Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....
bovin-q5e9h0   	---------------------MPPDFWERCFWLWGLL--LW--LS----------------------------------VGSTGDAPPTPQTNCTDFQNANLLR----G---TNLKVQFLLFTPLDPSCGQLVEESS----DIQNSGFNATLGTKLVIHGFRALGTKPSWIDRFIDALLRAADANVIAVDWVYGST---------AAYFSAVENVIKLGLEISRFLRKLL-ALGVSESSIHIIGISLGAHVGGMVGHFY----NGQLGQITGLDPAGPEYTRASLEERLDPGDALFVEAIHTDTDNLGIRIPVGHVDYFINGG------QDQPGCPTSIY-AGYSYLICDHMRAVHLYISALENSCPLVAFPCTNYKDFLAGQC---------LDCFNPFLLSCPRIGLVEQ--GGVKIE---PLPKEVKVYLLTTSMAPYCVHHSLVEFHLQEPRNKDTCITVTFLS-SSVTSSVKITIPRH----QRVGKGVLAHPSPQCQINQVKLKLQASHRVWKKDQTTIIGRFCTAPLPVNDNKKM-VCLPEPVNLQASETVSHDLKITCI-----------------------     =====>
danre-q6dbu8   	------------------------MIY--RKIIWGILY--V--TL----------------------------------M----LFDTHRAQECEEMTDLNFKD-SLAG---TSLKVRLLLYTRADPSCGQLLSHQE----PFSNSQFNVSSVTTFLIHGYRPTGSPPVWMKQFVEFLLNRRDMNVIVVDWNRGATN--------MNYWQVVKNTRKVANNLTDLIQKMK-DNGANLSSIHMIGVSLGAHISGFTGANF----NGEIGRITALDPAGPEFNGRPPEDRLDPSDALFVEALHTDMDALGYRNLLGHIDYYANGG------ADQPGCPKTIL-SGSEYFKCDHQRSVFLYMSSVNGSCPIIAYPCESYTDFQDGTC---------MDCGKFKSAGCPIFGYDSVRWRDTLVQL---E--QTRTYFQTNKASPFCKVGYKVDIVSWNQKTHWGYLTIKLSNGT-EETQVELNHKSLKFERFQETSVLAQFERDIQPVKKITLKFCPRKGL-RPRKKLRLLHIRLTPL--QNHLRP-LCRYDLLLE---------------ESKDVTFKPIPCEDSNF------     =====>
danre-q6nyz4   	------------------------MAW--K-WIKAFVYLSV--CV----------------------------------TSALGDDEEASASKCADFNNTTWLEYRQA----TKLQVQYLLLTRKNANCASLFTQDCLNHTQKHTAYFNSSLPTKVIVHGYRALGSKPSWVSGLAQALLREEDVNVLVVDWVYGAS---------FAYNLVVENYKEVAVQISVLINQLT-KYGSTLESFHFIGVSLGAHVSGFVGTLF----HGKLGRITGLDPAGPMFKSADPFDRLDSSDALFVEAIHTDSDYFGISIPVGHVDFFLNGG------MDQAGCARSRFASMYGYVICDHMRALHVYMSALNGSCPLIGFPCSGYEEFLAGKC---------ITCDDPFNGTCPQIGLLKN--SGITAT---PLPNQEKVYLLTTASGPFCAHHILVELNVSRLDKTAE-VQLILKSIGHPETELNLKLYTD----ETRYKTVAAHPEQLCKIDSMQLINTG-GRFYRQ-GDIHFEYICISEIPQTRGMDP-LCVKN-IHIGRGVPWSHDFVQVC------------------------     =====>
dolma-ppla1    	----------------------------------RLI------------------------------------------MFVGDP-SS--SNELDRF-----SV-CPFS---NDT-VKMIFLTRENRK-HDFYTLDTMNRHNEFKKSII-KRPVVFITHGFTSSATEKNFV-AMSEALMHTGDFLIIMVDWRMAACTDEYPGLKYMFYKAAVGNTRLVGNFIAMIAKKLVEQYKVPMTNIRLVGHSLGAHISGFAGKRVQELKLGKFSEIIGLDPAGPSFKKNDCSERICETDAHYVQILHTSS-NLGTERTLGTVDFYINNG------SNQPGCRY-II-----GETCSHTRAVKYFTECIRRECCLIGVPQSK---N-------------PQPVSKCTRNECVCVGLNAK-----------KYPKRGSFYVPVEAEAPYCNNNGKII---------------------------------------------------------------------------------------------------------------------------------------------     =====>
