Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....
anasp-ALL0969  	---------------------------------------------MKRF--------LKYLS----LGLLS-TCFAAKPGLSAERISLFYPPFGEFSLPVSSLETFAK-----------EGKIDSDLQFYAQRA--TPAQLAQLREFLQQRFD-VTPTFISQIT----YS-PIGEQVLQRLGDIVQT---DSRRNG-FYALRSALILSAA--KP-QGFSVINVLRNFPSDNLRLNFSEGVRIVD----DLSQLTKNRDRVVA---SLQQSAVAQA-----IVSNQNLSQLP--DLRSPGKFRWQIV-NFTLNDPQ-----------RNRRLPVDLYLPQANTDTQGQPPFPLVVISHGIASDRYSFIYLAEHLASYGFAVAVLEHPGSNAKRFEQYFAGLAS--PPEPREFIDRPLDIKVLLDELQRLEK-SDPRLQGKLNFQQIGAIGQSFGGYTVLSLGGAKINFNQLNQDCNPD---N-SSLNISLLLQCEANQLLPQ-DYQLQDSRIKAVIAINPISSSIFGESGISKIKLPVMVVAGSQDIFAPPVPEQIRPFTW-LPNPYKYLVLIDNATHFTLIGDSP--QG--NNVLPVP-SGLLGPDRTA-AYSYLRALSVAFLKANLLNSPEYRSYLQPPYAQS--I-SQAPLNLSILQSLTAEQLMETRE-------------------------------------------------------------------     =====>
anasp-ALL2050  	----------------------------------------------MRITW---KSIKIFAGLVCTFSLTQ-FFATNTPVQAAETVVVRFGLF-AESIPVADLQKAAE-----------TGEFPSSLNLFTRRL--SEQQRRTIIGALRMRVP-LNVVTISRLL----NT-QIGTTILNDLSTAVV----RKDQSG-AKALRASLVLGST--AP-QGLSILSFIAAYPSQSLEINLPQAFQVAG----SLNNAFWRTQQFML---AISPQLD--P---------TKPQISLPFDPSQPGNAQVQVL-KLNLNDQK-----------RDRQIPVDIYWSTS-----ATQEKPVIIYSHGMGSVRTDLHYLAEHFASHGYIFVALEHPGSNQANTDLASKGKVR--LLQPQEFLNRPQDVSFVLDVLEKLNQATGNPLQGKLATDNTMVIGYSFGGGTALSLAGAELQITGIRERCQNK--L--TILSLGETIQCVAQELPEK-TYQLRDNRIKQAIALTPTTSLMFGETGLTKVQIPTLIVAASADKTTPALTEQIVGFSK-IPS-PKWLVGIIGGTHLSVKDPSATLDQVDKPNTPLTGGEIVGEQATD-VRQFVKAIALAMAAQLTPEAEKYAVFLTPDYAQL--A-STQSFPFRIVTEIPPQAIPIGKQ-------------------------------------------------------------------     =====>
anasp-q8yqi8   	-------------------------------------------MSLIRL----YRTS----I----LVVSVCILLASNSALAAERVVLKYKVF-RETIVVEELSTFAQ-----------TGALSSSLRINLALAR---QNPKVIRQYLTTPIK-VSPVLLDRVL----NS-PVGNIILDELSQVIHT---PSRSAD-RQALRSALVLSAS---GDGQVTLIEIIQNYPTPNVEIDGERLGDAYR----QLRSLQARLENLFS---F----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
anavt-q3m8w1   	---------------------------------------------MKRL--------LKYLS----LGLLS-IGFAAKPGLSAERISLFYPPFGEFSLPVSSLETFAK-----------QGKIDGDLQFYAQRA--TPEQLTQLREFLQQRFD-VTPTFISQIT----YS-PIGEQVLQRLGDIVQT---DSRRNG-FYALRSALILSAA--KP-QGFSVINVLRNFPSDNLRLNFSEGVRIVD----DLSRLTKNRDRVVA---SLQQGAVAQT-----VVSNENLSKLP--DLRSPGKFRWQIV-NFTLNDTQ-----------RNRRLPVDLYLPQANTDTQGKPPFPLVVISHGIASDRYSFIYLAEHLASYGFAVAVLEHPGSNAKRFEQYFAGLAS--PPEPREFVDRPLDIKVLLDELQRLEQ-SDPRLQGKLNFQQIGAIGQSFGGYTVLSLGGAKINFNQLNQDCNPE---N-SSLNISLLLQCEANQLLPQ-DYQLQDSRIKAVIAINPISSSIFGESGISQIKLPVMMVAGSQDIFAPPVPEQIRPFTW-LPNPYKYLVLIDNATHFTLIGDSP--QG--KNVLPVP-SGLLGPDRTA-AYSYLKALSVAFLQANLLNRPEYRSYLQPSYAQS--I-SQAPLNLNIWQSLTAEQLMEIRE-------------------------------------------------------------------     =====>
