Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....790..5....800..5....810..5....820..5....830..5....840..5....850..5....860..5....870..5....880..5....890..5....900..5....910..5....920..5....930..5....940..5....950..5....960..5....970..5....980..5....990..5....1000.5....1010.5....1020.5....1030.5....1040.5....1050.5....1060.5....1070.5....1080.5....1090.5....1100.5....
9burk-b1g6q9   	------------------------------M-DGAK-----------------------------------QFSR---SRDINAKVARILTKRSA-VAHEHLTERV----RTASGVDRDTAAAPTTRAPTPWDTW-SYGLDIIQRSVMFLDTLRERGTAYRERARQDPKPVLHFDYESVLDGRQFERPVNYALLKIKPPEGV-IV-----------------D---PRKRPYLIIDPRAGHGPGIGGFKDDS-QAGVALRGGH-PVYFLIFFPDPEP--GQTLLDVCAAEQQFVKRLRTLHPDS-PKPALVGNCQGGWAAMMIAASDP-DDTGPIVINGAPMSYWSG-AWSEGQGDNPMRYAGGILGGSWLASFAADLGAGKFDGAHLVQNFESLNPANTLWDKYYHLFHNVDTEPP----RFLDFERWWGDYYLMNREEIEWITHNLFIGNKLWS-GDVRGS-------SG-KAFDLREIRSPIILFASLGDNITPPQQAFNWVADLYGSTEEIKARGQVIVGLMHQDIGHLGIFVSGKVAKKEHTQIVSVLEAIESFAPGLYGMSITERK-DAN------------GETEYEVEFREHRLEEIAAHFNRFEREDEKPFEAVAQLSEFNQRAYELFAQPIVQAMSNETTARLLREFHPLRLQRWAF-------SD-LNPWLAWLPSAASAVKTHRQPAEA--DNPWRAIEQSGSQMISASLDYYREMRDAGTEATFFTIYGNLFS-LYLADAKPAAESG---AKSG-TGPDSDPRDLPFVKEALASIREGGYTEAIARAAALLSRKGE--PLPLSRLVTRKELAQAYA----SYLPDLPADQWRRIRGEQEIIVSFEQDEAIATLPVLVADRK--DRARFITLLDELLKDERVQSTGPTEAQRAMFDRIRQALTAKP---------------------------TPGRSVAAL-ARP--------------------------------------------------------------------------------------------------------------------------------------     =====>
9burk-b5wax2   	------------------------------M-DAET-----------------------------------LLSH---SQDITAKITRVLQKRTQ-NAQRHLNDRVNDSLGLDHNDS--APASSAPAPFTALNAW-QYTVDAAQRSLLFWDTLYRRGNEFVERSVSDPTPVLHFDYDMLLDGRTFERPVNYALLQLRPLEGV-GV-----------------D---VRKRPYLIIDPRAGHGPGIGGFKDDS-QAGVALRAGY-PVYFVVFFRDPEP--GQTLLDVCNAEQRFVRKVRSLHPDS-PRPAIIGNCQGGWAAMMLASSDP-DETGPIVINGAPMSYWSA-AWSEGEGDNPMRYAGGMLGGSWLASYAADLGNGKFDGAYLVQNFENLNPANTFWDKYYHLYSNVDTEPP----RFLEFERWWGSYYLMNREEIEWITRNLFVGNKLWS-GGVKDS-------SG-QTFDLREIRSPIILFASMGDNITPPQQAFNWVADLYGSTEEVKARGQVIVGLTHKSIGHLGIFVSGKVAKKEHTQIVSVLETIETFPPGLYSMTINEVR-NAA------------GELVYDVEFHERRLEEISAHLNRFGRIDEKPFEAVAEWSTLNQRMYELLAQPFVQAMSNETNARMLRQFHPLRWQRWAV-------SA-MNPWLGWLPAAAQSVRDNRQRAGA--DNPWSKLEHSGSQMISASLDYYREMRDAATEAGFFSVYANMYA-TFLGKASADG-------AAA-QAGAINPRELPFVRTALQAVGEGGYTEALARAAFLLSVKGE--SLPLARYEMRKEIAESYA----EYLPDITSDHWRRIRGEQEIIVSFEPHEAIATLPKLLSHSE--DRERFLQLLDKLMADERVLNGPHDAAQKTALERIRAVLGSHV---------------------------SRKRTAHLP----DGTRT---------------------------------------------------------------------------------------------------------------------------------     =====>