dolma-ppla12   	------------------------------------------------------------------------------------------------G---ILPE-CKLV---PEE-ISFVLSTRENRD-GVYLTLQKLKNGKMFKNSDLSSKKVPFLIHGFISSATNKNYA-DMTRALLDKDDIMVISIDWRDGACSNEFALLKFIGYPKAVENTRAVGKYIADFSKILIQKYKVLLENIRLIGHSLGAQIAGFAGKEFQRFKLGKYPEIIGLDPAGPSFKKKDCPERICETDAHYVQILHTSS-NLGTERTLGTVDFYINDG------SNQPGCTY-II-----GETCSHTRAVKYLTECIRRECCLIGVPQSK---N-------------PQPVSKCTRNECVCVGLNAK-----------EYPKKGSFYVPVEAKAPFCNNNGKII---------------------------------------------------------------------------------------------------------------------------------------------     =====>
drome-CG10163  	---------------------MRA-----QFTMQKSTAQMIIAVC-LICQSLAVEDKDKATNPLNIDSVQKHNVKLLSEQLNRGWR-AFCDAPVDEGVMSLFQG-------INPSDARLHVMTITNQSVELPIKSIS----QIKDFDINPERKTLIYVNAFHTADSYFSVQEHLTLLQNSRRDLNVIVVDFAKDVA---------QLYYAVRHHLSVNGYFVYKLLRAL-KDAGIAVQDITLAGHSVGANIAALGAQLFAKENKQLVGQLLAIDPATMCRTTDI---LVKQSVALRVVVLHGEGDVFGVRVPLGHIDIYPNGIGYFPRRKLQPGCE---------SKICSHMYPFILFMEALIEGVMIPATKCESWAKFRQGDCNFQNTIN---------------IGL------------IYPANAKGLYFCMTQPNPPFTYMEHGLRYKARRP--------------EKSSEKNRIKF--------------------------------------------------------------------------------------------------------------     =====>
drops-q29fi0   	------------------------------------TLLVAVAVAVLLPSMRALAQENKPKTPASIETIQKHNIQLLTEQLNRGWR-AFCDAPVDEGVMSLFQG-------INPSDAALHVMTVTNRSVELPIKSIS----QLRDFDISPERKTLIYVNAFHTADSYFSVQEHLSLLQNSRRDLNVIVVDFARDVA---------QLYYAVRHHLSVHGYAIYNVLKAL-REAGIAPQDITLAGHSVGANIAALGAQLFARGSKQLVGQLVAIDPATMCRTTDI---LVKQGVAERVVVLHGEGDVFGVRVPVGHIDIYPNGIGYFPRRKLQPGCD---------SKICSHMYPFVLFMEALIEGVMIPATKCESWAKFRQGDCQFQNTLN---------------IGL------------IYPSTARGLYFCLTQPNPPFTYMEHGLRYKTSPARTRGP---------EKSAKSGK-----------------------------------------------------------------------------------------------------------------     =====>
human-Q8WWY8   	--------------------------------MLRFYL--F--IS----------------------------------LLC--LSRSDAEETCPSFTRLSFHS-AVVG---TGLNVRLMLYTRKNLTCAQTIN-------SSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATT--------LIYTHASSKTRKVAMVLKEFIDQML-AEGASLDDIYMIGVSLGAHISGFVGEMY----DGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGG------LDQPGCPKTIL-GGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKC---------VSCGTSQKESCPLLGYYADNWKDHLRGK---DPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLMFSTGSLI-GPRYKLRILRMKLRSL--AHPERPQLCRYDLVLM---------------ENVETVFQPILCPELQL------     =====>