anavt-q3mc00   	-------------------------------------------MSLIRL----YRTS----I----LVVSVCILLASNSALAAERVVLKYNVF-RETIAVEELSTFAQ-----------TGALSSSLRINLALAR---QDPKVIRQYLTTPVK-VSPVLLDRVL----NS-PVGNIILDELSQVIHT---PSRSAD-RQALRSALSLSAS---GDGQMTLIEIIQNYPTPNVEVDGERLGNAYR----QLRSLQARLENLFG---F----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
crowt-q4c090   	---------------------------------------------MKSFSLNSLFRTLTSVV----LGTIT-SLTLSLPSYAAQKVYFVFDSI-GVSIPVSDLENYAE-----------TGELSQQLDRYFSLAGASEEDRNAFREALSTPAPIKDPVRFSRLL----NT-DEGERILNYFGKVINI---QGGRNG-KFLIRGALVQAAL--DD-EGLTLINFLNKLST-NVQIDLKKAIRLAR----QVELVVDGTYLFIEKVTELAAKEAEKT-------KQLDFSQLT--DPRQKGNFTVKKKLGMSLTKNV-----------NV-TFILMFINR-KL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
crowt-q4c0f2   	-----------------------------------------MFGFLSSLKV-SAEKNLKNIT----LGTLA-AVLTVLPVYAQSRLVFIYPPI-NLSLGIDSLELFAN-----------EGVINKELAYYMNLAGVNDEEKQAFREALLKKAD-LNPVEVSRFF----NS-PMGQELLQRVGHLFSI---QGGRNG-VYAIRGAMVQAAF--DEEEGLTLLNFLRHLPV-NMQFNLEEILRAAT----YLELLGQGTNAIVTEMKSISAQTREQE-------TVPNFSNIR--DIRQRGDYGVGPSRRLRLFDES-----------RQREFDVVLVQPQRWR----EGKTPVIIFSHGLASRPEDFKEDVLQLVSYGYVVALPQHPGSDFNQLQEMLQGFSRE-IVKVDEYVDRPLDVSYVIDELERRNR---REFEGRLDLNNVGVMGHSFGGYTALALAGAKLNFDSLEEICGRN--L--WGPNLSLLLQCRALELPRK-DYDFREERITSTLVINPVTSAVFGPEGLSQVSIPVLLAAGSSDPATPAAIEQLQAFVW-INTDDKYFALVEGQAHVNFTKLDAQMQAV---LDSLPD--LTLPNQKV-IDTYGNALLVAFAEVYTAKNEEFRPYLTSSYA--YYISKEPN-PLHLVQDDAE---IPFSELFNRSKSAR-SRAIY-------PRNIIPSND------------------------------------     =====>
crowt-q4c2s2   	---------------------------------------MNFLKFLSPFIF--------NVV-EGFTPILLSLVLGVSPCNSAENIILKAGLL-NHKIAVEDLDEFLE-----------TGEISSSLQPYQFLL------TSEIQEVLSQNIN-IDPVIAEQFLNDIFKS-DDGQRLLKQISQALPD---SSSSE-----LKEGLKLLLK--QT-NNFNFINFLRVYPQETLTIDLSKAAILGL----KMNESFLHSRLINA---QFKKGLKN---------S-SNIEIQPKFDPTVSGQKSISIE-RNVLYDRS-----------RNRYIALDIYTAKK-------THGPLVVMSHGFASDRRFLRYLAKHLTSYGITVVSVEHPGSDIHALLKTATGINSSQILPSEEFIDRPQDISLVLNKLTLLNE-NTRKFKGKFNTQEVSIIGHSFGGYTALALGGASLDLKTLRSFCQKESPL---KRSPADWLQCAAGELPYP-QRNFQDNRIRQIIIFNPIIGELFGN-NLSQIKVPTLILSASDDGITPTISHQLKPFQE-LST-EKYLIMAMGGTHMSVTDMNSMNSM--MGQSTLV-REIMGEKAEP-VRRLVRGVSLAFIQQLTEEKSRYKVFLTPSYIES--L-SQGNLNFRLGTELPMTVKTW-I---NVTNMKQPEANLWSLKSKLTPIQNIQQYFVNARQLLLQPEYSTEKLNDLFTGLLHNHDDKLDKWS     =====>
