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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....
9arch-q2y4y6   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGFDKIAVFGISMGGKAAIIASTKTKE-ID--AVVADSSAVGFVESMNLRDR----V---SMGSS-------KVF---------------S-FFVSETLVAYFYELMTGI----SEDDNKAVNYIDRINTPIL-----------------IIHGDKDKIVPLKDAHLL-YEKAKEPKFI-------------------------WIVKNTGHHKA-------------------------------------HN-----------------------------------------THRAEYEERLLNFFDENLKSGTSCDYIQKLFLSVCVDN----ELGGCLYR     =====>
9clot-q3cb62   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLIEDEVKD--------------------TKEIQINFTNSDTEQIIVE----N---------PIVGKLFKPK---EKNNLPAIIIVGGSTGGLFWTEQMAALLSTKGYATLALNYFDVQ-------NH-NLPSELIEIQIEYFKKALDWLKAKPGVDKNNISMIGISKGSELSLLFGSYFPKSLT--SIITYVPSSHVFEGISMR--------EHQVKSSWTYKNHPIDFIQYPIDSKF---------SKDMNPIDIRKIHDTALNTATSKQLESARIPIENIKCPIL-----------------MISGEKDSTWPSSKMCKDMMQTLKEQNNHYQS--------------------KHLDFNNMGHAFF-LPNLPPMIDHP---------S----------ISAYNAA-----------------------------------------NANKNAWEATLNFLAEHFN-------------------------------     =====>
9eury-c1vei1   	----------------------------------------------------------------------------------------------MVSGIAPGTAVTITARTFD----------------REGRQWASFATFTASSKGVVDIETHAPDA-GTYETVSPMGL--IWSMRPTDGESSI------YAPPE-GGSDLTLTASADG-----RQ----IGQQTV------TR-WFGPKKLHTEASP----D---------GLLGTLFRPS---GDGPYPGVMVLHGSGGQPAV--GSALMLAAHGYAAFAPQYFGPP--------D-AVPDQLAEVPLEYLQRGYDWLTSRPAVRDGSVGLLGTSKGAELALLAGATFDW-VG--AVAAYAPSGIVWAGLTY---------GGEMTSSWTLDGDPVPFVPTAFPPS-VIADYVA-SWPLGGSVSLRPTYEVGLEQASTERISEATIPVENIDGPVT-----------------LVSGGDDRLWPSATFGRMVVRRLRNHEHPYPV--------------------RHVTTETAGHAIS-FPYQPTTGLTAISSP--PPGTTMALG-----GSPEGLA-----------------------------------------RANKESWPVVLSTLEGGLS-------------------------------     =====>
9firm-q1x1n8   	-----------------------------------------------------------------------ALEIS------PLQALAGEPWKIRVSGLTPGAPVTLVAEQQD----------------NKGIKWESHAVFHADQSGVVDPAVQAPVS-GSYEGADPAGL--FWSLRPVAGVKPAGT----FAKSL-EPQMITVSVEVEG-----ER----ILAQEV------ERLYLLPGVKRVEVRE----S---------GVVGTLFLPA---GEGRRPAIIVLGGSDGGTYE--PAAAIYASHGYVTLALAYFGM---------E-GLPDSLVNIPLETVGKAIEWLESRPEVDKDAIGVWGASKGAELALLAASHYPQ-IK--AVVAKSPSAVVFEGISKD------S-GKNHQSSWTYKGEPLSFVPTIFTEE-LAGSYFA-AVAKKEPWSTAPLYEYALQN--QEAVEKATIKVENINGPVL-----------------LVSGGRDGAWPSGKMAEMIMQRLREKGHPFPD--------------------MHLHYRDAGHQIS-TPYSPTTVYW--LTL--PGGFIEDLG-----GTPEGNA-----------------------------------------AASMDSWPKIIDFFARHLGGKQ----------------------------     =====>
9flao-q1vpk2   	MLETAVRYKLMKIITIIKSGLKIISAT-ILLIFIPSVLF--YSCISSYPSSRVKSQLFNSDTKPCQTLEIKTGKKGTLQVT-PNISYSDDIVAIHITGLQPFQIGSLKLSVTD----------------SKDIRWESVACFQANESGEINPENQAPIAGGSYEGKHTMGL--FWSLKPEKLSSFH-F----DT-----DLNFTISFDTGD-----GD----RLTRTILRK--SYENIENHNITKKEIR-----N---------KMVANFYLHE---TDTQRPTLVLLPGSGGNFQH--RKAGYIASKGYNVLDLKYFGA---------K-NLPENLENVPLEYLHNAINWLKNKPAVDSSKIALMGRSKGAEYALLYASKYND-VK--ALVSEVGSSVTWSSKRY------------IKSPWSYNGKGVPKARGGIRYL-------K-S-TGGKAQVQLPYMLSAFEK--TKRIEKSSIKIENIKCPIL-----------------LISGEDDLQWPSTMMSNRIKARAEKYKFNYEI--------------------KHYSYENAGHQFDDLPFIPQLDFSNI--------STWKSG-----GNFQGNA-----------------------------------------LASIDSWNRIFIFLNKQLGTIELNK-------------------------     =====>