human-lipi     	---------------------------------MRV--YIF--LC----------------------------------LMC--WVRSDNKRPCLEFSQLSVKD-SFRDLFIPRIETILMMYTRNNLNCAEPLFEQN----NSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATT--------FIYNRAVKNTRKVAVSLSVHIKNLL-KHGASLDNFHFIGVSLGAHISGFVGKIF----HGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGG------NKQPGCPKSIF-SGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYKDYKTSLC---------VDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQRLMLKSL--TYPERPPLCRYNIVLK---------------DREEVFLNPNTCTPKNT------     =====>
human-psplip   	---------------------MPPGPWESCFWVGGLI--LW--LS----------------------------------VGSSGDAPPTPQPKCADFQSANLFE----G---TDLKVQFLLFVPSNPSCGQLVEGSS----DLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGST---------GVYFSAVKNVIKLSLEISLFLNKLL-VLGVSESSIHIIGVSLGAHVGGMVGQLF----GGQLGQITGLDPAGPEYTRASVEERLDAGDALFTEAIHTDTDNLGIRIPVGHVDYFVNGG------QDQPGCPTFFY-AGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRC---------LDCFNPFLLSCPRIGLVEQ--GGVKIE---PLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLS-SNITSSSKITIPKQ----QRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKM-VCLPEPVNLQASVTVSCDLKIACV-----------------------     =====>
mouse-LIPH     	--------------------------------MLRLCF--F--IS----------------------------------FMC--LVKSDTDETCPSFTRLSFHS-AVVG---TGLSVRLMLYTQRDQTCAQIIN-------STALGSLNVTKKTTFIIHGFRPTGSPPVWIEELVQSLISVQEMNVVVVDWNRGATT--------VIYPHASSKTRQVASILKEFIDQML-VKGASLDNIYMIGVSLGAHIAGFVGESY----EGKLGRVTGLDPAGPLFNGRPPEERLDPSDALFVDVIHSDTD--GYKEALGHIDFYPNGG------LDQPGCPKTIF-GGIKYFKCDHQMSVYLYLASLQNNCSITAYPCDSYRDYRNGKC---------VSCGAGQIVPCPRVGYYADSWKEYLWDR---DPPMTKAFFDTAETKPYCMYHYFVDIVSWNKSVRRGFITIKLRGEDGNITESKIDHEPSAFEKYHQVSLLARFNRDLDKVAEISLLFSTGSVV-GPKYKLRVLQMKLRSL--AHPDRPHLCRYDLVLM---------------ENVETSFQPILCSQQQM------     =====>
mouse-psplip   	---------------------MRPGLWETCFWLWGPL--LW--LS----------------------------------IGSSGNVPPTTQPKCTDFQSANLLR----G---TNLKVQFLLFTPSDPSCGQLVEEGS----DIRSSEFNASLRTKVIIHGFRALGTKPSWIDKFISAVLRAADANVIAVDWVYGST---------GVYYSAVENVVKLSLEISRFLSKLL-ELGVSESSIHIIGVSLGAHVGGMVGHFY----KGQLGQITGLDPAGPEYTRASLEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGG------QDQPGCPAFFH-AGYNYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDC---------LDCFNPFLLSCPRIGLVER--GGVMIE---PLPKEVKVYLLTTSSAPYCVHHSLVEFYLKEKRKKDTSIEVTFLS-NNVTSSVKITIPKQ----QLEGRGVMAHPNPQCQINQVKLKFQVSSRVWRKDRTPVVGTFCTAPLPVNDSKKT-VCIPEPVRLQAGVPAFQDLKIACV-----------------------     =====>