crowt-q4c3w0   	---------------------------------------MTQNKKLLRK----YMLI----F----VLAVFGLLFTKQSVQAAERVVLKYSVL-RESVSVEELSKLAK-----------TGETSRSLKTYLKLAN---RKPEELRSLLNRNVD-VDPVFLSKVL----NS-FAGGMVLNPIGEVIHT---PSKRAN-KESLRGALVTSAL---SDNNIRLIEIFENYPTEEIHVDGDRLVEVYQ----NIEGFLDGLPRLPF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
crowt-q4c3z6   	----------------------------------------------MNY------LTRICLG----ISFAL-IPLIPRPVLSAETLYFIYGPL-KFPLSVESLEIYAE-----------EGRITKEFAFFASQF--DEKNLTELRETLRKRHK-INGVKFSRLL----KT-PLMEDLLKSMGEIFST---HPNHNG-FYAIRGALISAAINQPE-EGWTAIDIMKAFPTEGMSIDTELATKMMQ----NSQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
glovi-q7nm82   	---------------------------------------MRKQARMRNF-----RRRLTQVG----GGLLG-AVLCAVPADAAERIFFNYGLL-GLSLPVTELETYTR-----------TGVMSERMAFLASLA--GAKDVVGLRDALNTPLP-FSQAQVAQLT----YT-PLGERTLQRIGNLLRT---DADNNS-FLALRAASILAAG--DP-QGLTLLNFLRYYPLQTLRIDVAFGAQLAV----EVGNAFDLGETTFS---AIEKQADAAP------PAPPPPANLG--DPRPAGPLGFQVR-SLVFANPRYAGAQAWLRQASTPMIAADVYLPEG-----LGRPAPVVVISHGLASDRTTFAYLARHLASWGFAAAVLDHPGSDKQLAASIFSGSAT--SSGPGEFIARPQYVSSLLDELERLVR-TDPTWRGRLDPKQAGIAGQSLGGYTALASGGAGIDKETVRLGCEKSDRLG-DIVNPSLLLECGALALPTSAPTQLGDARIKAIFAVNPIGVALFGRKELARIAVPTLIVSANKDAFARPLLEQLLPFSV-LTTSEKYLVLARNATHFTPAIDPT--ET--QSVLPIP-AQFVGPSPEPYFFAALNALSLAFFKTHLAGETAYRAFLQPGYVRS--L-SQEPFGFSLVNALDSPEVQRLIEL-ERQKQ---------------FRVIQADN-------------------------------------     =====>
prom9-q317s6   	-----------------------------------------MNFNKI------IIIK-LFF-----IIINFQFLFNIPKANAAEEIKIIYSIF-SRTIKVNSLKTFAQ-----------EGESTKKLRRILRATR---STDKEIRSVLNKDFE-LPITIASKLV----YS-EIGNVFLTRLSSIIHPPRADDQRTG-MLALRASVIQGIN--IGNGKINMINFFEGYPTKTIILDVNALSKVMN----KVESISE----LLD---FFTNSPLEKIKTN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
prom9-q31ah8   	--------------------------------------------------------MK----YIFLIFIGIFGLFFNNGSKAAEKINIKFEEM-KIPLTIEQLSKLEK-----------YKEDSTELINWLKNN--GFIKVFELSKFLEFPIF-KEEGINRKLL----RS-WIGRKILTELSKTITV---PNDKNGVE--IYNTIENLLE--DK-KEVSTLDIIKALPSEEIYLDIDNLILIIT----SWKNELAMQQDLISKLNNLERTTKE---------------ALKNAENKSNP--NLIKI-NKKIYAPH-----------RVKALEIELWKNYKTN----D-DKELIIFMPGLGGEINNFEWIGNELTKRGWPIAFIDHKGSNLKAFVEVLEGNEAI-PGGVDFFLYRIKDLDAVLKAHQNGA--------FGLPNDSYILMGHSLGALIALLYEGNKPNY-QLKERCNSSLTDF-AVTNLSKLLQCQLSEITFS--EKNNANKASAIIGFNSFGSLVWPKVNSSGIEIPTLLIGGTYDLITPLMNEQLRVFSA-LNNPSNRFLIIEGASHFSPIRINNNY--IENNDVFKISESFIGSDPIS-VQDLSSKFIVEFIKNIKDQE----VPTV--IKNQ----KDLGLDFHLLDLETIKELLKN---------------------------------------------------------------------     =====>
