Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....
9burk-Q5YEW3   	MRSIRL-KRLI-----AAVALGGAAAATQAASPLPRLNVDKTQISVSGLSAGGFMANQLGYAYSGTFM-GVGIFAGGPYMCAGHSNY---TSCMYNATITSSMRSAMQASIDNWSG-AHIDPKAHVANQRVFLFVGNSDTTVGPNPMDAVHAQYQHNGVRRTA-RVRGRNSTAHVFPTDFDATGNNACNSTASPYIANCGYDGAKAVLSRIYGTLQPRNDA-PAGANYIEFDQTAFTN-----NPGMASTGWVYVPANCAAG--AQCRLHVALHGCQQSTGHIGDRFVKNTGYTRWADTNNIIVLFPQAKTDNTPRN-TAASGMLPNPNACWDWVGWYGSNFAQKTGTQAAAIKAMVDHVASARP-------------RLRLPAPTGVQTSGATSSSMVISWAAVQGAAGYNVYRDGTKVNATAVSGTSYTDNGLSPGTTYQWTVRAVNAQGPRPAVGP-ATGTTT----GTAAVCFTSSNYAHVSAGRAYVSMGYTYANASHQNMGLWNVFVTTTLKQTGPNYYVIGTCP     =====>
acisp-Q9ZNH8   	MAFNFIRAAAA-----GAAIALCGVASVHAAVNLPALKIDKTQTTVSGLSSGGFMAVQLHVAYSATFAKGVGVVAGGPFYCAEGSVVNATGRCMASP--TGIPTSTLVNTTNTWAGQGVIDPVANLQNSKVYLFSGTLDSVVKTGVMDALRTYY-NSFVPAANVVYKKDIASEHAMVTDD---YGNGCSTKGAPYISDCNFDLAGAMLQHLYGTLNARNNATLPSGNFIEFNQSEFIS-----NHGMATTGWAYVPQACQAGGTATCKLHVVLHGCKQNVNDVQQQYVRNTGYNRWADSNNIVMLYPQTSL--------------AATNSCWDWWGYDSANYSKKSGPQMAAIKAMVDRVGSGG----------TTNPPVDLPAPTGVKPSGATASSMAIGWNAVSGGPSYNVYRNGNKTNALPVTATNFTDTGLAASTTYSWTVRAADGNGAEGAVSAAASGTTLAASGGGTGTCTTASNYAHTMAGRAYVYGGYTFALGSNQSMGLWNIFVNKTLKQTSPNYYVIGTCP     =====>
calma-PHAZ     	MKTRML-VGWA-----AAAVL--AAGPAWAVQSLPRLNIDKSQISVSGLSSGGFMANQLGVAHSSTFM-GVGVFAAGPYMCAGHYNY---TACMYNATISDGQLSTMQSSINHWSG-SQIDDKAGIAKQKIYLFVGTSDSTIGPNPMDALRKQYANNAVPTGNDEYIKRSGAAHVFPTDFDAAGNNSCGSTSSPYIANCGYDGAKAVLTRIYGTLNPRNDT-PPASNYIEFSQASFTN-----NPGMAATGWVYVPSDCAAG--AQCRLHVALHGCQQSYAQIGDKFIKNTGYTRWADTNRIVVLFPQTKVDNTSRS-TAASGLLPNPNACWDWIGWYGSDFAQKGGSQISAIKAMVDHLASGAP-------------TSTLPAPTGVSTSGATDTSMVISWASVQGAAGYHVYRNGAKQTTTPVTGTSYTDTGLTPATTYQWTVTAVDGQGAESVPSAAASGTTTGAA-PPPATCYTASNYAHTTACRAYAAWGYAYAKGSNQNMGLWNIYVITTLKQTGPNHYVIGTCP     =====>
