ESTHER Database

Home
Search
Tools
Families
Biological
data
Basics on AChE
ESTHER definition
What is up?
Acknowledgments
& disclaimer


MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....900..5....910..5....920..5....930..5....940..5....950..5....960..5....970..5....980..5....990..5....1000.5....1010.5....1020.5....1030.5....1040.5....1050.5....1060.5....1070.5....
ailme-d2hpm8   	-------------------------------QLGAVYTEGGFVEGVNKKLAL-FG---DYVDIFKGIPFAAPPKALETPQRHPGWQ------------------------------------------------VSRNLPVMIWIYG-AFLVGAGHGANFLNNYLYDGEEIATQGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLWDQHM-----------------------AIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPHNKGLIQRAISQSGVALCPWAIQRNPLFWAKRIAEKVGCPLDDTARMAKCLKVTDPRALTLAYKMPLAG-MEY-PMLHYLGFLPVVDGDFIPDDPVNLYANAADIDYLAGSNNMDGHIFASIDMPAINKDKQ-EVTE----EDFYKLVSGLTIAKGLRGANATFDIYTESWALDASQETKKKTVVDFETDILFLVPTKIAVAQHRANAK--SAKTYSYVFSHPSR----MPTYPKWVGADHADDIQYVFGKPFATPLGYRTQDRTVSKAMIAYWTNFARTGDPNMGHSAVPTLWNPYTVENGNYLEITKKIDRNSMKQHLRTNYLRYWTLTYEALPTVTGNGAAPVPPSGDSDAAPAPP---SGDSDAAPVPPSGDSDAAPVPPSGDSDAAPAPPSGDSDTAPAPPSGNSEGAQMP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
anoca-g1kdb8   	EVTMARWGFLFL------T-FAFCLGTAGAAKLGIVITEGGFVEGVNKKLGL-FG---NYVDIFKGIPFAAPTKTLEDPQPHPGWPG--TLEAKEYKQRCLQSNLMQTDVRGSEDCLYLNIWVPQGKK-----TVSTNLPVMVWIYGGAFLWGGGQGPNFLQNYLYDGQEIATRGNVIVVTFNYRLGPLGFLSTGDANLPGNYGLKDQHM-----------------------AIAWVKRNIRNFGGDPDNITIFGESAGAVSVSLQMLSPHNKGLIKRAISQSGVGLCSWAIQKDPLYWATKVAEKVGCPTDNTTTMANCLKVTDPAALTLGYHLDVIG-LKY-PLVHYLAFSPVIDGDFLPDAPEKLFDNAADIDYIAGVNNMDGHFFASIDMPALNRPLA-KIKP----EDVYNVAQGLTMEKGVEGAFRTFSLYTQVWTDSVNQEVMKRTVIDLETDYIFLVPTQQTLALHQQHAK--SAKTYSYVFSQPSR----MLIYPSWVGADHADDLQYVFGKPFVTPLGYRPQDRTVSKAMIAYWTNFAHTGDPNKGELSVPIGWVPYDTLQGYYLEINKDLNYDSVKHGLRNQYVQFWSTSYRNLPDV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
bovin-balip    	------LGASRL------GPSPGCLAVASAAKLGSVYTEGGFVEGVNKKLSL-FG---DSVDIFKGIPFAAAPKALEKPERHPGWQG--TLKAKSFKKRCLQATLTQDSTYGNEDCLYLNIWVPQGRK-----EVSHDLPVMIWIYGGAFLMGASQGANFLSNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDSNLPGNYGLWDQHM-----------------------AIAWVKRNIEAFGGDPDNITLFGESAGGASVSLQTLSPYNKGLIKRAISQSGVGLCPWAIQQDPLFWAKRIAEKVGCPVDDTSKMAGCLKITDPRALTLAYKLPLGS-TEY-PKLHYLSFVPVIDGDFIPDDPVNLYANAADVDYIAGTNDMDGHLFVGMDVPAINSNKQ-DVTE----EDFYKLVSGLTVTKGLRGANATYEVYTEPWAQDSSQETRKKTMVDLETDILFLIPTKIAVAQHKSHAK--SANTYTYLFSQPSR----MPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFARTGDPNTGHSTVPANWDPYTLEDDNYLEINKQMDSNSMKLHLRTNYLQFWTQTYQALPTVTSAGASLLPPEDNSQASPVPP---ADNSGAPTEPSAGDSEVAQMPVVIGF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
