Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....
9acto-d4q9n1   	-----MSVTTPRR------E-ASLLS-RA---VAV--AAA----AAA------TV--ALAAPAQAANPYE----RGPNPTESMLEARSGPFSVSEERASRLGADGFGGGTIYYPRE------NNTYGAIAISPGYTG-TQSSIAWLGERIASHGFVVIAIDTNTTLDQPDSRARQLNAALD--YML---TDASSSVRNRIDASRLAVMGHSMGGGGTLRLASQ----------RPDLKAAIPLTPWHLNK--------------SWRDITVPTLIIGADLDTIA-------PVSSHSEPFYNSIPSSTDKAYLELNNATHFAPNIT---NKTIGMYSVAWLKRFVDEDTRYTQFLCPGPRTGLLSDVDEYR-------STCPF----     =====>
9acto-e9lvh8   	----------------------------------------------------------------MANPYE----RGPNPTDALLEASSGPFSVSEENVSRLSASGFGGGTIYYPRE------NNTYGAVAISPGYTG-TEASIAWLGERIASHGFVVITIDTITTLDQPDSRAEQLNAALN--HMI---NRASSTVRSRIDSSRLAVMGHSMGGGGTLRLASQ----------RPDLKAAIPLTPWHLNK--------------NWSSVTVPTLIIGADLDTIA-------PVATHAKPFYNSLPSSISKAYLELDGATHFAPNIP---NKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYR-------STCPF----     =====>
9acto-e9lvh9   	----------------------------------------------------------------MANPYE----RGPNPTDALLEARSGPFSVSEERASRFGADGFGGGTIYYPRE------NNTYGAVAISPGYTG-TQASVAWLGERIASHGFVVITIDTNTTLDQPDSRARQLNAALD--YMI---NDASSAVRSRIDSSRLAVMGHSMGGGGTLRLASQ----------RPDLKAAIPLTPWHLNK--------------NWSSVRVPTLIIGADLDTIA-------PVLTHARPFYNSLPTSISKAYLELDGATHFAPNIP---NKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYR-------STCPF----     =====>
9acto-f7ix06   	-----MSVTTPRR------E-TSLLS-RA---LRA--TAAAATAVVA------TV--ALAAPAQAANPYE----RGPNPTESMLEARSGPFSVSEERASRFGADGFGGGTIYYPRE------NNTYGAIAISPGYTG-TQSSIAWLGERIASHGFVVIAIDTNTTLDQPDSRARQLNAALD--YML---TDASSAVRNRIDASRLAVMGHSMGGGGTLRLASQ----------RPDLKAAIPLTPWHLNK--------------SWRDITVPTLIIGAEYDTIA-------SVTLHSKPFYNSIPSPTDKAYLELDGASHFAPNIT---NKTIGMYSVAWLKRFVDEDTRYTQFLCPGPRTGLLSDVEEYR-------STCPF----     =====>
9bact-a3hta1.2 	-----------------------------------------------------------------------------------------PALMTSETS-------LPTHTIFRPQNIEAFGGSNKLPVIAWGNGACFDSPWEHVNFLNEIASHGFLVVAIGTMPKQTDVRSKSQKLLDAID--WAIAQNNDPTSPYFQKIDTEQISVSGMSCGGLQTLEVADD-----------PRVSTVGVFNSGVLGNPGGGMPGMPQVTKDQLQNIKVPTLYLLGGESDIAYGNGMDDFSRINHIPVFVGNL--D---------VGHGGTYGQ-PHGGEFARVALNWYLWQLKGDEEAGKLFSTNPPGLSKWEGWVVE--------KKNMD---     =====>
