MSA from Cobalt (Ncbi)
Cobalt
Color code Main amino-acide (aa) at this position Non majority aa at this position 50% conservation Catalytic site Catalytic site in alignement
Position ....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....480..5....490..5....500..5....510..5....520..5....530..5....540..5....550..5....560..5....570..5....580..5....590..5....600..5....610..5....620..5....630..5....640..5....650..5....660..5....670..5....680..5....690..5....700..5....710..5....720..5....
ailme-d2h794 ------------YGRLLGRSQA----VQ-VGSSWRQVDQ-----------------------------------------FLGVPYAAPPLAESRFQAPEPLNWTGSWDATK---PRASCWQPGTRA-PA-----------SPGVSEDCLYLNL----FVPQNV--APNASVLVFFHNAMEGKGAGGQLAIDGSFLAAIGNLIVVTAGYRVGVFGFLSS-GSGEVSG-NWGLLDQRAALTWVQTHIRVFGGDPRRVTLAADRGGADVASIHLLTTRAADSRLFRRVMLMGGSAFSPAAVISQGRAQQQAAALAEEISCPTS-----SIQEMVSCLRQKPASVLNDAQTKLLAVSGPFHYWGPVVDGQYLREAPARALQRT-PRAKVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDADAGVRAAATWYYSLEHST--DDYASFSRALENA-TRDYFITCPVIDMA-SHWARRARG-NVFMYHAPESYGH-------------------------------------------SSLDLLADVRSAFGLPFYPAYEGQFTLEEKSLSLK-------IMQFFSNFIRSGNPNYPHEFSRKA-PEFAAPWPDFVPRAGGESYKELSVLLPSRQGLKSADCSFWSKYIRSLKAAAAGGEAG------------------------------------------ =====>
anoca-g1kl79 -------------GTFLGTSQV----IR-VGSNWKRIRE-----------------------------------------FLGIPYAAPPVADGRFRPPQAFTPVEMWNATMIRMSRDSCWQPGDGE-VS-----------PSSVSEDCLYLNI----YIPDNS--GGNLPVLVFFHNGVSGIDQPRRTIIDGSYLAGVGNIIVVTANYRVGVFGFLST-GSSVARG-NWGLLDQEAALKWTQQSIASFGGDPGQIAAAADGSGADITSIHLLAS-TADSSLFKRMLLMGGSAFSPVSTINEKKAGAQAAVLSRELGCPSD-----SPEETVSCLRQLPAKALNDAQTRLLAISGPFQYWSPVVDGSFLQESPAVALQRP-QPLKIDLLIGSSQQDGLISRAKAIK-RFEESQGRGDSKTAFYQALQNSLGGEDADPIVQDAATWFYSLQHSS--TEYASFSRALENA-TRDHFIICPTIDMA-RHWADQDRG-NVFMYHVPESSSVA-----------------------------------------SLSLEFLPDIQYAFGLPFHPEYENWYPPEEKTLSLA-------IMQYFANFIKSGNPNGPYKFSKKV-TGIASLWPMFWADTGGDNYKEFTASLKNQKGLKKAECSFWSDYIKTLKMSA------------------------------------------------ =====>
bovin-thyro ------------HGQLLGRSQA----IQ-VGTSWKPVDQ-----------------------------------------FLGVPYAAPPLGEKRFRAPEHLNWTGSWEATK---PRARCWQPGIRT-PT-----------PPGVSEDCLYLNV----FVPQNM--APNASVLVFFHNAAEGKGSGDRPAVDGSFLAAVGNLIVVTASYRTGIFGFLSS-GSSELSG-NWGLLDQVVALTWVQTHIQAFGGDPRRVTLAADRGGADIASIHLVTTRAANSRLFRRAVLMGGSALSPAAVIRPERARQQAAALAKEVGCPSS-----SVQEMVSCLRQEPARILNDAQTKLLAVSGPFHYWGPVVDGQYLRETPARVLQRA-PRVKVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEAADAGVQAAATWYYSLEHDS--DDYASFSRALEQA-TRDYFIICPVIDMA-SHWARTVRG-NVFMYHAPESYSH-------------------------------------------SSLELLTDVLYAFGLPFYPAYEGQFTLEEKSLSLK-------IMQYFSNFIRSGNPNYPHEFSRRA-PEFAAPWPDFVPRDGAESYKELSVLLPNRQGLKKADCSFWSKYIQSLKASADETKDGPSADSEE---EDQPAGS--GLTEDLLGLPELA----SKTYSK =====>