9sphn-q2n9j1   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKIRHLTA-------A----IAL-AI--VAP-IPASAEPVAPTEIIV----GQ---------DMPGAFFAVP--EGTGPFPAIILLGGSEGGDSTARRMAPRFLAQGYAIFGLPYYSPAWGDREQQFP-ALSDAFDGIAIEKAEMARAWLAERDEVRADDIGIWGVSKGGEFALLAGSYLDG-FA--AIAAIVPSDVVWEGWGPGRE-------SGTVSSFSWQGEPLPFVPYEGMAE----EFAN-P-TGPNGRARLRLPHDRGRNANPDRAVAARIPVERIDEPVL-----------------VAGGDADLVWNSGEMAQIVAERRAAAGLP--T--------------------VSLIFTDAGHSLS-GDGTPNP------------------------YSNDEEL-----------------------------------------SAQRIVWPATLEFFATYLKD------------------------------     =====>
agrtu-ATU3652  	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIV--A---------L----IIH------RPLTKRQKMVAY-DVEQLE----G---------KVRGALLQGT----NSGKTGVIVLGGSSGRVDT--TRAGLFANTGARALALQWFGG---------A-NQPPGICEIPLETFVDATDLLISR---GCDRTVFVGTSKGAEAALLASTIDHR-IN--VVIAISPSSVVLGNIGAGVD----GISWPERSSWSFKRSPLDFVPADINWQ-------K-DY-RDGLVSYRSFFEKCLSN-DVQLNERARIPVESSPADLI-----------------LVAGGDDALWPSGYFARQILQSRQAHGRQ--A--------------------TLIFDKDAGHRIL-LPGETTQ-----------RSKLHAHG-----GSDEADA-----------------------------------------KLGQNAWRAIRELL------------------------------------     =====>
antel-q2f6g5   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QC--------------------IHHRYHGTGHLIE-PPYTPHCKNSYHKT----YRMLVHWG-----GEAKPHC-----------------------------------------DAQEKSWENILEFYHMNISKSTMKSHL-----------------------     =====>
bacld-q65ly2   	-----------------------------------------------------------------------MITLQPVLHI-PAVSKWDEKINLKISGLQPFDTIDIIVTVKD----------------EADAEWRSHAVFQANRLGEVDPAAAAPLK-GTYQSKDQMGL--FWSMQAVESSCS--F----YKKSV-HPSAYRIEVKQKE-----RI----ILSKEI------KRVLLSETVDRLEVNE----D---------GLCGTFFRPL---AVNRPPAIIILGGSDGGLDE--TMAGMLANYGYATLAIPYFQY---------K-QLPKKLVEIPLEYFQKAIDWLGRQEGLHHRQIGICGRSKGGELALLIGSHFPE-IR--FVVSHVGGGVVFQGVGLK------K--FRQTSSWSLNGAPLAFAPLPMFSLPQLWNMMK-HKLTRQPHAFLDLYQKALRK--VKDDHPAIIKAELIKGPIL-----------------LTSSTDDLVWPSASMNEKIEERLKKNRFSYSV--------------------KHLYFEKAGHNIR-PPYFPTSGRKS---------RKIAYG-----GKTEYDA-----------------------------------------IAAQTFWQELLLFLEKATAPGN----------------------------     =====>
bora1-q2l1v4   	------------------------------------------------------------------------MSVLTLTIE-PADALIDAPRRIVVDGALPGAEVTLATATSR-----------------AGVIWRAAARFVADAQGRVDLGRDAPLS-GSYDGVALMGL--IWSQAPDVAGRREAF----NQPVT-EALVTEVTAASGE-----TQ----ANA-RL------VQRLAGAGVTRQEVCE----D---------GLVGTLYLPA---GPGPHPAVMILNGSGGGINE--PRAALYASHGYAAFALAYFKA---------P-GLSDYISNTPLEYFQRGLRWLRRRVRPAHDFVALSGQSRGGELVLLLGATFPEEVS--AVVAYVPGAVVHSGQNAADP----K-IGREGPTWLLDGKPLTHVWENNRSA----SWKP-FDDGPAPHRHERAILTALQD--PDAVARARIPVERIQGPVM-----------------LLSATDDGSWPSSLYSGMVRDKLAEVSHPHEV--------------------QWLDFQDAGHLIV-FPYVPTTQMVY-AHP--VSGKISTSG-----GNPKDNA-----------------------------------------RADEESWAGVLQFLHDAVAKAAEGEA------------------------     =====>
borbr-q7wk25   	-------------------------------------------------------------------------MPPRMSVA-PERALIDVDREIRIDGFGPYACIDVTA-EMR----------------MCGVPWRSRATFLAGADGSLDLGRDSPVS-GDYAEPDAMGL--VWSMQCQD-PPRAVF----PPDRT-DALTVHITASDGR-----HE----AHA-TL------VQEFLAEGVRHQAVRARAGGM---------SLSGELYTPP---GPGPHPAIIYMNGSSGGVNA--PRAALFAARGYQCLALGVFNY---------E-DRPKYLNDMPLEYLEQALRWVRDTLNPRDGFVAISGISRGGEMSLLAASHFPELVS--AVVAYVPSPVMHGVVSAGAP----G-TGRDAQVWTLGGKPLPHLWQDNATA----DWEA-AYASDPPYRQTHAFMSASRD--ARAFERARIPIERYPGPLM-----------------LISASDDGFWPSTAYSEIVARQRQAAWPARPA--------------------EHYVCRGAGHHVH-YPNLPATLISK-PHA--MSGLLLDAG-----GTPPANA-----------------------------------------HGNAGSYRAMLDFLERARAS------------------------------     =====>