calja-f6u4n2   	THTMGRLQLVVL------G-LTCCWAVASAAKLGAVYTEGGFVEGVNKKLGL-LG---DSVDIFKGIPFAAPTKALENPQPHPGWQG--TLKAKDFKKRCLQATITQDDSYGHEDCLYLNIWVPQGRK-----QVSRDLPVMVWIYGGAFLMGAGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNITIFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQKNPLFWAKKVAEKVGCPVEDTARMAKCLKVTDPRALTLAYKMPLAG-MEY-PMLHYLGFVPVIDGDFIPDDPVNLYANAADIDYLAGTNNMDGHIFASIDMPAINKDKQ-EVTE----EDFFRLVSGLTVTKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDILFLVPTEIALAQHRANAR--SAKTYTYLFSHPSR----MPTYPKWVGADHADDIQYVFGKPFATPLGYRPQDRTVSKTMIAYWTNFAKTGDPNMGNSAVPTHWEPYTTENGSYLEITKKIDSNSMKRGLRTNFLRYWTLSYLALPTVTDQGATPVPPTGDSEATPVPP---TGDSEATPTPPSGDSEAAPAPPSSDSEAAPAPPSGDSEAAPAPPSGDSEAIPVPPTDDSEA-----VPVPPTDDSKGAQMP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
canfa-f1phd0   	AHAMGRLELVVL------G-LTCYWALASAAKLGAVYTEGGFVEGVNKKLGL-FG---DYVDIFKGIPFAAPPKALENPQRHPGWQG--TLKAKDFKRRCLQATITQDNTYGEEDCLYLNIWVPQGKK-----EVSRNLPVMIWIYGGAFLMGAGHGANFLSNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALCPWVIQRNPLFWAKRIAEKVGCPLDDTARMAKCLKVTDPRALTLAYKMPLAG-MEY-PMLHYLGFIPVVDGDFIPDDPINLYANTADIDYIVGTNNMDGHIFASIDMPAINKNKQ-EVTD----EDFYKLISGLTMIKGLRGANSTFDVYTKPWARDATQETKKKTVVDFETDILFLVPTETALAQHRANAK--SAKTYTYLFSHPSR----MPIYPKWVGADHADDIQYVFGKPFATPLGYRPQDRTVSKAMIAYWTNFARTGDPNMGHSAVPIHWDPYTVESGNYLEITKKMDHNSLKQHLRTDYLRYWAVTYEALPTVTGDEATPAPPSGDSNATPAPP---SGDSNAPPAPPSGDSNAPPAPPSGDSNAPPAPPSGDSNAPPAPPSGDSNAPPAPPSGDSNA-----PPAPPSGDSNAPPAPPSGDSNAPPAPPSGDSNAPPAPPSGDSNAPPVPPSGDSNAPPAPPSED-----------SEGAQM--------------------------------------------PIVIGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
cavpo-h0uyx7   	MLRMGRVLLAVV------G-LACCLAVAGAAKLGVVYTEGGFVEGVNKRLSL-LG--GDSVDIFKGIPFAT-AKTLENPERHPGWQG--TLQATDYKKRCLQATITQSSTYGEEDCLYLNIWVPQGRK-----QVSENLPVMVWIYGGAFLMGAAQGANFLSNYLYDGEELATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPDNITIFGESAGGASVSLQTLSPYNKGLIRRAISQSGVGLSPWAIQHNPLFWAQKIAKKVGCPEDDTAAMASCLKATDPRSLTLAYRLPLVT-QEY-PVVHYLGFIPVIDGDFIPDEPLNLFANAADIDYLVGTNSMDGHLFATVDMPAIDKSHK-SVTA----EDFYWLVSGLTVSKGLDGARAAFKIYTESWAQDPSQETKKKTVVDLETDILFLMPTETALAQHSANAK--SARTYAYLFSVPSR----MPIYPKWVGADHADDLQYIFGKPFATPLGYRAQDRTVSKAMIAYWTNFARSGDPNTGLSSVPTRWYPYTMENGNYLEINKNLNSNSMKQHLRTQFLRFWALTYQALPTVAEGAI-------GPAVTPMPL---TGHHSHRS-----------PVLVTG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
