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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....730..5....740..5....750..5....760..5....770..5....780..5....
9bact-d4im31   	-------------------------------------------------------------------MTAVKKY------ALLPLCGLT----LFCA-RA--------------------Q-MPATNYDES-QVPAY--TLPDPLTTI----------------------AGKKVTDAETWTSERRPELLSLFESEVYGKAP-GRPEGLHFEVLSEDRYTLGNM-ATRREI--AVYFTE--SDAHFMTILLYIPNK---RTDAVPVFLGLNFKGNHTICDDPLVTES---------------------------VSRMKPREE-GGS-EVRAKGFPRAAAASRWPVEMLIANGYGLATIYRGDIDPDYDD-GFQ----N--GVHPLFYREGQTKPAP---DEWGTIAAWAWGLSRAMDYLETD-------EDVDASRVAVIGHSRHGKTALWAAAVDPRFAMAVSNDSGCGGAALSRRCY-----------------GETVARIN--SLFPHWFCGNFN--------RYS--------GNEAALPVDQHELIALIAPRPVYIASAVE----DRWAD--PKGEF-LAGVHATPVYELFGLVGLS--------GTE-LPQT--DAPVLSGHIGHHVRSGDHDITLYDWR----QFVKFADKHLKR--------------------------------------------------------------------------------------------------------------     =====>
acic5-c1f4y4   	--------------------------------------------------------------MTSEQMHARMMRLLGIEA-MRPGPS------G----------------NP-------AA-PNHANYDEA-TANPY-PKLPDALTMD----------------------NGQKVTSAKMWWTERRPQIVADYAKYVYGEVP-KHVPAVHWQVLVVDHEHVGFTPVVAREVVGTVDNSSDPQISVKIRMMVVTPAN---VKGPVPVLMMFGPTDFPAPNQPTRQQYQQINDAMKAAMEHE---NPALTQVFAEHPAWEPMAPPP-------FRFPQLNQDGGLPNTWELVQAGWGFAMLDPQSVQADNAA-GLT----E--GIIGLVNHGQ--PRSP---EQWGALRAWAWGASRGLDYLKTD-------PDVNGSEVGIEGVSRYGKAALLTMAMDQRFAMVLVGSSGKGGATPLRRNF-----------------GEAVETLASSEE-YHWMAGAFL--------KYAAAKAKFAPMNASDIPVDSNDLIALCAPRLTFISYGIPERGDAKWLD--QRGSW-MATVAASKVWTLLGAKGLVPPVTENYRVAP-MPPV--NHGLLGGKLAWRQDDGGHT-DAPNMI----FFIHWAAKWFGYQPRG----------------------------------------------------------------------------------------------------------     =====>
actmd-c6wh70   	---------------------------------------------------------MITR-S---GHLRLSLA----------LLTALALT-G--TAL--ATAAPTPSPPTALAVEDDGADC---PVALPGSTP-ANPRLPDPFTRI----------------------DGSRVTSLADWR-CRRAEIRELAERHVYGDKPAK-PASVTGTVSRT-------------SI--SVTATHQ-GRTASFSAGVDAPS-G---AGPFPAVIVVGGFGA---------------------------------------------------------------------DTAAIKAAGAAVISYDPLAVGREGTP-RSS----KQGAFYTLHGAS----------SPTGLLAAWAWGASRIIDVIEQSGS-----ATIRADGIGVTGCSRYGKSAFAVGAFDQRVALTMPIESGSAGAPAFRSIAGESG----------------AQPLSSAYGEQPWLGDAF-SAYT---------------GNPNALPIDTHQVIGMIAPRGLLLLENPH----VDWLA--ARAGS-VASLAGAEVYKALGA---------------------------ADNISYWSDVQDGTHCASRSEWR-GPIQDNIREHLLKSGNA---PQVFRIS-----AKKAGN--LAQWRDWQTPVLTGGGE--------PTS-------------------------------------------------------     =====>
beuc1-c5bve3   	-----------------------------------------------------------------------------------------------------------MTAEL-------TD-AFGVNLDEA-AVGRV--DL-------------------------------LPVPDGATWGER-RARILELFGDHVYGVSP---PLDVELAERDVAASSGDGI-AV-RQS--RLVMSRA-GREHGVDLLALAPPR------VRVVVVALNFDGNHTVSADPAVRLP---------------------------ATWVPDRAGV-PTRGTTASDEGRGALAASWPLSLLADAGIALVTVYAGDLAPDDAGLGAR----S---LTATL----DLPTSG---APMGTIGAWAWGMRAVARHVH---------GMFDGVPVVALGHSRLGKAALWAAAQDEVFDAVVSNQSGCGGAALTRRRF-----------------GENIAAIT--TRFPHWFTPAFA--------TYA--------GREHELPVDQHLLLAALAPRPVHVGSAAD----DLWAD--PAGEH-AAVLAARPFYREG----------------------------GGSALGYHLRPGAHALTAEDWG----HYAAFLRAHVAPHG------------------------------------------------------------------------------------------------------------     =====>
celju-b3pks4   	----------------------------------------------------------------------------------------------------------------------SGAGCYVPALPAYANLT-AVAALPDPFRAL----------------------NGNRITSKYDWT-CRRAEVNKQAQFYELGEKPEPGSNAVTASASGN-------------SI--TVTVQDA-GRSISFSASIQLPSSG---TAPYPAVIGMGG-SSLNNNG---------------------------------------------------------------L-----LSRGVAVINFNNNDIAEQTNG-SSR----GLGKFYTLYGNN----------HSAGAMTAWAWGVSRLIDALEKTPA-----ARIDAKRLGVTGCSRNGKGALIAGALDERILLTIPQESGSGGSAAWRVSDAQRS--AG----------QNVQTLSQIVTENVWFRSNF-------S-QFA--------NTATRLPFDHHQVMGLVAPRALLVLENTS----MEWLG--NVSTY-TASVAAREIWTALGI---------------------------TDRMGVSQ-LGGYQHCVFPSSQQ-AVLDAFVDKFLRGVSSA--NTNVMRTD-----GNYSVD--RARWINWTTPTLQ----------------------------------------------------------------------     =====>