9burk-b5wqb7   	------------------------------M-DQVT-----------------------------------QPPR---NQEIALKILRLLHNRLE-EARQRFGQRTSDAIKGGDGAS--AATIPNPAQFTPWGAW-HYTADFAQRSVLFWDTLRQRGNEFIERNKAGIKPALHFDYDVVLDARHFERPVNYALLSIRPREGV-VV-----------------D---MKKRPYLIIDPRAGHGPGIGGFKDDS-QVGVALRAGH-PVYFVVFFQEPEP--GQTLLDVCAAEQQFVRKVRELHSDS-PKPAIVGNCQGGWAAMMLASSSP-EDTGPILVNGAPMSYWSG-AWSESEAPNPMRYAGGILGGTWLSSLSADLGNGKFDGAHLVSNFEYLNPANTFWDKYYNLFANIDTEPA----RFIEFERWWGSYYLMNREEIEWITRNLFIGNKLWS-GEVSGP-------SG-KSFDLRAIRSPIILFASMGDNITPPQQAFNWVADMYSSTEEIKVRGQVIVALMHEDVGHLGIFVSGKVAKKEYTQIFNVLETIETLAPGLYGMSIKEAK-GAD------------GKTEYEVSLTEHRLEEAVEHFNELRREDEKPFEAVAAMSEFNQRAYELFVQPVVQHASNETTARLLRDFHPLRLQRWAF-------SD-LNPWLAALRPMADAVRASRQPSSD--LEPWRTAEQRGSELISASLDQFRAVRDASIEALFFSIYANLFA-MHDPDLLGEQ--------EA-GTSAADPRSLPFVQAALASLRQGGYNEAVARTAFLLAPRGE--PLPLSRIETVQQLVDEYA----DYLPHLPPADWRRIRGEQELIATFEPQQAIQTLPALLASPE--DRNRLLTLLDKLLADRRVLRIPPTPAQEEALRAIRSVLGATT---------------------------ALESQPQKA--RAPRVRAT--AS----------------------------------------------------------------------------------------------------------------------------     =====>
9gamm-c6n5e9   	-------------------------------------------------------------------------------------------------------------------MGYSMEKQDTELPYQIWRDFFSYQTDYWQRSILFLDTLRDRANNMMEHEQQGLPPLLDFKYELVLDGKTLEPKTNYALVKILEIGDVCF-----------------DKCFDPTAAPVIVVDPRAGHGPGIGGFKRDS-EIGIALHTGH-PVYFVIFYPEPIP--HQTLADVLVTMRHFVEKAQALHEGK--PPILYGNCQAGWMLALLASDCV-GSVGLTVMNGSPVSYWANSE----EEANPMQLLGGLSGGVWSARFLSDLKDGTFDGAWLVSNFEMLNPTTAIWDKYYGLFDDIDGEHD----RFLEFERWWSGFYQFSQEEIIATVNNLFIGDQFER-GEMVIH-------KG-CIYDLKRIHNPIVIFASQGDQITPPRQALHWIRTIYPDTQALKKAKQRIVYLLHPSIGHLGIFVSAKVVRLQHRAILEHSAAIEQLKPGLYEMIIVNPTG-----------DPDCSKEQYHVRFEERDITELC-AS-----NSTKPFEKIRQMSEANDSIYQSVAQPFVQKMSNPFLSWWLEKTHPMRLSRYVF-------SEQVNPVMKPIELWGQSINADRQMITE--NNYFKKTEHALAEMIRDSFESVRKTRNTFITSLFEALYGKSN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9rhob-a0p290   	------------------------------MRDIFDALEKG-----QNEFLESLHDATAWGPSERFTALQAQATE---LSNLGELMGRGLSKHLT-RISDDHKSRWQATVAEYGKAVK-DMGG-AQEAGSLYQAWEEYWQDATQRTVLTMDVLRQRGDNFMDHEEAGCPPVLIYDYEVVLDGADLPRPSCYMLLKIIPPADL-PC-----------------RDPKPFKRPYIIIDPRAGHGAGIGGFKPDS-QVGVALHDGH-PVYFVAFKRMPEK--GQTLADVTHAEAAFVRKVMELHPEA-PNPVVTGNCQGGWATLLLAAMNP-DLTGPIILNGAPVSTWSG-R----VGENPMRYNAGVLGGTWNAMYYSDLGHGIFDGADIVQNFEMLNPARNYFGKYYDLYSKVDTEPK----RFLEFERWWGGYFLLNEAEMKWIVEQLFVGNRLSK-NEAQLE-------TG-RNVDIKHIRAPIIVFASYGDNITPPQQALNWIIDTYTDEREIAIRGQRIIYMIHEQVGHLGIFVSSKIAKKEHTEVTSTLKTIEALAPGLYEMTIDDYE-GPL------------LEREFTVSFHERKMEDLA-KIDDGR-DDEIPFAAVARASEQQAEFYDVCVRPFVQAFVTEQSADLRRKSHPLRMQRALF-------SS-LNPALGWLPGIAERARNERSPASA--GNPFVELEKVNAALIEQSMDLFRDLRDTAYENLFYSIWGTPYM-RWFGRSKQPGR--------T-LKRKDELRSLPPVQAALMHIEEGGFCEAVIRMLILLADSRG--NVRRDRLERSARVLTQDE-----PFKSLTADERSFILQEQTMIVEFAPEQALETLPKLLKTQE--ERELAAKVVRFVPGAIDE----MTPHTLETLQQFHEVLGLPPVSEDIL-HDPLAVTDVSVEPG-------------KEDTRAAQEEAASNAPAKTPAKR-------TAPVKAASAAAVPSK------SSPRKPATRK-------APAR------------------------------------------------KTAVSRKPRSTAKKPQESAE     =====>
