSK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16f30   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRD--LI--------------S-----------------------------VA--------------------------------L-LL----VMVGLG----YA-----QVHPDIAEDAYLD-------SLGL-LRKYG-YPAEEHIVETDDGYLLGVHRCPGSPVSPPA----------------------------------------------------------------------------------------------------------------------------------------------AGKPVVLLQ--HGMLSSSADYI---LM----GP---Q-TSL----------------------------VYM-----LAD--------------------------A-G--FD-VW-----MGNSRGNRYSN---------------------------------------------RHRSRN---------------------------------------------------------------------------------------NQ--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-----VFWD-FSWHE-------VGIIDVPNVIDYI-LA-----R-T-----------------------------------------------------------------------------------G----Q--QR-L-Q---YVGHSQGTTVFW-VMMSQH---P---------------------------Y-YNQRV--KSAHL-L------A-PAAYMH------RTR--SPYVIFLAAYLH-----------------------------T-TELMLQM-MGTYY-------FAPTNE----MD--I-QGG-----I-DKCRD-----GAP-----------F-QQMCTITT--------------------------------------------------------------------------------------------------------------------FLMAGF--------N-------S--QEVNY--------TML-PVMHGHS---PA-------------------G------ASAMQ----MIHHAQTV-R-----------S----------------QI---FRQYDFGP----T---------------QN-------------------------------------M---------------------IRY--------------------------G---SLTPPNYNL---N-NV-Q---AP-T-LL-YHST-N-----DWL-ATP-------------EDVLL-LASQ------------L-PN-VR-----K-------------R--YL--V-P-MH-EFNH--MDFVWAIN-------VRSLLYNELL-ADLRAYA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16gz0   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I------AIS-LLAL----LV------------KL-E-------A------------------------------------------------F-------------------LS-------TVEL-ATKYG-YRIATHHIQTDDGFLLELHRITGSGSTMYD----------------------------------------------------------------------------------------------------------------------------------------------KRLPPVLLM--HGLFASSADWV---LL----GP---G-NAL----------------------------AYL-----LSD--------------------------M-G--YD-VW-----LPNVRGNRYSR---------------------------------------------KHISYT---------------------------------------------------------------------------------------PN--M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-----KFWD-FSWHE-------IATYDLPAIIDYT-LN-----V-T-----------------------------------------------------------------------------------S----K--EK-L-H---YIGHSQGTTVFF-VMCSER---P---------------------------E-YNEKI--LLAQG-L------A-PIAFME------HMN--SPLLKVMVQNLD-----------------------------A-ISTIADF-FSLNE-------FKPIPS----VV--L-EVA-----K-YLCPQ-----SK------------P-DNLCVNIL--------------------------------------------------------------------------------------------------------------------FQITGA--------N-------P--DQVDP--------KMV-QLLLGHI---PA-------------------G------SSTKQ----ILHFAQEV-R-----------S----------------GL---FQQYDYGK----L---------------KN-------------------------------------M---------------------FVY--------------------------N---QPEPPVYNL---S-EL-W---RL-L-AS-TMDP-M-----IIC-LSR-------------R-------------------------------------------------------------MFCG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16je0   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-TVYYL--R---CW-------LVM-TL-----L---------------------------------------------------------------------------KL--T-----SSIN---PDAL-------LKTS-IAQHD-YPVELHKVPTEDGFILTATRIPK-P----------------------------------------------------------------------------------------------------------------------------------------------------GHTPLLIM--HGLFGCSVDYT---AQ----GP---G-KAL----------------------------ALL-----AHD--------------------------A-G--FD-VW-----MGNNRGTTYSK---------------------------------------------KHEHLD---------------------------------------------------------------------------------------E--KS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-----AYWH-FSFHE-------LGLYDLSALVDYV-LK-----V-T----------------------------------------------------------------------------------N-----Q--KK-L-H---YIGHSQGSTQFL-VLTTLR---P---------------------------E-YNDVF--ISTHL-S------A-PVAYIH------HAT--NPA-VILTKRAD-----------------------------E-LEAASRL-TGIYE-------LGGR----------------------G-AGS-----YVDAIIRANQLGFIP-LDLILLNL--------------------------------------------------------------------------------------------------------------------WYVMGY--------H-------D---SINR--------TML-PDLLKYS---PA-------------------G------GSIYQ----VLHYIQLF-N-----------A----------------RN---FQQYDFGS----E---------------EN-------------------------------------L---------------------KRY--------------------------G---TAQPPSYPL---H-KI-T---AP-T-YI-YYGE-S-----DNL-NQP-------------ADLDA-LAER------------LP-N-LQ-----L-------------K--FK--V-P-VR-RWNH--VDFLYGNG-------AHR-LYRMIL-AKMLDS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16je1   