celju-b3pks5   	----------------------------------------------------------------------------------------------------------------------SGRDCFVPALPAYANLASSIAALPDPFRGL----------------------DGESISSKHDWT-CRRAEVSKQAQYYELGEKPEPDTDAVTAAVVDN-------------TI--TVTVEDN-GSAIAFSATIQLPTTG---VAPYPAMIGMGG-SSLNNTE---------------------------------------------------------------L-----LNRGIAVINFNNNDIAEQTNG-SSR----GRGKFYTLYGSN----------HGAGAMTAWAWGVSRLIDALEKTPD-----SQIDTRYLGVTGCSRNGKGALIAGALDERIALTIPQESGSGGSAAWRVSDAQKA--AG----------QNVQTLSQIVTENVWFRSSF-------A-QFS--------STATRLPFDHHQVMGLVAPRALLVLENTS----MEWLG--NVSTY-TAAVVAREIWIALGV---------------------------TDHMAVSQ-LGGYWHCTLPESQQ-PLVDAFVDKFLKGITTA--DTDVVRTD-----GEYTVD--RARWIDWETPGLH----------------------------------------------------------------------     =====>
chagb-Q2GMN0   	MLSPALASSLLVVLGAAGAHAQQRQALWGQCGGSGWNGPTACVDGAYCFQQNQWYHQCIPG-SDRSPSPTNPPQ----------QSSTLT---T--SRV--TV---APPTSTSPAPGGGGTTC--PATPSGQGSP-VANALNDPFTFH----------------------GGGKVSSKADWT-CRQAEISKLLQQYELGTLPPK-PSSVTASFSGS-------------TL--SISVSEG-GKSISFSVSINNRPSS---SGPHPAIINFGTFGGL-------------------------------------------------------------------P-----VPAGVATINFNNDEIAQQQDQ-SSR----GKGKFYDIYGSG----------HSAGALTAWAWGVSRIIDALELTRA----QTNIDPARIGVTGCSRNGKGAMVAGALEPRIALTLPEESGAGGSGCWRIATWQKN--RG----------ENVQESKQIVTENVWFSTNF-------N-SQV--------NNVNALPFDHHMLAGLIAPRALYVMENTD----MEWLG--KVSTY-GCMGIARKQWEALGA---------------------------LDSFGYSQ-VGGNSHCSFPSSQQGSELNAFIGKYLLNNPNA-GNTNIFRST-----GNQNFD--LNSWSPWTVPKLS----------------------------------------------------------------------     =====>
dict6-b5ybv1   	-------------------------------------------------------------------------------------------------------------------------MQRSERYPKPKDLP-LLYDLPDPFTF----------------------FDGSRGENLEDWDR-RRQEIKELYQFYMYGYYPDTSEEEVDYKVNEN-------------TV--SIRIRKG-NRETTFNARFSLPEEK-NFNPPYPVIVVIGFIGEHI---------------------------------------------------------------------PYITSKGYSVVIFDPYQVAKDDFT--------HQGAFYEIYPYSK--DV-R---KSAGVLMAWGWGASKVMDIICKGAF-----SKIDPYKSVITGFSRFGKAAILAGAFDERFLIVNPHASGAGGTALFRYAS---------------PSSEPFSNLQ-SPSEAHWFNDIF-R-------EFD---------DVNRLPFDQHLLLALCAPRGLIITGGYA----DLWTD--PEGTW-RAFLEAKKVYEFWGY---------------------------AERIRFAYREGGHTICREDIDNL-IDFCEFIFNKTKRGG------------------------------------------------------------------------------------------------------------     =====>
dyafd-c6vy01   	------------------------------------------------------------------------------------MMRILFLVVTWCLV------------------------VFPKLSH---AQDVQ--RLPDPLLFN----------------------NGKKVKSAKDWERR-RQEIRETMTREMYGAAP-QQPKNMRFEVFDLDKNALGGK-ATRKQV--TIHITEK-GRQAKFDLLIYIPNQ---AKQPVPAIIGLNFIGNQAIHPDPGIKLT---------------------------TAWVENSRMFPCGADGRATDACRGVNASQWAVDSILARGYALVTLYREEVASDRKAQAFQ----T--GIHPLYPEL---QQRE---DNFGTIAAWAWALSRGLDYLETD-------RDIDAKRVAVFGFSRLGKAALWAGATDRRFAAVLSNESGAGGGKQFRRGV-----------------GEDINRLC--TAFPHWFARNFA--------HYR--------GKDSELPFDQHFVLSLIAPRPVYLATAED----DKNSD--PQGEF-ATARAADAVYRFLGTNGFP--------DGA-FPPL--NQPL-MGQIGFHIRPGGHDVKMFDWI----QILNFSDLHLQK--------------------------------------------------------------------------------------------------------------     =====>
