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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....
9acto-b5i1i1   	------------------------------------------------------------------------------------------------------MKPTI--AGFEYQRVPV---AED-----VSLQVAV-------GG--T----GT---PVVLLHGFPQTHLMWRHVAADL-AV-DHAVICPDLRGYGDSDK--------PRED-S----PDTYSKRTMAADVVTLARRL-----G-------H--P-RFALAGHDRGALVAFRAGLDHPDA------------------------------VSHLACLDILPTLDMWNAL-----H---GTSAAVAFHLYLMAQPPGLAERMISASA----DAFFGH-FLDVWANRPD-----AIPPQVRAEYLRACREA---VPSIVADYRAS--AGVDVEHDEADRAA---ENRLGMPVTVLQQDW--GAALG----------YEATALWQ--------------------------AWADD--------LRHTT-VSCGHFMAEEAPADVAKALRELMLRGE--------------------     =====>
9acto-c4ri15   	---------------------------------------------------------------------------------------------------------MF--QGFKDERI-----NVG----EVDLRVRH-------AG--E----GP---PVLLIHGHPRTGSTWHRVAPRL-VELGHTVVCPDMRGYGRSGK--------AEIRPD----HAQQSKRAVARDLVHLMTSL-----G-------H--S-HFAAVGHDRGCYVALRMALDHPDR------------------------------VSRLVVLDGIPISEALARC-----D--A-TFAHDWYHWFFFAQPDKPE-RAILADP----DAWYGA-A----RP--D-----AMGAENYQEFRAAIHDP-PTVRAMLEDYRAG--LSIDREHEEADRRA---GRTVRCPTLFLWSTR--DDL--------VELYGDPLAVWQ--------------------------PWAD--------DLRGAP-IESGHHVAEENPLALAAAVHHFLS-----------------------     =====>
9acto-d1xj46   	------------------------------------------------------------------------------------------------------MTPTG--TGFDYRRITV---ADG-----VALNTAV-------MG--S----GP---AIVLLHGFPQTHLMWRHVAADL-AA-DHTVICPDLRGYGDSDK--------PLDT-D----GTVYSKRTMAADVVALAGAL-----G-------H--E-RFALAGHDRGALVAFRTGLDHPGR------------------------------VTHLASLDVLPTLDMWDVM-----H---GVGAAVGFHLYLMAQPPGLPEQMIAAAP----DAFFGY-FLDLWSGSSG-----AVPDDIRAAYLRACREA---VPSIVADYRAS--AGIDIEHDQADRAA---GNRLRMPVTVLQQDW--GAALG----------FEAAALWS--------------------------PWAAD--------LHHAT-VTCGHFMAEEDPAEVTRSLRALMRR----------------------     =====>
9acto-d1xn59   	---------------------------------------------------------------------------------------------------------MF--EGFELTRC-----EGN----GARLRVRH-------GG--G----GP---PVLLLHGHPRTHATWHRVAPLL-AAAGHTVVCPDLRGYGESDK--------PPSDPE----HRPYSKRAMADDCLAVMRRL-----G-------H--E-RFAVVGHDRGAYVATRLALDHPHA------------------------------VSALSVLDAVPLGEALHRC-----D--A-RFAARWWHWFFLGQTDKPAERLIDADP----DAWYGG------TP--G-----QMGAEAYEDYRRAIHDP-ATVHAMCEDYRAG--LGVDREHDDTDRRA---GRRIRCPLQVLWATR--DDM--------ADLYGDVLDVWR--------------------------DWAGD-------RLDGGP-IASGHHIAEEAPAELVTLVRGFWQAAGAHA-----------------     =====>
9acto-d3cwx4   	-----------------------------------------------------------------------------------------------------MHPLSI--PGFDVHRVQV---DDG-----VTVEAEV-------GG--S----GP---PVVLLHGFPQTRLMWRHVAADL-AA-DHTVICPDLRGYGASDK--------PAET-G----PEVYAKRTMARDVARLATEL-----G-------H--E-RFTLAGHDRGALVAFRAALDHPEA------------------------------VARVLLLDILATLDMWDAM-----H---GVSAAVGFHLYLMAQAPGLPETMIRSSA----DAFFGY-FLDAWANDAD-----AVPAAVRRHYLDSSARA---VPSIVADYRAS--AQIDVAHDSADREA---GNRLAMPVTVLQQDW--GAALG----------YHAEGLWR--------------------------AWAPD--------LRHRT-VSCGHFMAEEDPALIAAEIRALASR----------------------     =====>
9alte-a3j9g2   	-------------------------------------------------------------------------------------------------------MTLG--ANFRSIKVL----TDD-----IEINVAH-------GG--S----GP---PLLLLHGYPETHVMWHAVAPAL-AR-HFHVVCPDLRGYGDSDK--------PKGGPD----HSAYSKRAMAQDMVEVMASL------------GH--Q-TFMVAGHDRGARITHRMALDHPDR------------------------------VLKACIMDIAPTLHMFRNT-----D--Q-NFATGYYHWFFLIQPNGLPEHLIGADP----GYYLTE-KLKHWSAP----GAV-FSDEAVAEYVRCFSKP-EAIHASCEDYRAA--ATIDLKHDENDLE-----RKIQCPLLVLWGSR--GFVNRT---------YDVLDVWR--------------------------ERG-T-------QVQGKA-LDCGHFLPEEVPEAVIAELLAFFNPVHE-------------------     =====>