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-VQRGL--L---WW-------FLL-SL-----C---------------------------------------------------------------------------GP--A-----NCDD---PDEL-------LKSS-IAKHG-YPVELHKVTTEDGYILTNARIPN-P----------------------------------------------------------------------------------------------------------------------------------------------------RNTPLLIM--HGLFGCSVDFT---AQ----GP---G-KAL----------------------------ALL-----AHD--------------------------A-G--FD-VW-----LANNRGTTYSK---------------------------------------------KHESLD---------------------------------------------------------------------------------------L--KS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-----AYWR-FSFHE-------LGLYDLSAIVDYV-LK-----H-T----------------------------------------------------------------------------------R-----R--KK-L-Q---FIAHSQGGGQFL-VLTTLR---P---------------------------E-YNDVF--ISAHL-S------S-PVAYLH------HAT--SPA-VILTTRPE-----------------------------E-IEAGARL-TGFYE-------ISGR----------------------G-NGS-----YVDAIVQATRKGLIP-LDLILINV--------------------------------------------------------------------------------------------------------------------WYVMGY--------H-------D---SFNR--------TMF-LDLLRYS---PA-------------------G------GSVYQ----VLHYIQLY-N-----------A----------------KS---FQQYDFGS----A---------------EN-------------------------------------L---------------------QRY--------------------------G---AVEPPLYPL---Q-KV-T---TP-T-YV-YYGE-S-----DNI-IQP-------------PDVHA-LADQ------------LP-N-LR-----L-------------R--YK--I-P-DR-RWNH--LDFLYASS-------AHR-LYRMIL-GKMGPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16je2   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNWL--S---CIQ------LLL-AG-----R---------------------------------------------------------------------------VL--V-----RAID---PNEF-------LKST-IAKHN-YPVELHPVTSPDGYHLTMARIPN-P----------------------------------------------------------------------------------------------------------------------------------------------------NRPVLFLM--HSFLSSSSDYT---VH----GP---R-KSL----------------------------AFS-----GFD--------------------------E-G--FD-VW-----LANGRGNTFSR---------------------------------------------SHRSMN---------------------------------------------------------------------------------------P--SQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----QFWD-FSFHE-------VATLDLPAMIEYV-LN-----A-T----------------------------------------------------------------------------------G-----R--SK-V-H---YVGHSQGGTNFL-VMASMR---P---------------------------D-VNEKI--ASAHL-S------S-PVAFWS------RNT--TPM-SYLYDELM-----------------------------T-LIAMFDQ-IGLYE-------VGGR----------------------S-AGS-----MMEYVEKAIDGGCIS-QDMLMLGL--------------------------------------------------------------------------------------------------------------------WMVVGE--------H-------S--ETLNK--------TTI-EAVRKVF---PA-------------------G------ASIRQ----GLHFLQMM-K-----------S----------------ER---FCLFDYGE----Q---------------EN-------------------------------------L---------------------RRY--------------------------G---KAVPPSYSL---G-KV-T---AP-V-AL-YYGM-N-----DPF-VAI-------------KDLEV-LVEK------------LP-N-VV-----L-------------K--HK--M-A-DP-KWNH--VDFIFGSN-------GYE-AHQLVI-EWAKKYDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16m61   