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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....
9arch-d1j9b3   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETIAKTFVTFLNESEF-----EKAHG---LFNKDVAEALPV--DKLNATWNGLIDQYGAFTGIEN-----ISSTEEKG-YETVFVTCNV--SKTFLDAKIAFDNDEKIAGLHFRPI----Y--PYQPPEYADPDSFTEIECTVGT-GKWKLPGTLTIPKG---E--GPFHAVVLVAGSGPEDMDETIGP--NKPFKDLAWGLATEGIAVLRYDKRTYRYPEECI-AMIKNDNFTVNDETIDDAIAAVDLLRETERIDPDNISVLGHSWGGYLAPRIAARD--EN-ISGLIFLAAGARS-LPDLIIEQTEYLASLD------GKMDEKEV---KSLEELRAQAMKVKE-L-NISK----GE--ILL---G-APKSYWEDLSDYDPVETARNL-TCPILILQGERDYHVTI-VDYEMWIKGLPGKNNLCFILYSDFNHLFMAVPGTGE-ATPAD-LFIPGHVAPIVIDDVADWVKNQK---------------     =====>
9arch-g2mpx0   	-------------------------------------------------------------------------------------------------------------------------MKRRQYLAA-LGAA----------------GGAVLAGCSGTSDDDPATTGTTNDTETQTEAPDTETTPQQND------------T--E--------SELEAITQDFLEALIAESF-----DE---AYDYASPEFAQSVPQ--DNLVQQWEANIIPLGEFNQFTS-----IDYQGEEQGFDVVGAQAAF--ADGRAEFSVQFDEQII-EG--FVFN-----VDAWSPPAYVDESAFTEQELTLAASGDCELGTTVTIPDT---N--EPVPGVVLVHGSGDQGRDQQVGP--NRTFKEIAWGLATRGVAVLRYDQRPVACEI--D-----RTEATVDDLVTDDAVTALERLREYDRIE--ETFVAGHSLGGRLAPRIAAQD--DE-VSGVIMLAPLAEP-ISDAIVRQTEYQLDLN------SNLSDEQR--QSKLAQAKALAERIRT-L-DIGD----DE--LINLGGGERGKPFFRTLQEYDHVETAVSL-DIPRFILQGERDYLVTVEDDLAIWEEELARDPAVQIKRYETLNHRFQ--PGEGM-GRPSE-WSDPNPVDKQVVVDLATFISDQSQNPSQSNG-------     =====>
9bace-b3cfy2   	---------------------------------------------------------------------------------------------------------------------MNFSFL-YKWALV-LGLLL---------------GHVVA----------VF----------------------------------------------AQDANID-RAEHVYELFVENQA-----DSIHA---LLNKNLQEKLSP--EVFRDMFKQSEKQFGKLQSKGE-----WRKESAE-GITLYHRDLKF--ERYDLRFLLSFDADGEMNTIRLMPVPAA----STAKPVVYNKEKMLERDITVGA-DGFKLPGTITLPV-----GKKKVPVVILVHGSGPQDRDETVGP--NKPFRDLAWGLAERGIATIRYDKRTKVYGAACVPEG---REIDYDTESVDDAIAIVAWAKTLPEVDADSVYVLGHSLGATLAPRIAERA--DG-LTGIILVAALARP-FEDAIVEQMTYISSLT------DSSARAK----EQIAEIKKQADNIKK-L-G--TPDFDDKLPLLL---N-VPRPYWEFANAYKPVEVASKL-TLPMLILQGERDYQVTM-QDFGLWRFGLLRNKNAFFKSYPKLNHMLQ--EGSGK-ATPFE-YNQASPVVGYVMDDIVSFIHNGSLL-------------     =====>
9bace-b5cv17   	------------------------------------------------------------------------------------------------------------------------MKN-IQWLSI---ALL---------------AACLQ----------AH----------------------------------------------AQ-QNNMQRAQQILQWMKNAQS-----DSIYA---CFDAKMQQAVPL--SQLNNMWSQMEQQLGTLVEEKE-----WKQDAIG-GTIVYYSDLKF--ERAPIRFMVAFNQERKVNGLRLLPVPAE----EKPQVIPFDSIHLEESPIEVVT-GTYKLPGVITRPK-----GKNNLPIVILLQGSGPHNKDGQIGP--NKIYQDMAWGLASQGVAVLRYDKRTYVYGKSASPKG---KDITPEEEVIEDAISASQLAASLPFVDAQKVFIAGHSLGGLLAPLIATRC--PS-VKGLILLAAPSRP-QDDILKEQLHYLASLN------GDTDEQ---------LLMQQYQQ------------------IKA---S-APEAYWDYLNKYAPVMTAHSL-TIPMLFLQGERDYQVTM-QDFAMWKLGMFGKPNVTFRSYPSLNHCFM--EGTGK-STPME-YNHPGRVSEKVIKDIAEWAIHQNE--------------     =====>
