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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....
9pero-q58fc1   	----------------------------------------------------------------------------------------------------------------------------------------SKTFIVIHGWTVTGMFESWVPKLVSALYEREPSANVIVVDWLTRANQHYPTSAAYTKLVGRDVAKFVTWIQKELQLPWERIHLLGYSLGAHVAGIAGDLTD---HKISRITGLDPAGPTFEHADNQDTLSKDDAQFVDVLHTNTRGSPDRSIGIQRPVGHIDIYPNGGTFQPG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
bovin-lipli    	----------------------------------------------------------------------------------------DRITGG-KDFRDIESKFALRTPEDTAEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVAKFMNWMADEFNYPLGNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEALRVIAERG---LGDVDQLVKCSHERSVHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNMGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESNTYTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLLYTEVDIGELLMLKLKWISDSY-------FSWSNWWSSPG------------FDIGKIRVK--AGETQ-KKVIFCSREKMSY-LQ--KGKSPVIFVKCHDKSLNRKSG----------------------------------------------------------------------------------------------------------     =====>
canfa-lipli    	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNMGYEINKVRAKRGSKMYLKTRSQMPYKVFHYQVKIHFSGTESDAQTNQAFEISLYGT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
cavpo-lipli    	--------------MNI-----DRKIL------------------------------------------------------NKALAKEKVANCQ-KDYTDIESKFARRTPENTVEDTCHLIPGVTESVANCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLRRAQHHYPESADYTKLVGEDVARFINWMEDEFKYSVDNVHLLGYSLGAHAAGVAGSRTN---TKVSRITGLDPAGPNFEYAEATSRLSPDDAQFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGSFQPGCNI--QDALRVISQKG---FGDMDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIYFSGTETTTYTNQAFEISLYGTVAESENIPFTLPE-VSANNTYSFLIYTEVDIGELLMLKLKWITESY-------FSWSSWWGRPT------------FTIEKIRVK--AGETQ-KKIVFCSREKVSK-LQ--KGKEAPVFVKCHDKSLNKKSG----------------------------------------------------------------------------------------------------------     =====>
chick-lipli    	MERGRGMGKTALLA-VLCLCL-------------------------------------------------------------RG-AAGSDPEAE-MNFEGIESKFSLRTPAEPDEDVCYLVPGQMDSLAQCNFNHTSKTFVVIHGWTVTGMYESWVPKLVDALYKREPDSNVIVVDWLVRAQQHYPVSAAYTKLVGKDVAMFIDWMEEKFNYPLNNVHLLGYSLGAHAAGIAGSLTK---KKVNRITGLDPAGPTFEYADAPIRLSPDDADFVDVLHTYTRGSPDRSIGIQKPVGHIDIYPNGGGFQPGCNL--GEALRLIAEKG---FSDVDQLVKCSHERSIHLFIDSLLYE-EKPSMAYRCNTKEAFEKGLCLSCRKNRCNNLGYKVNRVRTKRNTKMYLKTRAQMPYKVFHYQVKIHFFGKTNVTKVDQPFLISLYGTLDESENIPFTLPE-VSSNKTFSFLIYTEVDIGDLLMLKLQWEKDTF-------FSWSDWWTPFA------------FTIQRVRVK--SGETQ-KKVVFCSRDGSSR-LG--KGEEAAIFVKCLEQPVSRKRGGAKKASKENSAHESA-------------------------------------------------------------------------------------------     =====>