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDT-IEAAD-YPAEIHVVTTKDGYILKLHRIPDPALLKDTDY---------------------------------------------------------------------------SE--------------------EQ------------------------------PL-----NEPGGCQGVVLLM--HGLFSTAADFV---VT----GP---E-SGL----------------------------AFV-----LAD--------------------------A-G--FD-VW-----MGNARGTRFSR---------------------------------------------KNLNHT---------------------------------------------------------------------------------------P--KE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----AFWD-FSWHE-------IGIGDLSAIIDYM-LR-----Q-T----------------------------------------------------------------------------------N-----Q--QS-L-F---YVGHNQGITALL-VLLSEK---P---------------------------R-YNRKI--SIAAG-M------A-PVAYLG------SGN--NEIVKNLAKFND-----------------------------Q-LWVQFGS---VFF-------LTPTEN----VL--Q-FLG-----N-IICSG-----EAP-----------T-QTVCSDLL--------------------------------------------------------------------------------------------------------------------AEMFGY--------S-------S---DQAK--------LLL-PGMLDNA---LS-------------------G------ISTKQ----LVHYGQLI-Q-----------S----------------RK---LQQFDYKN----F--------------LTN-------------------------------------M---------------------QRY--------------------------K---QVKAPEYNL---S-KV-T---VP-F-LL-FSGS-R-----EFF-TSS-------------ADFQK-LVKN------------LP-N-VE----------------------SQ--S-E-LP-GWGH--MDFIYNAQ-------VYLKVYSRII-EVMQNFTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16mc6   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTA-S------LT--------------------------------T-LL------ITAG----AI-----QRA-------LAG-------TEQL-VKRMG-LPVEKHRAVTSDGYVLTMFRIPANNTN---------------------------------------------------------------------------------------------------------------------------------------------------SPVAFLQ--HGLIASSADWV---IL----GP---G-KSL----------------------------AHS-----LVT--------------------------A-G--YD-VW-----MGNFRGNTISR---------------------------------------------KHVSLD---------------------------------------------------------------------------------------PA--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-----QFWD-FSWHE-------IGLYDLPAMIDYV-LK-----K-T-----------------------------------------------------------------------------------G----Q--KT-L-H---YVGHSQGTTAFF-VMASMK---P---------------------------E-YNSKI--LSMQA-L------A-PIAFMG------QMK--SPFIRAIAPFST-----------------------------Q-IEWTMRM-LGVNE-------LLPSHK----MM--I-AGG-----Q-KACED-----TST-----------L-QEVCVNVI--------------------------------------------------------------------------------------------------------------------FLICGY--------D-------S--AQLNR--------TLL-PTIVQHT---PA-------------------G------ASVKQ----LAHYAQGI-N-----------S----------------GR---FRQFDHGV----V---------------GN-------------------------------------V---------------------MNY--------------------------G---SSTPPSYPL---K-RI-T---AP-V-FL-HYGD-N-----DWL-AAV-------------SDVRL-LYRQ------------L-GN-GT-----R-------------L--LR--V-P-EK-QWNH--LDFIYATG-------AKSLLYNRVM-DLMNRYNNAMPEKYRMEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16mc7   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEI-AVRHG-YWAESHTIKTSDGYLLTLHRIPCGRVGCAG-----------------------------------------------------------------------------------------------------------------------------------------SSGGKGSGQPVFLQ--HGLLSSSADWL---LS----GP---D-KAL----------------------------AFI-----LAD--------------------------A-G--YD-VW-----LGNARGNTYSR---------------------------------------------KHVSMS---------------------------------------------------------------------------------------S--DE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-----AFWD-FSWHE-------MALYDIPAEIDFV-YG-----M-RE-----------------------------------------------------------------------------LEQNDT----R--RN-L-L---YIGHSMGTTMAF-VMLANM---P---------------------------E-YNDKI--QAVFA-M------A-PVAFMG------HVK--SP-IRLLAPFSH-----------------------------D-IEMILKF-FGGNE-------FMPQNK----II--R-YLA-----K-YGCEL-----TEA-----------E-KYICENTV--------------------------------------------------------------------------------------------------------------------FVLCGF--------D-------K--EQYNA--------TLM-PVIFGHT---PA-------------------G------TSTKT----VVHYAQEI-H-----------D---------------SGN---FQQFDYGE----A--------------EN--------------------------------------Q---------------------RRY--------------------------G---QPQPPSYSL---D-RI-S---TP-V-AL-FYAN-N-----DWL-AGP-------------VDVAN-LFNR------------LTKT-SI-----G-------------M--FK--V-P-ND-NFNH--VDFLWGND-------APEVVYKQLM-MLMKRYK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16md1   