9bace-d1jpq4   	----------------------------------------------------------------------------------------------------------------MIKKNLLKGIC-LLWLLL---------------------AV--T----------PV----------------------------------------------LQAQDRAQQAFELLDRLIAGQG-----DSVYV---HLDDNIRKMLSV--EMLNGLFKQLEQQAGKYQSHGE-----WKTEPIN-GMTIYYCDVKF--ERLPLRFLTAFNPDGKVNTIRFVPVPAE----KTTPPTTSVQDKIKETDIQVCT-GNFKLPGTLTLPK-----NGKDLPVVILVHGSGASDRDETVGA--NKPFRDLAYGLAERGIAVIRYDKRTKVYGADSAPAG---KEITFDEESVDDALSAIKLARSIPTINPERIYILGHSLGGTLAPRIAQRS--DKVPAGIILLAGAARP-LEDLFISQVKFLASAL------PSTKDIE----KEIAELQKQVDNVKR-L-G--TDTFDITTPLPM---N-LSQAYWMLANQYKPLEVVRKL-TLPILVLQGERDYQVTM-QDFELWQSALAKHPNAIFKSYPRLNHLFQ--EGEGK-STPLE-YSRPSSIPSYVTDDIAAFINRPKPGN------------     =====>
9bace-d2eut8   	-----------------------------------------------------------------------------------------------------------------------MGVI-GRWALI-L-LLL---------------GNVYG----------GF----------------------------------------------AQDANTA-RAQHIYELFVAGQG-----DSIHA---ALNRELQEKLAP--ALFNDSFRQAEKMFGKSISKGE-----WKTDSAQ-GITIYYSDVEF--ERYNLRFLVAFDADGALNTIRLVPAPAA----STAQPVAYDKTKMDERDITLGA-DGYKLPGTLTLPKRAVGPDACRVPCVILVHGSGPHDRDETIGP--NKPFRDLAWGLAKRGIAVVRYEKRTKAYGAACVPAG---RELDYDTEAVDDAVAIVEQVRALPELAPDSVYVLGHSLGGTLAPRIAGRS--KG-LAGIIILAGLARS-LEDALEEQFYYTSSLT------DSSVNVK----VQLDELKQQLANVKK-L-G--TEEFDETISLPL---G-QPRSYWLFANAYKPVEVAAKL-KLPIFVLQGERDYQVTM-EDFGLWRSGLLRCKNAYFKSYPKLNHLLQ--EGSGK-ATPFE-YSHASPVPAYVMDDIASFVRGKQNTL------------     =====>
9bace-e2nfw0   	---------------------------------------------------------------------------------------------------------------------MSFSFL-YKWALV-LGLLL---------------GHVVT----------VF----------------------------------------------AQDANMD-RAKHVYELFVADQG-----DSIHA---LLNKNLQEKLSP--EIFKDMFKQSEKQFGKLQAKGE-----WKQESAE-GITLYYRDLKF--ERYSLRFLLSFDADGSMNTIRLMPVPAA----STAKPVAYNKEKMQERDITVGA-DDFKLPGTLTLPV-----GKKKAPVVILVHGSGPQDRDETVGP--NKPFRDLAWGLAERGIATVRYDKRTKVYGAACVPEG---RNIDYDTESVDDAVAIIAWAKELPEVDADSVYVLGHSLGATLAPRIAEQA--DG-LTGIILVAALARP-FEDAIVEQMTYISSLT------DSSANAK----KQITEIKKQADNIKK-L-G--TPEYDDKIPLLL---N-LPRSYWEFANAYKPVEVASKL-ALPILILQGERDYQVTM-QDFGLWRFGLMRNKNAFLKSYPKLNHMLQ--EGSGK-ATPFE-YNQASPVVGYVMDDIASFIHNGNLL-------------     =====>
9bace-f3pyb6   	-------------------------------------------------------------------------------------------------------------------MMRRIGII-YRWLFL-LGFLL---------------GNVYE----------AF----------------------------------------------AQDADMA-RARHIYEWFVAGRG-----DSIHA---ALNKDLQEKLAP--VVFNDTFRQTERTFGKLKSEGD-----WQRDSAA-GITIHYRDLEF--ERYSLRFIVAFDADGRMNTIRLAPVPAV----STAKPVTYDDTKISEKDIAVGA-DGFKLPGTLTMPKFAAASGMRRVPCVILVHGSGPNDRDETVGP--NKPFRDLAWGLAERGVAVIRYDKRTKIYGMNCVPAG---RVLDYDTEAVDDALAAILQARTLPEIAADSIYVLGHSLGGTLAPRIAERS--EG-LAGIIVLAGLARP-LEDALEEQFTYISSLT------DSSANAG----TQLAELKRQLVNVKK-L-G--TDAFDDKIPLPL---G-QPRSYWEFANEYKPVEVAAKL-KLPIFVLQGERDYQVTM-EDFGLWRFGLLRCKNVFFKSYPKLNHLLQ--EGSGK-ATPFE-YNRASPVPAYVMDDIASFVKGKRALP------------     =====>
9bace-f7lla2   	----------------------------------------------------------------------------------------------------------------MIKKNLLKGIC-LLWLLL---------------------AV--T----------PV----------------------------------------------LQAQDRAQQASELLDRLIAGQG-----DSVYV---HLDDNIRKMLSV--EMLNGLFKQLEQQAGKYQSHGE-----WKTEPIN-GMTIYYCDVKF--ERLPLRFLTAFNPDGKVNTIRFVPVPAE----KTTPPTTSVQDKIKETDIQVCT-GNFKLPGTLTLPK-----NGKDLPVVILVHGSGASDRDETVGA--NKPFRDLAYGLAERGIAVIRYDKRTKVYGADSAPAG---KEITFDEESVDDALSAIKLARSIPTINPERIYILGHSLGGTLAPRIAQRS--DKVPAGIILLAGAARP-LEDLFISQVKFLASAL------PSAKDIE----KEIAELQKQVDNVKR-L-G--TDTFDITTPLPM---N-LSQAYWMLANQYKPLEVVRKL-TLPILVLQGERDYQVTM-QDFELWKSALAKHPNAIFKSYPRLNHLFQ--EGEGK-STPLE-YSRPSSIPSYVTDDIAAFINRPKPGN------------     =====>