caebr-q618n9   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFR------------------------------RRLMYPTVQRIEVEE----SFPPDAGARPKVTGTIFKPP---GTGPFPTIIDISGTGGGLNE--QKRAALDSRGFVVLCLAFFKY---------K-SLPEDLLTVELQYFEDAINYITSLPYT-RDRIVFQGVSFGGTLVMFLTTKF-PKIK--AVCSINGSFAMD-QFAHVR------------------VNGKCPPIGIF-KA----DGAH-VKFLNDLMVYTDM-----------------------------------------------SALDDLSTPTIYANSYLSARLRDAGRKFE-----------------------VNFVPGGHLLD-PPCFPHHPMVYSNIA----GLFQTYG-----GDTSLHG-----------------------------------------RSEFEVWERTVRFFSEHLGAPTPLPDYLRHSAKL----------------     =====>
caebr-q61db2   	----------------------------------------------------------------------------MLH-VDKPDSLQAEKIHITASGLEEWRCYTFILRLHY----------------DRG-TYASFCVIQADSLGNIDFARDAPI-RGMYHDVDPMGL--FLSIEPTQKVRHGHFFK--TYDPN--TFYYTLQLLNDS----EEI----LDEIHL------KKHWKHPLVQQINVAE----S---------GLYGTLFKPP---GDGPFPTVVFIPGSNGMLES--GYAAVLASEGFATFTFVYYAY---------KKDLPRSIPEVDIEFFAKPIEYVQSLPYC-SKKIGLVGQSFGGLTANFLSTKY-HQVS--AVVALNCSAAYCRDIAVMR------------------ENGKPMEVQLL-------DEGM-SDFINGVLRQKPAFNDLY----SKLTPTTSIPWWRASKDTVYRIV---------------QCYDDMLVDGVPSRDNICKNLKETGHSVE-----------------------SELVPGGHFLY-FPYFPHHGIIYNAQI----NLMWGFG-----GECYQHS-----------------------------------------KSQETTWAKNVEFFRKHLGRGTKIPDWNRETRVSLPNSESIAQSKL----     =====>
caebr-q61dm1   	----------------------------------------------------------------------FSRIMKHLN-IDKADSLQPEHVHITANGLRPGGTYRFDMQLRH----------------NYG-SHASYCVLKADENGNIDMKTAKPL-RGTYFEADGMGL--FLSMTPCEDFAYGGYLR--CTPPI--PFFYLLILSDES----GTK----LDEMYI------KKHWMHPLLTRTEIEH----D---------GFCGTLFKPP---GDGPFPCVMDISGTGGGLHE--HKGAMLASEGFVVICVAFFQF---------K-DLPYKMEDVDVEYFLKPIEFVLGLPYT-TNMLGIQGVSFGATIVDLLSTRY-PQIK--AVVSINGPHAQS-HYCLLK------------------EHGKPMDVPYL-------DDSK-LFFINTILATAPCFKTLT----PVLTPETSIPWHRIPKDTAYR---------------LIGSVDDLCAPSIHSNLHIQKKLQETGHYVE-----------------------LELVNGGHIME-PPYFPHHDIVYAKFQ----GFYCGYG-----GEIVLHA-----------------------------------------KSQERTWANTINFFKRKLGSPPPMPDWMRLTKVDGPLRPIVNKNE-----     =====>
caebr-q61x68   	---------------------------------------------------------------------------MSIH-VDKPDSMQNELVEIQALGLTPNQIYTFRMTLKH----------------DYG-THRSEATFKSDPAGRIDLKCASPL-RGSYHDADPMGL--FLGMKPCEDFAYGGYLR--CTPPI--PFYYHLQLFNSV----GTL----IDETYI------KKHWMHPKLERIEMED----D---------GFCATLFKPP---GDGPFPAVLDLSGTGGGIHE--HKGAMLASEGFVVLCVAFFQY---------K-YLPNKMEEVNMEYFSKPIEYLANLPYT-LNVIGIQGVSFGATIVDLLATRHGDKIK--AVVSINGPQVVS-DYLYMQ------------------ENGEPIPHLSHGQV----TLEH-CQFINGVMCSHRNFQIMT----EKLTPETEIPWSRIPTDVKIRVLVSDFSRIT-VLIIFQGSVDDLCQPSVHATLYRQRRLKETGHDVEVRVQK---YILEFIQNQKKFVFQVEMVNGGHIME-PPYFPHHELVYAKYQ----GFYCGYG-----GEVLLHA-----------------------------------------KSQEKTWANSIKFFQRALGKTKHIEDWQRLELILPPRGESKL--------     =====>
caeel-C31H5.6  	------------------------------------------------------------MWLLSKFFKKISRKMKHLH-IDKPDTLQPEHVHITASGLQPDRTYRFDMKLRH----------------NYG-SHAAYCVMKADKDGNIDLKEQKPL-RGTYFEADGMGL--FLSMTPSEDFAYGGYLR--CTPPI--PFFYLLQLSDDS----GTK----LDEMYI------KKHWMHPLLTRTEIEY----D---------GFCGTLFKPP---GDGPFPCVMDISGTGGGLHE--HKGAMLASEGFVVICVAFFQF---------K-DLPYKLEDVDVEYFLKPIEFVLGLSYT-TNMLGIQGVSFGATIVDLLSTRY-PQIK--AVVSINGPHAQC-SYSLLK------------------EHGKQMIVPEL-------DDSK-LYFLNTILVTAPCFKTLT----PILTEENSIPWHWIPKETAFR---------------LIGSVDDLCAPSIHSNLHIQKKLQETGHYVE-----------------------LELVNGGHIME-PPYFPHHDIVYAKFQ----GFYCGYG-----GEIVLHA-----------------------------------------KSQERTWANTINFFKRKLGSPPPMPDWTRLFIVNAPLKPIENRSRL----     =====>