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ME--KLLT------SIL-L-AT----LI-------ALIHAA-------------------------------------------------------P---SYGDAT--RAF-QVEDADARLT-------VPQL-IQKYN-YPVEVHHATTEDGYELELHRIPS------L----------------------------------------------------------------------------------------------------------------------------------------------PGSPVVFLM--HGLLCSSADWI---II----GP---N-NAL----------------------------AYL-----LAD--------------------------Q-G--YD-VW-----MGNARGNRYSR---------------------------------------------RHTSLT---------------------------------------------------------------------------------------PN--M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----AFWQ-FSWHE-------IGYYDLPAMVDYT-LN-----Q-T-----------------------------------------------------------------------------------N----Q--SK-L-H---YIGHSQGTTTFF-VMASTR---P---------------------------E-YNEKI--RLMQA-F------A-PVAFTE------HVR--SPLLKVMSRFQN-----------------------------S-LTALFAT-FGVGE-------FLPNNA----IL--H-EVA-----Q-LFCSK-----DV------------D-WNLCLNVI--------------------------------------------------------------------------------------------------------------------FQIAGS--------D-------P--DQVET--------QIV-PILIGHT---PA-------------------G------AATKQ----VVHFAQGM-R-----------S----------------HL---FRRYDFGK----I---------------KN-------------------------------------L---------------------AVY--------------------------G---TPQPAEYNV---T-DI-S---AP-I-MM-YYGL-N-----DYL-AEP-------------KDVLR-LSGM------------F-RN-LE-----G-------------C--KQ--M-A-ID-SFNH--LDFLMARD-------VRRLLYDEVI-GRIREWSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q16ms7   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT-------P----------------------------------------------FQLFLVVSSAVTPTIS------------ELFFDNKDGSLT-------TPQI-LAKYG-YKPETFRIETYDGFVVEMHRLTASPVSGRF---------------------------------------------------------------------------------------------------------------------------------------------DPTKPPVLMI--HGLLGSSADWI---MT----GP---Q-NGL----------------------------PYL-----LSN--------------------------L-G--YD-VW-----LGNARGSRYSR---------------------------------------------EHTYLT---------------------------------------------------------------------------------------E--DM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----EYWD-FSWHE-------IGIYDVPAMIDFV-LK-----T-T-----------------------------------------------------------------------------------K----F--RK-L-H---YVGYSQGTTAFF-VMNSLI---P---------------------------R-YNEKI--IKLHA-L------A-PAAYMS------HLS--NPVFKYLSTHLN-----------------------------T-VTNIVSV-LGINQ-------FMPASS----IF--P-HIA-----S-AICAV-----N---------------EQQCFNIM--------------------------------------------------------------------------------------------------------------------FVLSSG--------E-------Y--RNINP--------QII-PILVGHI---PA-------------------G------SSGKQ----IFHYAQEV-T-----------S----------------GH---FRQYDYGV----D--------------NN--------------------------------------T---------------------EIY--------------------------H---SLDPPDYNL---T-NV-H---AP-V-AI-YYSL-N-----DQL-ANP-------------LDVGR-LAQE------------L-PN-LV-----S-------------L--NQ--V-P-NP-SFSH--MDFILSTN-------AKDELYLDII-ASIEADTRHEQRFNRSH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q17bm3   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEKHG-YPAELHSVTTKDGYILTMSRIPSPR-----------------------------------------------------------------------------------------------------------------------------------------------------KIPILMM--HQVYGCSVDFT---IL----GP---G-KAL----------------------------AFL-----AHD--------------------------Q-G--YD-VW-----MGNVRGNMFSR---------------------------------------------GHVSLD---------------------------------------------------------------------------------------S--NK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-----AFWK-YSFHE-------IGFYDVPAMVDYI-LY-----L-T-----------------------------------------------------------------------------------G----R--DR-L-H---YIGHSQGSVVFL-VMTSLH---P---------------------------Q-YNQKI--TSAHL-S------A-PAAFIS------RST--VP-VTSMSGEIL-----------------------------S----ALQL-VDSMG-------FHSIGDRFNSEP--M-LYV-----K-KAIDA-----SVI-----------R-EEWIMETA--------------------------------------------------------------------------------------------------------------------YYLAGE--------D-------R--EGFNM--------SVM-PDLTSAF---PA-------------------G------GSIRQ----LTHFVQSF-R-----------S----------------GR---FAQFDFGR----E--------------GN--------------------------------------L---------------------KRY--------------------------G---HSTPPAYPL---D-LV-T---VP-V-AI-YYGS-N-----DQF-VAV-------------EDVDL-LAKK------------L-PN-VV-----L-------------K--YL--H-P-NA-KWNH--IDFLYGKE-------APAV-YRKLL-AVIHSYERR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q17bm4   