9bact-g9by57   	--------------------MDGVLW-RV---RTAALMAALLALAAW------ALVWASPSVEAQSNPYQ----RGPNPTRSALTA-DGPFSVATYTVSRLSVSGFGGGVIYYPTGT-----SLTFGGIAMSPGYTA-DASSLAWLGRRLASHGFVVLVINTNSRFDYPDSRASQLSAALN--YLR---TSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ----------NPSLKAAVPLTPWHTDK--------------TFN-TSVPVLIVGAEADTVA-------PVSQHAIPFYQNLPSTTPKVYVELDNASHFAPNSN---NAAISVYTISWMKLWVDNDTRYRQFLCNVNDPALS-DFRTNN-------RHCQ-----     =====>
acide-PBSA     	------MH-LPRSRWDIPFK-------EE---TTMTHHFSVRALLAA------GALLASAAVSAQTNPYE----RGPAPTTSSLEASRGPFSYQSFTVSR--PSGYRAGTVYYPTNA-----GGPVGAIAIVPGFTA-RQSSINWWGPRLASHGFVVITIDTNSTLDQPDSRSRQQMAALS--QVATLSRTSSSPIYNKVDTSRLGVMGWSMGGGGSLISARN----------NPSIKAAAPQAPWSASK--------------NFSSLTVPTLIIACENDTIA-------PVNQHADTFYDSMS-RNPREFLEINNGSHSCANSGNSNQALLGKKGVAWMKRFMDNDRRYTSFACSNPNSYNVSDFRVA---------ACN-----     =====>
gamho-LIPA     	-----MCSSV-REREGETMQASQSLL-SLFTIAAC--STALMGCLEAADQGGLDEELELGSAEQE---------AGTFPP-VSDFAATGPFSTTSGSL-------GLSCTVYRPSNLGQ--GGVTHPVILWGNGTGS-SPSTYAGLLRHLASHGFIVAAADTSN-----AGNGSEMISCLN--SLVSANGSVLSPFYQKVDTARVGASGHSQGGAGTIMAGRD-----------SRVTATAPLQPYIGFIPFGGLFLDSSI-----RQQRGPMFLVSGSSDTIA-------VPTINQLPVYNGVN--QPVWWATRSGASHFEP--V-GSAAPSAARSPRGSALAS------------------------------------------     =====>
morsp-lip1     	-----MFIMIKKSELAKAIIVTGALVFSIPTLAEVTLSETTVSSIKS------EATVSSTKKALPATPSDCIADSKITAVALSDTRDNGPFSIRTKRISRQSAKGFGGGTIHYPTNASG---CGLLGAIAVVPGYVS-YENSIKWWGPRLASWGFVVITINTNSIYDDPDSRAAQLNAALD--NMI-----ADDTVGSMIDPKRLGAIGWSMGGGGALKLATE----------RSTVRAIMPLAPYH-DK--------------SYGEVKTPTLVIACEDDRIA-------ETKKYANAFYKNAI--GPKMKVEVNNGSHFCPSYR-FNEILLSKPGIAWMQRYINNDTRFDKFLCANENYSKSPRISAYDY------KDCP-----     =====>
pseae-PA3734   	-----------------------------------------------------------------------------------------------------------STSVYYPADIAA--SDAKLPVITFVGGILS-NAGNYHELMKLWASHGFIVVISSD-FINSFP------LMHALGILEVAKLDRDPASALHGRADFSRTLVAGHSAGGQATLQSASLSAQALQLIEPRLKLVGALPIEPGPLAI---------------GSTVKTPTLLLTGLADVVV-------PPLSWPILWQGPLIRDVPAWGATATTATHFSPLRQ-IEYNEFAGISVAWVLYQGKNDAQARDYFVGR-YYKLASDIQFNDPLRLLRPSRNKLAAAL     =====>
psemy-a4y035   	----------------------------------------------------------APLPDTP---------GAPFPA-VANFDRSGPYTVSSQSE-------GPSCRIYRPRDLGQ--GGVRHPVILWGNGTGA-GPSTYAGLLSHWASHGFVVAAAETSN-----AGTGREMLACLD--YLVRENDTPYGTYSGKLNTGRVGTSGHSQGGGGSIMAGQD-----------TRVRTTAPIQPYTLGLG----HDSASQ-----RRQQGPMFLMSGGGDTIA-------FPYLNAQPVYRRAN--VPVFWGERRYVSHFEP--V-GSGGAYRGPSTAWFRFQLMDDQDARATFYGAQCSLCTSLLWSVE--------RRGL----     =====>