calja-f7id21 ------------HGKLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFRAPEPLNWTGSWDASK---LRASCWQPGTRT-SM-----------SPGVSEDCLYLNV----FIPQNV--APNTSVLVFFHNTMEGKGSEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSGEVSG-NWGLLDQVAALTWVQTHIRAFGGDPRRVSLAADRGGADVASIHLLTARATNSRLFRRAVLMGGSALSPAAIISHERAQQQAVALAKEVSCPMS-----SSQEVVSCLRQKPASVLNDAQTKLLAVSGPFHYWSPVVDGQFLREAPARALKRT-LQVEVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSS--DDYASFSRALENA-TRDYFITCPIIDMA-SAWAKRTRG-NVFMYHAPKSYGH-------------------------------------------GSLELLVDVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PDFASPWPDFVPSAGGENYKEFSTQLPNRQGLKKADCSFWSKYISSLKASADGAKGGQLAESEE---EELTAGS--GVKEDLLSLQEPY----SK---- =====>
canfa-q1ert3 ------------HGQLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYATPPLAESRFRAPEPLNWTGSWDATK---PRASCWQPGTRT-LE-----------SPGVDEDCLYLNV----FVPQNV--APNASVLVFFHNTLEGRGSEGPLAIDGSYLAAIGNLIVVTAGYRVGIFGFLSS-GSGELSG-NWGLLDQLAALTWVQTHIGVFGGDPRRVTLAADRGGADVASIHLLTTRAADSRLFRRAILMGGSAFSPAVVISQGRAQEQAAALAEEIGCPTS-----STQELVSCLRQKPASILNDAQTKLLAVSGPFHYWGPVVDGQYLREAPARALQRT-LRAKVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDADAGVRAAATWYYSLEHST--DDYASFSRALENA-TRDYFITCPVIDMA-SHWARRARG-NVFMYHAPESYDH-------------------------------------------RSLELLADVQYAFGLPFYPVYEGQFTLEEKSLSLK-------IMQFFSNFVRSGNPNYPHEFSRKA-SELAAPWPDFVPRTGGESYKEFSVLLPNRQGLKSADCSFWAKYIQSLKAVADEAKQELSAESEE---DDEPADS--GLI------GEPG----SKSYSK =====>
cavpo-h0vf67 -------------GWLQGRSQA----VQ-VGTAWKQVDQ-----------------------------------------FLGVPYASPPLAERRFRPPEPLNWTGSWDATK---PRASCWLPGVHT-PT-----------PPGVSEDCLYLNV----FVPGNL--ASRAPVLVFFHNAAEEDVSKGQLAIDGSFLAAIGNLIVVTANYRTGVFGFLRS-GSSEVTG-NWGLLDQVAALTWVQIHIGAFGGDPRQVSLAADRAGADVASIHLLTTRAAGPRLFRRVLLMGGSALSPAAIISPSRAQQQTMALAEEVNCPTS-----SSSEVESCLRQTPANILNDAQTKLLAVSGPFHYWGPVVDGQYLLEDPARALRRP-PLAKIDLLIGSSQDDGLINRAKAVK-RFEESQGRTESKTAFYQALQNSLGGEDSDASVLAAATWYYSLEHSQ--DDYASFSRALENA-TRDYFIICPTIDMA-RRWAKRARG-NVFMYHAPESYGH-------------------------------------------GSLELLADVQYAFGLPFYPAYKGQFSLEEKSLSLK-------IMQFWSNFIRSGNPNYPHEFSWKA-PEFAALWPDFVPGAGGESYQEFSSMLPIRQGLKQADCSFWSKYIQVLKTPADAALDGQSTESED---EGLLAGS--ELEPNFLDLPEPG----SKSYSK =====>