caeel-K05B2.4  	-------------------------------------------------------------------------MSPVIL-VTPEDSLVHENVSIVVNGLEYQKNYLLELRLLH----------------KVG-IYRSYGVFKSTVTGCIDLSKIAPI-RGTYSGVNESGL--FESLEPTDTVRYGGYCN--CTPPV--DFKYQL------------------------------LRLMHPLVERIEVEE----AYPEGTTGKPKVTGTMFKPP---GNGPFPTIIDISGTGGGLNE--QKGAALASRGFAVLCLAFFKY---------K-DLPYELQEVELRYFEDAINFVTSLPYT-NDRIGFQGISFGGTLVMFLTTRF-KQHF--RFIN----------------------------------------------Q----GIED-IWYLNDLMVYTDMVRNL------KLEDGAGFKFEDSSPETAFR---------------FSLAVDDLSTPTVFVGKVLSEKLRNLNRKVE-----------------------VHYVSGGHLLD-PPCFPHHEAVFSAFA----GTFQAYG-----GETSLHG-----------------------------------------KSQFEVWEKTVQFFSEHLGAPTPLPDYSRHLAKL----------------     =====>
caeel-T05E7.1  	-------------------------------------MENQTKCNISYRRIRIDKKKPPKTALKIKCLFTFSGFQEMLH-VDKVDSLQTEKVNIRASGLVEWSCYTFILRLHY----------------DRG-TYASFCVARSDSLGCIDLSRDAPI-RGTYTEVDQMGL--FISIEPTQSIRPGHFFK--TYDPK--TYYYTLQLLDDS----KKI----IDEIHL------KKHWKHPLVEQINVEQ----N---------GLYGTLFKPP---GKGPFPAVIFIPGSNGMLES--GYAAVLASEGFLTFTFAYFAY---------KKDLPKLIPDVDIEFFEKPIEYVQNSPYC-SGKIGLVGQSFGGLTANYLSTKY-HQVS--AVVALNCSAAFCRDNAVMK------------------ENGKPMETQIL-------DEGM-SDFVNQVLRQKPAFRDLY----SNLTPTTSIPWARAPKNTAYRIV---------------QCYDDMLVDAVPSIINICGNLRKTGHHVE-----------------------SELVPGGHFLY-FPYFPHHGIIYNAQI----NMLWGFG-----GECYQHS-----------------------------------------KSQETTWKKNVEFFKKHLGDVKRIPEWKRESTVTLPVSTKSSKSLQCKL-     =====>
caeel-W03D8.8  	---------------------------------------------------------------------------MPIH-VDKPDTMQNELIDIVADGLRSNQIYTFRMILKH----------------DYG-THKSEATFQADPAGRIDLKYAKPL-RGSYYDADPMGL--FLGMKPCEDFAYGGYLR--CTPPV--PFYYLLELFDSS----GTL----IDSTYI------KKHWMHPKLIRTELEE--------------DFCATLFKPP---GDGPFPVVLDISGTGGGIHE--HKGAMLASEGFVVLCLAFFQF---------K-YLPQKMEDVDMEYFAKAINYLIDLPFT-KNVIGIQGVSFGATIVDLLTTRHGDKIK--ALVSINGPQVVS-DYLFMQ------------------ENGAPIPHLSHGQV----TLEH-CQFINGVMCSHRNFQIMT----EKLTPETEIPWERIPSDVKIRVIVSVRADVQRKFCELQGSVDDLCQPSVHATYYRQRRLKETGHDVETVKVPSDVFFFNRNSENNPINSEVELVNGGHIME-PPYFPHHELVYAKYQ----GFYCGYG-----GEVVLHA-----------------------------------------KSQEKTWSNTIKFFQKALGNTKKIQDWDRLTVVVPPRKKSKL--------     =====>
caucr-CC0882   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR-----------------------AFTLTASAIA-----AL----LLGCGSASAAPDCAPRAPTATTAKEVGE----Q---------GLVAQFLQPT---TPGKHPALLILGGSEGGSAGVRQLAKPFAEQGYAVLALSYFAA---------P-GLPATAEELPLEYFDRAVAWLAAQPSVDPKAIGVYGVSKGAEASLLVASRNPA-LK--AAGAGVGTSFVWQGISTT--------GGAAKSSWTLAGKPVDYLPYGPGVRFDPSNYMA---------FIYGLYDTGLKA--ADAHPQAAIPVEKIHGPVM-----------------LISGRADAMWSSSAMSDAVVARLKAKGFAHKV--------------------SHLAYPDAGHTAG-MPALMGG-------S--DKGADEAVG-----GTVEGNR-----------------------------------------FARTDMWPKLVCFFDGALKR------------------------------     =====>