chick-e1bvq6   	---MAHWAILSF------A-LCCCLGVAQAATLGVVLTEGGFVEGESKRRGL-FG---SYVDIFRGIPFAAPPKALQDPQPHPGWDG--TLKAKKFKNRCMQMTLTQTDVRGKEDCLYLNIWIPQGKR-----EVSTNLPVMVWIYGGAFLLGGGQGANFLDNYLYDGEEIAVRGNVIVVTLNYRVGPLGFLSTGDPNMPGNYGLKDQHM-----------------------AIAWVKRNIKAFGGDPDNITIFGESAGAASVSLQILSPKNAGLFKRAISQSGVSLCSWVIQKDPLTWAKKVGEQVGCPTDNTTVLANCLRATDPKALTLAHHVELIS-LPG-PLVHTLSITPVVDGDFLPDMPENLFANAADIDYIAGVNNMDGHFFAGFDLPAINRPLQ-KITA----SDVYNLVKGLTADRGERGANLTYDLYTELWGDNPEQQVMKRTVVDLATDYIFLIPTQWTLNLHHKNAR--SGKTYSYLFSQPSR----MPIYPSWVGADHADDLQYVFGKPFATPLGYLPKHRTVSSAMIAYWTNFARTGDPNSGNSEVPITWPPYTTEGGYYLEINNKINYNSVKQNLRTPYVNYWNSVYLNLPLIASTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
crigr-g3iim8   	---MGRLEVLFL------G-LTCCLAAACAAKLGAVYTEGGFVEGVNKKLSL-LG--GDSVDIFKGIPFAT-AKTLENPQRHPGWQG--TLKAKDFKKRCLQATITQDNTYGQEDCLYLNIWVPQSRK-----QVSHNLPVMVWIYGGAFLMGSGHGANVLKNYLYDGEELATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHM-----------------------AIAWVKRNIAAFGGDPDNITIFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQKNPLSWAQRIAEKVGCPTDDTSKLARCLKITDPRALTLAYKLPMTS-QEY-PIGHYLGFTPVVDGDFIPDDPVNLYDNAADIDYLTGVNNMDGHLFATVDVPAVDKTNQ-DVTE----EEFYKLVKGHTFSKGLKGAQTTFDIYTESWAQDPSQENKKKTVVAFETDILFLIPTEMALVQHKTHAK--SGKTYSYLFSYPSR----MPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTLSKAMIAYWTNFARSGDPNMGNSPVPTHWYPYTLENGNYLDITKTMTSNSMKEHLRTKFLKYWTVTFEVLPTVTDDQDTLPPPVDDSEAAPVPP---VDDSPASP-----------VPPTDDSQAAPVPPTDDSQAAPVPPTDDSQAAPVPRRLSGCPRRLSGCPCAPNRRLSGCPSTPNR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
cteid-d4hne5   	--------------------------------------------------------------------------------------------------------------------------VPQGS------SVSTNLPVMVFIYGGAFLMGGGQGANFLSNYLYDGQEIADRGNVIVVTFNYRVGALGFLSSGDAEAPGNYGLWDQHA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
danre-2balip   	---MAMLG-VFI------S-AALFLGTAHGASLGAVLTEGGMVQGKSHSVGL-F----RYMDTFKGIPFAAPPKRFEKPVAHPGWEG--VLKTTDYRKRCLQLNLLATDVIGSEDCLYLNIWVPQGR------TVSSNLPVMVFIYGGAFLLGGGQGANFLDNYLYDGEEMADRGNVIVVTFNYRVGALGFMSTGDDGIPGNYGLWDQHA-----------------------AISWVHRNIKAFGGNPDNITLFGESAGAASVNFQIITPKNKGMIRRAISQSGVALCPWAISRNPRQFAEEIATKVGCPIDS--GMADCLKRADPKAVTLAGKLKLTSSPDA-PIVHNLYLSPVIDGDFIPDEPETLFGNAADIDYIAGVNDMDAHIFATIDIPSINNALT-TTPV----EEVQALATALSRDRGQDAGIATFQEYTVNWGDKPNKEKVKQTVVELETDFMFLVPTQAALYLHTDNAK--SARTFSYLFTESSR----IPVFPLWMGADHADELQYVFGKPFATPLGYFPCHRDVSKYMIAYWSNFAQTGDPNKGESKVPVTWPEFSNPGHQYLDINNKMNKNNVKQMLRTRLVYYWTTVFASYPTVRN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