chick-thyro ------------HGDLIGKSKA----VR-IGSEWKNISQ-----------------------------------------FLGIPYAAPPLAERRFNPPEPFAWEKTWNATV---ARSTCWQPGDRE-TP-----------SYSVSEDCLYLNV----FVPVTT--VKNMSVLLFFHSGGSGSTEAGKTIIDGSYLAAVSNTIVVTADYRVGVFGFLSVAGSAEASG-NAGLLDQLAALKWVQQNIGSFGGDPSMVSVGADRGGADIASIHLLTE-TINMGLFRRMLLMGGSAFSPASIITKRRAQAQAAVLADDVGCPSS-----TSEEIVSCLRQLPARVLNDAQTKLLAISGPFQYWGPVVDEVYLQEPLAKALQRP-QLRKVDLLIGSAQQDGLISRAKAIK-KFEESQGRTNSKTAFYQALQNSLGGEDSNLFIENAATWYYSLEHST--DDYSTFSRALENA-TRDQFITCPIINMA-NHWAANSRG-NVFMYHVPASSSES-----------------------------------------SSGLELLLDVQYAFGLPFYPKYEEQFTLEEKSLSLQ-------VMQYISNFVNSGNPNYPHSFSRKM-SRLLPPWPMFLPNDDGDNYKEFTISMPTLKGL------------------------------------------------------------------- =====>
crigr-g3in46 MRQTPTDLSVHTQAFCLAASSLPLFLVPVALNSWQTLPLSSAIIDPSIKHFDVAHISTTATSNFSVARDFCLQECSRHQACLVTTLQIQPGGVRCVFYPDTHNCM-------HSLRSQTCWLLLREEAEYIYRKSGTPRLLSGVASAPSVRIDPFGQLQGGSRVIKVSNASVLVFFHNTMEMEGGGGQLTIDGSILAAVGNFIVVTANYRVGVFGFLSS-GELRINQPAITIRDT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- =====>
danre-f1qfr0 -----------DHGTLLGESEV----KPITGSDSKRVTY-----------------------------------------FLGVPYARPPIGDLRFSPPQPADWTGTWNATF---SRSSCLQPGDLT--------------DSTSSEDCLYLNV----FVASSV--EKNVPVLVFFHNSAS-------DLLDGSYLAAVGNIIVVTASFRVAAFGFLSA-GSSALPG-NYGLQDQAAALGWVQKNIALFGGDPTKVTVGAERNGADIASLHLTSP--SASSLFSRALLMGGSVFSPAVVMSSSKAQAQTSSLARELDCPAA-----DPSQLLDCLRSKPAHSINAAQTKLLAVSGPLQAWSPVVDGNVVREKPSVALQSG-RFHKAEILLGSSFEDGLISRAKNIK-NFEQLQGRADSKTAFYAALSNSLGGDDANAFVKEAATWFYSLQHSPTPSGYNVFSRALENA-TRDLFIICPTVDMA-EFWAANTQT-GVYMYHLPENAAYN-----------------------------------------SVDLSVPMDVQYLFGVPLAAEKRDLFSYKEKTFTLQ-------IMNYMANFIKSGNPNLPLAASRTSFGKFLPPWPQFMPHVGGRAYKELSSTLVNRKNLQRSQCSFWSQYVPALTSSTAKFSCGTSAEETG---VQTPTQEPKPLTPASFTLTPSRQKSEKDAYN- =====>
gasac-g3n792 -----------GHGTLRGVVVE----TS-LGSDRKRVVQ-----------------------------------------FLGVPYARPPTGSLRFEAARPSDWSGDWDATR---PRPSCIQPGDED--------------SPSSSEDCLYLNI----FTPASL--RGRVPVLVFFFNPSANQS---PGLLDGSALAAVGDVVVVTASYRTAALGFLST-VSSGLRG-NYGLSDQEAVLRWVNAHISLVGGDNRTVTVGSERGGADVTSLHLLSS--PSPPPFQRMMLMGGSVFSPSLVQTSSASRRRAVHLAKELGCVTSDLPDGDDDKMAACLRAAPVSALNAAQTKLLAVSGPFQSWAPARPSS----------S-RPSLHGVDLLLGSSQHDGLIGRARKIK-DFEALRGRADGKTAFYEALSRSLGGVTGSDPLKEVAAW-YSLDHGASPAGYNRFSRALDNA-TRDLFIICPSLQMA-SHWANSKA--NVFLYHQPATSSHN-----------------------------------------RADASVPLDVQLVFGTPHHPMSSQRFTSSDRRLSLA-------MMTYVSSFIKSGNPN------------------------------------------------------------------------------------------------------------- =====>
gorgo-g3s7h8 ------------HGRLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFQEPEPLNWTGSWDASK---PRASCWQPGTRT-ST-----------SPGVSEDCLYLNV----FIPQNV--APNASVLVFFHNTMDGEESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSGEVSG-NWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADHGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPTS-----SSQEVVSCLRQKPASVLNDAQTKLLAVSGPFHYWGPVIDGQFLREPPARALKRS-LRVEVDLLIGSSQEDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHVPESYGH-------------------------------------------GSLELLADVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPRAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGQSAESEE---EELTAGS--GLREDLLSLQEPG----SKSYSK =====>