proma-q7v9e9   	-----------------------------------------MNINKAKG----YLIS-MML-----IVTN-LIF---YPAYSAEKITFYISIL-SRSITVEELENFSK-----------RGVKSQFLKRVLKNQ-----NEREIREILRKEYK-APIKLTSRLL----YS-KIGGVILKRVSKIIYPYRIPEESIS-IVALKAATIEAIA--KGDETINIISFIKAYPSKVIAIDVSELLKVIN----KVESTNE----LVR---FFSNAPLDKLKKDSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
proma-q7vbe1   	---------------------------------------------MSLYSILSARRII----ASCLLAILTAGNCTGNWLHAAERVDFHFDDM-TIPIPIDELNLWNSDLNKKNSDKLIDPTNKSELSFWLNML--GFKSREALSEFLETPLV-KDKSMARQLL----RS-WVGRKLLDQISDLVVL---DQDKTGIK--VFNTLEILLE--EQ-ETVSLLDLLKALPAEVIHLDLDGWFKVLD----NWRNELKLQQKLLTDLRDLSPK-VS---------------LLTPLQNTDRGLKESLNE-FVAINASH-----------RSEQLKVQVWKPLKRK----ISRENWIAFMPGLGGDQDHFRWLARSLSHQGWEVVILDHPGSNTKAMHSLVEGTDPF-PGGAEVFLYRLADLQAVLKAKKEGT--------IDLKGKRLVLMGHSLGALTAFFASGALPQK-GLEGRCNQALYDL-SITNLSRLLQCQIVDIPLE--KTKGISYLSAIVGINSFGKLLWPESLSAETNVPVFLTGGTFDLITPAISEQLGLLLSTKPNKFSRALIVEGASHFSPIEVDEQEDQTINSDIYQISDALVGSHPSS-VRSILATEIIRFLDNLEKEK----PLTV--KTNN----LSTNLKFHIIDRISIKKIIAN---------------------------------------------------------------------     =====>
promm-q7v3r8   	-----------------------------------------MNQSKKHS----YRSL-MALC----LGLGLSLFSTMPKAEAAKEVALVSGAF-RRSISVSDLEYLAK-----------TGKARGLLKDALKFGR---QNPETVSKLLNKKLE-LPIGLTSRLM----TT-RIGNVIINRISKIIYPLNVPNPSVS-VPAFRAGVINGMQ--IGKGGLNAIHFLKAYPNETMTINLPALFGIMQ----KAESIAG----LVK---FFSDSPLDGLKGSKP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
promm-q7v6l0   	--------------------------------------------------------------MIGLFGALLFGLAGVSPLRAAERLEVQLEGM-VIPVWIRELVDLGR----------PGGSSSSELITWLNLL--DADSRFDLFELLQAPLL-TDQSMARQML----RS-WAGRQLLDAVSDLVRV---DDDSSGIV--LFNTLELLLN--SQ-SEVTAQDLLEDLPAENVRLDLDALLQVAS----RWRRQLQQQQQLVLTLGRFPATQVP---------------VLQEL--AGKEVFAAGPE-FKPLPVAH-----------RTKPLQLELWRPPDGT----PLRSSWVVLMPGLGGSQDHFRWLALSLQRKGWPVVVLEHPGSDAKAVHALLKGQRLA-P-GAEVLPDRLADLQAVLQAREQGT--------LVLPGQKLVLMGHSLGALTALLAADMTPEP-GLYTRCRKALDDL-PLTNLSRLLQCQLVDVQMP--KLQSIPQLEAIVALNSFGSLLWPRHGAVPLSVPVLLTGGTLDLITPPLTEQLDLLLAISPHPASRVVLVEGASHFSPVRVEGQMGEGRGDDLFQLGEELVGREPLA-VQRLLAVEIQIFLEQVEAGE----ALQG--ATHQ----QVGDLRLHRLDRNAAKRLRKSQ--------------------------------------------------------------------     =====>