phlpa-LIP      	-----------------------------MFRFR--IAFVAVATYL------TLASG---VVFECPDSVQKFNNEELLRCLQDGWE-RVCEANVDTTVLNYYPG-------AAVRDVKLYLFGKDAVHTYHLADLCD----LCANEDFHKGKKTMVFVSAFPPAEGYSVLSE-LWKLRQAYQDCNLVVVDFASNVE---------QLYSTLHANFDHAAHTVKKVLHYVIDGSYVLPQDCYLVGFSFGAQVAARGAVLLNEECDLLPHYLLALDPAPSCDGVNY---VT-KDVAKKVVSLHTNTGHYGVEVD-AHVTLFPNGK-----VRLQPCCK---------TNVCSHYLSVELLVEALCKPNSVLFVKCQDWQTFKKAKCDYRNVLA---------------LEL------------ETPHSSEGTYYCHTADHSPYGLGNAGLKP--------------------------------------------------------------------------------------------------------------------------------------------     =====>
polan-pla1     	----------------------------------------------------------------------------------------------------MSPD-CTFN---EKD-IVFYVYSRDKRD-GIILKKETLTNYDLFTKSTI-SKQVVFLIHGFLSTGNNENFV-AMSKALIEKDDFLVISVDWKKGACNAFASTKDALGYSKAVGNTRHVGKFVADFTKLLVEKYKVLISNIRLIGHSLGAHTSGFAGKEVQKLKLGKYKEIIGLDPAGPYFHRSDCPDRLCVTDAEYVQVIHTSI-ILGVYYNVGSVDFYVNYG------KNQPGCN---------EPSCSHTKAVKYLTECIKHECCLIGTPWKKYFST-------------PKPISQCRGDTCVCVGLNAK-----------SYPARGAFYAPVEANAPYCHNEGIKL---------------------------------------------------------------------------------------------------------------------------------------------     =====>
poldo-q6q252   	------------------------------MNFKYSILFICFVKV-------------------------------LDNCYAADDLTTLRNGTLDRG---ITPD-CTFN---EKD-IELHVYSRDKRN-GIILKKEILKNYDLFQKSQI-SHQIAILIHGFLSTGNNENFD-AMAKALIEIDNFLVISVDWKKGACNAFASTNDVLGYSQAVGNTRHVGKYVADFTKLLVEQYKVPMSNIRLIGHSLGAHTSGFAGKEVQRLKLGKYKEIIGLDPAGPSFLTNKCPNRLCETDAEYVQAIHTSA-ILGVYYNVGSVDFYVNYG------KSQPGCS---------EPSCSHTKAVKYLTECIKRECCLIGTPWKSYFST-------------PKPISQCKRDTCVCVGLNAQ-----------SYPAKGSFYVPVDKDAPYCHNEGIKL---------------------------------------------------------------------------------------------------------------------------------------------     =====>
polga-P83542   	------------------------------------------------------------------------------------------------G---ITPD-CTFN---EKD-IELHVYSRDKRN-GIILKKEILKNYDLFKES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
polpi-pa1      	------------------------------MNFKYSILFICF-------------------------------------------------GTLDRG---LIPE-CPFN---EYD-ILFFVYTRQQRD-GIVLTEETLQNYDLFKKSTI-SRQVVFIDHGFLSNGNNENFI-AMAKALIEKDNFLVISVDWKKGACNAFASTLDYLGYSTAVGNTRHVGKYVADFTKLLVEQYKVSMSNIRLIGHSLGAHTSGFAGKEVQELKLNKYSNIDGLDPAGPSFDSNDCPERLCETDAEYVQIIHTSN-ILGVYSKIGTVDFYMNYG------SHQPGCGR-FF-----SPSCSHTKAVKYLTECIKHECCLIGTPWKKYFST-------------PKPISQCTKDTCVCVGLNAK-----------SYPARGSFYVPVEATAPYCHNEGIKL---------------------------------------------------------------------------------------------------------------------------------------------     =====>