danre-Q6P004   	-LMMMMLG-VFI------S-AALFLGTAQGASLGAVLTEGGMVQGKSHSVGL-L----RYMDVFKGIPFAAPPGRLQKPVPHPGWEG--VLKATEYSKRCIQLNLLQTDTMGSEDCLYLNIWVPQGK------TVSYNLPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGNVIVVTFNYRVGSMGFLSTGDADAPGNYGLWDQHA-----------------------AISWVHRNIKAFGGNPDNITIFGESAGSTSVNFQIISPKNKGLIRRAISQSGVALCPWAINRNPRKFAEEIAKKVGCPTDS--GMVACLRRTDPKAVTLAGKVRLATSATE-PIVHNLYLSPVIDGDFIPDEPDTLFGNAADIDYIAGVNDMDGHIFATLDIPSINNALA-TTTE----EEVQALATALSKDRGQDAGIATFQEYTVNWGSKPNKEDIKKTVVEMETDYIFLVPTQTALYLHSDNAK--SARTYSYLFSESSR----IPIFPLWMGADHADELQYVFGKPFTTPLGYFPRHRDVSKYMIAYWTNFAQTGNPNTGESKVPVTWPEFSNPGHQYLDINNKINTNSVKKMLRTRLVYYWTTVFASYPTVRN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
danre-celip    	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPNTGESKVPVTWPEFSNPGHQYLDINNKINTNSVKKMLRTRLVYYWTTVFASYPTVRN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
danre-q4qrh4   	---MMMLG-VFI------S-AALFLGTAHGASLGAVLTEGGMVQGKSHSVGL-L----RYMDVFKGIPFAAPPGRLQKPVPHPGWEG--VLKATEYSKRCIQLNLLQTDTVGSEDCLYLNIWVPQGK------TVSYNLPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGNVIVVTFNYRVGSMGFLSTGDADAPGNYGLWDQHA-----------------------AIAWVHRNIKAFGGNPDNITIFGESAGSTSVSLQILSPKNKGLIRRAISQSGVALCPWAINRNPRKFAEEIAKKVGCPTDS--GMVACLRRTDPKVVTLAGKVKLATSATE-PIVHNLYLSPVIDGDLIPDEPDTLFGNAADIDYIAGVNDMDGHLFATLDIPTINNALA-TTTE----EEVQALATALSKDRGQDAGIATFQEYTVNWGSKPNKEDIKKTVVEMETDYIFLVPTQTVLYLHSDNAK--SARTYSYLFSESSR----IPVYPLWMGADHAEELQYVFGKPFTTPLGYFPRHRDVSNYMIAYWTNFAQTGNPNTGESKVPVTWPEFSNPGHQYLEINNKINKNSVKQMLRTRLVYYWTTVFASYPTVRN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
dicla-b2ze90   	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLGYRVGTLGFLSTGDSGLPGNYGLWDQHT-----------------------AIAWVHRNIRSFGGDPDKITIFGESAGGASVSFQTLTPHNKGLYKRAISQSGVALCPWAINKNPRRFAEEVALKVNCPTDQ--SMAACLKMTDPALLTLAGSLSISSSPDH-PLVNNLVLSPVIDGDFLPDEPSNLFHNAADIDYIAGVNDMDGHLFTALDVPSVNSHLV-DTPI----EDVKRLLGTYTKEKGKAGLENAYSTYTSTWGSNPNKETIKKTVVEIGTDYIFLVPTQAALYLHAANAT--TGRTYSYLFSQPNRMGGIGRPYPSWMGADQADDLQYVFGKPFTTPLAYWPGHRDVSGYMIAYWTN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
epico-d3tjh1   	--------------------------------------------------------------------------------------------------------MLQTSSFGSEDCLYLNIWVPQGRQ------VSSDLPVMIWFYGGGFMVGGSMGPNFFNNYLYSGQEIATRGNVIVVSVGYRVGTLGFLSTGDSRLPGNYGLWDQHA-----------------------AIAWVHRNIRSFGGDPDNIIIFGESAGGVSVSFQTLSPHNKGLFKRAISQSGVALCPWGLNRNPRKVAEEVAVNVGCPTDD--RMVACLKSTDAKNLTMAAPRVKFGTPDY-PAVKYLVLSPVADGDFLPDQPENLFHNAADIDYLVGVNNMDGHLFSSKDIPNFNNKNQ-EIPV----EDVKRLLAAYTKEKGQAGFETAFAEYSSNWESTPSQISIKRTAVDIGTDYMFLVPTQTAIYLHAANAR--SGRTYSYLMSEPSLLARPGKPYQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