cloac-CAC3407  	------------------------------------------------------------------------MKNVKIIIE-PQCSMIDEKTNILVQGLVPYEIITIKALSLDYYRIGAKNNNPDNWKWVKKTNFESFAVFKADDKGTVDLSKDAPIK-GSYTRVDSMGL--FWSMVSTQQQDYTLKKSLSSCPFL-TSMEVILKVEVCG-----KE----LVSSKC------KKLFVSSDVKCQYVTE----N---------NLVGKYFTNK---NSKIKKGIIVLSGSEGGIHNASQIAALLASHGYPSLALAYFGM---------D-TLPATLNEIPLEYFEKAIDWIITKGDISPNNLTVFGRSRGGELALLLGSTFKK-IT--SVIAVAASPILFG-----TN-------TTKLSSWKYKGEDIPYLNLKINIISFLKNALT-DKLHGRTINFSKLYTNAIKN--PDAIETYMIPIENTNGSIL-----------------MLSGDNDHIWPSSKLCKLGIERLKQHNFSFYY--------------------DFLEYK-AGHHIY-FPYQPIY-------------KYN--------GSNENMA-----------------------------------------ISNRESWNKILEFLQKL---------------------------------     =====>
clobe-q2wku2   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKWRKAMEYRT----E---------ELYGDFYEND------EKPLVIVIGSVQPGIPIISKELLEYLKSKFNVLLLAYFGV---------G-DLPKRLERIPLEYFIKAINHFKNKLNLNDEDIVLMGSNKGGELVLLLISKYIN-PS--VAIACVPSCYVWQAIPKGIM----N-ILIPKSSWTFKNKDIPFVRFRYNREV------I-NDIKNKKYNSSHLFS-----IQTNKNKNALIKVDQYKGRLL-----------------LISTEKDHYWPSKGMCEFIEKSRKGY-----T--------------------KHIVFNCDGDQLL-KYKEPSME--------------------------------------------------------------------------------IMDFLEL----------------------------------     =====>
clobe-q2wqv7   	-----------------------------------------------------------------------MENNCTISIM-PETSKVDEPVTIKISGLLKNERVLIRALSNDYYCINTSI-----FDVGNKADWESYAVFVADESGTIDLENAKPVE-GTYKEADKMGL--FYSMTVKENYKTKIPIRLSDIGEN-RDYTMTFQVERNG-----RV----ISSKTH------KRIYCDEIISSVDVVE----D---------KLLGRYFTSK---ENIPKPAIIVLSGSDGRLEKAQAIAEIFAMHGYSALAVCYFGL---------E-GTNKSLSCVELECVENAIDWLKKQSTVAKNKIGIYGRSKGGEMVLLAASIFKD-IS--CVIANTPSCYVYEGLKANKF-------PSKHSSWMYKGREIPYIKFSFSILI---RTLV-KMMIGNKEPMAWMYRKLIED--GNA-YEAMIPVEKINGPIL-----------------MASSLKDKIWPSKTHCEIIVELLRKAHFKHEY--------------------KHITYEKSGHMLT-VPYQSIY-------------PSNKYP-----DDIDGFA-----------------------------------------KANINCWNETINFIDKWSRQDI----------------------------     =====>
danre-q5rh34   	---------------------------------------------------------------------------------------MDEKFQVVIKNLLPNQEVTLHSLHQS----------------EDKDFWEAFGHYISDEHGTVTVAKDESL-GGTYEGTEQMGL--LWSLRPVPGSRPALRLR--KMNVL-TPMVINISVYNGHLSQG-FSQASLLATTVT------ERWYMAPGVKRVNIKE----K---------GVLGTLFLPP---GSGPYPGVLDLWGGGGGLIE--YRSALLASHGFASMALEYLSP---------E-K--LKMTEVDGTYFEKAYQILQNHPLVQKDKMAVLGLCFGSAITLTMTAYSR-VIKPQCCVCISGSHAIPVDKCL--------------------FEVFEDIKKLNGK--------I-QVNEDNHLIHRNTILPIP----S--DPALKVDVGRIKCPLL-----------------LVNGTDDQNWATVESAEDMEMMMKKAGNRQLL--------------------TVLTYPDAGHLIE-PPYTPHFRATNFLLHKMNEKVVMLWG-----GQTKPHA-----------------------------------------YAQEDSWKKILAFFREHLYGSSVKAKL-----------------------     =====>
danre-q5rh35   	MLKIERR------RTGRDHGN-IVT-----DSN-------------QFIEERNV-YYRTTMLAPVRTVSTANRTSPLLT-VQPRRGLVDEKFQIVITNLLPNQEVTLHSLHQS----------------EDKDFWEAFGHYISDEHGTVTVAKDESL-GGTYEGTEQMGL--LWSLRPVPGSRSALRLR--KTNVL-TPMVVNISVYNGHLSQG-FSKTSVLATTVT------ERWYMAPGVQRVNIRE----N---------GVRGTLFLPP---GPGPYPGVLDLWGGGGGLVE--YRSALLASHGFASMALEYLSP---------D-E--LRTADVDVSYFENAYQILQNHPKVQKNKMAMLGLSFGSAITFSMAAYST-IIKPQCCVCISGSHVVPVDKSL--------------------FEVFEEIKKNMDK--------V-HVNEDNHVIQRGMILPIP----S--DPAQKIDVGRIKCPVM-----------------LVNGGDDQNWASVESAQDMEMMMEKAGNRHLL--------------------TVLTYPDAGHLIE-PPYTPHFRATNFILQEMKEKIVMLWG-----GQTKPHA-----------------------------------------YAQEDSWEKILAFFHQHLYSSNIRAKL-----------------------     =====>