ponpy-q5ref0   	---------------------MPPGPWESCFWVGGLL--LW--LS----------------------------------VGSSGDAPPTPQPNCADFQSANLFE----G---TDLKVQFLLFVPSNPSCGQLVEGSS----DLQNSGFNATLGTKLIIHGFRVLGTKPSWIDKFIRTLLLATNANVIAVDWIYGST---------GVYFSAVKNVIKLSLEISLFLNKLL-VLGVSESSIHIIGVSLGAHVGGMVGQLF----GGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGG------QDQPGCPTFFY-AGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRC---------LDCFNPFLLSCPRIGLVEQ--GGVKIE---PLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLS-SNVTSSSKITIPKQ----QRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKM-VCLPEPVNLQASVTVSRDLNLACV-----------------------     =====>
rabit-Q9BDJ4   	--------------------------------MLRFYL--F--IS----------------------------------LLC--LVRSDTDETCPSFTKLSFHS-AVVG---TELNVRLLLYTRKNYTCAQIIN-------STTFGNLNVTKKTTFVVHGFRPTGSPPVWLQDLVKALLMVEDMNLVVVDWNRGATT--------VIYTQASNKTRKVAIILKEFIDQML-ARGASLDDIYMIGVSLGAHISGFVGKMY----NGQLGRITGLDPAGPLFNGKPPQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGG------VDQPGCPKTIFEAGMQYFKCDHQMSVYLYLSSLRKNCTITAYPCDSYRDYRNGKC---------INCGLPQGKPCPLLGYYADNWKDYLSEK---DPPMTKAFFDTAEKEPYCMYHYFVDIITWNKSIRRGSITIKLKDEAGNTTESKINHEPVTFEKYHQVSLLARFNQDLDKVAEISLVFSTGAVI-GPKYKLRILRMKLRSL--AHPERPQLCRYDLVLT---------------ENVETPFQPIVCQKLQM------     =====>
ratno-P97535   	---------------------MCPGLWGTCFWLWGSL--LW--LS----------------------------------IGRSGNVPPTTQPKCTDFQSANLLR----G---TNLKVQFLLFTPSDPGCGQLVEEDS----DIRNSEFNASLGTKLIIHGFRALGTKPSWINKFIRALLRAADANVIAVDWVYGST---------GMYFSAVENVVKLSLEISRFLSKLL-ELGVSESSIHIIGVSLGAHVGGMVGHFY----KGQLGRITGLDPAGPEYTRASLEERLDSGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGG------QDQPGCPAFIH-AGYSYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDC---------LDCFNPFLLSCPRIGLVER--GGVKIE---PLPKEVRVYLQTTSSAPYCVHHSLVEFNLKEKRKKDTSIEVTFLG-NNVTSSVKITIPKD----HLEGRGIIAHQNPHCQINQVKLKFHISSRVWRKDRTPIVGTFCTAPLPVNDSKKT-VCIPEPVRLQVSMAVLRDLKMACV-----------------------     =====>
ratno-q6p6s8   	QTPGWERRTGRLCGVAPVLVFGTHDLL--RLPMLRLCF--L--LS----------------------------------FMC--LVKSDTDETCPSFTRLSFHS-AVVG---TGLSVRLMLYTQRDQTCAQVIN-------STALGSLNVTKKTTFIIHGFRPTGSPPVWMEELVQSLISVQEMNVVVVDWNRGATT--------VIYPHASSKTRKVALILKEFIDQML-AKGASLDNIYMIGVSLGAHIAGFVGEMY----SGKLGRITGLDPAGPLFNGRPPEDRLDPSDAQFVDIIHSDTDALGYREALGHIDFYPNGG------LDQPGCPKTIF-GGIKYFKCDHQMSVFLYLASLQNNCSITAYPCDSYRDYRNGKC---------VSCGAGHIVSCPSLGYYADNWREYLWDR---DPPMTKAFFDTAETKPYCIYHYFVDIISWNKSVRRGFITIKLRGEDGNITESKIDHEPSAFQKYHQVSLLARFNRDLDKVAEISLLFSTKSVV-GPKYKLRVLRMKLRSL--AHPDRPHLCRYDLVLM---------------ENVETFFQPILCSKQQM------     =====>