9bact-c0aed1   	-----------------------------------------------------------------------------------------MTAAQPSPT-MTNE--RL--AGFTQHKID----TGE-----AVINTFV-------RG--S----GE---PLLMLHGYPQTHLMWHKVAPAL-AE-NYTVVLTDLRGYGDSSC--------PPDGEN----HLGYSKRAMARDQVEVMRQL-----G-------F--E-RFYLAGHDRGARVCHQMLLDYPEK------------------------------VRRAVLLDIIPTSEMYART-----D--K-EFASIYFHWFFLILPNDLPEKLLAGNP----EAWIRR-TAGSLGSR-G-GG-DAFPEDVMAHYVEKFSNP-AVIHATCEDYRAG--ATVDLEHIAAA-GA---RGKIPVPLLVLWAAP--YLR--------NLSEPDVLGIWR--------------------------QHAA--------DVTGYPVPGCGHFIAEEAPEDTIKAIRHFFDDKG--------------------     =====>
9burk-a2w6y6   	--------------------------------------------------------------------------------------------------------MSF--DAFAPFRVT----VQD-----TEIFGVK-------GGA------GP---PLLLLHGHPQTHMIWHRVAATL-AK-HFTVIATDLRGYGASGK--------PPTDAQ----HTPYSKRAMAADQVAVMRHF------------GF--D-HFHLCAHDRGARVAHRLALDHAHA------------------------------VDRMMLLDIAPTLAMYEKT-----D--R-AFATAYFHWFFLIQPAPLPETLIGDHT----DAYIER-VMGNRSAG----LAP-FAPDALDAYRAALAQP-GAVHAMCEDYRAS--ATIDLEHDRADLER---GNKVACPLRVLWGAD--GIVGRC---------FDPLDEWR--------------------------RVA-R-------DVSGRA-LECGHYIPEEAPAALVDEMLAFFDAREAGA-----------------     =====>
9burk-a2wg62   	MRPRPDCDGAPPA------------RI---NPGPKNCPSRCSVS------------------------LA----DWFLKVTTGMNSRKPYRLIHQLDSNRDQETTMF--EGFRNVSAT----VDD-----VPIHAVC-------GGR------GP---ALLLLHGHPQTHAIWHKVAPTL-AE-HFTVIAADLRGYGDSGK--------PPGAAD----HANYSKRRMALDQVELMRGL------------GH--R-RFAVIGHDRGGRVAARMALDHPDA------------------------------VTHLVTLDVAPTLAMYEQT-----S--F-DFARAYWHWFMLVRPAPFPETLIRADP----DLYLKQ-TIGARSAG----LAP-FTADAYAAYLRCLSDP-DTAHGICEDYRAS--VTIDLEHDRATLAS---QQRIGCPFMALWGAH--GVIEQC---------FDPLAEWR--------------------------AYA-P-------DVIGGA-LRCGHYIPEEAPEQLLERVLPFLTE----------------------     =====>
9burk-a2wja0   	------------------------------------------------------------------------------------------MTS-------------S--PASRGSTSK----QAA-----SRFA----------GE--S----AGPDRRCCYRTAYPQTHVAWRLIAPAL-SK-SHTVVVPDLPCYGDSRI--------LDDR-------SRWTKRRVANALVGLMDRL-----G-------Y--E-RFSVAGHDRGARAGYRLALDHPAR------------------------------VCAYVSLAVVPTLDAFATI-----D--D-TFALNAWHWFFLAQPADLPERMLAADP----DAYIDT-ALAKMAGG----L-DRIDPAALDAYRVAFRNP-HVRHAICEDYRAA--ASEDLDHDASDFAA---GRKLACPVLVLWSAR--EQKAAR---------TSPVDIWS--------------------------RWAE--------HVTGNE-LPGGHLLAEDAPNEVLSALERFLV-----------------------     =====>
9burk-b1fma7   	------------------------------------------------------------------------------------------------------M--STTTPSIVHHTVT----ANG-----IRQHFID-------AG--S----GP---VVVLLHGFPETSFAWRFQIPVL-AQ-RYRVIVPDLRGYGETDK--------PA---------AGYDKRNMARDLVALLDTL-----G-------I--G-RIALVGHDRGARVATRFAKDFPER------------------------------LERLVVMDNVPTRIVAQNM-----T--A-QTARAYWFFLFHQVA-DLPEALIAGKE----AEWLSY-FFSDWCYNPH----AI-SGEAFDTYVRAYRRP-GAVRGALADYRAN--AEDV-KQDL--ADA---DVKIACPTMAIWGEDFYAVGKM----------FDMKSVWE--------------------------SMATHL--------RAEPIAQCGHLPQEEQPERVNALLLDFLKSWEG-------------------     =====>
9burk-b1fvy3   	---------------------------------------------------------------------------------------------------------MF--EGFSDASAT----VDR-----VRIHAIQ-------GGR------GP---ALLLLHGHPQTHAIWHKVAPAL-AE-RFTVVAADLRGYGDSGK--------PPGDPA----HANYAKRRMALDQVELMRGL------------GH--E-SFAVIGHDRGGRVAARMALDHPQV------------------------------VTRLVTLDVAPTLAMYEQT-----S--F-EFARAYWHWFMLVRPAPFPETLIRANP----DLYLKQ-TIGARSAG----LAP-FTPAAYAEYLRCLSDP-ATAHGICEDYRAS--VTIDLEHDRATLAS---QQRIDCPFMALWGAQ--GVIEQC---------FDPLAEWR--------------------------AYA-P-------DVQGEA-LPCGHYIPEEAPQRLLERVLPFLSE----------------------     =====>
9burk-b1fw54   	--------------------------------------------------------------------------------------------------------MAF--ENFTPFRVA----AGD-----ADIFGVK-------GGA------GP---PLLLLHGHPQSHLIWARCAERL-AQ-HFTVIATDLRGYGASGK--------PASDAA----HTPYSKRAMAAEQVAVMRHF------------GF--E-RFLVCAHDRGARVAHRMALDHADA------------------------------VERLMLLDIAPTLAMYEAT-----D--R-TFATHYFHWFFLIQPEPLPETLIGANP----AAYVDA-VMGSRHAG----LAP-FEPASLDAYRAALAQP-GAVHAMCEDYRAS--ASIDLEHDRADIER---GHKIACPLRVLWGEN--GVIEKC---------FDALAEWR--------------------------HVA-R-------DVSGRS-LRCGHYLPEEAPDELLAEMLSFFEAIER-------------------     =====>