9baci-c3bs81   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPTGSEAKGVGTANFDPSYKIPAYVKPELYTEQEVLIGS-GDIKVPAKLTIPKK---K--GLIPAVVLIPGDGEVDHDSRLYA--LKPFKDIALGLASQNIAVLRYEKRTNKRFKFF-------KDYTVSDEFTEDAVQAVKFLRETDKIEVGDIFLIGHCRGGWMLPDILERKEMEG-VAGGVVLSAPNPQ-V--SAVEMLLNKTDLS------GLSSE-------ELKLCREQLRMIQY-L-PI-DKINTKE--FRL---A-PSVKWWHSLKDYIPSQSSMLK-DFPFLVLQGGRDINITE-DDFEKWKEVLSENRNAVFSYYKKLNHAYV--EGEGP-GTMEE-YLLPGNVPEYIVEEIGNWIKEKIKVVN-----------     =====>
9bacl-c6j737   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTV-HRNVTYAFQT--AAVPVNLTLRLNAAGEIDDMYIAAAA----SSAYQKPAYEDAAAYTEREVTVGE-GAMALPGTLTLPVG---N--GPFPAVVLVHGSGTNDRDEAIGS--AKPFRDLAVGLAAQGIAVLRYDKVTYEHTFKVA----ADSKFTLKKETVDDALKAVALLKQTPEIDASRIFVAGHSQGGYAMPLIIAGDTSGD-IAGTILLSGPSGK-FADVLVEQQAELVSRVKELGLDP---APYE---QQAAMYTSIAAMVND-P-QYTVDHMPEQ--FPT-----QPAYWWFEQKNYVPAELAKQQ-SVPMLILQGENDWQVTM-KQFEGWKTALQNRKDVAFKSYPQVNHLLA--KVDGL-SIGAE-YAQPSNVFKEIIDDIAAWVQGIK---------------     =====>
9bacl-f5lh06   	MKKHLPIWQSAVIA---SMLLAGAVPAAAASAGTVNAETAAAG--PVSASDTN-AATVLAPLRLVSETAGAKVAWNNEERTVTLSLGSDTI-TLAIGKSTALINDKEVELGAAVQIKDDK--TFVPLNFL-TE--------------ALHTAVSWDPQ-----NGKLI----------------------------------------------IPKGDLKAAASAFASHWLQGEN-----ESAVS---YFNSDLKKSLNA--NQLTYISQYYTNMYGPITGQLG-----AGTTSNSV-HENVYLTYET-QSTLPFQMTVRFDKQDRIDDLYIPPYYS---PDTYRKPSYDDSGAYVEKEVTLGE-GRLALPGTLTLPSK---P--GPHPVVVLVHGSGANDRDESIGG--SKLFRDMAVGLAAQGIATLRYEKVTREHPFKSA-----TPAFTVQDETVADAVYAVNQLAKTEGIDPQRIFVAGHSQGGMVVPRVIDGVKDVK-LAGAVVLAGPTNS-IEDVVLEQSKYQLEVSRERGLDT---SILE---QQVAFWEQQLKLIKD-P-QYSVDNLPKD--LAL-----SNAYWWMDFRNYSASEIAKKQ-DKPMLILQGDNDAQVLA-YHLDKWKEALKDRTNVEYKLYPKLNHVFA--EVDEK-STGAE-YNEPANTPASVIKDIADWVKKTK---------------     =====>
9bacl-h3sft0   	MG--KSSWKWMIAG---CLLFGSMAPLAMAQ---------------EAGAATE-SAAELVPLRQAAESIGALVEWDQQTKTITVTFGDRVW-TVDSASGRSEVNGTAVTLGAGSLQGKEKGLHYIAWGAM-KE--------------ALQIQGKW--V-----NGKVL----------------------------------------------ADEADWKTRAAQFTVQWAALAEAPQEEAQLAS---LLTPELKEATKV--AHLSRLAQQIIPMVGKPTQFVQ-----ASSDNDGV-HQNVQVLFKT-DKDLMLSLTLRYKENGLLNDVFYS-YLP---SGNYQPPAYDDASLYKEETIFIGD-GQFKLPGTLTLPAAANAA--GTYPVLVLVHGSGANDRDESIGA--AKTFRDMAIGLAKEGIATIRYEKRTREYPVQSA----AIPRFTVKEETVDDAVLAVKWAGQDKRLNKDRIYVLGHSQGGMLIPNIVKADTGNA-IRGAVIAAGPSGP-LEDLMIEQMERQLQYAKDNGQPAEVVAAAE---GQLKMWQQMVAIIKD-E-QYTLDNLPAN--FPL-----PNASWWIDFRNHHGGEIAKDQ-KVPLFIIQGDNDVQVGK-EHLDGWKKALQNRTNVQYKLYSKLNHVFV--ESDKP-STGQE-YIIPGNVPEQVMKDIAAWIRSN----------------     =====>