crigr-lipli    	---------------------------------------------------------------------------------------------------------------------------------------------------------------------REPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEPLKKAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
danre-Q803Y3   	-----MVEKSLKIA---LCFLCVILCHSFSAFAAAPDESAPLNEDAENFFPTD------------------------------------------SAVLHDKISYNMRKSLDLGDGACYLQPGKKESIVACGFNATLRTILIIHGWTMSGMFESWMHKLVAAVQRRESEANVVVVDWLGLANQLYPDAVNHTRRVGQSIATLLDWLQEEEQLQLENVHIIGYSLGAHVAGYAGTFVN---GIIGRITGLDPAGPMFEGADSYNKLSPDDADFVDVLHTYTRGALGVSIGIQEPIGHIDIYPNGGDVQPGCTF--GEFLSAA-------SGNFMEAMKCEHERAVHLFVDSLMNK-DHVSYAFQCTGPDRFKKGICLSCRKNRCNSIGYNAKKMRKRRNSKMYLKTRADTPFGGYHYQMKMHVFDRKNAENADPTFYVKLYGSYNDSSNLIVDVTEGIGLNLTNTFLVFTEEDIGELLKISLRWEGPSD--------SWTSAIKHLGSSFFSWSSAASQKILEVRRIRVKAGETQ-KKFTFCAEE---TEI---SPGEEIMFVKCRDGWEVKPRKRLHY------------------------------------------------------------------------------------------------------     =====>
danre-lipli    	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFVAVAGLLTK---HKVNRITGMDPAGPTFEYADSLSTLSPDDANFVDVLHTNTRGSPDRSIGIQRPVGHIDIYPNGGTFQPGCDL--QNTMLMVATTG---LRNMDQIVKCSHERSIHLFIDSLVNQ-DHESMAFRCSSRDSFNKGMCLSCRKNRCNKVGYAVNKIRTRRSSKMYMKTREMMPYKVFHYQVKVHFFGKTQLSYTDQPMKISLYGIHGEKENIPYIMPT-LNTNSTVSFLLTTDADIGELLMVKLLWEKDTL-------ISW-PWWNSDT------------FHIRKLRIK--SGETQ-SKIIFSAKESEFSYLS--RGGEAAVFVKDKEA---------QSSRKNQRLHKMKMHGSSFKQNTE--------------------------------------------------------------------------------     =====>
danre-q6p2u2   	MMFNKGRVSSAFL----ISWMYFVYISSG--------------------LETTID--PTAES------------------ITLSDIIGNATEWM-MDFTDIESKFSFRTLEEPEDDLCYIVPGQPQSIKDCNFNTETKTFIVIHGWTVTGMFESWVPKLVTALYEREPSANVIVVDWLSRAQQHYPTSASYTKLVGKDVAKFVNWLQAEIDYPWEKLHLLGYSLGAHVAGIAGLLTK---HKVNRITGMDPAGPTFEYADSLSTLSPDDANFVDVLHTNTRGSPDRSIGIQRPVGHIDIYPNGGTFQPGCDL--QNTMLMVATTG---LRNMDQIVKCSHERSIHLFIDSLVNQ-DHESMAFRCSSRDSFNKGMCLSCRKNRCNKVGYAVNKIRTRRSSKMYMKTREMMPYKVFHYQVKVHFFGKTQLSYTDQPMKISLYGIHGEKENIPYIMPT-LNTNSTVSFLLTTDADIGELLMVKLLWEKDTL-------ISW-PWWNSDT------------FHIRKLRIK--SGETQ-SKIIFSAKESEFSYLS--RGGEAAVFVKDKEA---------QSSRKNQRLHKMKMHGSSFKQNNE--------------------------------------------------------------------------------     =====>
danre-q7t359   	------MKTLI------KIVLCFLMISQL-T-----DGATF-----------------------------------QG---NRADTEPEARMKMRYEP---KSVFRVYTDGEYTEDTCALELFQPHTLDACGFNSSLPLAIIIHGWSVDGMMEKWISRLASALKSSEGNINVLIADWLTLAHQHYPIAAQNTRIVGQDIAHLLSWLEDFKQFPLGKVHLIGYSLGAHISGFAGSNLAMSGRTLGRITGLDPAGPMFEGMSHTDRLSPEDAKFVDAIHTFTLQRMGLSVGIKQPVAHFDFYPNGGSFQPGCQLHMQNIYAHLAQHG---IMGFEQTVKCAHERAVHLFIDSLLNK-DKQIMAYKCSDNTAFDKGNCLDCRKNRCNTLGYDIKKVRTGKSKRLFLKTRSHMPYKLFHYQFRIQFINQ--IDKIDPTLTVSLSGTLGESENLPITLVEEISGNKTFTFLITLDTDIGDLMIMRFTWEGNPV---------WANMWNTVKT-IIPWGKKSKGPQLTFGKITVKSGESQ-RKTTFCPQTDEGMSI---EMLQEKVFVRCEKQKPGGIKHTHLRH-----FHIQS--------DL-----SFWMGDS---------------------------------------------------------------------     =====>