dyafd-c6w6a8   	-------------------------------------------------------------------MTALTNH------HMKKTAILCMLLAAPFW-----------------------A-AFAQNYDES-KVPHY--TLPDVLKTA----------------------SGKTIRSEEKWEKLRRPEVLRLFEDHIYGQMP-VGYDSIRYALTEDDRPEMDGK-AVLKQI--GVTVFRN-GNSVQINVVLFVPTQ---AKKPVPVFLLINNRGKDL-------------------------------------------------------TDPTRAKKSEFWPAEMVVDSGFAIAAFHVSDLAPDNKD-TYM----T--GVLQKLYPEQ--LKKD---NGMKAIGAWAWGASRVMDYFGTD-------KDIDSKKVIVVGHSRGGKTSLWAAAQDRRFAACVTNCSGNTGAALARRQF-----------------GERISRIN--TTFPHWFNNNYK--------KYN--------DKENALPVDQHMLIALIAPRPVYATNASK----DLWAD--PKGTF-LAVKAAEPVYALYGVKPEL--------PKE-MPGI--DMPVIGPHFGYHNHEGEHNMTAYDWD----KFIRFAKQF-----------------------------------------------------------------------------------------------------------------     =====>
dyafd-c6w6k0   	-------------------------------------------------------------------MKI----------K--LLSTLLLITFASAFAQQ-----AANRPTV-------VA-GFPVNYNED-SVGTY--TLPELLKTA----------------------DGKPVTTARQWTEKRRPELLRLAEENQFGKMP-PKPKDLSFHAFDDGTPAFDGK-AIRKQV--TVYFTKD-TSEHRMNLLIYTPAK--A-VKPVPLLMNISFTAYNQIIDDPGLRVG---------------------------EIWNKEGKK---------VKADKPTPFGKLNVEQFIDAGIGFATVYYGDIEPDFKD-GLT----H--GIRKTYLKPGQTEPAA---DEWGAISAWAWGLSRAMDYFETD-------RQIDTKRIALQGASRLGKTVLWAGIRDPRFKMVIASISGEGGAALARRNY-----------------GETIRHISDPSRYLYQFAPNYH--------GWA--------GRVNDMPIDAHMLVALMAPRPLLLQTGST----DYWSD--PKGEF-LSAVAAAPVYRLFGETAPS--------TSATMPAA-GDTALLMNRLGYFMHEGGHTVLPEDWQ----LFIRYMQKYL----------------------------------------------------------------------------------------------------------------     =====>
fibss-c9rky6   	------------------------------------------------------------------------------------------------------------------FVEDHRSECQIGNIPSS----VNNAKLPDPFMGL----------------------DGKRISSKADWK-CRREEIGAMYEKLMFGTKPRN-PEKVEGSYSGG-------------KL--TIKVTDK-GKSGSFSVKISNAGTK---DKPKPAMIGFGG-GMMGGCG---------------------------------------------------------------SLGNATNGLDIAQITFNPDDVAPES----------GGGMFFQLYNQ------------GQGTIIAWAWGVSRIIDALEKTPE-----AGIDVKHLAMTGCSRWGKGTLAVGAFDERIALTIPQESGSGGASLWRVGAQVNKQKGK----------QFVQGLSSAGTEGKWMISSF-------K-NYD--------GKENTLPFDQHMLVAMVAPRALLILDNAG----QEWLG--EVPSN-YCGQASKEVYDALGA---------------------------TENYTYSQ-EGGHGHCQLPNGQF-DEVKDFMNKFLLGKDAKTGKIDYTKNT-----QTINFK--KSEWIDWETPSLK----------------------------------------------------------------------     =====>
halud-c7npw0   	------------------------------------------------------------------------------------------------------------MDHT-------TS-PAEYLAPSA-LPAQP--ALPDPLVTF----------------------GGGDVETVTDWKQHRRPEIRRAFEHYVYGYAP-ARPS-ID-IETKQTTTVLDGR-ATLTER--TIHIAELPADAPSIDLAVFTPAT--R--DTAPVFLGLNNTGNHGVIDDSAVTIT---------------------------DTA---AES---------GLEDRGVASEYWCLEQLIDRGYGLATFHPADIDPDRDD--PT----D--GIRQYYDDLP--VPSV---AHWGTIATWAWGLQRGVDALSED-------RTVETDGIAVIGHSRLGKAALLAGALDERIDLVVPHQSGTGGVTPARDND-----------------QETIAAIT--EAFPHWFNDVFP--------AFG--------GRPERLPVDQHLLVSLVAPRPLMDTEGAR----DYWTN--PGRAL-DSVRAADPVYELHGETGIV--------NDGLRSGDDAITPETVGRLLQYRRETAHTLNRGYWD----AILDFADIHLS---------------------------------------------------------------------------------------------------------------     =====>
hypje-q7z9n1   	--------------------------------------------------------------------------------------------------------------------GAGGATC--SALPGSITLR-SNAKLNDLFTMF----------------------NGDKVTTKDKFS-CRQAEMSELIQRYELGTLPGR-PSTLTASFSGN-------------TL--TINCGEA-GKSISFTVTITYPSSG---TAPYPAIIGYGG-GSL-------------------------------------------------------------------P-----APAGVAMINFNNDNIAAQVNT-GSR----GQGKFYDLYGSS----------HSAGAMTAWAWGVSRVIDALELVPG-----ARIDTTKIGVTGCSRNGKGAMVAGAFEKRIVLTLPQESGAGGSACWRISDYLKS--QG----------ANIQTASEIIGEDPWFSTTF-------N-SYV--------NQVPVLPFDHHSLAALIAPRGLFVIDN-N----IDWLG--PQSCF-GCMTAAHMAWQALGV---------------------------SDHMGYSQ-IGAHAHCAFPSNQQ-SQLTAFVQKFLLGQST---NTAIFQSD-------FSAN--QSQWIDWTTPTLS----------------------------------------------------------------------     =====>
