ESTHER Database

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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....
9bact-d8pbw6   	-----------------------------------------------------------------------------------------------------------------VVLAPGYGESKR--DYVPLAYYLAGNGFHVVRFDNVNHVGESDGLVTQFRLEDMETDLETVLDYVAAQWPGRSIGLVATSLAGRVALKVA---GRVPHL-GLLALINGIMDVQHTLQAVHQE----DLIGE----HLAGARKGVVNILG-LTIDADRWLEHAVQGGYADLRSTEQDAERLHAPVVLFHAEQDAWVDPSSIEAVGAAMGENLRHSYVVPGALHRLQESPRKA-----RTVYRQIAL----CCQEELW-----PARSMARTVEPSHREIGVQNRAERERSKK---------------------------------------------------------     =====>
9bact-d8pdl3   	-------------------------------------------------------------------------------HDV-------------PTR-------TDSTQYPLVLLCPGYGTTQQ--AYVALAYTLAACGLQILRYDHSRHIGLSDGDPTQTTLTSLEDDLDTVLSFAQKEFPGIPLTVLAPDLLGRIVLRRQ---DWHRRV-NRLLLLNPALDIRNCLTSLHQR----DLVGE----HLAGTRLGLGNLMG-IPLDIDHFVADAVTGRYTENTALQEDLSHCGTDVVFLT---------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9delt-a6g1j0   	--------------------------------------------------------------------------MSTEESVLRLEDGRQIVIWHSRPQS------EEPV-RGTVLLAPGFCARMY--SLAAMAAYLCANGFAVYRYDPLDHRGPSSGELADFTMTTGRYSMDQVLDWLARERGVESLGVIATSLSARIAYRVA---SERDNV-AYLVTAVGVTHLRATLERVFGV----DHMAS----PPEQLP-ETVVFEERHHIRTLGFATDAHELGWNPAETTRAELDRASVPIVAFIARDDDWVLESEVEEALDLANHPERRMCKLEGSGHNLAKNPRIA-----QAMLRELTGAVMALETGGEWLRAGLPPSFPAIEREPTFEMLTAQVIAERRRSVR---------------------------------------------------------     =====>
9vibr-q4a538   	---------------------------------------------------------------------------------------------------------------------------MD--HFAGLAEYLSSNGFHVIRYDSLHHVGLSSGDINEFSMSIGKDSLLTVIDWLKG-RNIEKLGLIAASLSARIAYEIA---NEI-DL-SFLVTAVGVVNLRDTLERALKY----DYLQL----PIEKLP-EDLDFEG-HNLGSEVFVTDCFKHKWDTLDSTINKMKNLDVPFIAFTANDDNWVKQSEVLDLLISLNSEKCKLYSLIGSSHDLGENLVVL-----RNFYQSVTKAAIALDNDSLDLDV--------NMTEPRFEDITSVTVKERRLKNQIENESLE--------LV----------------------------------------     =====>
clob1-a7fqm2   	MYHTANIKNTKTKKYKILFLIPILIILIAINAIGFYNGNLIYVRACIEPTSRNSTNMYDTYKSTFD--ERRFNTLKKENITINSKYGYTLKG---------TYMENPHKTKNSVVIVHGIRSSRW--ESMKYADLYLDKGFNILIYDSRYH-GLSGGSDVTYGY-YEKYDLDQCIDWLERKNPGGIIGAHGESLGASTILLHSKMNLSKNRV-KFYVADCPYSNLEELLKNKLNEE----LHI-----NNKIITDSLLFYSGA----CA----LLKSKFLYSSVSPIDSIKTVQTPIMFIHGDKDIYIPKKMSEEMYNIK-PGIKEIYIAPNAGHAQAYLYNKKEY--RKNLYKFIDKY--------VKIN-----------------------------------------------------------------------------------------     =====>