9burk-b5wju3   	--------------------------------------------------------------------ML----AWVFPPHADPSA-----FYNAQTPNDQRDVMAF--ENFTPFRVA----VGD-----VDIFGVK-------GGA------GP---PLLLLHGHPQSHLIWERCAAPL-AR-HFTVIATDLRGYGASGK--------PLSDAE----HTPYSKRVMAADQVAVMRHF------------GF--E-RFLVCAHDRGARVAHRMALDHADA------------------------------VERLMLLDIAPTLAMYEAT-----D--R-TFATHYFHWFFLIQPEPLPETLIGANP----AAYVDS-VMGGRHAG----LAP-FDPAALDAYRAALAQP-GAVHAMCEDYRAS--ASIDLEHDRADIER---GNKIGCPLRVLWGDK--GVIEKC---------FDALEEWR--------------------------HVA-R-------DVSGRA-LSCGHYLPEEAPDELVAEMLSFFEAVEQ-------------------     =====>
9burk-b5wka2   	------------------------------------------------------------------------------------------MSSESFRH-DSHD--HF--PSFSGLQVD----AGD-----VSFSGVI-------GG--S-----GP--AVLLLHGYPQTHLAWRYIAPRL-AH-SFTVVAPDLPGYGKSKT--------GADC-------PRWTKRRVGDSLVAMMTQL-----G-------H--E-EFAVVGHDRGARVGYRLALDHPSR------------------------------STHYAALAVVPTLDAWNGV-----D--M-RFGLANFHWFLLAQPFDLPERLLSADP----DAFIDA-ALGNMAGG----L-DDIDADALTAYRQAFRDP-SVRHAMCEDYRAA--AHEDLENDAADRAA---GTMLQCPVLALWPDS--F--RGK---------TSPLDIWR--------------------------CWAS--------NVRGKA-LNGGHLLPEERPQEVTAELLPFLARR---------------------     =====>
9burk-c9yew1   	-----------------------------------------------------------------------------------------------------MPMPWF--DGFEQRDFE----VNG-----VRIHARV-------PVKLP--GDRP---ALLLLHGFPQTHVLWQRVAQQL-AQ-DFYLVMPDLRGYGDSGK--------PAGLPD----HSNYSKRTLAADMVAVMDAL------------GI--E-RFGVCGHDRGGRVAHRLAVDHPER------------------------------VQGLCVIDIAPTLDMYAAT-----D--F-AYASAYYHWFHLIQPTPLPETMILGAP----LPYLHT-KLGGWGGT----GTTFIEPQAMAEYERCFLLP-GTVHSMCEDYRAS--ASMDLEHDRTSRELPDGAGRIACNTLVLWGER--GVVNRL---------FDPMALWQ--------------------------AQCAA-------KVSGAA-LPAGHFIPEELPDETARYLKEFFHG----------------------     =====>
9chro-a3iqm5   	-------------------------------------------------------------------------------------------------------MLML--ANFQNLVIQ----TSE-----VKINLVK-------GG--E----GY---PILLLHGYPQTHVMWHKIASQL-AE-EFTIIIPDLRGYGDSDK--------PIGMAN----HYNYSKRVMAQDQIEVMTQL------------GY--D-QFYLVGHDRGGKSCSPFNVRLSQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9cyan-b4vwm4   	---------------------------------------------------------------------------------------------------------MF--EQFTQHRIT----TSD-----TTINLVM-------GG--A----GY---PLLLLHGYPQTYVMWHQVAPVL-AQ-HFTVICADLRGYGDSDK--------PNSDPA----HLTYSKRVTAQDQVELMDIL------------GF--K-RFFAAGHDRGGRVLHRLMLDHPNR------------------------------VDKAAVLDIVPTRTIFQTV-----D--K-ELATAYEHWFFLIQPYDFPERLIGADP----EFYLKT-KIHQWSAT----QAG-FTEAAMAEYSRCFSQP-AVIHATCEDYRAA--ASIDLEHDEADID-----QKIQCPLLVLWGAK--GVMQRR---------YDVIQTWR--------------------------DRA-I-------DVRGQA-LECGHFLPEEAPQQTAKALLDFFKG----------------------     =====>
9entr-d4bjk3   	-----------------------------------------------------------------------------------------MQRAVMSTVIECGASPFI--PGFVLKNVRL---ANG-----LTLRVAV-------GG--S----GS---PLVLVHGHPQNHITWRKVAPEL-AK-DHTVIMPDLRGYGDSDK--------PASDPA----HRTYSKRMMAQDIVMLMEIL------------GY--S-RFAFVGHDRGGRVGHRLALDYPDS------------------------------LTSCTFIDIAPTATMYALT-----D--K-AFATRYFWWFFLIQPFPLPETMIAHDP----AFFLRK-HIAGQLKT----EGA-TSEDAFNEYLRCYQNP-EMIHAVCEDYRAA--ASIDLDDDAADAS-----ARIQCPLQLLWGAQ--GTVGQL---------YDVVDTWR--------------------------EKA-I-------NVQGEA-LPCGHSPQEEIPGIFIQKLQFFLRSVL--------------------     =====>
9prot-a8tkx7   	-------------------------------------------------------------------------------------------------------MIWF--DGFAVRDIT----TSG-----SVVRVRV-------GG--V----GP---PVLLLHGHPETHLMWRHLAPEL-AQ-RFTVVAADLRGYGESGK--------PPTTAD----HAPYSKRSMALDMAEVMTAL------------GQ--D-RFAVVGHDRGGRVAHRLARDHRNR------------------------------VAKLAVLDICPTLDMYECT-----D--M-AFARAYYHWFFLIQPYDLPERMIGADP----AYYLRS-KLAS-SAG----SDV-FPVEVVAEYLRHYARP-ETIHAICEDYRAS--AGIDLEHDRADR-----GRLLDVPILALWGAK--GVVGRT---------FDVLDVWR--------------------------RYTTE-------EVSGAP-LPCGHFLPEEAPEATLAALMPFLET----------------------     =====>