hypna-q0c4j0   	-------------------------------------------------------------------------------------AGILLLIGSSCTMLGL---------N---------Y-ASLDIDN---KPGAT----PAID--V----------------------S----ALISDPAE--RERLKGLLQETLYGAWP-EDLPVSFGDWRVIVPDYLEGR-GTLEEL--DITIG-----AGDGARTFQLVGAFPYGAVQAPVVIAQTFGSNCATFPEQPVTS--MDGDPCTVHDYGPILGFIVSAVF--------------------------GEYIAEAPVGLYFDAGFAYASFHASDFIPDDADEAGP----A---IDGL-------GGDP---NPGSTLMAWAYGFSAAITALEAD-------DRVGEGRMAVLGHSRHGKAALLAAAWDPRIDAVIAHQSGFAGAALSRSPS-----------------GERLDRMV--ESYPHWLAPQAA--------RYA--------AAPDTLPFDQHHLLALIAPRPLFMGNARR----DVWSD--PNSSY-RAAIAASEVWKAYGETGLK------------D-DI--THFDPAADIAFFLRPGGHSIVDDDIA----AFLAFLSAHMGETGELPNRMTAP---------------------------------------------------------------------------------------------------     =====>
lepmj-e4zh04   	---------------------------------------------------------------------------------------------------------------------NITCPPTPNPMPKASAFP-SVKTMPDPFF---------------------YLDGKTRVQSKDEWVQCRQPEILKLLQEYQYGYYPDHSQETVSATRSGN-------------TL--TITIAAG-GKTASIAATLTLPSG----SGPFPVIISIGGMDVK-----------------------------------------------------------------------SYTNAGIAVAAFDYTKVAADSNS--------KSGSFWTLYN--------G---KDIGVLTAWAWGFHRVLDGIEL-KV-----PEIDATKSGVTGCSRLGKAALAAGLFDKRIAVTMPMCSGVQGAGPYRY-S------------LS-GQGENLENAK--SGAGWWTSSGI-S-------QFV--------GKSTQLPYDAHTIVAAIAPRAVILSQNSG----DQFTD--SKGTAQITFPAAKVVYKWLGV---------------------------GEKLGMSIPSGGHCDQNG----Y-ADVLPFVQKVLQGKSTT------RDYDD------LKTWKAMPEAYPWGTDLPRDVGTMALYEYFRTESSCELYMFCARHSSLSTTSLLTSLQYCKKRQWLARRLP------------------     =====>
marmm-q0amv5   	----------------------------------------------------------------------------------------MMLIGCVS--MVL---------P---------L-VPTEN-D---GSPAR----PAID--T----------------------S----GLVPDEWEAGRAALRRRFEVEVYGDWP-GVAPASVSDQRLVEAGAYDGL-GRIEEW--DLDLG-----TVQARLVVILP---EAAAAPAPVIVMQTFCGTRTALGGRGDLSAPLNPAARECSEVNGWQGHLMTGVF--------------------------GRHIAEPPIETILARGYALAFLHPGEIVPDNPDDAPA----A---LDAL-------MPGR---ES-GAIIAWAWGYSRAIDALESD-------PRLDPARMAVWGHSRNAKSALVAAAFDTRIDLVLAHQAGTGGTTLTRSFA-----------------GESVAQIT--GTYPYWFNERYA--------SYG--------NNEDGIPLDQHELIALMAPRPLLIGGAWR----DAWSD--PQGSF-RAALGANPVYALYGSEGLR------------QPSL--GAFDPEADIAVFMRRGLHGVQPSDWH----AFLEFLDAHFHHSQ------------------------------------------------------------------------------------------------------------     =====>
marsh-a4auf2   	---------------------------------------------------------------------------------------------MTYS-SF--------------------A-QSTPIYDEN-KVPNI--QVPNPLFRF----------------------NGKKVNNTRKWIKKRRPELLKFFENNVYGSVP-GKLDEVSFKVVEQTNNAYNGR-SIRKQV--EVVLTKN-EHTLRFTVLIYLPKD----KSKSPLFLGYNFYGNHTITNDPEVIVT---------------------------EAWSRNNND-FGITNNTPTEKSRSARVNRWAIEKILDAGYGLATIYYGEVDPDKD--DFS----D--GLHSLFYSSG-QKPKT---DEWGSIAAWAFGLSRAMDYLETD-------IHVDASKVVVFGHSRLGKAALWTGATDERFAGVISNNSGCGGATLSKRKF-----------------GETIGIIN--KRFPHWFCDNFE--------QYN--------ENEEALPVDQHQLLALVAPRPLYVASAEK----DRWAD--PKGEF-LSAFYATPVYALFGKEGIT--------SKE-MPKV--NHPI-QNTVAYHVRTGKHNVTDYDWE----QYIKWASRFVK---------------------------------------------------------------------------------------------------------------     =====>
opitp-b1zmf4   	-------------------------------------------------------------------MRN-------------VLAALSLLFTLTSM-QA--------------------T-SRPARLDDT-PPPAY--TLPDPLVGA----------------------DGTRVHDRATWQHRRRPELLQLFAREVYGRTPLGRPEGMVFKVTTMEHAALGGA-ATRKEV--TVRFGRD-PNAPSMQLLLYVPNAVIARAERAPVFLGLNFYGNHTVHTDPAIALS---------------------------ARWIPAEAP-NGA-NHRATEAARGSDAQKWPVEQILARGYAVATVYCGDLCPDRPD-GLN----A--SVASWLDAAAGDQRAP---DAWGAIGVWAWGLSRALDYLETD-------PLVDASRVAVHGHSRLGKAALWAGAQDDRFALVISNESGCGGAALSKRIH-----------------GETVARIN--TVFPHWFARNFR--------RYD--------DHEEALPVDQHELLALVAPRPLYVASAED----DDWAD--PRGEF-LAVKAAEPVFRLFGQTGPS--------GED-VPRV--NEPS-GGALRYHIRPGPHGMTAQDWA----FYLAFADEWLKSALPAREPQR-----------------------------------------------------------------------------------------------------     =====>