fugru-2balip   	--------------------------------LGVVYTEGGMVEGVNIRLGF-R----RHMDIFKGIPFADMPGRFEKPKRHPGWDG--VLKAKEYRNRCLQVNFRMTDTRGSEDCLYLNIWVPHGS------SVSTDLPVMLWIYGGGFMIGGSMGAKFLDDYLFSGQEIAERGEVIVVTVGYRVGTLGFLSTGDSSLPGNYGLWDQQA-----------------------AIAWVHRNIRSFGGDPDNITLFGESAGGASVSFQTLTPHNNGTIRRAISQSGVALCPWAVNRNPRRFAEEVALKVNCPTDE--KMAACLKMTDPELLTLAGSLNKSRSPDN-PLVSNLVLSPVIDGDFLPDEPYNLFHNAADIDYIAGVNDMDGHLFTAFDIPSINSQLV-DTPV----DEMKRLLRSYTKEKGAEAAEIGFSTYTLSWGSNPNRETIKTTVVDVGTDYIFLVATQAALYLHAAHAK--TRRTYSYMFSEPSRLGGIAKPYPSWMGADHADDLFYVFGKPFTTPIIYWPRHRDVSRYMIAYWTNFAKTGDPNKGDLSVPVTWPQFTSTGHQYLEIHSKMDSGYVHQKMRMRYVHFWTSVLPNL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
fugru-4cxest   	--------------------------------LGVVQTEAGLVEGRTHRMGL-F----RTVEVFKGVPFADVPRRWEKPKAHPGWSG--ILKATKAQDRCLQVNLLQTKTRGSEDCLYLNIFVPHGG------QVSTNLPVMVYLFGGAFLLGASNDVAVLGDSLYDGKEMADRGGVIVVTVNYRVGTLGFLSTGDARLPGNYGLWDQHA-----------------------AISWVRRNIRAFGGNPDNITIFGQSAGAASVSYQMLSPYSRGLFRRAISQCGVALSPWALQKNPMALTKKIARKVGCWRSNEDEMLTCLKMSDPSGLTMAGKIDVLLLLGKGVVMDLLELAPVVDGDFIPDNPSRLFHNAARFDYMAGVNSMDGHFFAGVDVPNINTRNE--TTV----SQVRGLLAGLTKEKGSAAVDSAFGVYSAHWGSAPEQAMVKKTVADIETDFLFLVPTQLALQLHANNSS--GARTYSYLFNMKTR----IPGFPAWVEAEHAEDLQYLFGKPFSMPLVYFPRHRDLSGYMIAYWTNFAKSGDPNSGNSKVPALWPPFTKYHHPYLIINHKISKSSIGYDLRSDHVLYWRDTYSQLPSVHQEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
fugru-balip    	--------------------------------LGLVQTEGGRVQGQNIPLDV-V----RSVDVFKGIPFAAKPGLFEKPKPHPGWDG--ILQATRFAEQCLQINDLQTTSLGSEDCLHLNIWVPQGKH------VSSNLPVMIWIYGGGFMSGSSTGPGFLGNYLYSGQEIADKGDVIVVSFGYRVGVLGFLSTGDSRLPGNYGLWDQHA-----------------------AIAWVHRNIRLFGGDPDNITIFGESAGGASVSFQTLSPHNKGLVRRAISQSGDALSPWAVNEDPRTMAERVALKAGCPVDE--RMVACLRSSDARNLTMSTPYIPDGTPDY-PGIKHVLLTPVVDGDFLPDEPVNLFHNTAEIDYLAGVNDMDGFSFTSEDIHSLKNKTE-KTPV----DEVIRLLAAYTKDTGPEGFQVASDEYFSKWGASPSQETVQRTAVEIGTDYIFLVSTQAALYLHAAKAT--SAGTFSYLLSEPSLLAGPGRPYPDWMGADHTDDLQYVFGIPFAIPQVYGDKQRELSGNMIAYWTNFARTGNPNKGTLKVPVTWPNFTSAGQQFLDISAKMSESSIGEKMRHNFVRLWTKTLPGL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
gadmo-b0ze97   	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGDSGMPGNYGLWDQQA-----------------------AIAWVSRNIRSFGGDPDNITVFGESAGSASVSFQTITPHNKGLFKRAISQSGTALCPWAVNRNPRRLAEEVALKVNCPTDD--RMAACLKMTDPVSLTMAGTIPITSSPDA-PLVFNLVLAATIDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