comac-PHAZCAC  	MAFNFIRAAAA-----GAAMALCGVGSVHAAVNLPALKIDKTQTTVSGLSSGGFMAVQLHVAYSATFAKGAGVVAGGPFYCAEGSIVNATGRCMASP--AGIPTSTLVSTTNTWASQGVIDPVANLQNSKVYLFSGTLDSVVKTGVMDALRTYY-NSFVPAANVVYKKDIAAEHAMVTDD---YGNACSTKGAPYISDCNFDLAGAMLQHLYGTLNARNNATLPTGNYIEFNQSEFIT-----NHGMATTGWAYVPQACQAGGTATCKLHVVLHGCKQNIGDVQQQYVRNTGYNRWADTNNIVMLYPQTST--------------AATNSCWDWWGYDSANYSKKSGPQMAAIKAMVDRVSSGTG-------GTTPPDPVALPAPTGVSTSGATASSMAIGWAAVMGAASYNVYRNANKVNALPVTATSYTDTGLAASTTYSWTVRAADANGAEGATSAAASGTTLAASGGGTATCTTASNYAHTLAGRAYAAGGYTYALGSNQNMGLWNVFVTNTLKQTSTNYYVIGTCP     =====>
comte-PHAZ     	MRVQSWRSGVA-----ALALWGGVNLAAGAAVPLGQYNIATDQISVSGLSSGGFMANQLGNAYSASFM-GVGIFAAGPYMCAGLNNY---TACMYNASISSAQLNAMQSSIDSYSSAASIDAKSRIAAQKIYIFTGTSDYTVGPNLTDALQTQYLNNGVPQGNIAYVKRSGAAHVLPTDFDSSGNNACSSSASPYISNCGYDGAKAALTHFYGALNPRNDA-PATGNYIEFNQASYTNA----NPGMASTGWLYVPQSCASG--TQCRLHVVLHGCQQSTDKIGDKFVRNTGFSRWADTNNIIVLYPQTQVDNNNRS-TSKSGSLANPNACWDWIGWYGNNFAQKSGVQMTAIKAMIDRIASGAGSGTGGGNGGGTPTQPALAAPTGLGASAATSTSMQLDWAPVTSAAGYNVYRNGNKANALTVYATSYVDAALNPATSYSWTVRAVDGNGAESADSAAVSASTLTGS-NPAGTCTTASNYAHVQANRAYQQGGYAYANGSGQNMGLWNVFYTTTLKQTGSNYYVIGTCP     =====>
penfu-PHAZ     	-MFDSVKIAWL----------VALGAAQVAATALPAFNVNPNSVSVSGLSSGGYMAAQLGVAYSDVFNVGFGVFAGGPYDCARNQYY---TSCMYNGYPS---ITTPTANMKSWSG-NQIASVANLGQRKIYMWTGSSDTTVGPNVMNQLKAQL-GNFDNSANVSYVTTTGAVHTFPTDFNGAGDNSCSLSTSPYISNCNYDGAGAALKWIYGSLNARNTG-TLSGSVLSFAQGSYGA------NGMDTTGYLYVPQSCASGA-TVCSLHVALHGCLQSYSSIGSRFIQNTGYNKWADTNNMIILYPQAIPDYTSIHAIWNGGVLSNPNGCWDWVGWYGSNADQIGGVQMAAIVGQVKQIVSGFQG---------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
strex-PHAZ     	MKIRQLLVAALTAVGIAATTVGGATAAVPAPTPGSLQQYNIGSTYVSGLSSGGFMANQMHVAYSDVFE-GAGIFSAGPYDCAQNSVNTAQYACMDTFMARKTPAQ-LEQLTRDRATAGKVDPVANLSGDKVWLFHGTNDSTVKAAVNDDLATYYRDF---GADVVYDNSSASGHAWVSPL---GPNSCSSTTSPYVNTCGGDPVRDMLTHLLGSVNPASSS-ALTGKLVQFNQSGYAPGGSAGAISMGNEGFAYVPQSCQSG--ASCKLMVTLHGCYQYFGLVGNALMDKAYLNEYADTNDMIVLYPQATT------------MTGNPRGCWDWWGYKSADYAQKSGPQMTAVMNMARALGAGGE------------SSPALPAPTGLTVTATTATTASLSWNSVPGAASYDVYRDGTKVNSAPVTATTYTDTGLTTGTAYSYTVAGVDTAGTAGARTTPVTATT-----TGAAVCVTASNYAHTQAGRAHQSGGYTYANGSNQNLGLWNVLASSTIKETAPGYWVTC---     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....