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWS--L-VI------AIS-LLAI----LV------------KL-E-------A------------------------------------------------FVLLDE--KSL-QVEDADAKLS-------TVEL-ATKYG-YRIETHHIQTDDGFLLELHRITGSGSTMYD----------------------------------------------------------------------------------------------------------------------------------------------KRIPPVLLM--HGLFASSADWV---LL----GP---G-NAL----------------------------AYL-----LSD--------------------------M-G--YD-VW-----LPNVRGNRYSR---------------------------------------------KHINYT---------------------------------------------------------------------------------------PN--M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-----KFWD-FSWHE-------IATYDLPAIIDYT-LN-----V-T-----------------------------------------------------------------------------------S----K--EK-L-H---YIGHSQGTTVFF-VMCSER---P---------------------------E-YNEKI--LLAQG-L------A-PIAFME------HMN--SPLLKVMVKHLD-----------------------------A-ISTIADL-FSLKE-------FKPIPS----VV--L-EVA-----K-YLCPQ-----SK------------P-DNLCVNIL--------------------------------------------------------------------------------------------------------------------FQITGA--------N-------P--NQVDP--------KMV-QLLLGHI---PA-------------------G------SSTKQ----ILHFAQEV-R-----------S----------------GL---FQQYDHGK----L---------------KN-------------------------------------M---------------------FVY--------------------------D---QPEPPVYNL---S-RV-V---AP-V-SL-HYGP-N-----DYL-SVE-------------EDVLR-LAKQ------------L-PN-LI-----E-------------L--NR--I-D-ME-LFNH--LDFLIAKD-------VKEILYDKLI-SNIEQYNY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q17gr0   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKETGRSR-------TERY-IERHA-ITSECYDVTTEDGYQLKVFRLIPK---------------------------------------------------------------------------------------------------------------------------------------------------VKRRGVVLLQ--HGLRQSSASWL---LM----NQ------NL----------------------------PLQ-----LLE--------------------------Q-G--LE-VW-----LGNSRASTEGS---------------------------------------------SHTNLD---------------------------------------------------------------------------------------R--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----EFWN-FSFHE-------IGIYDMAAIVDFV-LV-----A-A----------------------------------------------------------------------------------G-----C--EQ-I-Q---IIAFSEGAAATL-ILLTKR---P---------------------------A-YNEKV--SRLNL-L------A-PAALLS------RSS--YTVLAALYVTFK-----------------------------P-ILP--------WS-------LQR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVT----------------------------------------GKDE---PS-------------------G------NSQKE----LEHLQHLM-L-----------S----------------GR---FVEYDYGA----K---------------RN-------------------------------------L---------------------VMY--------------------------G---TSKVPEYPL---C-KV-T---CP-V-VL-HYGG-A-----DRV-VHP-------------RDVKR-LSRK------------LA-N-SE-----Q-------------V--EV--M-C-HK-HMRH--LDFLTRKD-------AAVEV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q17gr1   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRSGGTSNQTVL----------------LLL-------VL---------A------------TITF-V-------A----------------GR-----AVRR-------T-----V-------DN--S----------DRS---R-------TEDY-ITQYE-INTERYRVTTDDGYQLIVYRLLPQVPA---------------------------------------------------------------------------------------------------------------------------------------------------QGAVLIQ--HGIRQSSAGWL---NL----EK------NL----------------------------PMQ-----LLE--------------------------A-G--ME-VW-----LGNSRASPESA---------------------------------------------GHLTFS---------------------------------------------------------------------------------------N-D--------S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQFWD-FSFHE-------IGFYDLAAMIDAA-LE-----I-SQ---------------------------------------------------------------------------------------R--KQ-L-H---LIAYSEGASAAL-TLLSER---P---------------------------E-YNAKI--TSVNL-L------A-PAAFMA------NSQ--FKLL--PKETG--------------------------------VQLIE------YD-------LLD--------------HG-----D-FTS-R-----T---------------------------------------------------------------------------------------------------------------------------------------------------------EAASNVYPM--VV----------EDI---VAK------------------------------------SKQ----IEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q17gr2   