promp-q7uzf3   	-----------------------------------------MKFSKS------LFPR-IFL-----ILFINQIFFNVPKAQSAEKIKIIYSIF-SRTVTVDSLKTFAE-----------SGNSSKSLRKILNATD---SSDEKIQSILNNEFE-IPITIASKLV----YS-EIGNVFLNRLSSILHTPNTNDERTG-MLALRSSIIKGLY--TGNGKINLVSFFESYPTKTVILNVNALSKVMN----KVQSISE----LLD---FFTSKPLEKIKTIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
promt-q46i63   	----------------------------------------------------------MKF-----KYIILLILFLNQSAKGAENLFLYKGTF-SRSIRIEELSKFKL-----------TKKPSNKLKNLIKITG---QKEKNLHKILSTKIE-FPIKTSSKLM----NS-RIGEVFLSRLSKIIHPNKISNIKLS-SKALRSGLLIGSF--NNNQKINLIDFLKAYPNKNIAFDLNALSKTLK----KVDSLKE----LIE---FYADSPFKKLKDGRS-------ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synel-TLL1717  	----------------------------------------MNNLSLKWFLW---PPLTVVAG----LGLLW-LRSGGLSATAAEQIIFRYGPF-ERSLPIADLEWFAT-----------TGQSSPKLASYLRLF--PPGHRQQLRLALQERLR-LSPVAVAQLL----YS-PLGQEFMVQAGRILQT---QSRQEN-ALALRAALILAAT--DP-NGLTVLSVMRHYPSPSIRFDLKEGLAILK----NFQHTIYKTETILN---VVRQRAIANQ-----TE--AIPASVQ--PLLQLGLWRWLEM-PWTAVDESPQR---LQLTGHARPVEADLYLPIVPA----GQRVPVVIVSHGLGASRYSYRYLCQHLASHGFAVIALEHVGSSARQVMSFPMGYVSS-RMAAQEFLDRPLDVTFVLNRLAAFPE-QLYPWAGRLNLERVAIIGQSFGGYTALALAGARLDFQQLRRHCTST--LL-TSFNVSLLLQCQAQALPAK-VYSLEDSRVQAVIAVNPITSALFSPESLGHLKAAVMFVAASSDAIAPPVEEQIYPFTW-LTGRDRYLVLMDNATHFSTIGEAS--PN--EPVLPVP-KALVGATPPR-SRAYLRGLSLAFLRLHLLGDEQARQWLTPAAAMA--L-SSPTYGLNLTQSLDPELLEKVAQA-VK---------------------------------------------------------------     =====>
synel-TLR1274  	------------------------------------MAIARTGKKWQWF------SLL----------GVA-AAFWGQTGLAAEEISLIYPPFGTFNIQVSDLATFAK-----------TGHTSPELRFLIQLL--PSDQGPNLRESLTTRMN-LEPTTVSQFV----KS-PIGQSFLERIGQVIRA---DNDVNG-GQALGEALTTAAS--SP-SGITLLSVLQAFPGKSVRVNGELGLKAVG----AFTRAIHQEQRAQD---FIERLAQLQP-------KTPLPASGL--YPDQKGPFQWQKQ-TIAFTNPNR----------TTGSIPADLYVPIG-----ITAPAPLIIISHGLASDRRTFAYLAEHLASYGLAVLAVTHPGSDASRIGSFLSGVPLDYENLPKDWVQRPLDLKFGVDAVAALVQ-KNPAL--KIDTKNVGLFGHSMGGFTVLAAAGGTVDWNAVKQRCLAAANDL-FIFNISVPLQCRSLGLADV-PSPLADPRVKSVIAVNPVSSLLIGERGMANIKVPVLIVSSSKDVFAPPLEEQILPFTW-LQAEPKYLAMLVPGTHFSALGVSA------AGVLPVP-NDLIGPNPQL-AQPFFKGVSAAFFGVFNQQNEQLRPFLSQTFLSQ--V-AQPTFQVYWVDRMNPQQLQEVLAG-RIGAQ---------------PRR------------------------------------------     =====>