hetga-g5c6q5 -------------GQLRGRSQA----VR-VGTAWKQVDQ-----------------------------------------FLGVPYASPPLADSRFRAPEPLNWTGSWDATE---PRASCWLPGTRS-PA-----------PPGVSEDCLYLNV----FVPENL--APNASVLVFFHNAREAEVSNGQLTIDGSFLAAVGNLIVVTANYRVGVFGFLSS-GSSELTG-NWGLLDQVAALTWVQSHIGAFGGDPRRVSLAADRDGADVASIHLM-TRATGPRLFRRALLMGGSVLSPATVISPSRAQQQAMTLAKEVNCPTS-----SSQAVVSCLRQTPANVLNDAQTKLLVAVIPFPSWGPVVDGRYLQEAPARALQRPPPRAKVNLLIGSSQEDGLISRAKAVK-RFEESQGRTESKTAFYQALQNSLGGEDSDAGVLAAATWYYSLEHSA--DDYASFSRALENA-TRDYFITCPMIDMA-RRWAKGTRG-NVFMYHAPESYSH-------------------------------------------GSLDLLADVQYAFGLPFYPAYEGQFSLEEKSLSLK-------IMQFLSNFIRSGNPNYPHEFSRKA-PEFAAPWPDFVPGTGGESYQEFSTLLPIRQHLKQADCSFWSKYIQALKAPTDGALDEQSIGSED---KNLLAGS--ELEQDFLDLPEPG----PKSYSK =====>
horse-f6qsc5 ------------HGQLLGRSQA----IR-VGTSWKQVDQ-----------------------------------------FLGVPYASPPLAESRFRAPEPLNWTGPWDATK---PRASCWQPGART-PL-----------SPGLSEDCLHLNV----FVPQNV--APGASVLVFFHNSMEGRVSEGQLALDGSFLAAVGNLIVVTAGYRVGVFGFLSS-GSSEVSG-NWGLLDQVAALTWVHTHIGAFGGDPRHVALAADRGGADVASIHLLTTRTANSRLFRRAVLMGGSALSPAAVISQERAQQQAAAFAKEVGCPTS-----SIQEMISCLRQEPANVLNDAQTKLLAVSGPFHYWGPVVDGQYLREAPARALQRF-PRAKVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEEADAGVQAAATWYYSLEHSA--DDYASFSRALENA-TRDYFITCPVIDMA-SHWARRARG-NVFMYHAPESHGH-------------------------------------------SSLDLLADVQYAFGLPFHPAYEGQFTLEEKSLSLK-------IMQYFSNFVRSGNPNYPHEFSRKA-PEFAAPWPDFVPRAGRETYKEFSALLPNQQGLKKADCSFWSKYIQSLKALAGEAKDELSAGSEE---EDQPAGS--GLREDLLGLPEPG----SMSYSK =====>
human-thyro ------------HGRLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFQAPEPLNWTGSWDASK---PRASCWQPGTRT-ST-----------SPGVSEDCLYLNV----FIPQNV--APNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSGEVSG-NWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMS-----SSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRS-LWVEVDLLIGSSQDDGLINRAKAVK-QFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHAPENYGH-------------------------------------------GSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEE---EELTAGS--GLREDLLSLQEPG----SKTYSK =====>