9bact-g5gcr0   	-------------------------------------------------------------------------------------------------------------------------MI-HRISIL-FSLL----------------LCLSA----------AV----------------------------------------------AQD---FGRSQRVLDWLQQQKG-----DSVYA---LCNAEMKAALTA--QQLGGIYAQLVRQAGTENGRGE-----WERTVVEGGIEVDGIRLDF--SQTSLMALLSWNGEGQLCGLFFRPTTP---------PQTVAIGGAENREVQIEN-GKIFLPGTLTLPTE----RKNPVALAVLLAGSGPCDRNETIGP--NALLRDLADSLAIHGIASIRYDKRTLVYGSACVEIS---GGMDYDKEIVDDALAALQQAGALPEIDTRRIFVVGHSLSGMLLPRIAQRA--TTPMAGIIALSAPARP-LAEVMKEQMNYLGRLN------NITPTE----------IDSAYR------------------AALA---P-LPKEYLKFDSKYRPLRTAQQL-TVPMLFIQGGHDYQVRQ-TDFQLWQQALGKRPNVDFRWMPTLNHLMA--ESPNM-SRPDD-YATRQLIAAPVVETIVDFIGRH----------------     =====>
9bact-h1xtg9   	-------------------------------------------------------------------------------------------------------------------------MHKLIFALI-VWLM----------------VGA-G-VQAQK--VEPS----------------------------------------------DEWQKPIALAAQFIDLLEQAQF-----DSAVG---YMDANMSKALPA--EKLRAMWQSLQQQMGNFKARSG-----VRTETVQV-YRVVYVTCEF--EKGKLDAKVVFDQQNKIGGLFFVPHQQA-Q--GWQPPDYVDTHAFTEIDTLKIP-TTWQLPASLSLPNG---P--GPFPAVVLVHGSGPNDRDETIGP--NKPFRDLAWGLATRGIAVLRYEKRTRIYPNIVD-SLH--GQFTLIEETVEDALAGVSFLRDIVEIDPEKIIVLGHSLGGYAIPRIARYY--PR-LAGLIIMAGSARP-LPDLLQEQYRYIFNLD------GQITAEEQ---VKLQELDSLIALIRN-E-NFLKKADPTQ--LIL---G-APPAYWLDLMQYDPLKMIERL-RKPILVLQGGRDYQVTK-RDFDLWKKHLKHNPKATFKYYYQLNHLFM--SGEGM-ATPQE-YEKPGHVDKQVIEDIATWIKSHF---------------     =====>
9chlr-d6tuj9   	------------------------------------------------------------------------------------------------------------------------------------MLRL-RH------EADIEEIPDYELTFAKTREEITK----------------------------------------------LATTDATVIAITVVEMARDGRF-----ADIEE---LFAPPLRAAVSA--ETVRVAWLAEIGKSGPVSTIGE-----PLLDQMGEGLVRVSIPVTC--EHGELTMVMSVDSKGLLNGFRLAPP-----ATSWTQPTYADPDSFDERDVTVGS-GPLAVSGTLSLPHG---R--GPRPGVVLLSGGGPFDRDETSGS--NKPLKDLAWGLASRGVAVLRFDKVTYTHSRRVA----NTRDFTMTDEYVPHALAAVHLLQQQPTVDSARVFVLGHSMGGKVAPRVATTE--AS-VAGLVILAGDAQP-MQHAAIRVTRYLAQLY------PGPDM--E---AMVETITRQAAMVDS-P-HLSPSTPTRD--LPF---D-LSASYWLDLRSYDPVMTAATL-DKPMLILQGGRDYQVTVEDDLSRWKAGLGHRPDVTIRVYDADNHLFF--SGTGP-STPTE-YEPAQHVDPAVVADIAEWLMPK----------------     =====>
9clot-c6pwe1   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSNKNI-----DEALK---QLSSDLKTGYGE--GIMKNYLSSVS-----FKGVDTK-PIDVKQEEAPL-GNVITLTYKVEGSSTTVDVKIKYDNDGQIYDLVFENT-PV--DSKYKLPSYANTDNFTEKNVTIGD-GKYKLPGVLSMPKG---K--GPFPAVVLVHGSGANDKDETYGD--TKVFRDVSAGLASKGIAVLRYDKRAKYYGALSS----VDTKVDLNGETVNDAVEAVNLLKKTEGIDSNKVFVLGHSLGAMLTSTIIKDCGDNG-AAGGIMMAGPVDF-L-DTLLEQSKYLNSIG------E----MNE---NQLKGMKSVYSTVK--N-KDFPGNLPENTPIFG---A--YPYYWLSVKNSTQVNDAVSI-KEPLLILQGKMDYQVDV-SNLDKWKNILKNKQNVNYKSYDKLNHFFI--ETNSK--SMEG-YGKAANVPDYVVNDIINWVDEYSK--------------     =====>
9clot-e4lu36   	------------------------------------------------------------------------------------------------------------------------MKKKIQIVIC-CLLCFL------------------MAACSGEKEKK-GQ-SDE-------------------------------------VADIVLSDKQSDMALQFVKDLTQRKY-----DKLQKDY-AYDEQMHKAVRE--DSFQKQLDAYNDSLGSLIEAEQ-----PYGQSYQN-STIIMIPCRM--EEQNTNIQVSLNEQDQIQGLFFKPYKSQKKA--AK---APDGVKEREVELQIA--DGKKLSGRLTTPAE---G--KSFPLVILLAGSGPNDMDETIYD--NKPFQDIAWGLAKKGIASYRYDKRTYTYPESFT------VKDTVEQEVIFDAVAAFSQMKQQKQIDTNKIYILGHSLSGYLIPRIAAET--DG-CAGYIMMAAPARA-LDELLMEQVTYLAKLD------GNLTKDEQAAIDQYKQDQQDLQRI-------DELSDAKI--FFG---G-MSKAYMKDLLSYDAVQQAADI-KVPVLCAQGLRDYQVTE-EDQAIWRKNFETHKNWKFTTYPNATHLMI--DGEGT-PTNEE-YKTKGHVNQAFIEDMASFIKK-----------------     =====>