synel-q8dkb8   	---------------------------------------MLKR------------LSPWLLA----LALPV-GTLFTSPAKAANFVSLTYGPF-QRSFPLSELEEFVS-----------TKEATGQLRGLMRLV--SKDDQAKLLEFLGMRLP-FNVVQTDQIL----AS-PIGKDLLKQFSQVTI----RRDQAG-EVALRGAMITAAA--SP-EGLSMMSFLKNYPGETINLDLRKLREMLT-----------KQDGIMG---MLGKLRP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp2-q8rsv9   	---------------------------------------MTMKRQLRNLKV--------WVM-VGLLS--LGGAWG-QRAIAAETLRLKLGPL-QQTLQLEDLETFAE-----------TGQVPRNFRPYGVFL------DGNLQKFLQRRLQ-IEPEMADQFFDQLWRS-PTGKQILAQIQTALPG---TSIQD-----LQATVDLALG--QG-VEISALNLLQAYPKQELTIDLTAVAGLLL----QLNLPNIQNQLLAP---RVTEALES---------TEPQIFQRSNFNPTAPGPQTVRRQ-S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp6-q5n208   	-----------------------------------------------------------------------------------------------------------------------------------MLV--PEATLKEARTALSARLP-LSPEVLRPVL----TNTDTLEIFLQQIGSLIRP---QPGESG-AAALRQALLTASE--QP-QGLTLIGLIKAFPGPLMQLDLDTGLKLFQ----RIRALEAETGAMLR---AIAAQMQEQP---------SLPSRNF--RPAQRGPYTVRQQ-NWDWVDSD-----------RTRRVPTTIYWPDR-----QGLSLPVVIISHGLGEDRGNFAYLAQFLASHGFVVVLPEHVGSSSRQFASAAAGFAN--PPGPQEAIDRPQDIRFVLDRLM-----LEPQWRFRVNTRRVAVLGHSYGGFTALMLAGAVIEPEKIRAACSSVERL---MLVPSASLQCSLGRLPRD-RYDLRDPRVVAVLPISPFASKVFEPAALNQVQTPTLLWSGSADLIVPTLAEAIQPFQR-LGSPNKHLVVAVNATHFSVLGE----SQ--GPATRLP-PALLGPSPEL-GRRALQQVSLSFLQTYLLGQSQARVGLTAAAAEQ--L-SNPVMPLLFSEQLPPAIARQN---------------------------------------------------------------------     =====>
synp6-q5n306   	---------------------------------------MFKPQSWF--------PTLLSTV----LGFGA-AVLTAAPSSAAERITVRWSGT-DVTIAVDDLANFAQ-----------GRPVGADLRAVLALL--SPEVQQSIRSALIAPVP-ISPNAIQQIV----NRGDTFSIFLTRVGNVIRA---EPPVSLTDPAIATAITTAAQ--SP-QGLSFLSAIQTFPSETILFDLNVFLSYIQ----QLNEQLLATEGVVN---RL--QQRSQP---------ADPALQQ--RYQAPGPNSVQVQ-SFNWQDPQ-----------RNRPVPTDLYLPSG-----TSRNLPLVVVSHGLGETRQTFAYLARHLASHGYAVALPEHVTTSARSFENVLVGISS--PPGPQALIDIPTDIRFVLDQLA-----TTPA-AARVQTQKAAVVGHSYGGYGALAVAGAPLSPVNARQQCEPLDRF---RNNLSTLLQCIAINLPQP-SYTLTDPRIVAAVAADGLASDVFGAAGLSQVTVPTLIWGGSRDVVTPPQPEAIAAFQQ-LGTRQKWLALAVKGTHFTVLPPNNQQPQ--GFQIPLP-PELIGPSQAA-GNLLFQGLTLAFLDQTFRGQPATLLPST--GTTT--I-ATPELTVLVTPQSP----------------------------------------------------------------------------     =====>
synp6-q5n3u2   	-----------------------------------------------------MNRS-LRWA----LGLW--VSLGFTPVQALETVTFSADGQ-VQQLAIADLAVLAQ-----------QGQASSDLSRLLQQAG---LNSQAVRRFLNSPLP-LSGSQLSALL----DL-GFGDRLVQELSRTLGAQ--AEQLQN-PTRIN-NRLAQLA---SQPRISVLQLLEVLPAQSLAIEIPRLLKVLLPLQTQFRSLGLDLADVVP---CLSDRSCSSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp7-q31jy0   	