9prot-a8tsz7   	-----------------------------------------------------------------------------------------------MVF-GQPM--MF--DGFDTRRIV----VDG-----VDVPVRT-------AG--S----GP---PVLLLHGFPQTHTAWHQVAPAL-SG-EFTVVVPDLPGYGASRG--------LEPTA------EKFAKRNLARLMVGLMDTL-----G-------H--G-RFALAGHDRGARIGYRLALDHPGR------------------------------ITRFAPIDILPTLEVWEAM-----N--W-QAALGSYHWLLLAQPAPLPENLVGADG----PGYVRH-LIDRWAGH-H----DRLDPTAVAAYARAFADP-AVVAAACADYRAG--ATLDVEHDRVDRDA---GRKIDCPVLLIWARR--YLK--------ERG-RRHLDVWR--------------------------SWAE--------DVRELP-LDCGHFVAEEAAQDCAAALLSFFSEEYHAR-----------------     =====>
9rhiz-c8srf5   	---------------------------------------------------------------------------------------------------------MF--DDFQSTKV-----EVG----EASLFVRH-------AG--S----GA---AVLLLHGFPQTQLMWRDVAPGL-TD-RFTVVCADLRGYGASSC--------PVSDAD----HAPYAKRAMAADMVAMMGKL-----G-------F--A-SFMVAGHDRGGRVAYRMALDHPDS------------------------------VDKLTVLDIVPTADAWDRA-----D--A-RLALGYWPWSLLAQPEPLPEKILAAAA----EAIVDN-ALGGWGSS----P-AVFPADVRQAYVDALRDP-AHLHAICEEYRAA--ATLDRKHDHADKAA---GRTIRCPVLALWSEQ--GALAEW-----YSDEGGPLALWR--------------------------GWAD--------DVRGQA-MPGGHFFPEEAPAQTAQALAAFFG-----------------------     =====>
9rhiz-q0g5e5   	---------------------------------------------------------------------------------------------------------MF--ENFQTRILK----GES-----AEIFVRT-------AG--D----GP---PLLLLHGYPQTGAMWHELAPKL-AE-DYSVVVPDLRGYGRSSA--------PANDEE----NLAYSKRVMGRDMLALMRAL-----G-------H--E-RFMVAGHDRGGRVAYRMALDNPDV------------------------------VTKLAVLDIVPVAEVWERM-----D--A-AAALKTYHWPFFAQPHPMPETLIGADP----VYFLDH-TIASWTKA-K-DL-SAFGEAAMAEYRESFRRP-AYVEASCNDYRAG--ATIDWRLDREDREA---GRKIGCPTLALWGAA--GIP--------ATG-ADIVEIWR--------------------------GWCE--------NVTGQP-IDAGHFIVEEAPEVTLAALSHFLRS----------------------     =====>
9rhob-a0nv58   	-----------------------------------------------------------------------------------------------MKN-DLPD--LF--PGFDSMTVD----VND-----VHLFCRI-------GG--S----GP---PLLLLHGYPQSHICWHKIAPQL-AE-HFTVVLPDLPGYGRSSV--------PPLSDD----HAAYSKRNIAAAMVELMKVL-----G-------H--T-TFSLAGHDRGGRVAYRLALDHPEM------------------------------LTKVAVLDILPTCDYWDRM-----D--R-LFGLKIYHWMFLAQAAPFPENMISAAP----VAFLDH-TLASWTAA-K-DL-SCFSKEAMTHNRDWFCEP-DRVSATCEDYRAG--ARIDYEHDRSDLDA---GKKIQPPLLALWGSK--GIA--------TSV-DDPLEVWR--------------------------GWSA--------NVTGAA-VACGHFLPEEAPQETVAALIAFFRNTAELS-----------------     =====>
9rhob-a3jvq1   	----------------------------------------------------------------------------------------------MDKNSYPKGVEMF--KDFVEERIA----GDG-----ATLFVRR-------AGPVG----AP---PLVLLHGYPQTSAMWHSVAPIL-AR-SFQIVCPDLRGYGRSDK--------PASDAV----HAPYAKRVMANDIVAIMKRL------------GH--E-RFLIGAHDRGARVAHRLGLDHPDR------------------------------VAAMALLDIAPTREMYANT-----S--A-AFAHAYWHWFFLTQPSPLPERMIGADP----EGFWKL-KCFNQARG----DNP-FSPEALAEYLNAFADP-TAIHASCEDYRAA--ATIDITHDDADQG-----RKLHMPVLTLWAKR--GVIETC---------FDALTLWR--------------------------QRA-E-------RVEGET-LDTTHYMAEEIPDDIAARMSDFFARNPIHSKANA-------------     =====>
9rhob-a3jxp1   	----------------------------------------------------------------------------------------------------MRN--EI--PGFSPGQVE----LDG-----VEIAFET-------GG--T----GP---AVLLLHGFPQTRAMWAEVGPRL-AE-RFTVVAADLRGYGESGK--------PKGV-------EAYSFRAMAGDMTALMSHL-----G-------H--G-RFHLVGHDRGARTAHRLALDVSDR------------------------------LLSLTLMDIVPTHLLLSHL-----T--H-PVARAYYHWFFLSQPQPFPEGMIAADP----DAYYES-CLLGWGGA---QL-SDFP--KLDAYRAAWADP-ECRRAMCDDYRAA--IDVDFALDEK--DL---GRRVDVPSLVLYGAD--GAM--------ARAYD-VPATWA--------------------------DRLSDM--------QAGT-VPGGHFFIDQSPEQTARALLDFLG-----------------------     =====>