solin-Q9TXF4   	------------------------------------------------------------------------------------------------G---AASS-NTYD---IGQ--LMAKYTVDLMN-------KNLGNQQSCQ-DINASLPVVFITHGFTSSAQVSTFK----------------IVDWSEAACTDGLPGVQW----------------------------KIPLNNIQYVGHSLGSHVSGFAAKNDNTFEGEYHAF-------------PDCARN----------------------------LFKGRQQ------ESQPACS--WY-----DVPCSHSEXXVYXTGVPS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
solin-q68kk0   	------------------------------MRKFAAIFVVFFVQC-------------------------------TH-LYSLAQARAEPDPGVVEY---LKQS-CVYG---NSSYINVYLYNSRFQG-------KNLGNQQSCQ-DINASLPVVFITHGFTSSAQVSTFK-DLANAFVQKGHTA-FIVDWSEAACTDGLPGVQFAEYNAAASNTYDIGQLMAKYTVDLMNKCKIPLNNIQYVGHSLGSHVCGFAAKHVKKLINKTMPYILALDPADPSFGSNKCGERICKSDAKRIVVFKTSI-LGIGENIIGHLLIVFDGG------KSQPACS--WY-----DVPCSHSESIVYATGMVSGRCQHLAVPWTAQQRINPIQWKFWRVFTSNIP-AYPTSDTTNCVVLNTN-----------VFKNDNTFEGEYH-AFPDCARNLFKCRQQ------------------------------------------------------------------------------------------------------------------------------------------     =====>
tetng-q4rtq6   	------------------------MLWGHR-WILLCVLTAG--FT----------------------------------SLSLGV---EENVKCADLNNTTWQQYRQHR---PKLQVQYLLLTRRNLDCAQEFSQESLNNT-----HFNVSRPTKVIIHGYRVMGSKPSWVKELAQALLRVEDVNVLVV-----------------------------AVQVSILINQLQ-GHGCKLESFHFIGVSLGAHVAGFVGTLF----TGKIGRITGLDPAGPMFKRADVYDRLDPSDAQFVEAIHTDSDNFGISIPVGHVDFFINGG------NDQTGCPHFGLALMYSRLICDHMRALHVYISALNGSCPLVGIPCNSYDEFLTGQC---------LNCD-VFKGKCPAIGLSKN--SGVVLS---PLPKEQKLFLLTSPSSPFCAHHILLELEVSPLEKRAE-LGVTLRT-GSVAVEQKLGLGTG----ATLYRSVLAHPMALCEIGTIELRNTG-SRFYRQ-GEVHVKSVCLSELPSLRREKP-LCVIK-FNVRRGTPCHMTWSRCVACSEAPQLAPPPSRPGSYPTLDAS     =====>
tetng-q4sfm7   	------------------------------MSRWLYLTPLL--LL----------------------------------L----IDQHTCDQGCDEFTDLSFSH-SFIG---TSVRVRLLLYTSEGGTCGSLVSHTD----PSAHPRFNFSRPTTFLIHGYRPTGSPPKWLSNITKLLLAGTHTNLIIVDWNYGAAN--------VNYLIAARNTHAVAENLTAFVERLK-EKGLSLSSIHMIGVSLGAHISGFVGANM----NGSIGRITALDPAGPLFTGTLPKDRLDPSDAQFVDVLHTDIDALGFRGPLGHIDFYPNGG------TDQPGCPNNIF-SGLSYFKCDHQRSVYLYMDSISRVCDSRAYPCQSYQDFLNGLC---------SSCERFGDAGCPVFGYYVTQWKDVLLKL---N--QTNVYFTTNSASPFCTAQYTVDVTVWNKAVRWGYLTVKLYSAD-QEAVATIDHTAFTFKRFTETRLLAQFDKDIKSVEKMSLKFSTGSVL-QPKYKLRVLRVRLTPL--EREERP-LCRYDIVAA---------------EDREVTFRPLPCEDS--------     =====>