opitp-b1zpb1   	------------------------------------------------------LGLSVPVDLPPEET--DPSRPAGLKR--NANGN------GWTD------AEGHFAVRS-------AW-GNWINYDLA-KAETG-SPLPDPLRLE----------------------NGELVKDAATWRERRRLEVLESFQREIYGRIP-QNTPTVTWAVVETDEHALDGR-ARMKRIVGSIDNSSYPEAKPSIGLTLYLPAE---AKGPVPVIVAITFDFPPGFRFPGA--------------------------------------------------------PEGPSALEQTLAHGWGYARFNPVTVQADDGA-GMK----E--GIIGLVNKGQ--PRAP---DQWGSIAAWSWGLSRIIDYFETD-------ADVDAKRLGVEGHSRYGKTALVAAAYEPRWAIAYASCSGEGGAKLHRHDY-----------------GENVDIVASSGE-YHWMAPNYL--------KYA--------GRWDDLPNDQHELIALVAPRPLLVTGGTT----DLWPD--PVGMF-KACVAAGPVYRLLGKKDLG--------RTE-MPAP--NEDVIDGDLAFRLHEGGHF-DLFDWP----TFLKFADRYLGKSEAMVGSRNAN---------------------------------------------------------------------------------------------------     =====>
opitp-b1zpu8   	-------------------------------------------------------------------MKRYRSP----------LLVFVVLA-ATLSAFAHSGRQDGSRIPLVYDVENTGAHYRAPSFPDFDWLP-IVRPLPDPFRFE----------------------NGTRSTSFRNWE-RRRNEIKAAIEKYEIGRKPDASDLTIAATYTPPAAGTSIGQ----LVV--VVTRNSN-AKTVTLTSKVFIPQGW--GEGPFPALIPMTFFASPTGPN-------------------------------------------------------------YGSLAAVLSTRPIATVDFVHNQVTRYGGG-DKT-----PDPFYQMYPEFK--APGGPVDSDSGQYAAWSWGVSRLIDGIVLASQQEENPLPIDPDYLAVTGCSYAGKMALFAGALDERVALTIPLESGGGGAPSWRVSQEIEGDRV-------------VEALT--HTDRRWFA-SQLFQF------SG--------NNVYKLPYDHHELMAMVAPRALLVTGNTD----FLWLS--NRSNY-VTSRATQRIYETLGI---------------------------GDRFGFYI-DGGHGHCQVPASQY-PAIANFVDKFLFGVEDADTQVRVHPYG-------EDFD-------------------------------------------------------------------------------------     =====>
paesj-c6d6m9   	------------------------------------------------------------------------------------------------------------------------MSNRKSHYASPADLP-LVKELPDPFVF----------------------EDGRRVQTLADWEE-RSQELQDLFHYYMYGYMPDASGEQVTYEKTEQ-------------GL--RVHVTRG-DTEDSFTARISFPPEDGVIGGTYPVIFTIGSLEGWRPDGQD-----------------------------------------------------------ATNYVEQANKRGYAVVTLLPQEIASDNAE--------RTGAFFKLYPYAQ--APDQ---NDVGIFIALGWAASKVLDAFEQQLY-----PEIDAARAAVTGFSRWGKASLVAGMTDKRFALVNPHASGAGGMAPFRYSFEGKGYPWG----IA-GRSEPLEALQ-SEGEAHWFSSVF-R-------QFS---------DLAALPFDQHELAALIAPRALLLTCGYS----DDWIN--PEGMY-VSYAEAEKVYRFLGA---------------------------EDQIGIAYRHGGHNRTQEDIDHL-LDYCDWRLKGIPPVHSD------FKSCL------YEPWK------------------------------------------------------------------------------------     =====>
palpw-e4t287   	---------------------------------------------------------------------------LGIKS-LRPGPS------G----------------NE-------NA-PNHANYDES-IANPC-PQLPDILTLK----------------------NGKKVTSADMWWKLRRPEIVEDFEREVYGRLP-KKIPAVTWTVKITDREFVGRTPVIAKQLVGHVDNSEYPLINVNINMVVVLPTN---VKGPVPVLIMFGPASLPSPAQPSAEDLAKINAAFREMMIKN---NPEMKAVLDKYPAYAPITKLA-G-----PSFFAPPTDGNSAPTEQLLAAGWGYAAVDPSSIQADNAA-GLT----R--GIIGLVNKGQ--PRKP---DDWGALRAWSWGAARALDYLETD-------PLVDAKKVGIEGVSRYGKAALVTLAFEPRFAVGLIGSSGKGGATLHRRVF-----------------GEAVESLTG-GE-YYWMAGNYM--------KYGASAATFGSKTGCDLPVDSHELIALCAPRLTFISYGIPEKGDAKWLD--QTGSY-MATVAAGAAFKLLGVKDIG--VSNDYLKEK-MPPM--LTGLLEGELAWRQHDGGHT-DAPNFQ----HFIPWASKMLKYNKTAK---------------------------------------------------------------------------------------------------------     =====>