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFCRKKKNCLGGCL----------------VLL-------VV----------------------------------------------------GV-----AMA--------------S-------SA--T----------PPS---K-------TLTN-AARYG-LAAHRHHVITHDGYRLALYRIRSHAHA---------------------------------------------------------------------------------------------------------------------------------------------------RGIVLLQ--HGIRQSSADWL---MI----DR------NL----------------------------PMQ-----LLE--------------------------A-G--FE-VW-----LGNSRASPETV----------------------------------------------HIKHL---------------------------------------------------------------------------------------R-N--------S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEFWD-FSFNE-------IGYLDLPAMIDTV-LT-----V-AR---------------------------------------------------------------------------------------R--SS-L-H---LVGFSEGSTASL-ILLSER---V---------------------------S-YNAKV--ASLNV-I------A-PATFMI------NSL--IKQF--AYIYE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFRDSFPV--SL----------QEL---VTGSEK---PL-------------------I------NSAKQ----LEHFHQLL-V-----------T----------------GR---FRHFDYGE---WD----------------N-------------------------------------V---------------------KYY--------------------------G---VERPPPYSL---W-RI-T---TP-V-TV-HYGT-A-----DGI-VPP-------------DDVRN-LAMQ------------LH-KSTK------------VR--------I---V-Q-HD-RFDH--RDFMMQPD-------AAVRVYPRVV-YAIVESSH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aedae-q17gr3   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LETDG-YQGRAHRVVTQDGYVLKLYQIWRDQQP-V---------------------------------------------------------------------------------------------------------------------------------------------VNSTRGTILLQ--HGIMHSSSDWL---VL----GP---G-RSI----------------------------AYQ-----LVD--------------------------L-G--YD-VW-----LANSRSTMNSH---------------------------------------------QHEKFC---------------------------------------------------------------------------------------T--CS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----EFWD-YSWHE-------QGFYDLPAMIDTV-LN-----E-T----------------------------------------------------------------------------------Q-----Q--QR-L-R---LLVYSEGGAMAM-VMLSTR---P---------------------------E-YNDKL--IALDA-M------A-PAAFVS------NTW--YRYLAIPFAKIP-----------------------------K-VFRVNNS-TFFFT-------SYSPYR----IT--------------------------------VEACQTE-YQICSDLY--------------------------------------------------------------------------------------------------------------------FQFLNG--------E-------S--VGMNR--------SWV-DRIYQAM---PA-------------------G------GSIKE----VLHYVQLI-W-----------T----------------RK---FAPFDHGP----S---------------KN-------------------------------------L---------------------RLY--------------------------G---QRTPPEYPL---D-RV-S---VP-V-NI-HYGL-R-----DKI-VDP-------------VGVMR-LGSR------------LI-N-SP-----R-------------V--RM--R-P-YD-ELQH--SDFIYGDA-------AYNMVYKDVL-MWITE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ailme-d2gz36   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQI-VSYWG-YPDEVCDIVTEDGYILGLYRIPYGKTNNDS--------------------------------------------------------------------------------------------------------------------------------------------SGSQVHVIYC--------WSTTWR---RS----YG---N-QSL----------------------------GFI-----LAD--------------------------A-G--YD-VW-----LGNSRGTTWSR---------------------------------------------KHKYLK---------------------------------------------------------------------------------------T--NS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEFWA-FSFDE-------MAKYDLPASIDFI-VK-----H-T-----------------------------------------------------------------------------------G----Q--EE-I-F---YIGHSQGTTIAF-ITFSTI---P---------------------------K-IAERI--KIFFA-L------A-PVFSIK------YSK--SPLIKMAYKWK------------------------------S---VIKAF-FGNKD-------FLPNTS----FK--R-FVG-----S-KLCPL-----KII-------------GKICRDIL--------------------------------------------------------------------------------------------------------------------FMIYGC--------D-------L--ENLNM--------VRT-IRAMHTSFHQPR-------------------CN--KQMSMILL----LQFFFQLF-N-----------S----------------SH---LRAFDWGS----P--------------VLN-------------------------------------L---------------------AHF--------------------------N---QSTSPFYDV---R-NM-N---VS-T-AT-WNGG-N-----DLL-ADP-------------EDVKN-LLSE------------IT-NH-I-----Y----------------HK----T-IS-YYNH--IDFLFGLG-------VYQQVYREII-AIIQGNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ailme-d2gz37   