clob2-d5w1r7   	MYHTANIKNTKTIKYKILFLIPILIILIAINAIGFYNGNLIYVRACIEPTSRNSTNMYDTYKSTFD--ERRFNTLKKENITINSKYGYTLKG---------TYMENPHKTKNSVVIVHGIRSSRW--ESMKYADLYLDKGFNVLIYDSRYH-GLSGGSDVTYGY-YEKYDLDQCIDWLERKNPGGIIGAHGESLGASTILLHSKMNLSKNRV-KFYVADCPYSNLEELLKNKLNEE----LHI-----NNKIITDSLLFYSGA----CA----LLKSKFLYSSVSPIDSIKTVQTPIMFIHGDKDIYIPKKMSEEMYNIK-PGIKEIYIAPNAGHAQAYLYNKKEY--RKNLYKFIDKY--------VKIN-----------------------------------------------------------------------------------------     =====>
clobh-a5hya5   	MYHTANIKNTKTKKYKILFLIPILIILIAINAIGFYNGNLIYVMACIEPTSRNSTNMYDIYKSTFD--ERRFNTLKKENITINSKYGYTLKG---------TYMENPHKTKNSVVIVHGIRSSRW--ESMKYADLYLDKGFNVLIYDSRYH-GLSGGSDVTYGY-YEKYDLDQCIDWLERKNPGGIIGAHGESLGASTILLHSKMNLSKNRV-KFYVADCPYSNLEELLKNKLNEE----LHI-----NNKIITDSLLFYSGA----CA----LLKSKFLYSSVSPIDSIKTVQTPIMFIHGDKDIYIPKKMSEEMYNIK-PGIKEIYIAPNAGHAQAYLYNKKEY--RKNLYKFIDKY--------VKIN-----------------------------------------------------------------------------------------     =====>
clobj-c1fqu8   	MYHTANIKNTKTKKYKILFLIPILIILIAINAIGFYNGNLIYVRACIEPTSRNSTNMYDTYKSTFD--ERRFNTLKKENITINSKYGYTLKG---------TYMENPHKTKNSVVIVHGIRSSRW--ESMKYADLYLDKGFNILIYDSRYH-GLSGGSDVTYGY-YEKYDLDQCIDWLERKNPGGIIGAHGESLGASTILLHSKMNLSKNRV-KFYVADCPYSNLEELLKNKLDEE----LHI-----NNKIITDSLLFYSGA----CA----LLKSKFLYSSVSPIDSIKTVQTPIMFIHGDKDIYIPKKMSEEMYNIK-PGIKEIYIAPNAGHAQAYLYNKKEY--RKNLYKFIDKY--------VKIN-----------------------------------------------------------------------------------------     =====>
clobk-b1ida1   	MYHTANIKNTKTIKYKILFLIPILIILIAINVIGFYNGNLIYVRACIEPTSRNSTNMYDTYKSTFD--ERRFNTLKKENITINSKYGYTLKG---------TYMENPHKTKNSVVIVHGIRSSRW--ESMKYADLYLDKGFNVLIYDSRYH-GLSGGSDVTYGY-YEKYDLDQCIDWLERKNPGGIIGAHGESLGASTILLHSKMNLSKNRV-KFYVADCPYSNLEELLKNKLNEE----LHI-----NNKIITDSLLFYSGA----CA----LLKSKFLYSSVSPIDSIKTVQTPIMFIHGDKDIYIPKKTSEEMYNIK-PGIKEIYIAPNAGHAQAYLYNKKEY--RKNLYKFIDKY--------VKIN-----------------------------------------------------------------------------------------     =====>
clod6-q18a60   	--MKNSFKNCISLRN--KFIIISIVFLLILLIVSYIFGKLVYNSSVGLEQLIKNEDIVKIFSERKDKPLEKLKNYKTSELMIQSSNNYKLES---------LFITSNIKTRDTMILVHGIGSSYY--EMLKVAYRYLDKGYNVLVYNQRNT-GNSGGDNYTFGL-YERYDLDSLVKFVKNKFPEGRLGVHGFSMGAGTAAMHSEINSKDDKV-DFYILDSPYSEMKDAIRMGVL---------------EKRIPDILINYVVT----CGDLYNKFKSGFWYSDVKPYESVEKSNVPILFIHGTKDTVCNYQNSKKMYDLVKHDKKDLWLIEGIGHVDGFEHDSTVY--FNKIFKFIDSN--------VLSDKS---------------------------------------------------------------------------------------     =====>