gasac-balip    	----------------------------------VVQTEGGGVEGQTIPLGR-S----RSLDVFKGIPFAARPGLFEKPKPHPGWDG--ILKATKFATRCLQKSMLQTSSFGSEDCLYLNIWVPHGQHGSPPPTVSSGLPVMIWFYGGGFMGGGSMGPNFLNNYLYSGQEIADKGEVIVVSVGYRVGTLGFLSTGDSSLPGNYGLWDQHA-----------------------AIAWVHRNIRSFGGDPDIITLFGESAGGASVSFQTLSPHNKGLLKRAISQSGVAFCPWALNSNPRPAAEKVAVNVGCPTDE--RMVACLKSTDARTLTMGAPLFTEGSPDD-PSITQQLLSPVVDGDFLPDRPANLFHNAAEVDYVAGVNNMDGHVFTAKDIPSLGDKNQ-ETPVFYCREDVKRLLAAYTKDMGPAAAEMAFAEYSSNWGTTPSPDHIKRAAVDIGTDYIFLVPIQAAIYLHAANAR--SARTYSYRFSEPSLLAGPSRPYNDWVGADHADDLQYVFGKPFTTPKAYGDRHRDLSGYFIAYWTNFARTGNPNKGNLEVPVTWPAFTSTEPQFVDINAKMNVSSTGRDMRLRFVRLWTSTLPSLQSHGVTDAQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
gasac-g3q258   	--MMEKLG-ILV------A-FAVFLESVSAASLGVVSTEGGMVEGQSIRLGF-N----RRMDVFRGIPFADVPGRFEKPKPHPGWDG--VMKTKEYKSRCTQVNMLMNDVRGSEDCLYLNIWVPHGK------SVSFELPTMIWIFGGGFLAGGSMGANFMDNYLYSGQEVADRGNVIVVTLAYRVGTLGFLSTGESDLPGNYGLWDQQA-----------------------AIAWVHRNIRSFGGDPDNITLFGESAGGASVNFQILTPHNKGMIRRAISQSGVAACPWAINKNPRSFAEEIALKVGCPTDQ--NMAACLKMTDPMKLTMAGALDLSSSADH-PVLNNLLLSPVIDGDFLPDDPSNLFSNAAEVDYIAGVNDMDGHVFTGLDIPSINSPLL-ETPI----VDVKRLLASYTKE-GPTALDYAYSTYTAEWGSNPSWETIKKTVVAIGTDYIFLVPTQVTLYLHASSAT--TGRTYSYLFSEPNRMGGIARPYPSWMGADHADDLQYMFGKPFSSPLGYWPRHRDVSGYMIAYWTNFAHTGDPNIGESGVPVAWPKFTSYGHEFLEINSKMDRNYVGQRMRIRYVHFWASVLPNLANAISK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
gorgo-balip    	MLTMGRLQLIVL------G-LTCCWAVASAVKLGAVYTEGGFVEGVNKKLGL-LG---DSVDIFKGIPFAAPTKALENPQPHPGWQG--TLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRK-----QVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAEKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAG-LEY-PMLHYVGFIPVIDGDFIPDDPVNLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNK-KVTE----EDFYKLVSEFTFTKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDLETDVLFLVPTEIALAQHRANAK--SAKTYTYLFSHPSR----MPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGHSAVPTHWEPYTTENGSYLEITKKIDSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGASEAPPVPP---TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA-----PPVPPTGDSGAPPVPPTGDSGAPPVPATGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPLTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVISF     =====>