dicla-lipli    	----------------------------------------------------------------------------------------------------------------------------------CGFNSSNPLIIITHGWSVDGMMESWVVRLATTLKTNLKDVNVVITDWLSLAHQHYPTAAQSTRTVGKDIAHLLQSLQVHYQYPVRKAHLIGYSLGA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
felca-lipli    	------MESKTLFLMALGIWLQSLTTT------------------------------------------------------RGWVAADDRITGG-RDFIDIESKFALRTPEDIAEDTCHLIPGVTESVANCHFNHTSKTFVVIHGWTVTGMYESWVPKLVAAPYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGKDVAKFINWMAEEFHYPLDNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESDTQTNQVFEISLYGTVAESENIPFTLPE-ISANKTYSFLIYTEVDIGELLMLKLKWKSDSY-------FSWSDWWSSPG------------FTIEKIRVK--AGETQ-KKVIFCSREKVSH-LQ--KGKASVVFVKCHDKSLNKKSG----------------------------------------------------------------------------------------------------------     =====>
human-lipe     	------MSNSVPLL---CFWSLCY-CFAAGSPVPFGPEGRLEDKLHKP---KA--------------------------------------TQT---EVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVK---GTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTR-SFGLSIGIQMPVGHIDIYPNGGDFQPGCGL--NDVLGSIA------YGTITEVVKCEHERAVHLFVDSLVNQ-DKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQ--------SWYNLWKEFRSY-LSQ-PRNPGRELNIRRIRVKSGETQ-RKLTFCTEDPENTSI---SPGRELWFRKCRDGWRMKNETSPTVELP---------------------------------------------------------------------------------------------------     =====>
human-lipli    	------MESKALLVLTLAVWLQSLTAS------------------------------------------------------RGGVAAAD---QR-RDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMLKLKWKSDSY-------FSWSDWWSSPG------------FAIQKIRVK--AGETQ-KKVIFCSREKVSH-LQ--KGKAPAVFVKCHDKSLNKKSG----------------------------------------------------------------------------------------------------------     =====>
macfa-lipli    	--------------------------------------------------------------------------------------MRK---KR-RDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMLKLKWKSDSY-------FSWSDWWSSPG------------FAIQKIRVK--AGETQ-KKVIFCSREKVSH-LQ--KGKAPAVFVKCHDKSLNKKSG----------------------------------------------------------------------------------------------------------     =====>
mesau-q5tld6   	------MESKALLLVVLGVWLQTLTAS------------------------------------------------------LGGVAAAD---GG-RDFTDIESKFALRTPEDTVEDTCHLIPGVAESVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESDKQFNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMMKLRWKSDSY-------FSWSDWWSSPG------------FIIEKIRVK--AGETQ-KKVIFCAREKVSH-LQ--KGKDPAVFVKCHDKSLKKSG-----------------------------------------------------------------------------------------------------------     =====>