9rhob-a3u2p4   	---------------------------------------------------------------------------------------------------------MI--PGFDSGTAP----VNG-----QRIAWSA-------GG--D----GA---PVLLLHGFPQTRALWSRIGAAL-AR-EHRVVAADLRGYGESSK--------PDGV-------ADYTFREMGNDMAALMTHL-----G------------------HDRGGRTAHRMALDHGDR------------------------------IATLQLLDIIPTHLLLTRL-----R--R-ETALAYYHWFFLAQPEPMPERMIGADP----DAFFDG-CLMGWGAA---DA-GDFDAGQLELYRTAWRDP-DTIRGMCNDYRAG--ATLDVDLDAA--DL---DRRILCPTHVLWGAD--GVM--------GRQYD-VPATWA--------------------------DRCEGT-------PRATP-IPGGHFFPDTAPDATADALQGFIADHAA-------------------     =====>
9rhob-a3v2t9   	---------------------------------------------------------------------------------------------------MEHP--MI--QGFTPSRVV----CGD-----ITLSVHR-------AG--Q----GT---PLILLHGYPQNHHCWEKVAPAL-AT-QFDVIIPDLRGYGDSDA--------PADDAD----HTTYSKRTMAADIAALMDAL-----G-------I--D-RAHVLGHDRGGRVAYRFALDHPDR------------------------------IIRLGIIEIVPTGDFWANW-----S--A-DLAMKAYHWTYLAQPAPLPERMIGADP----AGYIDW-TLIAWTMG-K-SL-GVFSDAALASYRAQAADP-AHLHAMCADYRAG--ATFDRALDEADKAA---GRKIAAPLHFLWAKG--GFP--------AQT-GDPAALWR--------------------------PWVQ--------QMTDAS-CVSGHFAMEENPQAVIDSFLPFFGVH---------------------     =====>
9rhob-a3vdy3   	------------------------------------------------------------------------------------------------------M--TP--QGFSTRTFD----HDG-----IEIAYDI-------GG--S----GP---PLLLLHGFPQTRALWWRVAPAL-AA-NHTVIAADLRGYGASSK--------PDDP-------ALYSFRHMGGDMLALMSDL-----G-------F--K-RFAVAGHDRGARTAYRMTLDAPDR------------------------------IARLALIDVVPTELILNGL-----T--H-PVARAYYHWFFLSQPAPFPETMIGHDP----DAYFES-CLLGWGAA---NL-SDFAPDQLAAYRKSWRDP-ACIRAMCHDYRAA--IDIDLAQDEA--DL---GRTVRAPTLIGWGMD--GAM--------GRAYD-VPDTWA--------------------------DRIETI--------TPAP-LPGGHFMIDSHPGAVTTALADFFA-----------------------     =====>
9rhob-a4eft8   	--------------------------------------------------------------------------------------------MHPAAASATPATRFF--DGFEERYLD----TAE-----GRIFYRI-------AG--D----GP---PLVLLHGYPQTSAMWHAVAPVL-AQ-TYQVICPDLRGYGRSLK--------PVTDAA----HAPYSKRAMAGDILALMDHL------------NH--T-RFLIGAHDRGGRVAHRLAADHPDR------------------------------VLALSTLDIAPTREMYRDA-----D--S-GFAHTYWHWYWLTLPHPFPERLIGADP----AFYWLS-KCGAGKAG----LSP-FVQQALDEYLTCFSAP-DAIHGACEDYRAA--ATIDITHDDTDIS------KLPMPLLALWGED--GAIEAH---------FDCLALWN--------------------------ERA-A-------DVRGWA-LPGGHYLAEQHPDKVLEAWIPFFAKATV-------------------     =====>
9rhob-a4ej77   	-----------------------------------------------------------------------------------MGRIQMLLDATAALSAAPHAKDFF--TGFVEDTIE----VEE-----GAIFCRH-------AG--D----GP---PLLLLHGYPQTSAMWHRVAPVL-AQ-KFTVVCADLRGYGRSHK--------PVTDAD----HTPYSKRATAQDMVQLMQAL------------GH--N-RFCIGAHDRGARVAHRLAADHRDR------------------------------VVALATLDIAPTQEMYRDG-----D--S-QFAQTYWHWYWLTQAHPFPEFLIEAES----DAYWLK-KCGSGSAG----LTP-FSHQALAEYLTYFRNP-AVIHGSCEDYRAA--ITVDARHDAAETG------PLDIPVLALWGRH--GAIERH---------FDCLALWR--------------------------ERA-K-------DVRGWA-LDGGHYLAEERPEEVIAAFRDFFHNALNDAGRAAVMAV---------     =====>
9rhob-a6fnn3   	-----------------------------------------------------------------------------------------------------MS--LI--PGFTDHTAR----VNG-----VTIAYSS-------GG--D----GP---PLALLHGFPQTRAMWAHIAPGL-AR-THRVICPDLRGYGASSK--------PDDV-------GEYSFRQMARDICALMDQL-----G-------H--A-RFALAGHDRGGRVAHRLALDAPHR------------------------------LTRLCVMDIVPTHTLLADL-----K--V-AVARAYYHWFFLAQPAPFPETMIGHDP----DAYFQS-CLLGWGGA---RL-TDFDPGQLAAYRAAWRDA-DTIRGMCNDYRAA--LDHDVTDDAC--DL---NQRIACPFLVLYGAD--GAM--------ARQYD-VAATWE--------------------------AKALET--------QAQT-IPGGHFFPDTAPKATLAALSAFFD-----------------------     =====>
9rhob-a9gw39   	---------------------------------------------------------------------------------------------------------MF--AGFDAGDAS----VNG-----QTIHYRS-------GG--Q----GP---PVLLLHGFPQTHVMWHAVAAQL-AE-NFTIVAADLRGYGHSSK--------PDGT-------AAFSFRHMACDQVALMRAL-----G-------H--D-RFHVVGHDRGGRVAHRMALDHQEA------------------------------VHSLTVMDIVPTHLLLDNL-----S--K-EVAEAYYHWFFLAQPYPFPETLIGHDP----DTYYES-CLLGFGAA---KL-SDFETDALDAYRAAWRDA-DTIRGMCADYRAA--LHIDFAHDSQ--DH---CRRIDTPSLVLFGSD--GAM--------AKSYN-VADTWR--------------------------EKLSHM--------TSTA-IPGGHFFIDQSPDETSLALETFLSGIT--------------------     =====>