hetga-g5anw7   	---MGRLELAIV------G-LACCLAAASAAKLGPVYTERGFVEGVNKKLSL-LG--GDSVDVFKGIPFAT-AKTLENPQHHPGWQG--TLKATGFKKRCLQATITQDSTYGAEDCLYLNIWVPQGRK-----EVSEDLPVMVWIYGGAFLMGAGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNRAGTARNYGLRDQHMAIAWVKRNIEAFGGDPNNITIFGESAGGVSVSLQTLSPYNKGLIRRAISQSGVALSPWAIQHNPLFWAQKVAEKVGCPTDDTARLAKCLKVTDPRALTLAYRLPLIA-QDY-PIVHYLAFVPVVDGDFIPDDPSNLFSNAADIDYLAGTNSMDGHLFATVDMPAIDKFYK-DISE----EDFYWLVSGLTTNKGLEGARAAFAIYTECWAQDPSQETKKRTVVDLETDVLFLMPTETALAQHRAAAK--SARTYSYLFSVPSR----MPIYPRWVGADHADDIQYVFGKPFVTPLGYRTQDRTVSKAMIAYWTNFARSGDPNMGHSAVPTHWYPYTTENGNYLNITSTLDSSSMKEHLRTKFLQFWALTYQALPTVAE-AT------------PVPL---VDDFEGVP-----------LPPTDGSEAAPAPPEDNSSEVPVPPTEGSLAPQMPIAIGF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
hetga-g5anw9   	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPD-PIVHYLAFVPVVDGDFIPDDPSNLFSNAADIDYLAGTNSMDGHLFATVDMPAIDKFYK-DISE----EDFYWLVSGLTTNKGLEGARAAFAIYTECWAQDPSQETKKRTVVDLETDVLFLMPTETALAQHRAAAK--SARTCFYQFSLPSR----DPGNPKWLGANHAAEIASVYGEPFTKPEVYQPQDRTVSKAMIAYWTNFAHSGDPNAGHSAVPTHWYPYTTENSNYLDITSTLDSSSMKEHLRTKFPQFWALTYQALPTVHLQVS------------PVPL---SDD---------------------------------SESPPTPSADGSQAPQMPIVLGF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
hiphi-q56p39   	------------------------------------------------------------------------------------------------------------------------------------------------------------GANFLDNHLYSGQEIADRGNVIVVTLGYRVGTMGFLSTGDSSMPGNYGLWDQHA-----------------------AIAWVHRNIRSFGGDPDNVTVFGESAGAASVSFQTLTPHNKGLFKRAISQSGVALCPWAINKNPRRFAEEVALKVNCPTDQ--TMAACLKMTDPALLTLAGSLSLASSPDS-PIVGNLLLSPVIEATSRANS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
horse-f7agv7   	---MGHLELAVL------G-LTCCLAVVSAAKLGVVYTEGGFVEGINKQLGL-FG---DYVDIFKGIPFAAPTKALENPQPHPGWEG--TLKATDFKKRCLQATITQDNTYGDEDCLYLNIWVPQGKK-----EVSRDLPVMIWIYGGAFLMGAGQGANFLSNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNITIFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQKKPLFWAKKIAEKVGCPVDDTSRMAKCLKITDPRALTLAYKMPLTG-TEY-PVLHYLGFLPVVDGDFIPDDPMNLYANAADVDYLAGTNDMDGHMFASLDMPAINKNKQ-DITA----EEFYKLVSGLTMTKGLRGANATFDLYTEPWALDSSQETKKKTVVDFETDVLFLMPTETALVQHRANAK--SAKTYAYLFSLPSR----MPVYPSWVGADHADDIQYVFGKPFATPLGYRSQHRTVSKAMIAYWTNFARTGDPNTGHSAVPTPWDPYTLENSSYLEINKKMDSSSMKQSLRTNYLRYWTLTYDALPTTIGEGAALVPPTDDSEAAPAPP---SGDSEAGPTPPSGDSEGAWMPAVIGF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
human-balip    	---MGRLQLVVL------G-LTCCWAVASAAKLGAVYTEGGFVEGVNKKLGL-LG---DSVDIFKGIPFAAPTKALENPQPHPGWQG--TLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRK-----QVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAG-LEY-PMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNK-KVTE----EDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAK--SAKTYAYLFSHPSR----MPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPP---TGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA-----PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