pedhd-c6xtt3   	-------------------------------------------------------------------MKNT-----------I-IISLCYFQLSFCL-AQ--------------------T-KKDYLQDES-KVENY--TLPALLRLN----------------------NGKQVKTTKEWENSRRPELLKTFAEEVYGKTM-ASSAALPYRIVSVNKNALNGI-ATRKEV--QILLSKS-KGARQLNLIIYTPNQ---IKEPVPVFLGLNFSGNQEMNTDTGITIT---------------------------KYWTRFAGEPGFSSAGIANEKSRARSEGRWNVELILSSGYGVATAYYGDLQLDRKD-IYS----LPDDFNKWYDPQKELKPDS---SQWGAIGIWAWGLSRALDYLEKD-------PSVNAKKVAVIGHSRLGKAALWAGAQDKRFAMVISNNSGEGGAAITRRKF-----------------GETIKRIN--TSFPHWFADNFK--------KYN--------DKEASLPIDFHELMALIAPRPLYVASASE----DLWAD--PVGEY-TALFYAGDIYKLYGFETFK--------DRN-PPAT--DTPVRAGVLGYHKRTGKHDITKYDWE----QYINFADLYLK---------------------------------------------------------------------------------------------------------------     =====>
pencw-b6h3u7   	-------------------------------------------------------------------------------------------------MM--FL---YPVLLSLISSGALAATC--PSLPSSPQLQ-SITTLPDPFSWH-------------------PLQHSGRVTTLSDWQ-CRQSHISTLLQQLELGTKPPA-PSSVTSTFSQN-------------KL--SITASNA-GKTISFTATITYPSSG---AGPYPAMIAYGG-LSI-------------------------------------------------------------------P-----LPPGVATITFDNSQIAQQNDQ-SSR----GKGLFYTLYGAD----------HPAGAMMAWAWATSLIIDRLEATPA-----ARINTARIGVTGCSRNGKGALVAGAFDSRIALTVPQESGTGGSGCWRLAAASEG--AP----------QDVQTAGEIVQENVWFSAAF-------N-TYA--------NDVDRPPFDHHMLAGLIAPRGLVSIDNAG----YQWLG--PWSSL-GCMGTARLIWQAMGV---------------------------PDRMGYSM-STDHPHCSFPDQQR-GDLFAFINRFMLGMEV---NTTVQKNY-----AGIAFD--SKPWVNWQVPTLT----------------------------------------------------------------------     =====>
pirsd-d2r0n7   	-------------------------------------------------------------------MLRYPCR------ALAITQALALLFAMNLSLA---------------------S-AEEFPTFDQ-LQPSA--ELPALLIDE----------------------AGKPITTAEAWSKK-RDTLKAQFQHWMYGRLP-PKPAQVKYETLFTDEKALGGK-ATVREI--RISFVEP-ALSKRQHVLLVTPNG----VEKPGVFIGMNFCGNHTVLPDTKIALP---------------------------EGWVGKGCV--GVENERATDAGRGAQTEVWNAELIVSRGYALATFYSGDIDPDTPD--L------ADGIGPAFYKPGQTAAEG---DDAGTIALWAWGFHRVADLVTTEFK-----DTIDASKIASVGHSRNGKTALLAAAMDDRFSIAIPSQAGCGGTAPSRGKV-----------------GEQVKQIN--KNFPHWFCDNFL--------LFN--------EHPDLLPFDQHALVAICAPRAVLFANAEE----DTWAN--PMGQF-EVLQAAEPVFKLLGTSGLA--------EAK-EPVM--NQ-LVGGRLGFFYRPGKHSMSTTDWT----AYLDFADQQWK---------------------------------------------------------------------------------------------------------------     =====>
plal2-d5su74   	-------------------------------------------------------------------MKNLVSIKLDLKNSVVPVLWLCLLATAVESAEPLSTNSQVGTQEA-------SP-GTPAINWDA-YPEST--ALPELLKLK----------------------NGTTVKTPEDWMKRRRPELQELIQREMFGYLP-AAQP-FTATVTKMVPDALAGK-ATLKEI--SLNFTQLPPEAPEIRLALWIPNR--HPAGKIPVFLTLNYCGNANVTTDPQTTIH---------------------------TDRYCSKKE---------WIGQRGGQADFWCVEQVIDRGYAFATYHESDTKADKNE--WT----D--GLFPYLKSDQ--VPAG---SQPATIALWAWGLLRCVDQLAQE-------PQLDPRRICLLGHSRRGKTVLFAAAMDERIALVVPHQSGTGGMALSRENN-----------------QETVERIN--RVFPHWFCGEFK--------KFG--------GNEPRIPFDQHAVASLVAPRLLLDTEGDQ----DAWAN--FPRSL-ETLKAIDPVWKLLGKTGLV--------GSGLITSVTEIQPGKVGELLQLRLPEKHTLTNEFWT----GILNYADLMLPKSTTP----------------------------------------------------------------------------------------------------------     =====>
podan-b2a9c4   	-------------------------------------------------------------------------------------------------------------------------------------------SLPDPFLPLKYTTTDNAAGSSTFARDVMTGNAPNRIRSRAEWYQCRQPEILQFLQEYQFGYYPDPTQEKVEATRSGT-------------TL--QITVTGPQNKRGSFRATIQLPSGA-SSSRPAPVVINIGGMQNQ-----------------------------------------------------------------------PYLQAGIAVAQFDYTTVAPDSNS--------KTGVFWSIYN--------G---RDIGVLTAWAWGFHRTLDAIQL-TV-----PEIDPYRVGVTGCSRLGKAALVAGLFDKRITVTMPMSSGVQGLGPYRYFT------------LS-GQGENLENSK--QGAGWWSNSKL-G-------SFM--------NHHENLPFDAHTIAAAIAPRALIIDQGTG----DQFVN--SKGTATVIFPAAKVVYDWLGA---------------------------GDKIGINVRSGGHCDMSG----L-YVFR------------------------------------MPDQFVWTEMLTEAVT-----------GSCP---LCKRSFSTPPPPETFTAWAPTTHPWPHRTLGQLPFRRRRLGNSR-----     =====>