stral-lipas    	------MHSTPRT---GTTQAPGLSR-RL---AAS--AAAVAAVVGL------TT-LSTPGAQAADNPYE----RGPAPTRASIEAPRGPYAVSQTSVSSLVVSGFGGGTIYYPTSTG----DGTFGAVVVTPGFTA-TESSMAWLGPRLASQGFVVFTIDTLTTLDQPDSRGRQMLAALD--YLT---ER--SSARTRIDGTRLGVIGHSMGGGGTLEAAKS----------RPSLKAAIPLTPWNLDK--------------TWPEVTTPTLVVGADGDTVA-------PVATHAKPFYSSLPSSTDRAYLELNNATHFAPNLS---NTTIAKYSVSWLKRFIDDDTRYEQFLCPLPVPDR--DIEEYR-------GTCPLGG--     =====>
strco-LIPA     	MQQNPHTHAAPGA---ARPVLRGVRR-RL---AAV--TAAVAAVLVL------GT-LTGPGAQAADNPYE----RGPAPTESSIEALRGPYSVADTSVSSLAVTGFGGGTIYYPTSTS----DGTFGAVVIAPGFTA-YQSSIAWLGPRLASQGFVVFTIDTNTTLDQPDSRGRQLLAALD--YLT---GR--SSVRGRIDSGRLGVMGHSMGGGGTLEAAKS----------RPSLQAAIPLTPWNLDK--------------SWPEVSTPTLVVGADGDTIA-------PVASHAEPFYSGLPSSTDRAYLELNNATHFSPNTS---NTTIAKYSISWLKRFIDDDTRYEQFLCPLPRPSL--TIEEYR-------GNCPHGS--     =====>
strex-lipas    	MPQ----HLLPARRQAARPSRPRTLT-GL---LAA--AAATAGLLLS------GLAPGAQAAAAAANPYE----RGPAPTNASIEASRGPYATSQTSVSSLVASGFGGGTIYYPTSTA----DGTFGAVVISPGFTA-YQSSIAWLGPRLASQGFVVFTIDTNTTLDQPDSRGRQLLSALD--YLT---QR--SSVRTRVDATRLGVMGHSMGGGGSLEAAKS----------RTSLKAAIPLTGWNTDK--------------TWPELRTPTLVVGADGDTVA-------PVATHSKPFYESLPGSLDKAYLELRGASHFTPNTS---DTTIAKYSISWLKRFIDSDTRYEQFLCPIPRPSL--TIAEYR-------GTCPHTS--     =====>
thefu-e9lvi0   	----------------------------------------------------------------MANPYE----RGPNPTDALLEARSGPFSVSEENVSRLSASGFGGGTIYYPRE------NNTYGAVAISPGYTG-TEASIAWLGERIASHGFVVITIDTITTLDQPDSRAEQLNAALN--HMI---NRASSTVRSRIDSSRLAVMGHSMGGGGSLRLASQ----------RPDLKAAIPLTPWHLNK--------------NWSSVRVPTLIIGADLDTIA-------PVLTHARPFYNSLPTSISKAYLELDGATHFAPNIP---NKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYR-------STCPF----     =====>
thefu-q6a0i3   	-----MAVMTPRR------ERSSLLS-RA---LRF--TAAAATALVT------AV--SLAAPAHAANPYE----RGPNPTDALLEARSGPFSVSEERASRFGADGFGGGTIYYPRE------NNTYGAVAISPGYTG-TQASVAWLGKRIASHGFVVITIDTNTTLDQPDSRARQLNAALD--YMI---NDASSAVRSRIDSSRLAVMGHSMGGGGSLRLASQ----------RPDLKAAIPLTPWHLNK--------------NWSSVRVPTLIIGADLDTIA-------PVLTHARPFYNSLPTSISKAYLELDGATHFAPNIP---NKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYR-------STCPF----     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....