tetng-q4szy0   	------------------------------MRCRGLLALLG--LL----------------------------------LLCEGQEQSGAGESCDNFTDLDLAH-CFLG---TSLYVRLLLYTRSNLDCGRELRHRR----LSEQPLFNASRPTTFVIHGYRPTGAPPIWIQHIVHLLAQQDDMNIVVVDWNKGAAN--------LNYFTAVTYTRQAAHNLTGFILTMQ-EEGASLSSVHLVGVSLGAHLAGYVGANL----KGRIGRITGLDPAGPMFTSATAEERLDPSDAMFVDVLHTDMNCE--------------------------------S-SGKSYFVCDHQRSVFLYLCALNRTCSLTGYPCASYSSFLEGQC---------LQCEAFRPSSCPVLGYDLSPWRDTLLKL---G--QTRVFFSTTAALPYRKSSYRVDMVTWNQYLRWGVVYIRLHGGR-TSTEARIDHKLLRFEQYTSTRLLAQFDEDLPQIQKISMRISTGNVI-GPRYKIRLVRVRFTPL--ERPDRLLMCRFDIIME---------------ENVEVAFRPLPCDSHL-------     =====>
vesge-q3zu95   	------------------------------------------------------------------------------------------------G-----PK-CPFN---TDT-VSMIIETRENRN-RDLYTLQTLQNHPEFKEKTI-TRPVVFITHGFTSSASETNFI-NLSKALVDKDNYMVISIDWQTAACTNEAAGLKYLYYPTAASNTRLVGQYIATITQKLVKQYKISMANIRLIGHSLGAHVSGFAGKKVQELKLGKYSEIIGLDPAGPSFSSNKCSDRLCETDAEYVQILHTSN-HLGTERILGTVDFYMNNG------KNQPGCGR-FF-----TEVCSHSRAVIYMAECIKHECCLIGIPKSK---S-------------SQPISSCTKQECVCVGLNAK-----------KYPSRGSFYVPVESTAPFCNNKGKII---------------------------------------------------------------------------------------------------------------------------------------------     =====>
vesmc-ppla1    	------------------------------------------------------------------------------------------------G-----PK-CPFN---SDT-VSIIIETRENRN-RDLYTLQTLQNHPEFKKKTI-TRPVVFITHGFTSSASEKNFI-NLAKALVDKDNYMVISIDWQTAACTNEYPGLKYAYYPTAASNTRLVGQYIATITQKLVKDYKISMANIRLIGHSLGAHVSGFAGKRVQELKLGKYSEIIGLDPARPSFDSNHCSERLCETDAEYVQIIHTSN-YLGTEKILGTVDFYMNNG------KNNPGCGR-FF-----SEVCSHTRAVIYMAECIKHECCLIGIPRSK---S-------------SQPISRCTKQECVCVGLNAK-----------KYPSRGSFYVPVESTAPFCNNKGKII---------------------------------------------------------------------------------------------------------------------------------------------     =====>
vesmg-pa1      	------------------------------MNLKYLLLFFCLVQV-------------------------------LHYCYSHGDPSL--SNELDRG---LIPK-CKLV---PEQ-ISFVLSTRENQN-GVFLTLDNLSKGGILPKSDLSSIPVIFLIHGFISSANNSNYV-DMTKALLEKNDCMVISIDWRDGACTHEFKILKFIGYPNAVKNTRAVGKYIADFTKLLMQKYKVSLANIRLIGHSLGAQIAGFAGKEYQKFKLGKYPEIIGLDPAGPLFKSNDCSERICETDAHYVQIIHTSN-NLGTERTLGTVDFYVNNG------YNQPGCYLSFL-----GEACSHTRAVKYFTECIRHECCLIGVPQSK---N-------------PQPVSKCTRKECVCIGLNAK-----------TYPKTGSFYVPVESKAPYCNNKGKKI---------------------------------------------------------------------------------------------------------------------------------------------     =====>