danre-q5rhg4   	-----------------------------------------------MKRWSTL-VGRFIMLAPVRTVSTESRRCPLLT-VQPCRGMVDEKIQIIIRNLLPNQEVTLHSLHQS----------------EDKDFWEAFGHYISDKHGKVTVANDVSL-GGTYEGTEQMGL--LWSLRPVPGSRPALRLR--KKNVL-TPMVVNISVYSGHLSQG-FSQTSALARTVT------ERWYMAPGVQRVDIRE----S-----------------------SGPYPGVLDLWGGGGGLIE--YRSALLASHGFACMALEYLAP---------A-M--LKLTDVNNTYFEKAYQILQNHPLVQKDKMAMLGLSFGSAITFSMTAYSR-VIKPQCCVCISGSHVVPVDKCL--------------------FKVIEDFTGLVDK--------V-PVNEDNHLIHRDMLLPIP----S--DPALKVDVGRIKCPLL-----------------LVNGTDDQNWPTVESAEDIEMIMEKAGNRHLL--------------------TVLTYPDAGHLIE-PPYTPHFRASNFILYDTKKKVVMLWG-----GQTKPHA-----------------------------------------YAQEDSWKKILAFLQEHLYSSNVKAKL-----------------------     =====>
danre-q5rhg5   	-----------------------------------------------MKRWSTL-IGRVIMLAPVRTVSTESRRCPMLT-VQPCRGMVDEKFQVIIKNLLPNQEVTLHSLHQS----------------EDKDFWEAFGHYISDEHGTVTVAKDESL-GGTYEGTEQMGL--LWSLRPVPGSRSALRLR--KMNVL-TPMVVNISVYNGHLSQG-FSQTSALATTVT------ERWYMAPGVQRVDIRE----N---------GVRGTLFLPP---GPGPYPGVLDLWGGGGGLIE--YRSALLASHGFACMALEYISP---------G-E--LKKTDVDNTYFEKAYQILQNHPLVQKDKMAMLGLCFGSVITFSMTVYSS-VIKPQCCVCISGSHVVPVNKCM--------------------FEVFEDIKKLMGK--------V-QENEDKHIVTREIILPIP----S--DPALKADVGRIKCPLL-----------------LVNGTDDQNWATNESAEDIKMMMEKAGNRHLL--------------------TVLTYPDAGHLIE-PPYTPHFRATNFLLHDMKVKVVMLWG-----GQTKPHA-----------------------------------------YAQEDSWKKILAFFHEHLYGSNVKAKL-----------------------     =====>
danre-q5spg7   	-----------------------------------------MYATL------KC-ALKPFARN--TLAKMHYSSGVSIRLLPSYKCSFEDPVHVTVSGLNPHQRVDLRSKITD----------------EGGRDFKALATYQADDSGQIDLKRDSSL-GGSFTGVEPMGL--YWALKAD---TISCKFK--LKDVT-RPALVDIEVVS-D----DKV----LAKVTN------ERHCLTDGVRRRPLNE----D---------RIRGTLFMPP---GKGPFPGILDTYILRGGHFE--LRAALLAKRGFAVLALAYQNY---------Q-DLPKSSDKFHLEYFEEGIDFLRQQPEVKGQKIGLLSISKSGDLALSMSTFLP-DIA--ATVWINGCNANSVVPLYYK------------------DMYIPPLTLDFKK--------K-KITPLGLVDMLDVVKDPM----SKEGLPSVIPIERAPGRFM-----------------FIASEANMNWRSAYHAKLACDRLKAHGK-KNY--------------------ELVKYEKAGHFIE-VPYMPFCFANFHSVL----KQPVLFG-----GEPKCHS-----------------------------------------EAQVDAWPRIINFFKKHLATADYNLSP-----------------------     =====>
danre-q5spg8   	-----------------------------------------MFAVL------KH-AFSPLARN--TLAKMHYSSGVSIRLLPSYKCSFEDPVHVTVSGLNPHQRVDLRSKITD----------------ENGLDFKASATYQADDSGQIDLKRDSSL-GGSFTGVEPMGL--YWALKAD---TISCKFT--LSDVT-RPALVDIEVVS-D----DKV----LAKVTN------ERHCLTDGVRRSPVTE----G---------RIRGTLFMPP---GKGPFPGILDTNVFRGAPFE--LRAALLAKRGFAVLALAFQGY---------Q-DLPKRADRFHLEYFEEGIDFLRQQPEVKGQKIGLVSISKSGDLALSMATFLP-DIA--ATIWVNGCNANTLVPVYYK------------------DICVPPLLFDVKR--------T-KITPLGLVDIGEVMDDPM----SKEGLPSVIPIERAPGSFM-----------------FVVSEADRNWRSAYYAKLACDRLKAHGK-NNY--------------------QLVKYEKAGHFIE-VPYMPFCLANFHGVA----GQPVFFG-----GEPKAHA-----------------------------------------EAQLDAWPKMINFFKKHLAATDHNPRSML---------------------     =====>
danre-q5u3w6   	----------------------------------------------------------------------MAEQSPLLT-VYPSSCLVDEKIEVEVKGLPADSKVTVHALVRS----------------DDGDDWEAFGHYTSDPSGTVKVSRDKSV-GGTFEGIEAMGL--LWSMRPVPETKPGRRFR--KTNVQ-TPVKVVFSVHEGHLDKG-FKHRTPLSSTAA------ERWYLTPEVQRVEVTE----G---------EIKGTLFIPA---GSGPFPAVLDLWGGQGGRVE--YRSALLASHGYVSLALEYVGL---------L-NAAGELQHADNSYFEAAFTFLQKHPRVCPDKVAVMGMSFGVSVTLGLTAYSE-IVEPKCVVCVSGSHIMPLKGSL--------------------ADVYAALQQNVHK--------I-RYDEKMRIIWRDLLLPIP----D--DPSQKVKMSEIKCPVL-----------------LIAGEDDQNWPASESAADMRKMMEKAGNSHLL--------------------TVLSYPGTGHLIE-PPYSPHVRFSDFKLLEAKTKVVVLWG-----GETEPHS-----------------------------------------RAQEESWKKTLAFLEEHLYGNSREVTRM----------------------     =====>