-----------------------------------------------------MRRS-LTAV----LSGLAVLFASAIPGKAAETVTLIYGPW-NRSIDVADLKHLAE-----------TGEARGFLGTILKLGN---QDPQQLQRFLNLSFP-FSLVQASDLL----YS-SLGTGLLDRAGTIVAPR--VSNQDG-RQALRAAILLSLS---KDGQISPVELLENYPTNM-RVNVDSLLGLIA----QV----GDLEALIR---SL-----GSG----------GSN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp7-q31ky3   	---------------------------------MPLFTFLSPKLRDFRQ----YLRI-WAWF----FLSLSLSFGSAKTAIAAERVTLLAGSW-ARSVELDDLRSLAV-----------TGQASGFLQDALRYGN---LQPKTVQAALNFSIP-LSPVLADRLL----YS-PLGNLALDRIGRILSPR--VSGQDG-RQALRGAILQSVA---RDSRFTLLELLDNYPTDA-RLDLLQIQQLQQ----DL----ALLSRLSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp7-q31q04   	-----------------------------------------------------MKTLLLGAF----ATATAAALFMPTSAQAANNVTLINGAW-ARSVTIGDLQAMAK-----------QDQVQGFTLDAVNITH---TQFQTVRDFLNRPIN-YKMVEADYLL----NS-ASGEKLLDQIGMVMAPR--TADADG-RQALRSAIILSLA---DDNRTTPLEIIQNYPTDA-RINLGALFAADA----KF----IP-DALAF---LDTNQQLAMQKTSIDWMIAQNPNTLSNRDFAQQEPLPLQES-----------------------PAPVRGLW-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp7-q31qe5   	-----------------------------------------------------MNRS-LRWA----LGLW--VSLGFTPVQALETVTFSADGQ-VQQLAIADLAVLAQ-----------QGQASSDLSRLLQQAG---LNSQAVRRFLNSPLP-LSGSQLSALL----DL-GFGDRLVQELSRTLGAQ--AEQLQN-PTRIN-NRLAQLA---SQPRISVLQLLEVLPAQSLAIEIPRLLKVLLPLQTQFRSLGLDLADVVP---CLSDRSCSSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synp7-q31sb2   	MHPSDTTKWKLISVAGLK----VCPVKPRH-----QPPRYLRPRARIHFCL---TRLLWSSG----FAFGL-WGAIALPSRPAETLRVSWADT-NLDLPVSVLENFQR-----------TGRFDRGFGFLNVLV--PEATLKEARTALSARLP-LSPEVLRPVL----TNTDTLEIFLQQIGSLIRP---QPGESG-AAALRQALLTASE--QP-QGLTLIGLIKAFPGPLMQLDLDTGLKLFQ----RIRALEAETGAMLR---AIAAQMQEQP---------SLPSRNF--RPAQRGPYTVRQQ-NWDWVDSD-----------RTRRVPTTIYWPDR-----QGLSLPVVIISHGLGEDRGNFAYLAQFLASHGFVVVLPEHVGSSSRQFASAAAGFAN--PPGPQEAIDRPQDIRFVLDRLM-----LEPQWRFRVNTRRVAVLGHSYGGFTALMLAGAVIEPEKIRAACSSVERL---MLVPSASLQCSLGRLPRD-RYDLRDPRVVAVLPISPFASKVFEPAALNQVQTPTLLWSGSADLIVPTLAEAIQPFQR-LGSPNKHLVVAVNATHFSVLGE----SQ--GPATRLP-PALLGPSPEL-GRRALQQVSLSFLQTYLLGQSQARVGLTAAAAEQ--L-SNPVMPLLFSEQLPPAIARQN---------------------------------------------------------------------     =====>
synpx-q7u3a7   	------------------------------------------MPTVKTR----RCRA-IALV----ASWGIGLIALASPALAAKNVALVSGAF-RRSIPVKDIEHLAN-----------TGEARGLLEQLLVLSK---QDPENVAKLLNQKLD-LPLVLTSRLI----NT-RIGEAIIRRVGQILYPIYTPQPEVS-IPALRAAVINGLH--NSGDGLTAVDFLKAYPNEVLAVNLPALFSVID----KAQSISG----LVQ---FFSDSPLDGLKEAKP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