9clot-f1tac1   	---MKKVTRLISLM-LIILILGGTAAYAA-----------------SENKQSV-SGDIYVPVKLACEAMGGQVSWDGKKQITTVKLGSNEL-KLFVNRCDIILNGKAKVLKEKVKVEEGR----TILPLS-VLNSQL----------GLKL------TCD---------------------------------------------------------DYIKLISMKFIGMVKAGKT-----ADASF---LLSKSFSKYATT--EFINSAL-------APAFSVIEPDVKTMTLAKNTV-HQNVFIPFTI--QTAKYNFIMRFDYNGKIDEFNQAA-DSS--QFTYSKPSYDNSANILKKEVAIGE-GEWKLPGTLTMPKG---K--GPFPAIILVHGSGPNDRDETLGP--LKPFRDLAVGLASQGVAVLRYEKRTLEYGVRIQ----SLPKLTMTEEFEEDAFAAANYLKTIDGIDASNITVLGHSEGGYDLPRILGTDKTGT-FKAGIIMSGCSRP-LYELLPEQYKYLAGLG------M----ATE---EQAEAAKAQAALIQD-K-SFNPENPPKG--YSL---G--TPYYFYDMKNYDVIGMAGQI-EKPVLVLQGERDYQVSTKTDYEGWKKAFEGKSNAEFKLYPKLNHMYM--EGEGQ-STPAE-YYVKGNVPQYIINDIAAFIKK-----------------     =====>
9eury-f7pnc4   	------------------------------------------------------------------------------------------------------------------------MRTRRRFLQA-ALTL----------------SIGALAGCSDDEGTTAADRPTGTPSPTATPGLTTTETPPRPETTTATSPETPTTT---------------------------------------------------------------------------------------------------------------------------PPETTTP-----KPGYKPPEYVDLASYSEQTLSLSATDSCELGATLSLPEE---G--NDLPGVVIVHGSGGHDRNGTYGQ--VQPYRDLALGLASEGVAVLRYEKRTYACSLSVD-----AASLTIDDEVTADALTAVDRLREQDCVNAGNVVVAGHSLGGMLAPRIAEQD--GD-LAGIAMLAAPARS-LPEIIVYQTRYQFERD------GDLSEEER--A-RLERIRTIADRVRA-G-EVGE----DE--LVW---G-GGRAYWRSLAAYDQISTAKAL-DRPILLQQGQRDDQVPPETELTRWREALGGSESVAIRTYGGLNHFFV--DGPGP-IATGE-LPGPGHVAEPVVTDLADWISGVTN--------------     =====>
9eury-g4gev6   	-----------------------------------------------------------------------------------------------------------------------MAPRRRTVLAA-VSTA----------------TASAVAGCAGFLTDETSDDGDDP-------------------------------------------AAATDVATALVEDLANERF-----ERASER--FRSDQRSRYGDP--GRLERLWLALTTTSGSFEEILE-----TEVTE-GQQLRAVEVTAAF--DGGDHDCTVVVDDEVQVRN---YGL-----SDEYERPSYVDPDAITTQSVSLSV-PDCSLPGTVTTPAA---G--DDVPGVVLVHDDGPMTADTPRGG--TKTFADLAEGLAMEGVATLRYDKRVPACDV--Q-----PAEYTLDRVTADDAAVAIERLRNVDGVDPERIVVAGHGLGGRAAPRIADRD--GS-LAGVVGLAPPARP-YPEFTFSQLEYKVSVG------SHEWADLT--A-TYETWGDEIDRVRS-G-EYEP----AE--RLL---G-KPGAFWDSIGDYDHLGVAAET-DVPVLLCQGERDFQVSVADDLEQWDDSFAGAT--TVETYADCNHLFM--PGEGE-PVAVA-YAVRNNVAEGVVNDIATWVREL----------------     =====>
9firm-b9y779   	----------------------------------------------------------------------------------------------------------------------MNKSIKKGFIGL-LLLSVV------------------LSGCQKTPAPAESNQPGT-------------------------------------DVQDKVTGSREEIAKAYVETLGAGDF-----DKLLQGF-AYDEQMQKASSQ----LQASLEPSLKQLGALKEIQT-----ANEIQQGG-YIIVQVPVLF--ENQNLCVNVVFDDQDQIAGVNFSEYVEPSNVAALT---LPEGAAEQELTLTMR--DGKDLPATLTLPQG---D--QPAPVIILVHGSGPNDRNETLYG--NTVFQDIAYRLAEQGIATVRYDKRTFVYGAECA----GDTQFTVEQETIQDAVDIVGLIAKQPEIDSSAIYVLGHSLGGLCMPRIAAET--PE-AAGYIMMAAPVTD-LASLMKMQYEHLAQFM------NT--DQEKASMEAMIAELDKLQQL-------DSLSEDEA--VV----G-AYPAYWKDLLSYDPVKTAETI-TKPVLVLQGEEDYQVPL-QEFETWKAAYGEKANWTFHSYSGLSHLMM--PGDFD-ANPNTYYMQKAVVDPRVTDDIAAFIHAQK---------------     =====>