9rhob-a3w7y0   	--------------------------------------------------------------------------------------------------------------------------------------------------MLFLDTLGERADNMIAHERQGMPPLLDFDYELLLDARTFERSANYALLRITRVGDDCW-----------------DDCVDEAKPPVIVIDPRAGHGPGIGGFKRDS-EVGMAMHEGH-PVYFVIFYPEPMP--GQTLSDVHYALRDFVSEVARRHPDT--APVLYGNCQAGWAATLLAADCD-GLTGPIVLNGSPLSYWSG-E----AASSPMRMMGALSGGAWAAHMISDLGDGRFDGAWLAQNFETLQPEKAIWDKYANLFAHADTERE----RFLEFERWWNGYYTLSREEILGITQNLFIGNRLEQ-GEMQLD-------AH-CTVDLKRISNPLIIFASDGDNITPPEQAMGWIGKLYPDTDALKAAGQRIVYMTHPRVGHLGIFVSGSVARLQHRAILESLDDVEALSPGLYEMVIDNPSG-----------DPDCETGDFEVRFEPREVDDLG-IA-----SDDAALKQVAQISRINEAVYSTFVSPWIRAATTPASAEALRALHPMRWTRTMF-------SEQVNPWMALIKSTAETLRETRSPLPD--DHPAIVAERALSARTGEGIGAWRKGRDAWITHVFGAMFGNFPFAAATTQAEKPSASS----KKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9rhob-a6e5f6   	---------------------------------------------------------------------------------------------------------------------------------------MPYVQDAFERWVLLLDTLRERADNMIAHERQGMPPLLDFDYELLLDARTFERSANYALLRITRVGDDCW-----------------DDCVDEAKPPVIVIDPRAGHGPGIGGFKRDS-EVGMAMHEGH-PVYFVIFYPEPMP--GQTLSDVHYALRDFVLEVARRHPDT--APVLYGNCQAGWAATLLAADCD-GLTGPIVLNGSPLSYWSG-E----AASSPMRMMGALSGGAWAAHMISDLGDGRFDGAWLAQNFETLQPEKAIWDKYATLFAHADTERE----RFVEFERWWNGYYTLSREEILGITQNLFIGNRLEQ-GEMQLD-------AH-CTVDLKRISNPLIIFASDGDNITPPEQAMGWIGKLYPDTDALKAAGQRIVYMTHPRVGHLGIFVSGSVARLQHRAILESLDDVEALSPGLYEMVIDNPSG-----------DPDCETGDFEVRFEPREVDDLG-IA-----SDDAALKQVAQISRINEAVYSIFVSPWIRAATTPASAEALRALHPMRWTRTMF-------SEQVNPWMALIKSTAETLRETRSPLPD--DHPAIVAERALSARTGEGIGAWRKGRDAWITHVFGAMFGNFPFAAATTQAEKPSASS----KKGM-NNYGMAF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9rhob-a9hui2   	-------------------------------------------------------------------------------------MNKSLRLATV----TP-TQSSQP-----------------VPEQTSAGANVPYAQDAFERWLLFLDTLRERADNMIAHDRLGMPPLLDFDYELLLDARTFVRPANYALLWITRVGDDCW-----------------EDCVDEAKPPVIVIDPRAGHGPGIGGFKHDS-EVGMAMHEGH-PVYFVIFFLEPVP--GQTLADVHYALRDFVTEVARRHPDK--APVLYGNCQAGWAAALLAADCD-GLTGPIVLNGSPLSYWSG-E----AASSPMRMLGALSGGSWAAHMIADLGDGRFDGAWLAQNFETLQPEKAIWEKYVNLFSHADTERE----RFLDFERWWNGYYTLSREEILGITQNLFIGNRLEQ-GEMQLD-------AH-CTIDLKRIRNPIIVFASEGDNITPPQQALGWIAKLYPDTEALKAAGQRIVYMTHETVGHLGIFVSGSVARLQHRTILESLEAVEALAPGLYEMVFDIPSG-----------GAKRKTSDYDVRFVKRDVEDLG-FG-----SDHGALAQVAQISRINEAAYSTFVSPWIKAATSPASAEMLRALHPMRWTTTMF-------SERVNPWMALVKSTADSVRETRDPLPK--DHPAILAERALLARTGESLASLRKARDAWLTHVFGAMYGSFPFATTTQTGQPPDTSN----KE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9rhob-b6yy40   	