9rhob-b5iy25   	-----------------------------------------------------------------------------------------------------MN--VF--AGFKEIDVD----VAG-----AAIHARI-------GG--S----GP---PLLLLHGYPQTHVMWHVIVDEL-AK-SHSVVMADLRGYGDSVA--------YD---------GDFTFRAMARDQVDLMKHL-----G-------F--A-RFDAVAHDRGARSAHRMVLDYPEA------------------------------VRSIALLDILPTLDVWRTM-----D--D-WLAKRYYHWMFLSQPGYMPQTLINSNP----VMFLHA-ALLGLSG----KK-DAFDPLALAEYERAAKNP-DVVAAWCGDYFEG--AGTDIDHDRADMG-----RTNDIPCLVLWGSQ--GVV--------AHH-VDPLMAWQ--------------------------AWFP--------KAEGHA-IDAGHFLVEEKPTEVLRSLEKHLSCIDISQK----------------     =====>
9rhob-b6av93   	---------------------------------------------------------------------------------------------------------------------M----GSK-----GPIAYSI-------AG--S----GP---ALILLHGFPQNRFMWHQIAPEL-AK-TYRVICPDLRGYGGSAK--------PLGV-------ENYSFREMGADILHLMDHL-----D-------L--G-RAHLIGHDRGARVSHRLALDAPER------------------------------LKTLTLMDIVPTHTLFSNL-----S--R-EVALGYYHWFFLALPAPLPDNMIGHDP----DTYFNS-CLTGLGTG---KE-PAFNDTALAAYRTAWRDP-ETIRAMCDDYRAG--ATLDFEQDAK--DL---DQRVTLPSLVLYAKD--GMM--------DKTYK-MHSVWS--------------------------DKLSNF--------AVKP-MRGGHFFPDHYPQDTLTELRNFLEQNS--------------------     =====>
9rhob-b6b2p5   	---------------------------------------------------------------------------------------------------------MF--KDFVEERIE----GEG-----ATLFVRR-------AGPTG----AP---PLVLLHGYPQTSAMWHGVAPIL-AR-SFQVICPDLRGYGRSDK--------PASDAA----HAPYAKRAMANDIVAVMRRL------------GH--K-RFLVGAHDRGARVAHRLGLDYPDH------------------------------VAAMALLDIAPTREMYTGT-----N--A-AFAHAYWHWFFLTQPSPLPERIIGADP----EGFWKL-KCFNQARG----DNP-FIPEALAEYLNAFADP-NAIHASCEDYRAA--ATIDIAHDDADQG-----RKLHMPILTLWAKR--GVIETC---------FDALALWR--------------------------QRA-E-------RVEGEA-LDTTHYMAEEVPGDVATRMSDFFARNPIHAKATA-------------     =====>
9rhob-b6bc75   	---------------------------------------------------------------------------------------------------------MP--ASPQSGTLQ----VNG-----QQIAYTL-------RG--D----GP---PLLLLHGFPQTKEMWEDTAPAL-AR-RFTVVTADLRGYGASSK--------PEGV-------EAMSFRNMAADQLELMRAL-----G-------F--I-RFHLAGHDRGGRTAHRLALDAPEA------------------------------VASLTVMDIIPTHLLLDKL-----T--Q-QVARAYYHWFFLAQPAPLPERMIGADP----QAYFES-CLLGWGGA---SL-SDFPAPALAAYRRAWADP-ACVHAMCNDYRAA--IDVDFHHDAR--DL---DRKAHCPALVLYGAD--GAM--------AKAFD-VAATWA--------------------------PHLQDM--------TAQG-IPGGHFFIDSSPRETGAALLEFLSPLPSL------------------     =====>
9rhob-b9nwp7   	--------------------------------------------------------------------------------------------MTIFEE-ADAK--LL--PEFTRQPIE----IDG-----KLVMTLC-------AG--S----GP---ALLMLHGDPQTHLCWHHIAPKL-SE-RFSVVLTDIRGRGETHK--------PDRDAR----ENAYTKRAMAEEQLAVMQAL-----G-------H--D-TFAIVSHDRGARVARRLTLDHPET------------------------------VTQLVVMDIIPALDFYEAL-----N--A-EIAQDYFYFSFLTQDPPVPERLIAGDR----EGFLRL-ILEGLSDK----S-VQYDQMAMAAYLKANATP-EAISAMCECFRAG--IHIDRLHDAENRRS---GRQITCPTLIMWGDK--GVVGKH---------FDVERIWH--------------------------GWCS--------DPSFAS-MPSGHFIPEEAPGAALAAIQNFLK-----------------------     =====>
9rhob-b9r347   	-----------------------------------------------------------------------------------------------MVK-TLPD--LF--PGFESHFVE----TAQ-----GPIFCRT-------GG--T----GP---ALLLVHGYPQSHVIWHKIAAGL-AK-SFTLVMPDLPGYGQSVI--------PPLSAD----HAAYSKRTMAQTMVEVMSHL-----G-------H--E-QFGAVGHDRGGRVVYRMALDMPDR------------------------------ISSAAVLDILPTFDYWNHL-----D--R-TFALKIYHWAFLAQPAPFPENMIAADP----IPFLEH-KLASWSAA-K-DL-SPFSEGALQHTRAWFSDP-VRIAASCEDYRAG--AHIDYDHDAEDRRA---NRTINPPFLALWGEQ--GIA--------ASI-EDPLSIWQ--------------------------TWCP--------HAKGKA-IKGGHFLPEESPREITQEILEFFSLQKIP------------------     =====>
9rhob-c7dbj7   	---------------------------------------------------------------------------------------------------------MF--EGFDTFDIA----LGE-----ITLHGVR-------GG--D----GP---PLLLLHGYPQTHAMWHKVAPDL-AR-DFTVIAPDLRGYGRSSK--------PVTDAT----HSPYSKRAMAADMVTLMAQF------------GF--D-QFDVGAHDRGARVAHRLGMDYPDA------------------------------VRRMCLLDIAPTREMYAST-----D--D-EFARAYWHWFFLIQPHPFPETMIAADP----QAYLNH-KTSSWGAG----HSH-FSDDAMADYSACWT-P-DTIHAACEDYRAA--ATLDIDHDNADGD-----AKLTCPLHVLWGQK--GIIERC---------FDALALWR--------------------------LRA-E-------TVTGHA-VPTGHYIAEERPDLVLAEFRYFFDACRK-------------------     =====>