vesvu-pa1      	--------------------------MEENMNLKYLLLFVYFVQV-------------------------------LNCCYGHGD-PL--SYELDRG-----PK-CPFN---SDT-VSIIIETRENRN-RDLYTLQTLQNHPEFKKKTI-TRPVVFITHGFTSSASETNFI-NLAKALVDKDNYMVISIDWQTAACTNEAAGLKYLYYPTAARNTRLVGQYIATITQKLVKHYKISMANIRLIGHSLGAHASGFAGKKVQELKLGKYSEIIGLDPARPSFDSNHCSERLCETDAEYVQIIHTSN-YLGTEKTLGTVDFYMNNG------KNQPGCGR-FF-----SEVCSHSRAVIYMAECIKHECCLIGIPKSK---S-------------SQPISSCTKQECVCVGLNAK-----------KYPSRGSFYVPVESTAPFCNNKGKII---------------------------------------------------------------------------------------------------------------------------------------------     =====>
xenla-q641f6   	------------------------MLL--SFYFNGLLL--V--GC----------------------------------LLS--WGRSDTEGQCHSFTDLNIHN-SIIG---TALKVQLLLYTPENPKCAQDLNEDN----STGFQYLNVTRKTVFITHGYRPTGSPPVWIDNIVTKFLDIQDFNVILVDWNRGATT--------VLYHNAAAKTRKVADILKRLIDNML-SQGATLDSIYMVGVSLGAHISGFVGKMY----NGSIGRITGLDPAGPLFNGKPPEERLHYTDAQFVDVVHTDTDGLGYKESLGHIDFYPNGG------TDQPGCPKTIL-SGSEYFKCDHQRSVFLYIASLTNNGDLVGFPCKSYRDYRIGNC---------TNCKEFLPLSCPVFGFYADKWKDHLVKK---NPPGTKAFFDTAAKDPFCIFHYYLDIMTWSSQTRRGYITIRLMSLNGNVTESKLDKDHATFEQYKEVSLLAKFDQDLDPMTRISVTFTTGSVI-GPKFKLRVLRMRLRPL--TNTNRPILCRYDFVLL---------------ENVEMEFNPIPCEDTNL------     =====>
xenla-q6pa23   	------------------------MLL--SFYFNGLLL--V--GC----------------------------------LLS--WGRSDTEGQCHTFTDLNIHN-AIIG---TGLKVQLLLYTRENPNCAQDLNEDN----STGFQYLNVTRKTVFIIHGYRPTGSPPVWIDDIVKKFLDIQDFNVIVVDWNRGATT--------VLYHNAAANTRKVADILKRLIDNML-SQGATLDSVYMVGVSLGAHISGFVGKMY----NGSIGRITGLDPAGPLFNGKPPEERLHYTDAQFVDVVHTDIDGLGYKESLGHIDFYPNGG------TDQPGCPKTIL-AGSEYFKCDHQRSVYLYISSLKKNCDLVGFPCKSYRDYRIGNC---------TDCKEFLPLSCPVLGFYADKWKDHLVEK---NPPGTKAFFDTAAKDPFCKFHYYLDFMTWSSQTKRGYITIKLKSLDGNVTESKLDKDHATFQQYKETSLLAKFDQDLDQISKISVTFTTGSII-GPKYKLRVLRMRLRPL--TNRDRPILCRYDFVLL---------------ENIEMEFIPIPCEDTNL------     =====>
xentr-q5xge9   	------------------------MLL--RFYFNGLLF--V--GC----------------------------------LLS--WGRSDTEEQCHTFTDLNIHN-SIIG---TGLKVQLLLYTRENPKCAQDLNVDN----STGFQYLNVTRRTVFITHGYRPTGSPPVWIDDIVKKFLDIQDFNVIVVDWNRGATT--------VLYHNAAANTRKVADILKRFIDNML-SQGATLDSIYMVGVSLGAHISGFVGKMY----NGSIGRITGLDPAGPLFNGKPPEERLHYTDAQFVDVVHSDTDGLGYKESLGHIDFYPNGG------TDQPGCPKTIL-AGSEYFKCDHQRSVFLYIASLTKSCDLVAFPCKSYRDYRIGNC---------TDCKEFLPLSCPVLGFYADKWKDHLVKR---NHPGTTAFFDTAAKDPYCIFHYYLDFMTWSSQIRRGYITIKLTSLDGNVTESKLDKDAAVFEQYKEESLLAKFDQDMDPISRISVTFTTGSVI-GPKYKLRVLRMRLRPF--TNRNRPILCRYDFVLL---------------ENIETEFIPIPCEDTNL------     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....