danre-q6gmj5   	--------------------------------------RDNMYAAL------KF-AFMPFAR---SLAKVHYSSGVSIKLLPSYKCSFEDPVHVMVSGLNPHQRVNLRSKITD----------------EGGRDFKASAIYLADDNGQIDLKRDSSA-GGSFSGVEPMGL--FWALKAD---LLSCKFK--LKDVT-RPALVDIEVVG-ED---EKV----LAKVTN------ERHCLSEGVRRSLVTE----G---------RIRGTLFMPT---GNGPFPGILDTYILKGGPFE--LRAALLAKRGFAVLALAYQNY---------Q-DLPKKADKFHLEYFEEGLDFLRRQPEVKGQKIGLLSISKSGDLALSMSTFLP-DIT--AAVWINGCNANSLIPLYYK------------------DMYIPPLTLDFKK--------K-KMTALGLVDMLEVVNDPM----SKEGLPTVIPIERASASFM-----------------FIASEADMNWRSVYHAKLACDRLKAHGK-NNY--------------------ELVKYEKAGHFIE-VPYMPFCLAAFHGVL----EQPVLFG-----GEPKAHS-----------------------------------------EAQVDAWQRIIIFFKRTLGS------------------------------     =====>
danre-q6ph28   	-------------------GH-LAT-----DNTAPMIIRHSNP-STMMKCWSTL-IGRFIMLAPIRTVSTESRRCPLLT-VQPCRGMVDEKFQVVIKNLLPNQEVTLHSLHQS----------------EDRDFWEAFGHYISDEHGTVTVAKDESL-GGTYEGTEQMGL--LWSLRPVPGSRPAIRLR--KTNLL-TPMVVNISVYSGHTSQG-FSQTSALATTVT------ERWYMAPGVQRVDIRE----N---------GVQGTLFLPP---GPGPYPGVLDLWGGSAGLIE--YRSALLASHGFACMALEYTTP---------A-K--LKKTDVNNTYFEKAYKILQNHPLVQKDKMAMLGLCFGSAITFSMTAYSS-VIKPQCCVCISGSHVVPVDKCI--------------------FEVLEDMKRRMGK--------V-PVNEDNHLIHRDTILPIP----S--DPDLKVDAGRIKCPIM-----------------LVNGTDDQNWATVESAQDIEMIMEKAGNRHLL--------------------TVFTYPDAGHLIE-PPYTPHFRATNVLLHK-KEKVVMLWG-----GQTKPHA-----------------------------------------YAQEDSWEKILAFFQEHLYSSNVKAKL-----------------------     =====>
human-ACOT2    	---MSNK------LL-SPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQF-LGSPQLRQVGQIIRVPARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRD----------------EKGALFQAHARYRADTLGELDLERAPAL-GGSFAGLEPMGL--LWALEPE---KPLVRLV--KRDVR-TPLAVVLEVLDGHDPDPGRL----LCQTRH------ERYFLPPGVRREPVRV----G---------RVRGTLFLPP---EPGPFPGIVDMFGTGGGLLE--YRASLLAGKGFAVMALAYYNY---------E-DLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLK-GIT--AAVVINGSVANVGGTLRYK------------------GETLPPVGVNRNR--------I-KVTKDGYADIVDVLNSPL----EGPDQKSFIPVERAESTFL-----------------FLVGQDDHNWKSEFYANEACKRLQAHGR-RKP--------------------QIICYPETGHYIE-PPYFPLCRASLHALV----GSPIIWG-----GEPRAHA-----------------------------------------MAQVDAWKQLQTFFHKHLGGREGTIPSKV---------------------     =====>
human-ACOT4    	-------------------------------------------------------------------------MSATLILEPPGRCCWNEPVRIAVRGLAPEQRVTLRASLRD----------------EKGALFRAHARYCADARGELDLERAPAL-GGSFAGLEPMGL--LWALEPE---KPFWRFL--KRDVQ-IPFVVELEVLDGHDPEPGRL----LCQAQH------ERHFPPPGVRRQSVRA----G---------RVRATLFLPP---GPGPFPGIIDIFGIGGGLLE--YRASLLAGHGFATLDLQSYNF---------E-DLPNNMDNISLEYFEEAVCYMLQHPQVKGPGIGLLGISLGADICLSMASFLK-NVS--ATVSINGSGISGNTAINYK------------------HSSIPPLGYDLRR--------I-KVAFSGLVDIVDIRNALV----GGYKNPSMIPIEKAQGPIL-----------------LIVGQDDHNWRSELYAQTVSERLQAHGK-EKP--------------------QIICYPGTGHYIE-PPYFPLCPASLHRLL----NKHVIWG-----GEPRAHS-----------------------------------------KAQEDAWKQILAFFCKHLGGTQKTAVPKL---------------------     =====>