corad-d5ene2   	---------------------------------------------MAVST-----------------QIRGKLSIQSEVVVFPSRNGKRLVGFIDRQQ-------ECGDDGDWVILTPKFGESKK--NSLQVAYQLAANGLRVLRFDHSNHIGESAGSIVDYSFSDAIADIQGAYDYLEAAFGSPRAQLVANSLSGRCALRVA---AIDPRV-TRLVLMVGVVNFRQTATEVYQR----DMVAE----YQQGQLQGVSDILG-HQVNVDAFLKDCIEQDMHDLGGSLQDVKRLNCEVFLFCAEQDVWVEMNDIVQLRDA--SDRVRLYRIPDAMHELRENPDAA-----QQANGALIY----LCSRGVL-----PEGAAFSVAHPLKRELMGQNKIERERLRAAAPLKGSENDFWQRYLEKYNVLESVGDFRDYLDLLGQCLGPIRAGQVYFDCGCGNGL     =====>
meti4-b3dx04   	-------------------------------------------------------------------------MNHSIPSEIRNAHGERLDFIYTP---------GSADNNTLIIIAHGITAHKDRPMLVTLTNYLAKNGIHSLRFSFSGH-GKSEGKFEEFTPTKEVGDLQSVFNALPG---WTKYGYVGHSLGAAVGVLFA---SQDPRV-SFLISLAGMAYTAAFAEREFGT----VTPGQGYMWDMPEFP-----------------LSKVLIEDMNRIDNVKEAAKKIKLPWLFIHGLADDVVPPQDSRDLFA-IASGPKKLVEIPGCDHLFPPPHDSFMAETVVNWLKELQLIS----------------------------------------------------------------------------------------------------     =====>
neori-c6v4w3   	---------------------------------------------------------------------------------------MST-QYLSTPTGKIAYQTFAGRSDDGILFMCGRASDMTSTKSEHLRLFCKENGITFTRFDYFGH-GLSDGDFQDGSISIWTQNALEVLKNVTT----GKQILIGSSMSGWMMFALA---KALPEKVKGLIGVAAAPDFTEDLDKQLTPETRQKLIEQGYFV---------FS----FDNGRELLVTRSFLED-GKKNLILDKVLSISCPVILLHSLADDIVSYQKSIRLLEHVAAPHAEVRLLRNADHRMNDPISLSVLEEAI---AQMRRP-HSFCPQENKS-----------VISKK--------------------------------------------------------------------------     =====>
phole-lxd1     	--------------------------------------------------------------------MENTQHSLPIDHVIDIGDNRYIRVWETKPKN------KETKRNNTIVIASGFARRMD--HFAGLAEYLANNGFRVIRYDSLNHVGLSSGEIKQFSMSVGKHSLLTVIDWLKE-RNINNIGLIASSLSARIAYEVA---AEI-DL-SFLITAVGVVNLRSTLEKALKY----DYLQM----EVNTIP-EDLIFEG-HNLGSKVFVTDCFENNWDSLDSTINKICELDIPFIAFTSDGDDWVCQHEVKHLVSNVKSDKKKIYSLVGSSHDLGENLVVL-----RNFYQSMTKAAVSLDRQLVELVD--------EIIEPNFEDLTVITVNERRLKNKIENEIIN--------RLADRVLASV--------------------------------     =====>
phole-lxd2     	--------------------------------------------------------------------MKNTQTSAPIDHMISLGDNRHIRVWETLPKN------QEIKRNNTIVIAAGFARRMD--HFAGLAEYLANNGFHVIRYDSLNHVGLSSGEINQFSMSVGKHSLLTVIEWLKG-RGIDQIGLIASSLSARIAYDVA---AEI-NL-SFLITAVGVVNLRSTLEKALKY----DYLQM----EINDIP-EDLDFEG-YNLGSKVFVTDCFDNNWDSLDSTINKTKDLDIPFIAFISNGDDWVCQQEVKKLVGNMNSDKTKIYSLIGSSHDLGENLIVL-----RNFYQSVTRAAIRVDSEVIDLVD--------DISEPNFEDLTIITVNERRLKNKIAKRNVR--------------------------------------------------     =====>