--------------------------------MQIELFTQR-----TAQYF----------------------EA---LAQQNQFLQVANSRRST-RLMKDFQKKQEKSKIK-GEALA-ASWAPYDTPKKVMDAWTHYLKESSERAILTMDALRESSDTYFDHMAKGCPPVLVYDYEVIVEGRNLPRPCNYMLLKIIPPEGT-EV-----------------F---DWKRPYVIIDPRAGHGAGIGGFKDDS-QVGVALRGGH-PVYFVAFHPMPEP--HQELSHVTHAEAAFLREIIARHPDS-PKPIVVGNCQGGWATAILAAVYP-DLVGPIVLNGAPMSYWSG-K----MGQDPMRYSAGLTGGIVPALLSADLGNGVFDGANLVQNFEMLNPGRNWFRKYYDLYTTIDSGEE----RYLEFQKWWNGFYYMTEEEFRWILDNLFIGNKLAK-NEAFLE-------PG-RPIDLKTIKSPIIVFSSYGDNITPPDQALNWIADTYTDDAEIEILGQRILYMLHDQVGHLGIFVSSSVAKREHTQVASTLKTIEAMPPGLYKLQIEEQK-GKG------------CDAKFKVSFARKTIDE-M-LLETGERDEEKAFAGVARFSESWEDMYDSTIGPVLKTMNSSQTAEVTRDLHPMRLANGAF-------AS-TNPFMFWPTMAAAAVKQNHKPNMA--KTPFHYWEEIVADSIEYGWDALKDMREAMIENSFLTFWASPQA-VEYGKALSFRR--------P-KVPMQDLHSLASIQNALKKIEKGGAAAAIVRIVLMIADTRT--EVRGEKLERFNEVLTTWA-----PFKSMDPKERNFLIHDQTLIARFEMEAGYNALPLLLKNEK--DKTFAYKAVTYIIGNEED----MAPNSLELWHCLKKTLKWG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9rhob-b9r693   	------------------------------MKDIFDAFEKG-----QNEFLNSLNDATAWGPSERFTALQAQGTE---LSNLAELMGRGLSKHFE-KITADHKGRWQLGLADMGKAVE-DLSK-GQRNGSLFDAWQSYWKDAAQRAVLTMDVLRQRGDIFLEHEEAGCPPVLVYDYDVVMDGADLPRPCCYQLLRIKAPEDG-EH-----------------REIKPWKRPYVIIDPRAGHGAGIGGFKPDS-QVGVALRDGH-PVYFIAFKRMPEK--GQTLADVTLAEAAFVRRIMEEHPDA-PNPIITGNCQGGWATLLLAATNP-DLTGPVVLNGAPVSTWAG-R----VGENPMRYNGGILGGTYNAMFYSDLGHGVFDGADIVQNFEMLNPARNYFGKYYDLYSKVDTEPH----RFLEFERWWGGYFLLNEAEMKWIVEQLFVGNKLSK-NEAQLE-------PG-RNIDIKQIRAPIIAFASFGDNITPPQQALNWIIDTYTDEREIAIRGQRIIYMVHDQVGHLGIFVSSKIAKKEHTEVTSTLKTIEALAPGLYEMTIDDYE-GGL------------LDREFSVSFHERKMQDLM-KIDDGR-DDEIPFAAVARASEQQAEFYDVAVRPFVQAGVTEQSAELRRKTHPLRVQRTMM-------SS-LNPMFGGLPGMAERVKEDRTPADA--NNPFSEMERVSAAMIEQSLDLFRDLRDTWYENLFYTVWGSPYM-RWFGRTHQPGR--------T-LKRKEDLRSLPPVQTALMHIEEGGFCEAVIRMLILLADSRG--NVRRDRLERSARVLTQDE-----PFKSLSPDARSFMLQEQTLIVEFAREQAIESLPKLLKTKE--DREMASKVVRYIPGAIDE----MTPHTLEMVQTFQSVLGLPPVSEDIT-ADPLVSGEAGAPDT-------------DGDTPKVTEKAASASPAP--QKA-------SAPKR----------------------AAKK-------APAKS--------------------------------------------AAARKPGPRKPRSTAGKKEEPAE     =====>
acicj-a5ft87   	--------------------------------------------------------------------------------------MTSERDTSR----R--WAGHGP---------AAVAGAASSAAAQLASAWPEYMIDAFQRGVLFLELLQQRVNEEIASTAWLMSTALRFDHEMVMSDSALLLPMNYSLLRITPPPGM-IA-----------------D---PRKRLVVVVDPRAGQGPGIGGFKVER-GISGAVHCTS-PCGHGT-GGHRHP--NKNI--------AYELKISQRTVEN-PRTEIME------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
acicj-a5ft95   	---------------------------MTIDFAAR-------------------------------------------------------HKPAP----G--RAGRGP---------AIAAGNAGPAAVQLATAWPNYMIDAFQRSVLFLELLRQRGNDEIAITARPVATVLRFDHDLVMSGQALPRPMNYSLLRITPPPGV-IT-----------------D---LRKRPVVVVDPRAGQGPGIGGFKAES-EIGDALDAGH-PVYFISFAATPEP--GQQFLDVVEGQVAFFERVVALHPGA-PRPFAIGNCQAGYQTLMVAMLRP-DLFGPCLVAGSPMSYWQG-V----HGKYPMRYAGGLLGGSWLTAMSSDLGRGRFDGTALVMNFDSLNPANWLWGKQYDVYTHIDTGGA----RYLAFEKWWGDFIQLNGDELQFLVDNLFIGDKLTR-GQLASS-------DG-RIFDLRNIRSPIIAFASTADNISPPPQSLGWILDLYRNVDEIRAADQTIVYCLDHKIGHLAIFVSTKVGAEQDEEFVQMIDVIDCLPPGLHEMIISPRPA--ETPR------GGFVTGDWIARFETRSLDDIR-ALGRNSPEDDRAFAAVARLSALNLAAYRRILQPLVRALANQPMADLTRALNPLRLSYTIF-------AD-RNPWMQVVRTMAAGVDAARRPVAA--DNPFLALQTQVSDQIIAGLDAYRAARDVMAEQVFFGVYGSPFVQALLGITDRTEA-----RPTPGPSPEQRALQEVHAKVYAAKLKSGGFDEALTRAVLYVLAADH--VLDQRCALALNAARWT--------IMHLSLAAFKAVVRDQAFLLLLEREQAIAALAVLVPEAD--ARTALLSQVRAIVGAA----GPPSSAESDRLLRLKQALAP------PPRRPT-------------------------------ATAAASGKPQA---VS-------H-------------------------------------------------------------------------------------------------------------     =====>
acide-c5t1r9   	-------------------------------------------------------MKTPTSPQKPRTSQRTTAGGKEAAVQGTHRQAEDLPPTVL----DHSEELLKS-APQDASSGM-KR----AAEAPSTQDYFDYQRDFFERTILFWDTLRQRANNMLEHERAGLPPLLDFKYETLLDARSFDRPVNYALLRITEIDGHCW-----------------EDCVDSDKPPVIIVDPRAGHGPGIGGFKRDS-EVGMAMREGH-PVYFVIFFPEPAL--GQTLADVLHVLRRFVEEVALRHPGN--PPVLYGNCQAGWAVTLLSADCA-GLVGPVVLNGSPLSYWAG-E----SGVNPMRLSGGLLGGSWLAHLTADLGNGRFDGAWLAQNFENLKPEKAIWEKYAQLFTNVDSEQA----RFLEFERWWNGFYFLSREEILAIVENLFIGNQLEQ-GVFQIC-------LG-CTADLRRIKNPIVIFASYGDNITPPHQALGWIPAVYSDTEDLKRAGQRIVYLTNRHVGHLGIFVSAGVARLEHRAILESLAEIEALAPGLYEMKIDNPSG-----------NPDCHKPTYSIRFESRQVEDLK-TD-----YPQEAFERVKQVSTFNEVLYRAFVSPWAQTLSTPWTAEVLKWLHPMRSSRYLF-------SETLNPWMKGVSVLAEPLARSRQPLAP--HHPLIEREREAAGQVTHALGRLREGRDAAVEQAFRLMFQRPD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aciet-b9mbf1   	-------------------------------------------------------MKAPTPTPKPQSSPSARPRRGKAAIQRVQRLAEDLQPAVL----DHSEELTKP-AAQETSSGM-KG----ATDALSAQDFFDYQRDFFERSIAFWDTLRQRANNMLEHERAGLPPLLDFKYETLLDARIFERPVNYALLRITEIDEHCW-----------------DDCVDPDKPPVIVVDPRAGHGPGIGGFKRDS-EVGMAMREGH-PVYFVIFFPEPAL--GQTLADVLHVLRRFVEEVAQRHPGK--PPVLYGNCQAGWAVTLLSADCA-GLVGPVVLNGSPLSYWAG-E----PGVNPMRLSGGLLGGSWLAHLTADLGNGRFDGAWLAQNFENLKPEKAIWEKYAQLFTNVDTEQG----RFLDFERWWNGFYFLSREEVLAIVENLFIGNQLEQ-GLFKIC-------QG-CTADLRRIRNPIVIFASYGDNITPPHQALGWIPAVYQDTDDLQQAGQRIVYLTNPHVGHLGIFVSAGVARLEHRAILESLADIEALAPGLYEMKIDNPSA-----------DPDCHKPSYSIRFEPREVGDLK-TD-----YPQEAFERVKQVSTFNETLYRAFVSPWAQSLSTPWTAELLKWLHPMRSSRYMF-------SETFNPWMRGVSMLAEPLARSRQPLAP--HHPLIEREREAAEQVTQALGRLREGRDAAIEQAFRLMFQSPDVLLSVLGTMGKTGDG----SAGRHKAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
acisj-a1w603   	-------------------------------------------------------MKIPTSPQKPRTSQRTTAVGKEAAVQWTHRQTKDLPPTVL----DHSEELLKP-APQDASSGM-KR----AAEAPSAQDYFDYQRDFFERTVLFWDTLRQRANNMLEHERAGLPPLLDFKYETLLDARSFERSVNYALLRITEIDGHCW-----------------DDCVDSDKPPVIIVDPRAGHGPGIGGFKRDS-EVGMAMREGH-PVYFVIFFPEPTL--GQTLADVLHVLRRFAEEVAQRHPGN--PPVLYGNCQAGWALTLLSADCA-GLVGPVVLNGSPLSYWAG-E----SGVNPMRLSGGLLGGSWLAHLTADLGNGRFDGAWLAQNFENLKPEKAIWEKYAQLFTNVDSEQA----RFLEFERWWNGFYFLSREEILAIVENLFIGNQLEQ-GVFQIC-------QG-CTADLRRIKNPIVIFASYGDNITPPHQALGWIPAVYSDTDDLKRAGQRIVYLTNPHVGHLGIFVSAGVARLEHRAILESLADIEALAPGLYEMKIDNPSG-----------DPDCHKPSFSIRYEPREVEDLK-AD-----YPEEAFERVKQVSTFNEALYRAFVSPWAQALSTPWTAEVLKWLHPMRSSRYLF-------SEAFSPWMKGVSLLAEPLARSRQPLAQ--HHPLIEREREAAEQVTHALARLREGRDAAVEQAFRLIFQRPD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