mouse-lipe     	------MRNTVFLL---GFWSVYC-YFPAGSITTLRPQGSLRDEHHKP---TG--------------------------------------VPA-T--ARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVK---GTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTL-SFGLSIGIRMPVGHIDIYPNGGDFQPGCGF--NDVIGSFA------YGTISEMVKCEHERAVHLFVDSLVNQ-DKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAH--------SWCNLWNEFRNY-LSQ-PSNPSRELYIRRIRVKSGETQ-RKVTFCTQDPTKSSI---SPGQELWFHKCQDGWKMKNKTSPFVNLA---------------------------------------------------------------------------------------------------     =====>
mouse-lipli    	------MESKALLLVVLGVWLQSLTAF------------------------------------------------------RGGVAAAD---AG-RDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENGKQHNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMMKLKWMSDSY-------FSWPDWWSSPS------------FVIERIRVK--AGETQ-KKVIFCAREKVSH-LQ--KGKDSAVFVKCHDKSLKKSG-----------------------------------------------------------------------------------------------------------     =====>
musvi-lipli    	------MESKALLLVALGMWFQSLTAT------------------------------------------------------RGGVAAADR---G-GDFIDIESKFALRTPEDTAEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGKDVAKFINWMAEEFHYPLDNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESDTQTNQAFEISLYGTVAESENIPFTLPE-VSANKTYSFLIYTEVDIGELLMLKLKWKSDSY-------FSWSDWWSSPG------------FAIEKIRVK--AGETQ-KKVIFCSREKVSH-LQ--KGKASVVFVKCHDKSLNKKSG----------------------------------------------------------------------------------------------------------     =====>
pagma-lipli    	----------------MKAWRVVFLYFLVLN-AVVQHVTSLEEELSDSI---------------------------FG---NFLDPLKDLIEHK-DDANQTVAKFSLRKPSHPDDDLCYIVPGKPDSLAACTFNSSSKTFLVIHGWTLSGMFESWVAKLVSALYEREQTANVIVVDWLTSAQNHYVVAAQNTKAVGQEIARFIDWIEETTNMPLENIHLIGYSLGAHVAGFAGSHAT---NKVGRITGLDPAGPDFEGMHAHRRLSPDDAHFVDVLHTFTRGSLGLSIGIQQPVGHVDIYPNGGSFQPGCNL--RGALEKIANFG---IFAITDAVKCEHERSIHLFIDSLLNE-QEAAKAYRCGSSDMFNRGMCLSCRKGRCNTVGYDISKVRKARNVQMYTKTRASMPFRVYHYQLKIHFSSKVNRSEMEPSLTVSLYGTNGEAENLELKLKEKIATNKTHSFLLVTEKDIGDLLMLKFKWEETNGWSTSNMLKMVSSWWSGDS----------DGANMEVHKIRIRAGETQ-QKMVFCVKDPESQKLT-----QEVTFVKCKDAWRTNSKQTPKRVTLEKH------------------------------------------------------------------------------------------------     =====>
papan-lipli    	------MESKALLLLALAVWLQSLTAS------------------------------------------------------RGGVAAAD---QR-RDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMLKLKWKSDSY-------FSWSDWWSSPG------------FAIQKIRVK--AGETQ-KKVIFCSREKVSH-LQ--KGKAPAVFVKCHDKSLNKKSG----------------------------------------------------------------------------------------------------------     =====>
parma-lipli    	----------------------------------------------------------------------------------------------------------------------------------CGFNSSNPLIIITHGWSLDGMMEGWVVRLARPLKTTLIDVNVVITDWLSLAHQHYPTAAQSTRTVGKDIAHLLQSLQVHYQYPVKKVHLIGYSLGA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ratno-Q8VBX1   	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DADFVDVLHTYTL-SFGLSIGIRMPVGHIDIYPNGGDFQPGCGF--NDVMGSFA------YGTISEMVKCKHKRAVHLFVDSLVNQ-DKP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