9firm-c0gei4   	-------------------------------------------------------------------------------------------------------------------------MRLYKLTFI-LLIL----------------LAVVTASCSTQTAPADP----------------------------------------------PLEGDVTDLAVDFVTKLSEEDF-----AGTVA---YYDANMRQALPE--SNLREVWEQLLGQAGPFVGILD-----TRVESDDE-YDAVLVTSEF--ESLVLDIRVVFNRDKRVAGLFFQPAQEH-YESEYRLPPYTDTAAFTEYEVTVGS-GEWALPGTLTVPLE---S--GSHPAVVLVHGSGPNDRDETIGP--NKPFKDLATGLSSRGIAVLRYEKRTKEHGQAMA-SQM--ETLTPKEEVIDDALAAVALLRSRDDIDPESIYVLGHSLGGTLAPLIGAED--RE-IAGLIILAGAARP-LEDIILEQYHYLAGLE------EKVTEETE---AALQDMQLRVERVKD-P-DLSLDTPADK--LPL---G-MPASYWLYLRDYNPAETAKTL-SVPVLILQGERDYQVTM-EDFTIWQDELSSRTDVAFKSYPGLNHLFM--KGEGP-GNPNE-YMQPGNVAQEVVDDIVSWLQVR----------------     =====>
9firm-c6laa8   	-------------------------------------------------------------------------------------------------------------------------MR-GKWMFTGLLLCL---------------ALMLLPAAAGRAA-----------------------LL---------------PQPD--------AESLKEDALQVAEDMQTGNF-----AAVT-E--KFNAEMAAALDE--DTLKSGWDSAVAILGDFLETIS-----AESY-EQGAYVVVDILEHY--ENNGMKLHIVYDGEGKIAGMQITYADVEEY-EEETQSEDGAAAYTEEEVTVTA-DERVPLGGTLTLPVD----VE-KPPVVILVHGSGSSDRDENING--NKPFADIAHGLAARGIAVLRYDKRYYVYPDCPDVGSA--EMVTLREESLDDVDAAIKLMQEDARVDGSHIFVLGHSLGGCLCPAIAAEH--PQ-LTGIISMAGSLRP-LWEISYDQNQEVIAAAEA----GNLTEEQQ--AQLAEAA-EQVEADTKILREDLDNQPDDG--MLL---G-IPARYWKSIKEYCGMNFINEV-KMPVLVLQGDADFQVYPEKDYALWQEALGGRDNVVFHLYEGLNHLMMPTQGKR---DITE-YAVKSHVDTQVIDDIAEFIMDVVK--------------     =====>
9firm-d6hj92   	-------------------------------------------------------------------------------------------------------------------------MKRTGWLFL-LIFTLI------------------LSSCSSSNEESASD-TTK-------------------------------------TQDVTITLTQKETCEKLANIICDGDI-----QALQNDF-TYLDEMGKAVKE--KNFQTQIMSFSKSCGSVVSLQT-----PYAQSYQG-NVAVFQPVIT--QKQKFNLQVTFA-GDKIAGIFFRPYQLPEET--M----KMDGIKQKEMDLKIA--TGGNIKGYLCTPEK---G--DKFPVMILLGGSGPSDHNETIGN--QKPFYELAKELGKQGIATYRFDKRTL--ENTFT------QTDTIQQEYIEDALSAIQLMQQQKQIDKQRIYVLGHSQGGYILPRLNEQT--KD-VAGYIFMAAPSRP-IEDSMVEQLTYLAKLD------GKVDAEEQKQLDEAETVRKQIKQI-------ASSKHDDT--LYF---G-MTRAYLMDLATYDPVKTAEKI-QVPVLLCQGLRDYQVTK-TDLKRWQQAFAEKANWTIRTYATANHAMS--KGSEQ-PSPKD-YNQEAGLDVTFVKDIVQFIK------------------     =====>
9firm-e2sid5   	----------------------------------------------------------------------------------------------------------------------------------------M------------------LAACSGKEEKK-ED-AKE-------------------------------------AVEIQLTDEQSRMATQFAKDLTQRRY-----EKLLKDY-SYDERMKETIKQ--KDFQKQLNSYNDSLGKLLEAET-----PYGQSYQG-STIIMIPCRM--EEQNTNIQLSLNEKNEIQGLFFKPYKTQKKS--AK---TPTGVKETTLNLKIS--NGKTLAGRLTTPSE---G--ESFPLVILLAGSGPNDMDETLYD--NKPFQDIAWGLAEKGIASYRYDKRTYTYPESFT------LQDTVEQEVIEDAVAAVKQGKLQSQINTKQIYILGHSLSGYLIPRIASQT--KD-CAGYIMMAAPARP-LDELFLEQVTYLASLD------GTITDKEQKVIDQYKQDQKDLANI-------DNLSDAKM--FFG---G-MSKAYMKDLLSYDAVKQAADI-EAPVLCAQGLRDYQVTE-EDYSIWKKAFENKKNWSFTSYPKATHLMI--DGEGK-PTSEE-YKTKGHVNQKFIDDIASFILK-----------------     =====>