pholu-LUXD2    	--------------------------------------------------------------------MENKSKYKTIDHVLCVEGNKKIHVWETLPEE------TSPKRKNPIIIASGFARRMD--HFAGLAEYLSRNGFHVIRYDSLHHVGLSSGTIDEFTMSIGKQSLLAVVDWLNT-RKINNRGILASSLSARIVYASL---SEI-NV-SFLITAVGVVNLRYTLERALGF----DYLSL----PINELP-NNLDFEG-HKLGAEVFARDCLDFGWEDLTSTINSMMYLDIPFIAFTANNDNWVKQDEVITLLSNIRSNRCKIHSLLGSSHDLCVFLVVL-----RNFYQSVTKAAIAMDNDRLDIDV--------DIIEPSFEHLTIATVNERRMKIEIENQAIS--------LS----------------------------------------     =====>
pholu-lxd1     	--------------------------------------------------------------------MENESKYKTIDHVICVEGNKKIHVWETLPEE------NSPKRKNAIIIASGFARRMD--HFAGLAEYLSRNGFHVIRYDSLHHVGLSSGTIDEFTMSIGKQSLLAVVDWLTT-RKINNFGMLASSLSARIAYASL---SEI-NA-SFLITAVGFVNLRYSLERALGF----DYLSL----PINELP-NNLDFEG-HKLGAEVFARDCLDFGWEDLASTINNMMYLDIPFIAFTANNDNWVKQDEVITLLSNIRSNRCKIYSLLGSSHDLSENLVVL-----RNFYQSVTKAAIAMDNDHLDIDV--------DITEPSFEHLTIATVNERRMRIEIENQAIS--------LS----------------------------------------     =====>
pholu-lxd2     	--------------------------------------------------------------------MENKSRYKTIDHVICVEENRKIHVWETLPKE------NSPKRKNTLIIASGFARRMD--HFAGLAEYLSQNGFHVIRYDSLHHVGLSSGTIDEFTMSIGKQSLLAVVDWLNT-RKINNLGMLASSLSARIAYASL---SEI-NV-SFLITAVGVVNLRYTLERALGF----DYLSL----PIDELP-DNLDFEG-HKLGAEVFARDCFDSGWEDLTSTINSMMHLDIPFIAFTANNDDWVKQDEVITLLSSIRSHQCKIYSLLGSSHDLGENLVVL-----RNFYQSVTKAAIAMDNGCLDIDV--------DIIEPSFEHLTIAAVNERRMKIEIENQVIS--------LS----------------------------------------     =====>
phopo-luxd     	--------------------------------------------------------------------MKSENNSVPIDHVIKVDNERHIRVWETFPKN------QCDKRNNTIVIASGFARRMD--HFAGLAEYLSTNGFHVIRYDSLNHVGLSSGEIDQFSMSVGKKSLLTVIDWLKSEHGIDQVGLIASSLSARIAYDIV---ADV-NL-SFLITAVGVVNLRNTLEQALKY----DYLQM----EIDEIP-EDLDFDG-YNLGSKVFVTDCFENNWDTLDSTINKTKNLNVPFIAFVANDDSWVQQHEVEELMSNINSDKTKIYSLIGSSHDLGENLIVL-----RNFYQSITKAAIALDSNLVGLVS--------EIIEPQFEALTIATVNERRLKNKIQSKSLA--------------------------------------------------     =====>
sheha-LUXD     	--------------------------------------------------------------------MECSNSCLTIDHVIQLDDDKEIRVWETLPKD------NTAVRNNTILIASGFARRMD--HFAGLAEYLSSNGFHVIRYDSLHHVGLSSGDINEFTMSIGKDSLLIVIEWLKG-RGVNKLGLIAASLSARIAYEIS---NDV-DL-SFLVTAVGVVNLRDTLERSLKY----DYLQL----EIEDLP-EDLDFEG-HNLGSKVFVRDCFKHNWVTLDSTKNKMKNLDIPFIAFTANDDDWVKKAEVLEMMNSISSTKCKLYSLIGSSHDLGENLVVL-----RNFYQSVTKAAISLDNDSVDLNV--------EIFEPKFEELTSVTVQERRLKNKIESEILE--------LMN---------------------------------------     =====>