ratno-lipli    	------MESKALLLVALGVWLQSLTAF------------------------------------------------------RGGVAAAD---GG-RDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAEKG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPE-VATNKTYSFLIYTEVDIGELLMMKLKWKNDSY-------FRWSDWWSSPS------------FVIEKIRVK--AGETQ-KKVIFCAREKVSH-LQ--KGKDAAVFVKCHDKSLKKSG-----------------------------------------------------------------------------------------------------------     =====>
ratno-q5d216   	------MRDPVFLL---GFWSLYC-CFPAGSLTTLRPQGSLRDEHHKP---TG--------------------------------------VPV-TITTKPSVTFNIRTSKDPEHEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQTREKEANVVVVDWLPLAHQLYIDAVSNTRVVGRRVAGMLNWLQEKGEFSLGDVHLIGYSLGAHVAGYAGNFVK---GTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTL-SFGLSIGIRMPVGHIDIYPNGGDFQPGCGF--NDVMGSFA------YGTISEMVKCEHERAVHLFVDSLVNQ-DKPSFAFQCTDPNRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFRVYHYQLKVHMFSYKNSGDIQPDLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEYLGDLFKIRLTWEGVSS--------SWYNLWNEFRSY-LSQ-PSSPSRELHIRRIRVKSGETQ-RKVAFCVQDPMKNSI---SPGQELWFYKCQNDCRVKN------------------------------------------------------------------------------------------------------------     =====>
sheep-lipli    	------MESKVLLLLALSVWLQSLTVS------------------------------------------------------RGGLVAADRITRG-KDFRDIESKFALRTPEDTAEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVAKFMNWMADEFNYPLGNVHLLGYSLGAHAAGIAGSLTN---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEALRVIAERG---LGDVDQLVKCSHERSVHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNMGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESNTYTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLLYTEVDIGELLMLKLKWISDSY-------FSWSNWWSSPG------------FDIGKIRVK--AGETQ-KKVIFCSREKMSY-LQ--KGKSPVIFVKCHDKSLNRKSG----------------------------------------------------------------------------------------------------------     =====>
spaau-q330h8   	----MGKENISFL----TVWIILGKIFAT--------------------FSSDPE--PNTTTTS----SSSSSSTVFVNTTITATALPTTAEWI-TDYTDIVSKFSLRTADIPDDDMCYIVPGKPDTIKECEFNNETQSFIVIHGWTVTGMFESWVPKLVSALYEREPSANVIVVDWLTRANQHYPTSAAYTKLVGRDVAKFVTWIQKELQLPWDRIHLLGYSLGAHVAGIAGDLTE---RKISRITGLDPAGPTFEHADNQNTLSKDDAQFVDVLHTNTRGSPDRSIGIQRPVGDIDIYPNGGTFQPGCDI--QNTLLGIALEGIKGLQNMDQLVKCSHERSIHLFIDSLLNI-EQQSLAYRCNSKEAFNKGLCLSCRKNRCNKLGYNINKVRRTRSTKMYLKTREMMPYKVFHYQVKVHFFSKDPLSFTEQPMKISLYGTHGEKEDIPFVLPV-LKGNTTMSFLITTDVDIGDLMIVKLRWEKDTI-------ISWSDWWGSSK------------FHVRKLRIK--SGETQS-KVIFSAKEGEFVYLV--RGGEDGEFVKSK--------EDNL-SRKEKLMHKLKTQGTLFGQSDA--------------------------------------------------------------------------------     =====>