loxaf-g3t9h6 ------------HGRLLGRSQA----IQ-VGTAWKQVDQ-----------------------------------------FLGVPYAAPPLAESRFRAPEPLNWTGSWDATK---PRASCWQPGART-PT-----------PPGVSEDCLYLNV----FVPESV--APNASVLIFFHNTMEGKGREGQLAVDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSSEVSG-NWGLKDEVAALTWVQTHIREFGGDPRRVSLAADRGGADVASIHLLTTRAVDARLFRRAVLMGGSALSPATIISQERAQQQAAALAKEVGCPTS-----PSQDLVSCLRLKPANILNDAQTKLLAVSGPFHYWGPVIDGQYLRETPARALQRA-PRAKVDLFIGSSQDDGLIDRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEGGDTRVEAAATWYYSLEHSE--DDYASFSRALENA-TRDYFITCPVIDMA-SHSTTTTNNNNSVVLSHPGNYGHN-----------------------------------------TGFLELLTDVQYAFGLPFYPTYEGRFTLEEKSLSLK-------IMQYFSNFIRSGNPNYPHEFSRRA-PEFAAPWPDFLPYAGGESYKEFSSLLPNRQGLKKADCSFWSKYIQSLKASADGANDQQSALSEE---EELPPGS--GLREDLLGLSGPG----SKAYSK =====>
macfa-g7pd01 ------------HGRLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFRAPEPLNWTGSWDASK---PRASCWQPGTRT-ST-----------SPGVSEDCLYLNV----FIPQNV--APNASVLVFFHNTMDREGSEGWPAIDGSFLAAVGNLIVVTAGYRVGVFGFLSS-GSGEVSG-NWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRAGADVASIHLLMARATNSQLFRRAVLMGGSALSPAAIISHERAQQQAVALAKEVSCPVS-----SSQEVVSCLRQKPANILNDAQTKLLAVSGPFHYWGPVIDGQFLREPPARALKRS-LRAEVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHAPESYGR-------------------------------------------GSLELLADVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPYAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGQSAESEE---EELTAGS--GLREDLLSLQEPG----SKSYSK =====>
macmu-f6yw28 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPYAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGQSAESEE---EELTAGS--GLREDLLSLQEPG----SKSYSK =====>
macmu-g7n054 ------------HGRLLGRSQA----IQ-LGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFRAPEPLNWTGSWDASK---PRASCWQPGTRT-ST-----------SPGVSEDCLYLNV----FIPQNV--APNASVLVFFHNTMDREGSEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSREVSG-NWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRAGADVASIHLLMARATNSQLFRRAVLMGGSALSPAAIISHERAQQQAVALAKEVSCPVS-----SSQEVVSCLRQKPANILNDAQTKLLAVSGPFHYWGPVIDGQFLREPPARALKRS-LRAEVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHAPESYGR-------------------------------------------GSLELLADVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPYAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGQSAESEE---EELTAGS--GLREDLLSLQEPG----SKSYSK =====>
mondo-f7ckd0 ------------QGTLKGKSEA----IQ-VGAEWKRIIQ-----------------------------------------FFGVPYAAPPLAQRRFSAPESFNWTGTWEATV---PRAKCWQPGFGKTSS-----------SSTVSEDCLYLNV----FVPQNL--GQNASVLVFFHNADENGRRRSQLDLEGSFLAAVGDIIVVTANYRVGIFGFLST-GSKEASG-NWGLLDQVAALKWVQAHIGSFGGDPRKVSVAADRGGADIASIHLVTT-TANSRLFKRAILMGGSVLSPAATISQKRAQEQAAALAGEVNCPTS-----PEGDMMSCLRQKPADILNNAQTKLLAISGPFHYWGPVVDGVYLQETPTRTLQRS-PRMKVDVLIGSAQRDGLINRAKAIKKSFQESQGRTSSKTAFYQALQNSLGGENSDASIEVAATWYYSLEHST--EDYSSFSRALENA-TRDYFISCPIIDMA-SHWARATRG-NVYMYYVPETYAQ-------------------------------------------NSLELLADVQYAFGLPFHPQYKQQFTLEEKNLSLK-------IMQYFSNFIKTGNPNYPYDFSRKI-LETTALWPEFLPHTNGDNYKEFSPGLPNQRGLKKAECSFWSKYIQTLKASTGEAESQQPLVAEE---E---LGS--VELQSHLGVPEEG----QKSYSK =====>