syns9-q3auf9   	------------------------------------------MSSTQTL----RRTL-LAWS----TGLSLSLFTIGIPSLAATDVALVSGGF-RRSIPVKEFEHLAD-----------TGEAIGLLGNLLEFSK---QDPEEISNLLNQELS-IPLVLTSRLI----NT-RIGEAIIRRVARIIYPIYTPQAEVS-VPAIRAGIVNGLN---QSDGLTAVGFLKAYPNQVMAVNLPALFAVIE----KTESIAS----LVK---FFADSPLDGLKDPNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synsc-q3ag63   	----------------------------------------------------------------------------MQPLHAATEIALVSGAF-RRSIPVKEIEHLAE-----------TGEANGLLEDLLDLSG---QDPNEVSQMLNQSLE-LPLVLTSRLI----NT-RIGEAILRRVARIIHPIYTPEPEVS-VPAIRAGVISGLQ---SEDGLTAVSFLKGYPNAVMAVNLPALFGVIE----KAESIAG----LVQ---FFSDSPLDGLKEAQP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
synsp-SLR1506  	MEKKITLRWGQWQQNCLELAQVSCPLLQSSNLVDPPPLINLDIASMVTFPL-NLRRWLQSVC----LGALT-AIAVQLPGKTAENIFFTYGPI-KLTVRVESLERFVQ-----------DGTVDSNLSFLFNLVGASEEKLAKLREIMGLRAE-VDPVVLSNFF----NT-SLGEDSLARAAVILNA---PWGANS-KYGIRAAIVQAAE--DPEGGLSLINFIKKYPT-DIHFQGEVVEERAR----AVELLVKASEHFIDKMIALSEIEAASE-------GDINFSALP--DPTEMGPYGVAPKETWWLNDQS-----------RNRRFYVDVYRPQRWK----EGKTPVLVFSHGLASRPEDFDNAAEKMASYGFVVALPQHPGSDILQAQALLNRTSRQ-GYYPTEFIDRPKDISYVIDELERRNA---SEFGDRLNLTQVGVGGHSFGGYGALAVAGATIDWDFLKSECRIG--Q--GVPNTALLLQCDALTLPRS-DYDFRDPRVVAVLAANPVNSAIFGVSGLHKVTVPVLLLGGSYDPATPFVLEQARSFPR-LASRDKYLTLMEGQAHVDFSKIDANIKNV---VESVEAVSLKLPDPNL-LHTYGSAVMVPFFQLYVAGDESFRPLVENGAAHAAYLSRDQEFKFYLISQKSEGALIKDIEEFRRTNGLTPPPNEF-------PPQTISDNF------------------------------------     =====>
synsp-SLR1944  	---------------------------------------------MIDF-----KRLLGIAL----TSSLL-VLASPSVIKGAETITFSIMPLGQFDISVKSLTDFAE-----------TGTIDPDFKFYTQHL--KPEELEKLRGLLNHSFK-FNSVEAFRFF----NT-TFGKEIAQQLSYIIAA---PTDQSQ-P-FLEGAIVTAAQ--NP-DGFKIIDVINAYGGSDLVLNLDTFKNTID----QADTLYQATDRIFT---WLGKQEI---------PSNPVPPNLKPLALAEPGPQKWTTQ-NLTIPRPNG------------QPVNVFVYLPQG-----NSSPAPLVVIAPGLNSNFQAFTYIADHLASYGFTIAGIDFPESDAARMQDSLQGLDA--FPDPNAWLEQPKDVTLVLDTLAQKAA-TDPAWQGKFDINNVGILGHSLGGYTAIASGGATLEWPELLQQCEQLNKPNQINLNPALLWQCQGVGSAPP-ASNLRESRIKAVLAINPVTNPIFGPDGMKNLAVPTLIVAGSKDIFAPPVPEQIIPFSL-IEGVNKYLLLVQNGTHLSFLEDTD----------NLP-EKIVGPGQDL-AYTYMKSLGLAFFDLYLQQDSSFKPYLTDSVVQQ--M-SQEPLPLQLVPSLTPAQLQQAMDI-NN---------------------------------------------------------------     =====>
syny3-p72989   	------------------------------------MDLVVMNV-RFPH----FCLS----L----MFASLLAGAGTLPLAAAERVVLTYSVL-RESISIEELGELSR-----------TGKVSPSLKAYLKMAN---KNPEELRGWLNRPFQ-ADPVTLSRVL----NS-FAGEYVLNQVGQVIHT---PSKRDN-KEALRGAIISSAE---KDNQVRLIEVLENYPTPELHVNGDRLMELYQ----QVEGLTAMLGRLPF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....