sussc-lipli    	------MESKALLLVALSVWLQSLIVS------------------------------------------------------REGLATADRISGG-RDFTDIESKFALRTPEDTVEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPISAGYTKLVGQDVATFIDWMAVEFSYPPNNVHLLGYSLGAHAAGIAGSLTK---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRAQMPYKVFHYQVKMRFSGTESDTHTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMLKLKWVSDSY-------FSWSNWWSSPG------------FAIEKIRVK--AGETQ-KKVIFCSREKKSH-LQ--KGKSSVVFVKCHDKSLNRKSG----------------------------------------------------------------------------------------------------------     =====>
sussc-q68j41   	------MESKALLLVALSVWLQSLIVS------------------------------------------------------REGLATADRISGG-RDFTDIESKFALRTPEDTVEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPISAGYTKLVGQDVATFIDWMADEFSYPPNNVHLLGYSLGAHAAGIAGSLTK---KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNI--GEAIRVIAERG---LGDVDQLVKCSHERSIHLFIDSLLNE-ENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRAQMPYKVFHYQVKMRFSGTESDTHTNQAFEISLYGTVAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMLKLKWVSDSY-------FSWSNWWSSPG------------FAIEKIRVK--AGETQ-KKVIFCSREKKSH-LQ--KGKSSVVFVKCHDKSLESLAETEQMYRRRNSTWSL--------------------------------------------------------------------------------------------     =====>
tetng-q4rsn3   	-----------------------------------------------------------------------------------------------------AVKYNMRKSLDLDREGCYLQAGNRGCLEECGFNATTKTIFIIHGWTISGIFESWMYKLVSAVMQRETEANVVVVDWLPMAQQLYPDAVNHTYAVGLDIAAMLNWLQDEQQLPLQNVHLIGYSLGAHVAGYAGTHVR---GTIGRITGLDPAGPLFEDVEKEQRLSPDDADFVDVLHTYTREALGVSIGIKRPIGDIDIYPNGGEVQPGCTL--GDVLA-V-------AGNFMDVMKCEHERAVHLFVDSLMNR-DHASFAYQCTGPDRFQKGICLSCRKNRCNNIGYNARKMRKRRNSKMYLKTRADTPFAGYHYQMKMHVFNRKNSDNADPTFYVQLFGAHKDTGDLLV------------------NDDIGDLLKIRLTWEAEGD--------SWSSVWKNLKKSFWGWKAK---PVLQIRRIRVKAGETQ-KKFTFCAQDPEKTEI---SSGESLTFLKCRDGWEVK-------------------------------------------------------------------------------------------------------------     =====>
tetng-q4rug9   	----------------MKAWQRGFLYVLALN-AARCCATSLGEELADSIFARTSDQTPALKAALRCSVSSKKTNPLSG---NFLEPLSDLRNRG-DDSNQTVARFSLRKPSHPDDDLCYLVPGRADTLAACTFNHTSKTFLVIHGWRLSGMFESWVSKLVLALYERERAANVVVVDWLTSAQNHYVVAARKTKMVGQEIARFIDWIEESTNAPAENIHLIGYSLGAHVAGFAGSHTT---SKVGRITGLDPAGPDFEGMHAHRRLSPDDAHFVDVLHTFTRGSPGLSIGIQQPVGHVDIYPNGGSFQPGCNL--RSALEKIANFG---IFAITDAVKCEHERSIHLFIDSLLNE-REAAKAYRCGSSDTFNRGMCLSCRKSRCNTVGYNISKVRKARNVQMYTKTRAAMPFRVYHYQLKIHFSSKVNRSEMEPSLTVSLYGTNGEAENLELKLKEKIVANTTHSFLLVTEKDVGDLLMLRFKWEETNRWSSSSMLKMLSSWWGGGA----------DGADVQVHRIRVRAGETQ-QK-----------------------------------------------------------------------------------------------------------------------------------------------     =====>