9rhob-q0fad5   	---------------------------------------------------------------------------------------------------------MF--EDFVEEYIE----GDG-----ANLFVRR-------SGPKN----AK---PIVLLHGYPQTSAMWHAVAPIL-SG-SYQVICPDLRGYGASDK--------PNSDAN----HYPYSKRAMAKDIVAMMKRL------------GH--N-KFLVGAHDRGARVAHRLGLDYPDR------------------------------IEAMVLLDIAPTREMYAGT-----S--A-NFAQIYWHWFFLTQPNPLPEKMISADP----EGFWKL-KCLNQAHG----QNP-FSPEALAEYLASFKDP-NTIHSTCEDYRAA--ASIDIEHDDADQG-----KKLTMPILALWAKF--GVIESC---------FNALDLWQ--------------------------QRA-L-------HVEGEA-LAATHYMAEEIPQEVTKHMLEFFSQYPIHKKETAQ------------     =====>
9rick-d0rqq9   	---------------------------------------------------------------------------------------------------------MF--SGFKKETIT----VEDQGFGKAEIVYRH-------GG--K----GE---PLLLLHGNPMSHITWHKIVDDL-KD-KFYVVVSDLRGYGESIG--------PEEGGD---NHINYSFRAMASDQIFLMKKL-----G-------F--D-EFKLVGHDRGARTSHRMCLDFPEK------------------------------IKKVGIFDIMPNRHIWTVQ-----K--K-NWAMSKWHWLLMMQPYDLPEKLLSSVP----AKYYMEKKLSKRGAT------LEFCKETFDEYVRCFNY--KTIRASCEDYRAS--PSCDLDHDNEDFEK---NNKIKCPIFVLWGNR--SDT--------GKVWGDVLNVWQ--------------------------NYSDQ-------KVQGEG-LDCGHYLQEEQPKKVLEWLKKFL------------------------     =====>
acicj-a5fvx7   	------------------------------------------------------------------------------------------------------MSGFF--EGFSESTADL---GDG-----RHFRLRS-------GG--S----GP---PLVMLHGMPQTHCMWHRIAPAL-AA-RFTVICPDITGYGNSYK--------PAASAD----HEAYSKRRMAQDIVDLAAHL------------GI--G-RFALVGHDRGARVSHRLALDHPDR------------------------------ISRLALLDIIPTIEHFERT-----D--M-RFAMGYYHWFFLAQPAPLPEDLINRDA----GYWLLS-QTARHKTA----RAV-FDEAAMADYRRAMADP-ATVTAICEDYRAA--ATIDLEHDRESRAR---RERIAAPLKVLWGSR--GLVGAL---------YDPLEIWR--------------------------GYASG-------PVEGQA-IESGHFLAEEAPEATLAALQEFLADG---------------------     =====>
actmd-c6whm5   	--------------------------------------------------------------------------------------------------------MVL--PGFTEQRVAV---AEG-----VRLHVAV-------GG--T----GS---PVVLLHGFPQTHLMWRHVAADL-AA-DHTVICPDLRGYGASDK--------PAD--D----GENYSKRVMARDVVALAREL-----G-------H--E-RVAVVGHDRGALVGIRAGLDHPDV------------------------------VTHLGVLDVLPTVESWEVL-----R---GRGAAVGFHLFLMAQRPGLAEAMISGAA----DEFFGH-FLDVWANDPA-----AIPADVRAEYLRASREA---VPSIVADYRAT--AGVDVAHDEADRAA---GRRLRMPVGVVQQDW--GAELG----------FDAAGVWR--------------------------GWAED--------LEHRT-VRCGHFMAEEAPGEVVGAIRALLAR----------------------     =====>
agrt5-a9cle4   	-------------------------------------------------------------------------------------------MRDSDNV-GDSI--FY--PGWRPFEME----ADG-----VQFSGVI-------GG--S----GP---PLLLLHGFPETHIAWRRMAPAL-SR-EYSLVIPDLPGYGRSLI--------LDHS-------ERFTKRRAARAVSSLMTAF-----G-------H--K-TFGVIGHDRGARVGYRLALDHPDR------------------------------VRGFASLTVIPTLDALASV-----D--H-EFALKNFHWFLFAQPDDLAEHLLDLDP----RGYLER-VLARMTEG----R-DFLKREATEAYHEAFSRP-SVREAIIEDYRSA--LREDLEHDRADRRD---GRKLRCPVFVSWPER--GSRSDR---------GSPIEVWR--------------------------RWAD--------EVTGGA-TSGGHLQPEDAPDEVLAMLIPFLSKSFLPGRA---------------     =====>
agrtu-ATU5495  	----MQCHRATTLDICNVLFFPCPVRAQPRFPMKCDCPSGWVYQTVREPVANDTVAPIRQMRASSFGGFVGRGTTYALREAFDRENSKMRQRARSFGM-PRSV--MF--ENFRLEMV-----KLP----ETKLRVRH-------GG--S----GP---PLLLLHGHPRTHTTWYKVAPIL-AE-HFTVICPDLRGFGQSGK--------PDDPYD----YEASSKRAKARDCVALMDHF-----G-------F--N-EFSLAGHDRGSYTAFRTAMDHPAR------------------------------VAKLAILDGVPILEALEHC-----N--A-RFATQWWHWFFFAQHDKPE-QAISADP----LRWYGG------------TE-DLMGKENYADFRLAVQDH-STIQGMLGDYRAG--VRIDHLHDREDRNS---GRKLQCPLRVLWSLR--DDL--------EDLYNDVLAIWQ--------------------------PWAEL-------PVSGLG-IDSGHHMAEEAPLEVARELKSFFLA----------------------     =====>