mouse-thyro ------------FGQLQGGSQV----IK-VGTAWKQVYR-----------------------------------------FLGVPYAAPPLADNRFRAPEVLNWTGSWDATK---PRASCWQPGTRT-PT-----------PPQINEDCLYLNV----FVPENL--VSNASVLVFFHNTMEMEGSGGQLTIDGSILAAVGNFIVVTANYRLGVFGFLSS-GSDEVAG-NWGLLDQVAALTWVQSHIGAFGGDPQRVTLAADRSGADVASIHLLISRPTRLQLFRKALLMGGSALSPAAIISPERAQQQAAALAKEVGCPTS-----SIQEVVSCLRQKPANILNDAQTKLLAVSGPFHYWGPVVDGQYLRELPSRRLKRP-LPVKVDLLIGGSQDDGLINRAKAVK-QFEESQGRTNSKTAFYQALQNSLGGEDSDARILAAAVWYYSLEHST--DDYASFSRALENA-TRDYFIICPMVNMA-SLWARRTRG-NVFMYHVPESYGH-------------------------------------------GSLELLADVQYAFGLPFYSAYQGQFSTEEQSLSLK-------VMQYFSNFIRSGNPNYPHEFSRKA-AEFATPWPDFIPGAGGESYKELSAQLPNRQGLKQADCSFWSKYIQTLKDA-DGAKDAQLTKSEE---EDLEVGP--GLEEDLSGSLEPV----PKSYSK =====>
myolu-g1nvv4 ------------HGQLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAEGRFWAPEPSNWTGSWAATK---PRARCWQPGVKT-PT-----------PSGVSEDCLYLNV----FVPQNV--APNASVLLFFHNMEAGA-DDGSLALDGSFLAATGHLIVVTAGYRVGIFGFLSA-GAGAVSG-NWGLLDQVAALTWVQTHIAAFGGDPRRVTMAADHGGADVASIHLLTAGAGGSRLFRRAVLMGGSALSPAAVISPERAQQQAAALAQEVGCPAS-----PIQEMTSCLRQKPADALNDAQTKLLAVSGPFHYWGPVLDGQFLREAPARALQRA-PRATVDLLLGSSQDDGLIRRAKAVK-ALEESQGRTSSKTAFYQALQNSLGGEDADPGVLAAATWYYSLEHSA--NDYASFSRALENA-TRDYFITCPVIDMA-RHWARRARG-NVFLYHAPQSYGH-------------------------------------------GSLEVLADAQYAFGLPFHPAYGGQFTPEEKHTALK-------VMQYFSNFIRSGNPNYPHEFSRKG-PEFAVPWPDFVPGTNGENYKEFSAQLPNRRGLKKADCSFWSKYIRSLKVS-DEAKDGLSAGSEE---EEQPAGS--GLREDL---PDPG----SKSYSK =====>
nomle-g1r1g0 ------------HGQLLGRSQA----IR-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFRAPEPLNWTGSWDASK---PRASCWQPGTRT-ST-----------SPGVSEDCLYLNV----FIPQNV--APNMSVLVFFHNTKDGEESEGWPAIDGSFLAAVGNLIVVTAGYRVGVFGFLSS-GSGEVSG-NWGLLDQVAALTWVQTHIRGFGGDPGRVSLAADRGGADVASIHLFTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMS-----SSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGQFLREPPARALKRS-LRVEVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHAPESYGR-------------------------------------------GSLELLADVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPHAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGQSAESQE---GELTAGS--GLREDLLSLQEPG----SKSYSK =====>
ornan-f7ejp8 ----------------NGRGPT----AL-LGLSWQSPWY-----------------------------------------SLGGF---FPLTETSFRLPVHQYGQDLWME-------RNHWSPGRDT-RG-----------PGGNSVCAEVIGV----GVPVNH--GPNASVLVFFHHPEGDGQRRGQLDLDGAYLAAVGDLIVVTATFRAGAFGFLST-GTDVARG-NWGLQDQVAALQWVQDHIANFGGDPERVTLAADRGGADVASVLLLWPRPAGSRLFGRAILMGGSAFSPAAVLSEKRAREQAAALAREVGCPDS-----DDEAMVSCFRQKPANILNDAQTKLLAISGPFQYWGPVVDGVHLPEPPAHALRRA-PLTEVDLLIGSSQQDGLISRARAIK-RFEERQGRNSSKTVFYQALQNSLGGADADPAIQVAASWYYSLEHSS--DDYSSFSRALENA-TRDYFITCPTIAMA-RHWAATGRG-NSFMYHVPDSYLR-------------------------------------------SGSELLADVRLAFGLPWYPHLAPRFSQGDRAAALA-------VMQYIANFVKSGDPNTQNDFSSKI-QGDLPRWAPFLPSATGENYKEFSARLPNRMGLKKADCSFWQDYIQTLRRSSG----------------------------------------------- =====>