podan-b2api8   	-----------------------------------------------------------------------MVH----------LASALLVA-S--AAF--AV---AAPANE----IFERQTC--SV-QANYPTQ-NNSKLPDPFTSA----------------------SGQKITTKADFE-CRQEEISKIMQQYEFGVYPPP-PDSVTGTMSGN-------------NI--QVRVTVG-SKSITFSAGIR-KPSG---SGPFPAIIGVGG-ASI-------------------------------------------------------------------P-----IPSNVATITFGNDAFGAQSGM-GSR----GRGQFYDLFGSS----------HSAGSLTAWAWGIDRLIDALEKTPA-----AGIDTTRLGVTGCSRNGKGAFVAGAFVKRIALTIPQESGAGGAACWRISDQQKS--SG----------ANIQTASQIIGEQPWFSKNF-------D-AHV--------RSITNIPQDHHFLAAMIVPRGLAVFEN-N----IDWLG--PVSTT-GCMRAGRQIYKAYGV---------------------------PNNMGFSL-IGGHNHCQFPSGQN-SELNQYINYFLLKSGTA-PG-SVERST-------SNAN--TDAWYPWAASAPTLS--------------------------------------------------------------------     =====>
prer2-d5ey31   	------------------------------------------------------------------------MR----------LISTIVL----CCAALCAQAQQGGQLPLAYQVENTGAAFAKPAMPAANELP-VIKDLPDPLKGV----------------------N-----GFSDWA-RKRSEIAALIQHYGIGEKPAVKKENIKARMSGD-------------TL--IVDVTVN-GQTLTLTSEIRYPK-T--GKAPYPLMIGSSMIALP---------------------------------------------------------------------RQLFEDRPIATMNFHEKQVNDYGQW-GKH-HERGEHNFDRLYPQL----------KDNGAYSEWAWGFSRLIDGLELLGPE---VTKIDTKRIGVTGCSYAGKMALYCGAFDERVALTIAQEPGGGGAAAWRYSHLQD---S-------------VENLD--KTDYHWFLESQLTNF------HG--------DSVYQLPYDQHELCALICPRALLLLGNPD----YKWLA--DDAML-VSAKAAKKVWERFGI---------------------------ADRMGWSI-VGGHGHCQLPECQW-PEVLAFIDKFLLGKDTKTSDIRVYS---------KTLI--K----------------------------------------------------------------------------------     =====>
rhom4-d0mg25   	---------------------------------------------------------------------------LGIDR-LRPG----------------------------------PS-PQEANTDEA-RVPPY--TLPDPLVTF----------------------DGRRITTPREWWEVRRPEIVAAFDREVYGRVP-PDVPSVRWEVVSTTRTVQDSIPVVVKKLVGHVDNSAYPAIEVHIDMTLVTPAE---ADGPVPVILHFSFVWPECMRPPAP---------------------------------------PP----------------GQRTWQQQVLARGWGYAELYPTSYQADHGA-GLT----A--GIIGLTNRGR--PRRP---DDWGVLRAWAWGASRALDYFETD-------PTVDARRVGIAGLSRFGKAALVAMAYDQRFAIGLIGSSGAGGAKLLRRVF-----------------GEQVENLASPAE-YHWFAGNFL--------KYA------GPLTPDDLPVDAHLLIALVAPRPLFIGAGNPEV-EGHWVD--ARGTF-LAAVHAEPVYRLLGKVGLG--------TDI-MPPV--GELLARGEIAFRMHEDGHT-NGPNWP----YFLEFASRYFEPDRNDQ---------------------------------------------------------------------------------------------------------     =====>
solue-q01ym8   	-------------------------------------------------------------------MRKS---------------IGLLLTLCWCA-SA--------------------Q-KTEAITDEA-KVPAY--TLPAVLALK----------------------SGQPVTDAKSWTTKRRPEILAIYEAEVYGKSP-ARPPKLNYEVKSVEKQALGGK-ATRKIV--TIFFSDK-PDAPKMDLLLYLPAA---AAKPAPVILGLSFGGIHTVANDPGVPLA---------------------------EQWTRDNRK------QPSAEKSRGGEASRWQVEKILAAGYGLATVYYEQIEPDFAG-GMK----Y--GIRPLFFKPGQTEPEP---GDWGAVAAWAWGASRAMDYLEKD-------KDVDARRVGLIGHSRLGKAAIWAGAQDARFTFIISNESGEGGAAISRRDY-----------------GERTTALN--TRFPHWFDGNYK--------KYN--------DRENEMPFDSHMALALMAPRGLYVASAEG----DQWSD--PKGEF-LGAANASPVWELFGKKGIG--------TMT-MPDL--HEPVGD-SVRYHIRAGKHDVTEYDWE----QYLKFAKAQWGR--------------------------------------------------------------------------------------------------------------     =====>
solue-q027r8   	---------------------------------------------------------------------M----------T--RIPILAILFAGAALAQA-----DKPPAAV-------VA-GIPVNYDET-KVGAY--KLPDPLVLT----------------------NGKPVRDAKTWTEKRRPEIVKLFEENQYGRAP-GRPAAEHFVVSENAAPAFDGK-AIRRQV--TIYFSAA-ADGPRMDLLLYLPAN--AEAQPAPVLLNAAFSANSNTVADPGVKVG---------------------------EVWGRDKKK---------IPASQGMSFGKINVARLIDAGFGFATVYYGDIDPDFPG-GVP----L--GVRALYLKSGQAEPAP---DEWGAIGAWAWGLSRALDYLETD-------RGVDAKRVAVTGVSRLGKTVMWAGAHDTRFALVIASCSGEGGAALSRRNY-----------------GETIAHLTEPTRYPYQFAANYA--------KFA--------HNVSEFPVDANLLVALIAPRPLLLQTGDK----DFWSD--PKGEF-LAARAADPVYHLFGKQGIE--------TDE-MPPA-G--TPIFHTIGYYMHAGGHGTIPSDWD----QYLAFLRMHLKP--------------------------------------------------------------------------------------------------------------     =====>