latch-h3b637   	---ISSWQ-DGK------G-CCCSLAVLSAVQLGAVYTEGGMIEGTTVKTGL-F----ESVDVFKGIPYAATPRRFENPEPHPGWTGTGLLKATKFRDRCLQLTLTQTTTRGSEDCLYLNIWVPQKRK-----KISTNLPVMVWIYGGAFFLGSSQGANFFNNYLYDGQEIASRGKVIVVTLNYRVGSLGFLSTGDKNGPGNYGLRDQHM-----------------------AIKWVKRNIAAFGGDPNNITIFGESAGGASVSFQMLSPYNVGYFKRAIMQSGVALCPWAIQKNPLYWAKQIAEKVGCSRNDTAALMNCLKITDPEAITLAWNLDVLN-LRS-PLVWNLPFLPVIDGDFIPDEPHKLFNNSANVDFIAGANDMDGHVFAGIDVPSINQMILGKTYP----EDLYKLTQGLILGKGVKGVNTTYALYTRAWGPDPSQKTIKKTIVDLETDYLFLIPTQAALELHSQHAKFRNAKTYSYLFTQPSR----MPVYPSWTGADHADDIQYVFGKPFYTPLGYRPRDRDVSGYMIAYWTNFAKTGDPSTGDSSVPTPWPPYTNQYSQYLDINSNLNRDSVKMRLRNEFVKFWTEFFPSL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
loxaf-g3ss16   	--TMGRLGLVVL------G-LTCCLAVASSAKLGAVYTEGGFVEGVNKNLGL-FG---GYVDIFKGIPFAAPPKALENPQRHPGWQG--TLKANDFKKRCLQATITQNNTYGDEDCLYLNIWVPQGKR-----EVSRDLPVMIWIYGGAFLMGSGQGASFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDSNLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNITIFGESAGGASASLQTLSPYNKGLIQRAISQSGVALSPWVIQKKPLLWAKMIAKTVGCPRDDTSEMAKCLKITDPRALTMAYKMPLAG-MEY-PMLYYLGFLPVIDGDFIPDDPIKLYANAADIDYIAGTNNMDGHIFSTIDMPAVDKPYK-TVTE----EDFYKLVRGITIAKGLRGANATFHFYTELWASDSSQEAKKKTMVNFETDILFLMPTKIAVAQHRINAK--SAKTYTYLFSHPSR----MPIYPDWVGADHADDLQYVFGKPFVTPLGYRPQDRTVSESMIAYWTNFARSGDPNVGHLAVPTQWYPYTLENDNYLEITKKIDGNSMKQHLRSNYLEYWNVTYQALPTVSDGEAVPVPPTDDPEAAPVPP---TDDPEAAPVPPTDDPEAAPVPPTDDPEAAPVPPTDDPEAAPVPPTDDPEAAPVPPTDDPEA-----APVPPTDDPEAAPVPPTDDPEAAPVPPTDDSEAAPV-----------PPTDDSEAAPVPPVDDSEAAPEPPMDDSEAAPDPSTGDSKEAQMPLGGHNGAPPLPPTLTLGPAPAP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
macmu-f7buk8   	--HMGRLQLVVL------G-LACCWAVASAAKLGPVYTEGGFVEGVNKKLGL-LG---DSVDIFKGIPFAAPTKALENPQPHPGWQG--TLKAKSFKKRCLQATITQDSTYGDEDCLYLNIWVPQDRK-----QVSRDLPVMIWIYGGAFLMGSGHGANFLSNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHM-----------------------AIAWVKRNIAAFGGDPNNLTLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVDDTARMAKCLKVTDPRALTLAYKMPLAG-MEY-PMLYYLGFIPVIDGDFIPDDPINLYANAADIDYIAGINNMDGHLFASIDMPAINKNNK-EVTE----EDFYKLVSGLTMTKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDILFLVPTEIALAQHRANAK--SAKTYSYLFSHPSR----MPVYPKWMGADHADDIQYLLAEPQARARVQPVSCVRVQSRPSAPWDLFSLCRDPNMGHSAVPTQWEPYTSENGSYLEITKKMDGSSVKRGLRTNFLRYWTLTYVALPTVTDQEATPVPPTGDSEVTPVPP---TGDSEATPVPPTGDSEATPVPPTGDSEATPVPPTGD