oryla-h2mqz5 -----------GQGVLEGVAVE----TT-VGSDRRRVIQ-----------------------------------------FLGVPYARPPIGALRFEAAQPADWTGTWDASK---PRPSCLQPGDGE--------------NSASSEDCLYLNV----FTPAAR--RGRVPVLVFFFNPSADET---PGLLDGSALAAVGNIVVVTASYRTAALGFLST-GASGLRG-NFGLTDQEAVLRWVNAYISLVGGDYNRVTVGAERGGADITSLHLLSK--P-RPLFQRMMLMGGSVFSPSLVQTSASARRRALDLAQELGCVTSD---STDEKLVSCLRAVPYRDLNAAQTKLLVTRDPFQFWSPVHQAV----------SKSSPFHKVDLLLGTSEADGLISRARRIE-EFEVLPGQVDDSMPFYQALSRVLGGANGNELLGEVV---SSLDHNPSAAGYSLFSRTLDNA-TRDLFIICPALQMA-ANWAESRA--NVFMYHQPAADAAD-----------------------------------------RGDSLVPWDVQLVFGAP---LYSQRFTSSDRRLSLA-------AMSYVSSFIRTGNPNPWPVTAES----VLPRWQPVTSSQAPPSYLELSPALKPQQGLSQTFCSPWGQLLARQSSE---AERRG----------------------------------------- =====>
otoga-h0x190 ------------HGQLLGRSQA----VQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAESRFRAPEPWNWTGSWNASR---PRASCWQPGILM-PT-----------SLEVSEDCLYLNV----FVPQNM--APNASVLVFFHNMVQGDGSAAWPTVDGSILAAVGDLIVVTASYRVGVFGFLSSEGSGEASG-NWGLLDQVAALTWVRTHIGAFGGDPRRVCLAADRGGADVASIHLLKTRATDSRLFRRAVLMGGSVLSPAAVISLERAQQQAAALAEEVSCPTS-----SSQEVVSCLRQKPANILNDAQTKLLAVSGPFHYWGPVVDGLYVHEAPARALQRS-PQMKVDLLIGSSQDDGLINRAKAVK-QFEERQGRTNSKTAFYQALQNSLGGKDSDARVQAAATWFYSLEHST--DDYATFSQALENA-TRDYFITCPVIDMA-SAWARRAQG-NVFMYHAPKTYGH-------------------------------------------DSLGVLADVQYAFGLPFHPAYDGQFSLEEKSLSLK-------IMQYFSNFIRSGNPNYPHEFSQKA-PGFAAPWPDFVPSAGGESYKEFSALLPSRQGLKKAECSFWSKYIRSLKATADGDKDELPAESDE---EELTAGP--GLREDLLGVPGPG----SKSYSK =====>
pantr-h2qwr1 ------------HGRLLGRSQA----IQ-VGTSWKQVDQ-----------------------------------------FLGVPYAAPPLAERRFRAPEPLNWTGSWDASK---PRASCWQPGTRT-ST-----------SPRVSEDCLYLNV----FIPQNV--APNASVLVFFHNTMDGEESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSGDVSG-NWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMS-----SSQEVVSCLRQKPASVLNDAQTKLLAVSGPFHYWGPVIDGQFLREPPARALKRS-LRVEVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHAPESYGR-------------------------------------------GSLELLADVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPRAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGKSAESE----EELTAGS--GLREDLLSLQEPG----SKSYSK =====>