9firm-g1vqj2   	------------------------------------------------------------------------------------------------------------------------MKKKIQIVIC-CLLCFL------------------MVACSGEKEKK-GQ-SDE-------------------------------------VTDIVLSDKQSDMALQFVKDLTQRKY-----DKLQKDY-AYDEQMHKAVRE--DSFQKQLDAYNDSLGSLIEAEQ-----PYGQSYQN-STIIMIPCRM--EEQNTNIQLSLNEQDQIQGLFFKPYKSQKKA--AK---APDGVKEREVELQIA--DGKKLSGRLTTPAE---G--KSFPLVILLAGSGPNDMDETIYD--NKPFQDIAWGLAKKGIASYRYDKRTYTYPESFT------VKDTVEQEVIFDAVAAFSQMKQQKQIDTNKIYILGHSLSGYLIPRIAAEM--DG-CAGYIMMAAPARA-LDELLMEQVTYLAKLD------GNITKDEQAAIEQYKQDQQDLQRI-------DELSDAKI--FFG---G-MSKAYIKDLLSYDAVQQAADI-KVPVLCAQGLRDYQVTE-EDQAIWRKNFETHKNWIFTTYPNATHLMI--DGEGT-PTNEE-YKTKGHVNQAFIEDMASFIKK-----------------     =====>
9firm-h1ayz6   	------------------------------------------------------------------------------------------------------------------------MKKKIQIVIC-CLLCFL------------------MAACSGEKEKK-GQ-SDE-------------------------------------VADIVLSDKQSDMALQFVKDLTQRKY-----DKLQKDY-AYDEQMHKAVRE--DSFQKQLDAYNDSLGSLIEAEQ-----PYGQSYQN-STIIMIPCRM--EEQNTNIQVSLNEQDQIQGLFFKPYKSQKKA--AK---APDGVKEREDELQIA--DGKKLSGRLTTPAE---G--KSFPLVILLAGSGPNDMDETIYD--NKPFQDIAWGLAKKGIASYRYDKRTYTYPESFT------VKDTVEQEVIFDAVAAFSQMKQQKQIDTNKIYILGHSLSGYLIPRIAAET--DG-CAGYIMMAAPARA-LDELLMEQVTYLAKLD------GNLTKDEQAAIDQYKQDQQDLQRI-------DELSDAKI--FFG---G-MSKAYMKDLLSYDAVQQAADI-KVPVLCAQGLRDYQVTE-EDQAIWRKNFETHKNWKFTTYPNATHLMI--DGEGT-PTNEE-YKTKGHVNQAFIEDMASFIKK-----------------     =====>
9firm-h1bcb2   	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIPCRM--EEQNTNIQLSLNEQDQIQGLFFKPYKSQKKA--AK---APDGVKEREVELQIA--DGKKLSGRLTTPAE---G--KSFPLVILLAGSGPNDMDETIYD--NKPFQDIAWGLAKKGIASYRYDKRTYTYPESFT------VKDTVEQEVIFDAVAAFSQMKQQKQIDTNKIYILGHSLSGYLIPRIAAET--DG-CAGYIMMAAPARA-LDELLMEQVTYLAKLD------GNITKDEQAAIDQYKQDQQDLQRI-------DELSDAKI--FFG---G-MSKAYMKDLLSYDAVQQAADI-KVPVLCAQGLRDYQVTE-EDQAIWRKNFETHKNWKFTTYPNATHLMI--DGEGT-PTNEE-YKTKGHVNQAFIEDIASFIKK-----------------     =====>
9firm-h1br03   	-------------------------------------------------------------------------------------------------------------------------MKRTGWLFL-LIFTLI------------------LSSCSSSNEESASD-TTK-------------------------------------TQDVTITLTQKETCEKLANIICDGDI-----QALQNDF-TYLDEMGKAVKE--KNFQTQIMSFSKSCGSVVSLQT-----PYAQSYQG-NVAVFQPVIT--QKQKFNLQVTFA-GDKIAGIFFRPYQLPEET--M----KMDGIKQKEMDLKIA--TGGNIKGYLCTPEK---G--DKFPVVILLGGSGPSDHNETIGN--QKPFYELAKELGKQGIATYRFDKRTL--ENTFT------QTDTIQQEYIEDALSAIQLMQQQKQIDKQRIYVLGHSQGGYILPRLNEQT--KD-VAGYIFMAAPSRP-IEDSMVEQLTYLAKLD------GKVDAEEQKQLDEAETVRKQIKQI-------ASSKHDDT--LYL---G-MTRAYLMDLATYDPVKTAEKI-QVPVLLCQGLRDYQVTK-TDLKRWQQAFAEKANWTIRTYATANHAMS--KGSEQ-PSPKD-YNQEAGLDVTFVKDIVQFIK------------------     =====>
9flao-d7vwv8   	-------------------------------------------------------------------------------------------------------------------------MIMKKLLTL-FFTVWF------------------LLSFSQ-DR--------------------------------------------------------KEIGNTFIKTLLADKN-----AEKAHS--YFDPSVAGQIPV--EQLKAISEQLQGQIGALKNILE-----V---NNEG-N-IYYFYTEF--EKTNLDVQLTFGENNKLLGFFLVPHKTFEKRDE-K------------TEFRIKS-DAVELKGTLLVPPS---D--NKKRLVIFVHGSGAHDRDETIGE--NKPFKDIAEYLFSHGIASYRYDKRIYSYPETFN------EKSTVEDETINDAVNVALYFKNNPEYKGYEIIILGHSQGAYMMPKIAEKA---K-VSKYVFMAGNARP-LEDLLVEQYEYLHSLD------PANVP-----AEAVQEIKKQVAFLNS-S-RFNLNSPKSE--LPL---G-QSAAYWKYLKDYNQLNEVKKI-KAPMLFVQGGRDYQVTE-KDFNLWKETLKNNKAAVFKFYPALSHLFI--SGSGK-PSPKD-YETKGKVDEQFLKDLTDFILK-----------------     =====>