sorc5-a9ev31   	----------------------------------------------------------------------------------------------------------------------SGASCPKPTLPAASSLP-VFDTHHDPFLSL----------------------SGSRITKKSEWA-CRRAEIKSQVETYESGSKPVVSKDNVTGQFSAN-------------RL--TVSVNDA-GKSASFSINISRPSGA--PAGPIPLVIGIGG-NNLDTSV---------------------------------------------------------------F-----TQNGVAMATFDNNAMGAQNGG-GSR----GTGTFYNLYGSN----------HSASSMIAWAWGVSRIIDALEKTPG-----ANIDPKRIAVTGCSRNGKGALTVGAFDERIVLTIPQESGAGGSASWRVSQAGAN--AG----------ENVQTLSSAASEQPWFRANF-------GSTFG--------NRVTSLPFDHHMVMGLVAPRALLVIDN-R----IDWLG--INSTF-TAGSIAQQIWKGLGV---------------------------PDKMGYWQ-TAAHAHCAFPSSQR-AALDAYVKKFLVGGGTA--DTNLLKGD-----GA-TAD--LNRWMKWTAPTLQ----------------------------------------------------------------------     =====>
sorc5-a9fw17   	----------------------------------------------------------------------------------------------------------------------PGAGCTVGPMPSVASLT-ANSKLPDPFKKM----------------------DGSRIASKSEWA-CRREEILQQAYKFIYGDKPVPAKGSVSGTVSTS-------------RI--TVEVKDG-GGSGSFNLTVNMNG----ATAPAPAIIGYGGLSGM-------------------------------------------------------------------P-----VPSGVATITFTAIES---TGT-SGA----KNGPFYSVYGSD----------HPAGYLTAQAWQISRVLDVLEQNPG------VIDPRRVGVTGCSRWGKGAFVAGVLDNRIALTIPVESGLGGTIGLRLVEVLDSYSGS----------EWPY---HGISYVRWLSEVALGQFTTGNNAGA--------DNTNKLPVDMHEMMGLIAPRGLYIVDNPS----TMYNGLDRNSAW-VTANVGKMIFEALGV---------------------------GNHIAYTG-AGG-SHCSWRSQYT-ASLNAMVDKFLKGNNAA--ATGNFATD-----LPNKPN--HMDHIDWTPPTLAGEL-------------------------------------------------------------------     =====>
sorc5-a9fwe6   	----------------------------------------------------------------------------------------------------------------------ASADCEVAALPEASALP-KVSKLPDPFTKL----------------------DGTSVSTKAEWH-CRRQEIRKQAEKYIYGEKPT--PDVVTGTVTEN-------------KI--SVHVEAQ-GKKIDFSADIVLPSKG---EAPFPAIINVGGKGGFGGIT---------------------------------------------------------------LGESRILDQGVAVIYYNHNEIGREGTA-EQSRGKPNPGKFYDIYGGD----------HSAGLLMAWAWGASRILDVIQASGG-----DIIDPTGIGVTGCSRNGKGAFAIGVFDDRIALTIPHETSTAGVPAYRI-ADVLG----------------KERTDHNYFGLNWLSNNF-EPFVFK--NNA--------SNAVKLPIDTHALIAMMAPRGLLVLENPH----QAQMG--APAGH-TATAAGAAVYKALGV---------------------------EKNVSYHSKVAETAHCSYKNEYT-DVLAKSIARFLKHEGEA---PGEFVVG-----SGGSLS--MADWVDWQAPTLE----------------------------------------------------------------------     =====>
sorc5-a9fya1   	----------------------------------------------------------------------------------------------------------------------------MPTLPEPSGLTEVNRKLPDPFTFF----------------------NGTKVTTKEQWE-CRRKEILAMAAKYLYGPVPPE-PDEVTGTVSGG-------------TV--SITAKAG-GKTETFSASISGSGSV-------IALKLSGG----------------------------------------------------------------------------IFPSGHKTLSFGSG----------------FEGKIRNLFGLS----------E-VNTNIANGWMIDRVMDVLEQNPG-----SGHDPTKVMVSGCSGCGKGAYLAGVFSRAP-VVVIVESGGGGVANLRQAEWFRHGEGGSVWQCSDAKPQSIDNLEDNGICGPWVTSAA-RWL----RSDP--------SKVYNLPFDTHMLLATIAPRHLVHFTNAN--GRNSWCHLGGTCEA-LSAWAAKPVWKALGV---------------------------PERMGFQM--YSANHCGASGSQT-ALAGEMFKRAFEGNTSA--NTDVMGILDNGVQQPVSEW--EDMWIDWDMDTVLQ---------------------------------------------------------------------     =====>
spild-d2qq29   	---------------------------------------------------------------------------LGIKK-LRPGPS------G----------------NE-------AD-PNHANYDES-KAEPC-PQLPDVLTTR----------------------NGKKVTTPDQWWKQRRPELIEDFEREMYGKLP-ANLPKVNWIVKVTDNEFVGRIPVIAKQLIGRVDNSAYPLINVNINMVLVLPQN---VKGPVPVMMMLGFPALPAPAQPSPADLEKLNVAFKEMMIKS---NPEMKAIFDRYPAYMPITRLP-G-----ANFFAPPPTGDSPPTEQLLAAGWGYCTIEPGSIQADNGA-GLT----R--GIIGLVNKGQ--PRKP---DDWGALRAWAWGASRALDYLETE-------PQVNAKQVGVEGVSRYGKAALVAMA