shewm-luxd     	--------------------------------------------------------------------MTNEDTFSTIDHAINLETGKTIRVWETFPKD------NSLVKNNTILIASGFARRMD--HFAGLAEYLSSNGFHVIRYDSLHHVGLSSGNINEFSMTIGKKSLLTVIEWLKR-RNINKFGLIAASLSARIAYDVA---NEI-DL-SFLVTAVGVVNLRDTLERALKY----DYLQL----PIEELP-EDLDFEG-HNLGSEIFVTDCFKHQWDTFNSTKNKMKDLNIPFIAFTANDDSWVKQNEVLELIESLNPEKCQLYSLIGSSHDLGENLVVL-----RNFYQSVTKAAIALDKGSLNLDI--------NIIEPKFEDITSVTVKERRLKHNIESLELA--------------------------------------------------     =====>
vibch-q5ek34   	----------------------------------------------------------------------------TIDHVISLSGNQQIHVWETPPTLKFN---SMPTRRNSILIASGFARRMD--HFAGLARYLSANGFHVYRYDSLHHVGLSSGTIDQYTMSIGKQSLEIVMAWLHN-RGVTDIGVIAASLSARIAYASV---NEL-DL-SFLITAVGVVNLRDTLEKALGF----DYLSL----PIQALP-NDLDFEG-HKLGAEVFVRDCFANHWDSFSSTVEQIRHLSIPFIAFTANGDDWVKQDEVIEMLSHIPRGQSKLYSLLGSSHDLGENLVVL-----RNFYQSVTKAAIALDSNSFDINI--------PFVEPTFEQLTIATVNERRMKNQIETETMM--------QA----------------------------------------     =====>
vibf1-q5dz04   	--------------------------------------------------------------------MKDESSFFTIDHIIELENGQSIRVWETPPKS------DTHKKNSTIVIAAGFARRMD--HFAGLAEYLSSNGFRVIRYDSLHHVGLSSGQIDEFSMSIGKHSLLIVVGWLRA-KGIQNLGIIAASLSARIAYEVI---NDI-DA-SFLITAVGVVNLQDTLEKALKY----DYLRL----PIDELP-DDLDFEG-HNLGSKVFVTDCLKNEWDTLGSTFKAVQGLNIPFIAFTANGDSWVNQSDVEKMIDNIDTTQCKLYSLIGSSHDLGENLVVL-----RNFYESVTRAAVALDKGSLDLDI--------EIVEPGFEDLTSTTVKERRLRNKIENELLE--------LA----------------------------------------     =====>
vibfi-LUXD     	--------------------------------------------------------------------MKDESAFFTIDHIIKLDNGQSIRVWETLPKK------NVPEKKHTILIASGFARRMD--HFAGLAEYLSTNGFHVIRYDSLHHVGLSSGCINEFTMSIGKNSLLTVVDWLTD-HGVERIGLIAASLSARIAYEVV---NKI-KL-SFLITAVGVVNLRDTLEKALEY----DYLQL----PISELP-EDLDFEG-HNLGSEVFVTDCFKHNWDTLDSTLNSVKGLAIPFIAFTANDDSWVKQSEVIELIDSIESSNCKLYSLIGSSHDLGENLVVL-----RNFYQSVTKAALALDDGLLDLEI--------DIIEPRFEDVTSITVKERRLKNEIENELLE--------LA----------------------------------------     =====>
vibha-1luxd    	----------------------------------------------------------------------MNNQCKTIAHVLRVNNGQELHVWETPPKE------NVPFKNNTILIASGFARRMD--HFAGLAEYLSENGFHVFRYDSLHHVGLSSGSIDEFTMTTGKNSLCTVYHWLQT-KGTQNIGLIAASLSARVAYEVI---SDL-EL-SFLITAVGVVNLRDTLEKALGF----DYLSL----PIDELP-NDLDFEG-HKLGSEVFVRDCFEHHWDTLDSTLDKVANTSVPLIAFTANNDDWVKQEEVYDMLAHIRTGHCKLYSLLGSSHDLGENLVVL-----RNFYQSVTKAAIAMDGGSLEIDV--------DFIEPDFEQLTIATVNERRLKAEIESRTPE--------MA----------------------------------------     =====>
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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