9flao-h7frs6   	-----------------------------------------------------------------------------------------------------------------------------------------------------------MLSFSQYNN--------------------------------------------------------KVIGESFIKLLLQEKK-----YQEAHS--FFDDTIKSKISV--KLLEDTELQLRNQLGGFKCIIE-----V---NNEG-N-TYFYYSDF--EKMKLDVKITFNDHSKIIGFFFTPHKEFKKVNSLG------------KDLKIRS-GNIDLKGTILIPEN---N--NLKKLVLFVHGSGPQDRDETIYE--NKPFKEIAEILFEKGIASYRFDKRTLTNPESFD------EKSTVDNEVTNDIIAIINYFKEDKQFKDYEIIVLGHSLGANLLARIANKS--NQ-ISKIILMAANARP-LEILVAEQYDYLYKLN------PSQEL-----LEAVNNVKGQIAFLNS-K-DFNVNSPKEK--LPL---N-LSAYYWQSLLDYNPLKEIKKV-KIPILILQGERDYQVSM-KDFELWKSTLKNNTKATFISYPKLNHLFM--SGDGI-SDPKE-YLIKGNVDAKVIEDVFDFVKK-----------------     =====>
9noca-h5rkp4   	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRIE----EKSAWSAPDYADPGLFDEHDITVGA-GAHAVPGTVTVPRG---P--GSCPAVVLLGGGGPFDRDCTFGP--NKPLKDLAWGLASRGVAVVRFDKITHTHPEV-T----ADPGFTATDEYVPHAVAAVDLLRATATVDPSRVFVVGHSMGGKLAPRVAAAA--PV-VAGLVLLAADAEP-MHRASVRVVRYLAATA------PSAQA--D---ALVETFTRAAAVVDG-P-DLSPQTPAAT--LPF---G-MGGAYWLDMREYDQVGAAAAL-PQPMLLLQGERDYQVTIEDDLARWRAGLGSRADVTIRTYPADNHMFF--PGAGP-STAAD-YEPPQHVDPAVIADIADWLSRH----------------     =====>
9plan-a6can6   	------------------------------------------------------------------------------------------------------------------------------------MLL----------------LATIALE-----TRAAE----------------------------------------------QAENTPESLAREFVTQLAQGDY-----REAVS---SFDSKMSHHLPE--DKLQKLWEGISGQWGELQEIQS-----IRLQKVPQ-YQITLVTCRF--EKGLLDVKVVFAANQQIAGLFFLPAG------RYQSPSYVKPNRFKETEVTIGT-GLWSLPGTLSVPVM---G--KKVPAVVLVHGSGPQDRNETTGP--NQPFRDLAEGLASQGIAVLRYEKRTKHHRLKMV-LLS--ESLTVREETIDDAVAAVQFLQSQAQIDRTRVFVLGHSLGGYLLPQLGAEA--QG-IAGLISLAGSARP-LEEIVLEQVKYLSALN------GEAAAESQ---QKLQELEKQVAMVKS-L-ELKPETPAGQ--LPL---G-IPASYWLALRGYDAAERARTL-QVPLLILQGQRDYQVTM-DDFARWKQALRNRKDVRFISYPKLNHLFM--AGEGP-GTPAE-YMIPGNVAEEVVRDIAAWIDDQK---------------     =====>
9sphi-a6eex5   	-------------------------------------------------------------------------------------------------------------------------MKKALLLFF-AMLLT-----------------TA--G--------FA----------------------------------------------QGVIALFSRSEEFFSLMNEQKF-----KEAQA---YFDTVAQKQTTP--EKLGEIWGSLTSNLGKFTSLDL-----VQSSVQGD-YYYVAADGNF--EKATQGFTLIFNKGQKLVGLRPRERAV---ESEYQIPSYADTTLFKQIEVHVKT-PGHDLVGLLTIPKN---G--SNFPLVVFVHGSGPSDMDETVGP--NKPFKDIAGGLASKGIASIRYVKRTVLYANEFT-----T-SFTVKEEVMDDALAAIALARTTPNIDKGQIYVFGHSIGGMLAPRLALLA--PD-LNGIILAAAPARK-LADIIADQNKYGASLAKDTTGLV------A---KQLTEALKKVDAARI-T--SLGTMKADS--VVL---G-LPAAYWVDLNNYNQVEDAKKLGKQRILVIQGGLDFQVSE-QDFNIWNTALSTKKNASMKLYPDLNHLLS--PQNEK-GTMSQ-YQVPINVSAVLVNDLVTWINSN----------------     =====>
9them-i2f1x3   	------MFRRILVS---TVLIASVLSFASIDVAEQYFNSFFNGKYPEAYELQNAEMKKAQPLSAM-------RNLRGQL-------------RMQVGDFLRVLDINEVPQGDLVSYLFACEFKAGIFDVI-ITLDA-EEKVA-----GFFIRPS--SYVEPET---ET----------------------------------------------VMIETGNEVVDTYINGFFSGKF-----EEIFE---LQTEQVKASLSP--EALKGAYANIVSMAGEFEEVLN-----LESSKSDG-MISFVLACRF--ANGIFDITVTLDKDEKVAGFYFRQSA----YSERELPDYADPSAYTEQDITVGK-EPYYLPAKLMVPNG---L--ESYPL