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------RF------LLT-MASLI--AAL---------GT---------------------------------------T------------------------HGY--FGKLHPTSPEVTMNI-------SQM-ISYWG-YPSEEYDVVTEDGYILGINRIPYGKKNSEN---------------------------------------------------------------------------------------------------------------------------------------------IGQRPIAFLQ--HGLLASATNWI---SN----LP---N-NSL----------------------------AFI-----LAD--------------------------A-G--YD-VW-----LGNSRGNTWAR---------------------------------------------RNLYFS---------------------------------------------------------------------------------------P--DS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEFWA-FSFDE-------MAKYDLPATIDFI-LK-----K-T-----------------------------------------------------------------------------------G----Q--DK-L-H---YVGHSQGTTIGF-IAFSTN---P---------------------------K-LAKKI--KTFYA-L------A-PVTTVK------YTK--SLLKELMLLPT------------------------------F---LFKLI-FGNKI-------FYPHHF----FD--Q-FLA-----T-EVCSR-----GTV-------------DLLCSNAL--------------------------------------------------------------------------------------------------------------------FIICGY--------D-------A--KNLNM--------SRL-DVYLSHN---PA-------------------G------TSVQD----VLHWSQAV-R-----------S----------------GQ---FQAFDWGS----P--------------AQN-------------------------------------M---------------------LHY--------------------------H---QPTPPYYNL---T-DM-H---VP-I-AV-WNGG-N-----DLL-ADP-------------HDVDL-LLSK------------LP-NL-I-----Y----------------HK----K-IP-PYNH--LDFIWAMD-------APQVIYNEIV-SMMGENNK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ailme-d2gz38   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------WQ------LLA-TTCWM--LLL---------GP---------------------------------------I------------------------YGY--HKKGRITNPEANMNI-------SQI-ISYWG-YPCEEYDVVTKDGYVLGIYRIPHGRGCPRT----------------------------------------------------------------------------------------------------------------------------------------------TPRPVVYLQ--HGLLASASNWI---CD----LP---N-SSL----------------------------AFL-----LAD--------------------------T-G--YD-VW-----LGNSRGNTWSR---------------------------------------------KHLKFS---------------------------------------------------------------------------------------P--KS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REYWA-FSLDE-------MANYDLPATIKFI-VE-----K-T-----------------------------------------------------------------------------------G----Q--ER-L-Y---YVGHSQGTTIAF-IAFSTN---P---------------------------E-LAKRI--KIFFA-L------A-PVVTVK------YTQ--SPLKKFTILSR------------------------------E---VVKAL-FGDKM-------FHPHTV----FD--Q-FIA-----T-KVCNR-----KLF-------------RHICSNFL--------------------------------------------------------------------------------------------------------------------FTLSGF--------D-------P--KNLNM--------SRL-DVYLAQS---SA-------------------G------TSVQN----MLHWAQAA-N-----------S----------------GL---FQAFDWGN----P--------------DQN-------------------------------------M---------------------MHF--------------------------H---QRTPPIYDV---T-KM-A---VP-T-AV-WSGG-Q-----DRV-ADL-------------KDIEN-LLPK------------IT-RL-I-----Y----------------YK----F-IP-HYNH--VDFYLGQD-------APQEVYQDLI-RLMDECLQN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ailme-d2gz39   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------WL------FLTTTCCLI--CGT---------LN---------------------------------------A----------------G--------RF--FNLENEANPEVWMNI-------SEI-ITYNG-YPSEEYDVTTQDGYILSVNRIPHGRRGA---------------------------------------------------------------------------------------------------------------------------------------------GSTGPRPVVYLQ--HALFADNASWL---EN----YA---N-GSL----------------------------GFL-----LAD--------------------------A-G--YD-VW-----MGNSRGNTWSR---------------------------------------------RHRTLS---------------------------------------------------------------------------------------V--TE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKFWA-FSFDE-------MAKYDLPGIIDFI-VN-----K-T-----------------------------------------------