human-ACOT6    	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLQHPKVKGPSIALLGFSKGGDLCLSMASFLK-GIT--ATVLINACVANTVAPLHYK------------------DMIIPKLVDDLGK--------V-KITKSGFLTFMDTWSNPL----EEHNHQSLVPLEKAQVPFL-----------------FIVGMDDQSWKSEFYAQIASERLQAHGK-ERP--------------------QIICYPETGHCID-PPYFPPSRASVHAVL----GEAIFYG-----GEPKAHS-----------------------------------------KAQVDAWQQIQTFFHKHLNGKKSVKHSKI---------------------     =====>
human-BAAT     	--------------------------------------------------------------------------MIQLTAT-PVSALVDEPVHIRATGLIPFQMVSFQASLED----------------ENGDMFYSQAHYRANEFGEVDLNHASSL-GGDYMGVHPMGL--FWSLKPE---KLLTRLL--KRDVMNRPFQVQVKLYDLELIVNNKVASAPKASLTL------ERWYVAPGVTRIKVRE----G---------RLRGALFLPP---GEGLFPGVIDLFGGLGGLLE--FRASLLASRGFASLALAYHNY---------E-DLPRKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQIGLSMAIYLK-QVT--ATVLINGTNFPFGIPQVYH------------------GQIHQPLPHSAQL--------I-STNALGLLELYRTFETT-----QVGASQYLFPIEEAQGQFL-----------------FIVGEGDKTINSKAHAEQAIGQLKRHGK-NNW--------------------TLLSYPGAGHLIE-PPYSPLCCASTTHD------LRLHWG-----GEVIPHA-----------------------------------------AAQEHAWKEIQRFLRKHLIPDVTSQL------------------------     =====>
human-acot1    	-------------------------------------------------------------------------MAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRD----------------EKGALFQAHARYRADTLGELDLERAPAL-GGSFAGLEPMGL--LWALEPE---KPLVRLV--KRDVR-TPLAVELEVLDGHDPDPGRL----LCRVRH------ERYFLPPGVRREPVRA----G---------RVRGTLFLPP---EPGPFPGIVDMFGTGGGLLE--YRASLLAGKGFAVMALAYYNY---------E-DLPKTMETLHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLK-GIT--AAVVINGSVANVGGTLRYK------------------GETLPPVGVNRNR--------I-KVTKDGYADIVDVLNSPL----EGPDQKSFIPVERAESTFL-----------------FLVGQDDHNWKSEFYANEACKRLQAHGR-RKP--------------------QIICYPETGHYIE-PPYFPLCRASLHALV----GSPIIWG-----GEPRAHA-----------------------------------------MAQVDAWKQLQTFFHKHLGGHEGTIPSKV---------------------     =====>
macfa-q4r4j8   	------------------------------MASSPAVLRASRLYPWSLKSWAQL-LRSPQMKQVGRIIRVPARMAATLILEPAGRCCWDEPVRIAVRGLAPVQPVTLRASLRD----------------EKGALFQAHARYRADAHGELDLEREPAL-GGSFAGLEPMGL--LWALEPE---KPLLRLV--KRDVR-TPLAVELEVLEGHDPEPGRL----LCRARQ------ERDFLPPGVRREPVRA----G---------RVRGTLFLPP---EPGPFPGIVDMFGTGGGLLE--YRASLLAGKGFAVLALAYYNY---------E-DLPKTMDVLHLEYFEEAVNYLLSHPEVKGPGVGLLGVSKGGELCLSMASFLK-GIT--AAVIINGSVANVGGTLHYK------------------GETLPPVGVNRNR--------I-KVTKDGYADIVDVLNSPL----EGPDQKSFIPVERAESTFL-----------------FLVGQDDHNWKSEFYANEACKRLQAHGG-RKP--------------------QIICYAGAGHYIE-PPYFPLCRASLHALV----GSAIIFG-----GEPRAHA-----------------------------------------MAQVDAWKQLQTFFHKHLGGQEGTIPAKL---------------------     =====>
mouse-BAAT     	--------------------------------------------------------------------------MAKLTAV-PLSALVDEPVHIQVTGLAPFQVVCLQASLKD----------------ERK-PVSSQAFYRASEVGEVDLEHDPSL-GGDYMGVHPMGL--FWSLKPE---KLLGRLI--KRDVINSPYQIHIKACHPYFPLQDLVVSPPLDSLTL------ERWYVAPGVKRIQVKE----S---------RIRGALFLPP---GEGPFPGVIDLFGGAGGLME--FRASLLASRGFATLALAYWNY---------D-DLPSRLEKVDLEYFEEGVEFLLRHPKVLGPGVGILSVCIGAEIGLSMAINLK-QIR--ATVLINGPNFVSQSPHVYH------------------GQVYPPVPSNEEF--------V-VTNALGLVEFYRTFQET-----ADKDSKYCFPIEKAHGHFL-----------------FVVGEDDKNLNSKVHANQAIAQLMKNGK-KNW--------------------TLLSYPGAGHLIE-PPYTPLCQASRMPIL----IPSLSWG-----GEVIPHSQ----------------------------------------AAQEHSWKEIQKFLKQHLLPDLSSQL------------------------     =====>
mouse-Q8BYI3   	-------------------------------------------------------------------------MAATLSVEPAGRSCWDEPLSIAVRGLAPEQ