anadf-a7h7k0   	------------------------------------------------------------------------------------------------------MPELF--PGFTVHDLE----TRG-----ARIHARA-------GG--S----GP---PVLLLHGYPQTHAIWHRVAGPL-AA-RFSVVAADLRGYGDSGK--------PPSAPD----HAPYSKRAMAQDLVEAMGLL------------GF--E-SFHVVGHDRGARVGHRLSVDHAAR------------------------------ARSLTVLDIAPTLAMYEQT-----D--M-DFARAYYHWFFLIQPEPLPERLIGADP----GFFLRE-KLRGWSQG----RWP-FEAAAFAEYLRCFEDP-ATIHASCEDYRAA--ATIDLEHDRADRDA---GRRVRCPVLASWGER--GTVHRC---------FRPLEEWR--------------------------RVADG-------DVGGGP-LPSGHYLPEEVPELLLRELLPFLERAETAPRA---------------     =====>
anasp-ALR0039  	---------------------------------------------------------------------------------------------------------MF--TNFEQTIVD----TTE-----ARINLVK-------AG--H----GA---PLLLLHGYPQTHVMWHKIAPLL-AN-NFTVVATDLRGYGDSSR--------PASVPH----HINYSKRVMAQDQVEVMSKL------------GY--E-QFYVVGHDRGARVAHRLALDHPHR------------------------------VKKLALLDIAPTHKMYRTT-----D--Q-EFATAYYHWFFLIQPDNLPETLIGANP----EYYLRK-CLEKWGKD----FSA-FHPQALAEYIRCFSQP-AVIHATCEDYRAA--ATIDLEHDELDMK-----QKISCPVLVLWGEK--GIIGRK---------YDVLATWR--------------------------ERA-I-------DVSGQS-LPCGHFLPEEAPEETYQAIYNFLTHC---------------------     =====>
artat-a1rb20   	-----------------------------------------------------------------------------------------------------MALTLL--TDATYHRVPV---APD-----VHLNVAV-------AG--S----GP---AVVLLHGFPQTHLMWRHVAVDL-AK-DHTVICPDLRGYGASDK--------PAEE-D----GGTYSKRTMAADVVTAARFF-----G-------H--D-RFALAGHDRGALVALRAGLDHPKT------------------------------VTHLLALDVLPTLDMWEIL-----R---GADAKVAWHLYLMAQSPGIPEPMIEATA----DSFFAS-FLDGWINNPE-----SITAEYRNEYLRASREA---VWSIVADYRAS--AGIDISHDRADRNA---GRTLDMPVTVMQQDW--GAALG----------YDAASLWG--------------------------AWAPA--------LKHMT-LNTGHFMAEENPMAVITAMRELMDR----------------------     =====>
artoc-c5frz3   	----------------------------------------------------------------------------------------MVVLGVPQCL-AGHGLSTF--EVCDSDSGS----TIR---GLCRGIHASSGADT------E----KP---ILVL---------------I---------------HGYPQTD----------------------LTYRDVG-----------GAIN--------DQPPHRVVLVGHDRGARICHRLTVDAATEHAR-------------------TGTDTAFTIVATALMDIVPTAIQWAAL-----A--DPAEASQTFHWPFLANVKL-ASAMIHAMG---ADSFVRQ-MMERWRGTSETAIARFEADDAMEVYMRPFRQMASVVRSSCADYEAG--STQDVQEQRHDQAE---GRRMAAPVLVLHS---CGMGER----------FDVQGEWK--------------------------AWVE---REQLLTVVQTG-EGIGHFVAEEDPEATVGAMQRWLEDISLSL-----------------     =====>
azoc5-a8i6b5   	------------------------------------------------------------------------------------------------MP-DLAD--LY--PGFEAHNID----TAA-----GRIFVRT-------GG--S----GT---PLLLLHGFPQTGVMWHKVAPEL-AK-THSLVIADLPGYGWSAA--------PEPGRD----HAPYSKRAMGEAMVRVMEHL-----G-------H--A-HFALMGHDRGARVGYRIGLDHPGR------------------------------LDRLVVLDIVPTMAMWHGM-----D--R-SRAMSVYHWMFLAQPHPLPETLIGKDP----GFYFDW-TLASWTRD-K-DL-SAFNPKALAHYRASCAVP-ERIRAMCEDYRAG--ATIDLAHDEADRAA---GRTIDCPVLAVWGAS--GIP--------AKG-ESPLNAWR--------------------------AFAP--------EVTGQA-VESGHFVCEETPEAVLAAVTPFLAQGR--------------------     =====>
azosb-a1k1f9   	------------------------------------------------------------------------------------MS-----VVT--EVAAAADAVLF--PGFARRRIEV---GAG-----VSIPCVS-------GGD------GP---PLLLLHGHPQTHAIWHKVAARL-AR-HFTVVASDLRGYGDASR--------PATTAD----HVRYSKREMAADQVALMRAL------------GH--D-RFSVLAHDRGARVAHRLAADHPQA------------------------------VSRMVLLDIAPTLAMYEQT-----T--E-TFARAYWHWFFLIQRAPLPERLIEADP----TAYLRD-VMGSRHAG----LAA-FDPTAFAEYARCLSQP-GAAHSLCEDYRAA--ATIDLEHDRADRAA---GRRLAMPLQVLWGQS--GIVQRC---------FRPLDEWR--------------------------RVA-D-------DVRGGT-LPCGHYIPEEAPAELLAAALPFLLAD---------------------     =====>
azovd-c1dng8   	---------------------------------------------------------------------------------------------------------MF--TDFKKDARQ----VNG-----VRITYRI-------GGE------GP---ALLLLHGHPQTHVIWHKVAPRL-AR-HFTVIAADLRGYGDSDK--------PEADAE----H-LYSKREMARDMVELMATL------------GF--S-RFDLLAHDRGARVAHRLALDHPAA------------------------------VRRLILLDIAPTLAMYAQT-----T--E-TFARAYWHWFFLIRPAPLPETLIEADP----ELYLRS-VMGSRSAG----MRP-FSDEAFAE