tetng-q4ruh0   	------------------------------------------------------------------------------------------------DYTDILSRFSLRTAEVPDDDTCYIVPGRPETIAKCNFNLETQTFLVIHGWTVTGMFESWVPKLVAALYEREPSANVVVVDWLTRASQHYPTSAAFTKLVGRDVAKFVTWIQNELRLPWERIHLLGYSLGAHVAGIAGDLTD---HKISRITGLDPAGPTFEHADKQDTLSPDDAQFVDVLHTNTRGSPDRSIGIKRPVGHIDIYPNGGTFQPGCDI--QNTLLGIASEGIKGLQNMDQLVKCSHERSIHLFIDSLLNA-EQQSMAYRCNSKEAFNKGLCLSCRKNRCNKIGYNINHVRTARGAKMYLKTREMMPYKVFHYQVKVHFFSESAQSFTEQPMKISLYGTNGEKEDIPFVLYV-HQIRPTHRECVKQAFLRCRVV-----LPCACL------TSCFTPQAGPQQ------------QHHRLLPPHHRRGRGRPDDCKAALGEGRHPQLVRLVGQQSGPHPQTAHQVR----GDPVQVRALPPPHTLAHVGRLLSGFPACFQGHLWSKRWRVRPPCQGGRSWRLCQVEGRPIEPEREADAQAENTRQPVQERCLRPRVHAAAAYRARHLSQPKPDARHW     =====>
tetng-q4sie5   	-------MSVV------KVLCCLLAIYQL-N-----EAKKI-----------------------------------RG---NRADVMAAEPNGVLKEPHVSLSTFRLFAEG---EDNCTVDPLQLHTLTSCGFNSSNPLIIITHGWSVDGMLESWVLKLATALKSNLIDVNVVITDWLSLAQTHYPTAAKSTRSVGKDIAHLLQALQARYQYPLRKVHLIGYSLGAHISGFAGSYLEG-PEKIGRITGLDPAGPLFEGMSPSDRLSPDDADFVDAIHTFTQERMGLSVGIKQAVGHYDFYPNGGDFQPGCDL--RNIYEHISQYG---LLGFEQTVKCAHERSVHLFIDSLLNK-DKQSRAYRCRDERSFDRGVCLDCRKHRCNTLGYNINQVRTGTSKRLYLKTRSQMPYKLHHYQFRVQFVNQ--MERIQPSLTISLTGTKEESGDIPITVTEPISGNTSLTFLITLDKDLGDLMFLKLRWDGAAL---------WKNVWKRVQT-MIPWGGAERQAQLTVGKISIKAGETQ-ERTTFCAMVHDEQQV---EISQDKVFVRCKE------------------------------------------------------------------------------------------------------------------     =====>
trout-lipli    	----MGKENTFLV----TVWIILANICVS--------------------FSSTPE--QTLFG------------------------NSNSTEWL-EDYTDIVSKFSLRTAEIPDDDLCYIVPGQPSTIPKCEFNPGYKTFVVIHGWTVTGLFESWVPKLVTALYKREPKANVIVVDWLTRAQQHYLTSAANTKLVGKDVAKFVNWLQKTLDYPWEKIHLLGYSLGAHVAGIAGLLTN---HKVSRITGLDPAGPTFEFADAQSTLSPDDALFVDVLHTNTRGSPDRSIGIQRPVGHVDIYPNGGTFQPGCDL--QNTMMMIATTG---IRNMDQLVKCSHERSIHLFIDSLVNAAEHQTMAYRCSSKEAFMKGMCLNCRKNRCNKVGYGVNKVRLPRNTKMYLKTREMMPFKLFHYQVKVHFFSSEKLAYTEQPMKISLYGTHDEKIDIPYTMPF-LNTNSTVSFLLTTDVDVGELLMVKLRWEKDAY-------FSWSDIWGNKN------------FHIRKMRVK--AGETQ-SRVIFSAKDGEYAYLI--RGKDDVVFVKSK--------EDN-MSRKEKTMHRLKMQGSHFKNNIA--------------------------------------------------------------------------------     =====>
xenla-q6p9h9   	--------MSVSLG---LLWICWASVLRLGQTSLLAEEGLLKDDTIANLLSDE--------------------------------------NDV-VPETHPHVKFNAHFSK--HDRGCFLFPGQDECLGNCNYNTSAKTFIVIHGWSMSGLFETWLHRLVGALQEREQYANVIVVDWMNLAHQLYPDAVNNTLVVGKDIAVLMDWLQDKANLSLENVHLIGYSLGAHVAGYAGNFVT---GRIGRITGLDPAGPMFEGAEAHKRLSPDDADFVDVLHTYTREALGVSIGIQMPIGHIDVYPNGGDFQPGCGL--SDVLGAIA------YGSIGDAVKCEHERSVHLFVDSLIHK-DKESFAFQCTDSDRFKKGICLSCRKNRCNAIGYNAKRMRSKRNSKMFLKTRAQMPYKVFHYQMKMHIFNYKSALESEPTFSVTLMGTLNDSVPLPLAVPGEIGYNFTNTFLVYTEDNIGDLLKIHLKWDGSKQ--------MWYSFWNSFQNY-WAK-NDVIDKELHIRRIRVKSGETQ-QKFTFCLENPESTLL---MPGSELVFVKCRDGWEVKPRKRVNL------------------------------------------------------------------------------------------------------     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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