------------------------------------G----Q--EK-L-Y---FIGHSLGTTIGF-VAFSTM---P---------------------------E-LAQRI--KMNFA-L------G-PVVSFK------YPT--GIFTSFFLLPN------------------------------S---IIKGV-FGTKG-------VFLKTG--------K-VSA-----L-KICNN-----KIL-------------WVICSELM--------------------------------------------------------------------------------------------------------------------SLWAGS--------N-------K--KNMNM--------SRM-DVYMSHA---PT-------------------G------SSMRN----ILHIKQLY-G-----------S----------------DE---FRAYDWGS----E--------------AEN-------------------------------------M---------------------NHY--------------------------N---QSRPPLYDL---T-AM-K---VP-T-AM-WAGG-N-----DVL-VTL-------------QDVAR-VIPQ------------IR-NL-R-----Y----------------FD----L-LP-DWNH--FDFIWGLD-------APQRLYSKII-ALMKSCS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ailme-d2gz40   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPKILSR---V-----WIV-SHRTEM------WL------LIL-VAYLF--QRN---------VN---------------------------------------SG----------------------------CMPTKAVDPEAFMNI-------SEI-IQHQG-YPCEEYEVVTEDGYILSINRIPQGLGQP---------------------------------------------------------------------------------------------------------------------------------------------KKTGPRPVVFLQ--HGLLGDASNWI---TN----LP---N-NSL----------------------------GFI-----LAD--------------------------A-G--YD-VW-----LGNSRGNIWSR---------------------------------------------KHKTLS---------------------------------------------------------------------------------------V--DQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEFWA-FSYDE-------MARFDLPAVINFI-LQ-----R-T-----------------------------------------------------------------------------------G----Q--EK-V-Y---YVGYSQGTTMGF-IAFSTM---P---------------------------E-LAQKI--KMYFA-L------A-PIATLK------HAK--SPCTKFLLLPD------------------------------M---MIKGL-FGRKE-------FLYQTR----FF--R-QFA-----I-YLCRQ-----MII-------------DQICSNVM--------------------------------------------------------------------------------------------------------------------LLMGGF--------N-------T--NNMNM--------SRA-NVYVAHT---LA-------------------G------TSVQN----ILHWSQTM-N-----------S----------------GE---LRAFDWGS----E--------------TKN-------------------------------------L---------------------EKG--------------------------N---QPTPIRYKV---R-DM-T---VP-T-AV-WTGG-Q-----DWL-SNP-------------EDVKT-LLSE------------VT-SL-I-----Y----------------HK----H-IP-EWAH--VDFIWGLD-------APHRMYNEII-HLMKQEETSFSQGMC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ajecg-c0p0h0   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRVPFIGRL-----------------------------------------------------FWNEY---LALFSSLVLISV-------------EVLLHV--V-TL-C-LPQP-IIQFCYRQ---S-----------------KVLFKALASPQGRRI------------------------RALQ------------------------------------------TSTSGKIASASDFLQ--------LCALWG---YEAEEHVVQTGDGYLLCLHRLPRKKGEDFFG---------------------V--------------------------------------------------------------------------------------------------------------N---AGEGARQKPVVYLH--HGLLMNSEVWV---CLTNEE-------RCL----------------------------PFQ-----LVE--------------------------K-G--YD-VW-----LGNNRGNKYSKKSI---------------------------------------------FHS---------------------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-STAFWD-FSIDQ-------FAFHDIPDSIEYILSV-------TSQ-----------------------------------------------------------------------------------------KS-L-S---YIGFSQGTAQAFATLSIH--------------------------------PTLNQKI--NLFIA-L-------APAMSPA------GLS--NGVVDALMKAS---------------------------------PNVLFLAFGRRS-------ILSSTP----MWQT-------------ILYP------P------------IFVRIIDISL--------------------------------------------------------------------------------------------------------------------SFLFNWSSV-NIN-S-----------------------DQK-LAAYPHL----------------------------FSFTSTKS----VVHWFQII-R------------------------------NKSFQMYDDDAGPLVN----IN----------------------------------------------------------------------NNS-----------------------------RYYKPAKFPT---K-NI-K---TP-I-VL-VYGG-R-----DSL-VDI-------------DVMLGELPNHT-------------------------------------L--A---T-S-IS-HYEH--LDFLWARD-------VADQVFPHIL-DALRSHG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ajecn-a6rf70   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVRD-------IPYYSRRVG-LDAESYRVQTEDGAVIPLWHLYDPKEYVPLASSDKN------------------CIGPP