acisj-a1w9c9   	-------------------------------------------------------MKTPTSPAKPQTSQSARPQGRKAEIQKVQRPAEDLQPTIL----GHSEESMKP-AAQEASSGM-KR----ATEALSAQDFFDYQRDFFERSILFWDTLRQRANNMLEHERVGLPPLLDFKYETLLDARGFERPVNYALLRITEIDEHCW-----------------DDCVDPDKPPVIVVDPRAGHGPGIGGFKRDS-EVGMAMREGH-PVYFVIFFPEPAL--GQTLADVLHVLRRFVEEVAQRHPGK--PPVLYGNCQAGWAVTLLSADCA-GLVGPVVLNGSPLSYWAG-E----SGVNPMRLSGGLLGGSWLTHLTADLGNGRFDGAWLAQNFENLKPEKAIWEKYAQLFTNVDSEQR----RFLDFERWWNGFYFLSREEMLAIVENLFIGNQLEQ-GLFQIC-------QG-CTANLRRIRNPLVIFASYGDNITPPHQALGWIPAVYQDTDDLRRAGQRIVYLTNPHVGHLGIFVSAGVARLEHRAILESLADIEALAPGLYEMKIDNPSG-----------DPDCHKPSYSIRFEPREVKDLK-TD-----YPQEAFERVKHISTFNEALYRAFISPWVQSFSTPWTAEMLKWLHPMRSSRYLF-------SETFNPWMRGVSMLAEPLARSRQPLAP--HHPLIEREREAAGQVTHALGRLREGRDAAIEQAFRLMFQSPDLFLSILGTMGKTGDG----SAGRHKTDGALI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
aroae-q5p962   	-----------------------------------------------------------------------------------------------------MNFPIPV---------PSAATLPMMDPFGFARSAFDYWRDAVERSVLFMDVMRHRGNQYLEHIEKTKPSVLGFETEVLMDGRELPRPVNYELMRVLPPAGI-EI-----------------D---PQRRPFVVVDPRAGHGPGIGGFKPDS-EIGVALRAGH-PCYFVGFLPYPEP--GQTVEDVVEAEVAFLRCVIERHPTTAEKPMVVGNCQAGWQIMMAAALEP-DLFGPILIAGSPLSYWAG-E----RGKAPLRYTGGLSGGSWMTALLSDLGNGLFDGAWLVQNFENLNPANTWWTKQYRVFANVDTEAV----RYLEFERWWGGHVVLGGQEIQYIVDNLFIGNRLST-AQLMTS-------DG-RRIDLRNVRSPVVVFCSRGDDITPPPQALGWVRDLYEGVDGIIANEQTIVYCVHDSTGHLGIFVSGSVSRKEHTEFTANMDYIDVLPPGLYETSISRAD--E-RAD------AGLIEREYLLEFTPRTVAELD-REIGHQPDDEARFATVARISEINLGLYRLFLQPWVRALATPSSAKWMRRMHPNRLGYRLL-------SD-RNPLTLSLPALAEKVRADRHPVGE--DNVFRRAETLVSEQIARGLDTWSDLRDKASEQLFMSIYGQPLLQVLVGLRA-DGQPH---RRRPGTELEHRRFIQRRQAELHDRIAAGGSHEAKMRSIIYVLGGAP--ATDERNFKRMRASRAEL-------EPSLKLADFKNLLREQFFILKHDREAALEAIPTLLKGQSAAQIDTHLNQIEHVLAAS----GELSAHAADRFKRIKSLFHRARPNATAVALTSPGAAPQSP------------------------SA-----------AMNEPAS--PAPIAKA-----------------AEPRQTV----TSGLPVSE-------------------SQG---AQASDTGRMPDGDKPAAAPGRRAPRKPRNA------------     =====>
azoc5-a8ih86   	---------------------------MAGESATPAPLQPGTWGQPGHQ-------AAPW----------------------SGVFAEAWSRAFT----G--TAPLPP---------GIGT--------LPAGPLVDYLVDAAQRSVLFIDLMRRRGNEQQDITSRPMATVLSFDHDVLVSGRALPRPINYFLSRIVPPPGA-KV-----------------D---PDKRPVVVVDPRAGQGPGIGGFKTQS-EIGEALANGH-PVYFIGFSAQPEP--GQTFLDVVEGQVSFFERIVAMHPDA-PRPFAIGNCQAGYQTLMVAMLRP-DLFGPCMVAGSPMSYWQG-V----HGKNPMRYSGGLLGGSWLTALVSDLGRGKFDGTWLILNFDSLNPANWLWGKQYDLYAAVDTEAQ----RYLGFEKWWGDFITLNGDEIQFLVDELFIGDGLTR-NEMRSS-------DG-TVFDLRNIASPLIVFTSLGDNISPPPQTLGWILDLYKDVDAIHAEGRTIVYCLNQTVGHLAIFVSAKVGAKEDEEMVRLMDLIDCLPPGLYELVISPASE--EEVK------AG--GHPWHSRFEARSLEDIR-AFGRNSVEDDRAFAAVRRVSEINLSLYRTFLQPAVRALANPHMAELLFATNPLRLSYSLF-------AD-SNPFMKPVAKAAAEVTAARKPVPP--DNPFLAVQKLWSDQISAGLDAFRDLRDRAVEQAFFGIYGSPVLQGMLGLNLDEKV-----RELPPTSPQKRAFLTQKMAEFRDRVDEGGFNEALVRSVLFVIAADR--QLDERCAAALKETCLR--------LTQLSISDFKSLVRRQFYILLLEGIAAVEAIATLVPDGA--ARQSLLNDAAAVAGAN----GTLTIGEQQNIEKLAEVLGVAAPHSPAPVLPA-------------------------------DTHRS--APST---LQ-------IAPAGA--------------------------------------------------------------------------------------------------------     =====>
azos1-d3p281   	----------------------------------------------------------------MMWP-----------------------------------------------------------MMDLARQAQDYWIDASQRSILFLDVLRRRGNTHFEHGARTAPNVLGFSFEFVADGRLLERPVNYGLVRIVPPAGV-AV-----------------D---DRKRPFIVFDPRAGHGPGIGGMKQDS-EIGVALKAGH-PCYFVGFLPDPLP--GQTVEDVCRAEAVFVEVVARLHPDADGKPCLIGNCQAGWQIAMMAATHP-DRVGPLLLAGAPLNYWAG-V----HGKNPLRYLGGLLGGTWQTALAGDLGAGIFDGAALVANFERMNPANTLWKKGYNVYSKIDTEEE----RFLDFETWWGSPVLLNAVEMQFIADELFLRNKLSS-GEIVFS-------DG-MRVDLRNIRTPIVVFCSWGDDITPPQQALGWILDLYDTDRELIAGGQTIVYALHQSIGHLGIFVSAKVANKEHDEFARTMDLIDVLPPGLYEAVFTEKT--TDMPH------PELVSGDHLVRFERRRLDDIR-ALGGNDAADDRRFATLARLSALNKGLYRATLGPVVNALATPQSAGALRAMDPYRLRFAAF-------SD-RNPLMALVPPLAEAVRAHRRPVPV--DNPLLGLQKAISEQIVLALDMARDVRDRATEGFFLTVYGSPQLQTLLGIDPNRPVPG---HGRPGRDLTREAAILRAVADLSARMDQGGLAEAGLRALLYIDLGRTQVGADERGFAMLRHIRRRLF-----ADRPFSLAYFKAMVREQYLLLLIDEERAVAAIATLLEDDPS-GRAGMLDAIRLVVAAS----GELSQDAGRRLDRVESLFASVSGKTMPAARGMVGIAGS--------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
azosb-a1k5s0   	-------------------------------------------------------------------------------------MQLFPSP----LAPSGHALQLLP-------AAFAGISGLFRHQLHTAAAAVHYLYDRWQRQILFIDVLRERGNQYIEHSRSGKPPVLAFDYEIIMDGRRLPDPANYALARIHPGPDCPPT-----------------D---PTRRPFVVIDPRAGHGPGIGGFKIDS-GIGIALQQGH-PCYFVMFFPTPEP--GQTIESVTRAEHAFLSRVNELHPEA-SQPLVIGNCQGGWALMMLAASAP-RVVGPILLAGSPVSYWAG-V----RGKNPMRYTGGLMGGTWLASLVGDLGNGRFDGALLVNNFELLNPANTFWGKPYGLFANVDEERE----RFLEFERWWGGHFLLNKAEMEWITQNLFVGNRLSA-GDIVSS-------DGRIRIDLRNIRSPIIVFASWGDNITPPQQALNWIHDLYEDVEDIRLNEQTIVYCLHEKIGHLGIFVSASVAQKQTNKLVGALELIDILPPGLYEAVIEDTH--PEMPG------REYVQGRFHVRFEPRSIDDIL-ALDD-GREDERAFEVVKRVALVNQGLYDTFVSPWVRLFSSELMAETFRNLNPARFERLWF-------SD-ANPLLWPLAPIAGLIAHKRVPASD--DNPFVQLEKQVSGQIEQSLNHYRDSRDHLQEQLFTTVYEAPLLQALVGLGQG-VV-R---RREQAHTWMEDEFRNLQRRVLTEDFEHGSVLDGIVRTIFFTKPDLL--GFDERPFNLLRQGLEHAG-----LGGRHALADLKQILKRQALLFLLDEDRALAGLPALLPTPE--LRRRALETAYALGRAR----GDLGEVFQQRYARVAAQLDVAPETAAEQAPVLEAPPTALA----------------------APSAPA-------D----------------D----GGPARRRR-------PRK-GTDERA--------------------------------------------------------------------------     =====>