ponab-h2pr87 ------------HGQLLGRSQA----IH-VGTSWKRVDQ-----------------------------------------FLGVPYAAPPLAERRFQAPEPLNWTGSWDASK---PRASCWQPGTRT-SM-----------TPGVSEDCLYLNV----FIPQNV--APNASVLVFFHNTMDGEESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSS-GSGEVSG-NWGLLDQVAALTWVQTHIRGFGGDPQRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMS-----SSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGQFLREPPARALKRS-LWLEVDLLIGSSQDDGLINRAKAVK-QFEESQGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHST--DDYASFSRALENA-TRDYFIICPIIDMA-SAWAKRARG-NVFMYHAPESYGR-------------------------------------------GSLELLADVQFAFGLPFYPAYEGQFSLEEKSLSLK-------IMQYFSHFIRSGNPNYPYEFSRKV-PTFATPWPDFVPRAGGENYKEFSALLPNRQGLKKADCSFWSKYISSLKASADGAKGGQSAESEE---EELTAGS--GLREDLLSLQEPG----SKSYSK =====>
rabit-g1siu8 ------------HGQLLGRSVV----IQ-LGASWKQVDQ-----------------------------------------FLGVPYAAPPLAESRFRAPEPSNWTGSWDATK---PRASCWQPGTRT-PA-----------PPSVSEDCLYLNV----FVPGNV--VPNASALVFFHNTMEGDRE-ERLEIDGSFLAALGDIIVVTAGYRVGVFGFLSS-GSNEVTG-NWGLLDQVAALSWVQTYIGAFGGDPRRVSLAADRGGADVASIHLLTASAKDSRLFRRAVLMGGSALSPAAVISPERAQLQTAALAKEVGCPSS-----SSQDVVSCLRQKPASILNDAQTKLLAVSGPFHYWGPVVDGRYLREAPARALQRP-ARAKVDLLVGSSQDDGLINRAKAVK-QFEESQGRSSSKAAFYQALQNSLGGEDADAGVLAAATWYYSLEHSA--DDYASFSRALENA-TRDYFITCPLIDLA-RLWAQSARG-NVFMYHAPESYGH-------------------------------------------GSLDLLTDVQYAFGLPLHPAYQGQFALQERGLALK-------TMQYFSNFVRSGNPNYPHEFSRKA-PEFAAPWPDFVPGAGGETYKELSALLPNRQALKRADCSFWSKYIGSLKATTAGAQDGQSAETGE---EELAAGS--GLREELP--EEPG----SKSYSK =====>
ratno-thyro ------------FGQLQGGSQV----VK-VGTAWKQVYQ-----------------------------------------FLGVPYAAPPLAENRFQAPEVLNWTGSWDATK---LRSSCWQPGTRT-PT-----------PPQISEDCLYLNV----FVPENL--VSNASVLVFFHNTVEMEGSGGQLNIDGSILAAVGNLIVVTANYRLGVFGFLSS-GSDEVAG-NWGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVASIHLLITRPTRLQLFRKALLMGGSALSPAAIISPDRAQQQAAALAKEVGCPNS-----SVQEVVSCFRQKPANILNEAQTKLLAVSGPFHYWGPVVDGQYLRELPSRRLKRP-LPVKVDLLIGGSQDDGLINRAKAVK-QFEESQGRTNSKTAFYQALQNSLGGEDSDARILAAAIWYYSLEHST--DDYASFSRALENA-TRDYFIICPIVNMA-SLWARRTRG-NVFMYHVPESYGH-------------------------------------------GSLELLADVQYAFGLPFYSAYQGYFSTEEQSLSLK-------VMQYFSNFIRSGNPNYPHEFSQKA-AEFATPWPDFVPGAGGESYKELSAQLPNRQGLKKADCSFWSKYIQTLKDA-DGAKDAQLTKSGE---EDLEVGP--GSEEDFSGSLEPV----PKSYSK =====>
sarha-g3wk69 ------------QGTLKGRSEA----IR-VGSEWKRIVQ-----------------------------------------FLGVPYASPPLAQKRFGAPESFNWTGSWEATV---PRANCWQPGFGKTSF------------SSVSEDCLYLNV----FVPQNL--GQNASVLVFFHNTGENGGRKKQLDLEGSFLAAVGDIIVVTANYRVGIFGFLST-GSSEASG-NWGLLDQVAALNWVQAHITSFGGNPQQVTVAADRGGADITSLHLLTT-TANSRLFKRAILMVSTIFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- =====>
sheep-thyro --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQFTLEEKSLSLK-------IMQYFSNFIRSGNPNYPHEFSRRA- |
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