azosb-a1k696   	---------------------------MPLSAGSGP------------AFLSV-------VPARR-PATRAGRRR--LATSVLARH-----DHLD-DLRVRLFARARRLSQRWAR-------QSSQRPPSPAE-TLAYALDCTRRAVLLADTLRQRGNDFLDYEATGQPPLLAFDYEVLIDGRQLPRPVNYCLVRIVPPDGV-EV-----------------D---ETKRPYLIIDPRAGHGAGIGGFKQES-QVGVALQAGN-PVYFAVFYPEPEP--GQTLACVAAAQLRFVREVAARHPRS-PKPALVGNCQGGWAVMALAAVDP-GIAGPVVLNGAPLSYWAG-V----RGRDPMRYLGGLAGGSWPSYLLGDLGHGHFDGAWLVQNFEGLNPANTVWTKYYRVFRGGEEEAR----RFLDFEKWWGGFVQLTADEMRGIVDDLFVGNKLAT-GGIPLG-------RG-QTLDLRRVRSPVVVFCSQGDNITPPQQALNWIADTYSCTREIKAHGQTIVYIIHADAGHLGIFVSGSVVRREFSQIAGTLANIEALPPGLYELTITDTHIDEH------------GVQQYDVSLHEREIEDILAHD--DSREDERAFHIVAAVSELNGRVYDLFVSPWVRQGASALSAWWMKELHPLRVQRRAW-------SD-LNPWLWWVPVARERLGEGP---EVGEANPWLSWETALSDVVEAGFDTVRDVRDAMLETLFHSIYGALDA-LGAGDRLAKARLF---SA---------GGAEDVAALALAAMTEGGVREAVVRMLLLLMKAGG--SVRRETLAYVQS-QLREA----HVFQELDAEALRALLVMQSTIVAYDPARALETLPALLPTPE--LRADALRVLRAVLPATAL----ARPQLQAAMEQFRETLGEQP---------------------------ASPA-----------------------------------------------------------------------------------------------------------------------------------------------     =====>
azovd-c1dgm6   	---------------------------------------------------------------------------------------------------------------------MADASADPPAPWTLWNDWCRYGLDVAQRSILFWDTLRQRGDNYLEHVRQGQPPLLHFEHETVLDGRTFARPVNYALLRILPPAGM-EA-----------------D---PRQRPYLIIDPRAGHGPGIGGFKDDS-EVGVILRERH-PVYFVAFFRLPEP--GQSLLDVCAAEQVFVRKVRELHPDS-PKPALVGNCQGGWATMMLAATDP-DSAGPVVINGAPMSYWGG-AWREGEGDNPMRYAGGLLGGTWLASLASDLGNGLFDGAHLVENFENLNPANTYWDKYYHLFANIDGEPP----RFLEFERWWGGYFLMNREEIEWITRNLFVGNRLWS-GETGAG-------RGKPVFDLRDIKSPIVLFASLGDNITPPQQAFNWVADIYASTEEIKARGQIIVGLLHQDIGHLGIFVSGRVARKEHAQIVSVLKSIEMLPPGLYGMAIHERP-GAG------------GKLEYEVEFHEHRLEDVSARLNRLQRVDEKPFEAVAALSEFNQRGYELFLRPLVRLMASERSAELMRQLHPLRLQRWAF-------SA-RNPWLWWLAPAAAAVRKQRQAPVASRDDLPHHGERLASELISASLDHYRALRDAAGEALFFQTYGSLFS-LILDESPPPA-------------ASAEAQELPFVQEALDAIGEGGYDEAFARVAALLARKD---ELSLARLVTKQEIVRDYA----DLLPRLPPETWRRIRGEQEIIVNYAREQALATLPALLAGPA--ERERLLTLLERLAADERVRRSEPSAEQRAMLERIHDVLGRAP---------------------------AVGQPTARS-A----------------------------------------------------------------------------------------------------------------------------------------     =====>
azovd-c1dif2   	-----------------------------MS--QET-------------FFA-----------QQ-ED---CFSS---FHNYVQHIGKLQKLQSD-NLQDGIRRRQEKSLQK--------LTACATRQIGP-GDWLDYLSDFNQRTLLFWDTLRRRADGTLEHRRAGYPALLKFNYELLLDGRDLPAPVNYSLLHILPGPSQ-TT-----------------D---PSLPPVIVIDPRGGHGAGIGGFKEDS-EIGESLRAGH-PTYFISFSHSSEP--GQTLSDIALAEARFIELVSERHAHA-GKPVLIGNCQAGWALMGLAALRP-ELPGLLIVVGAPLSYWAG-V----NGRNPMRYAGGLLGGAWMTRLGSDLGNGRFDGTWLVNNFENLDPAHALWGKYYDLFSSVDSEAQ----RFLDFERWWGSPNLFNSEEIETIVDELFIGNRLTG-GQ-----------N--TLTDLRKIEAPVVVFCSYGDNITPPQQALNWIADLYPSDLALHSSGRTIIYLKHASAGHLGIFVSGQVARREHRQLIGAIDAIKALPPGLFELIIDEVPHPDG------------GAQSYQVHFESRRIADILAE--DDGHD