ESTHER Database

Home
Search
Tools
Families
Biological
data
Basics on AChE
ESTHER definition
What is up?
Acknowledgments
& disclaimer


MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....380..5....390..5....400..5....410..5....420..5....430..5....440..5....450..5....460..5....470..5....
9dipt-q86ct9   	-------------------------------------------------------------------------------------HLSQINHDVEPNFVP--SNIQVYVPKPNGDKIVAPISEMIQRLKQ---KQNFGQDEVTIIVTGLPQT-SETVKKATRKLVQAYMQRYNLQQQQQQAQKYNS---ES-EEDNKRQRTSSEEDY---SEQAKNA-NTNTGDII-VIDLGSTLTNYKRYAMLDIEKTGAKIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9musc-Q94894   	---------------MAVAAMASPSS---GRMGG--NSVNQMLKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVAKPNGEKIVAPLNEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYSK---DSS-EDNNRQRTSSEEDY---SEQARNA-NTKSGDII-VIDLGSELPTFSSIAMLDTETIGGIFGKWIVKLTHDLQLPYETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9musc-Q94897   	---------------MAVAAMASPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTMERLESMSLEKGAELLQQV-YHLSQINHDIEPRYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQEQGQKYNR---DSA-EDNNRQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELTDFNSIAMLDTEKIGGIYGKWIVKMTHELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9musc-Q94933   	---------------MAVAAMASPSS---GRMAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLESMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGEKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNYQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPNFNSIAMLDTEKIGGIYGKWIVKMTHELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
9musc-Q94943   	---------------MAVAAMASPSS---SRMGD--NSVNQALKPSQWLSPQQLEGIQAVDDLTLDRLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKRNGDKIVAPLNEMIPLLKQ---QQNFGRDEVTIIVTGLPKT-CETVKKANRKLVQAYMQRYNLQQQQEQGQKYNK---DSS-E-ENRRRTSSEEDY---TEQAKNA-NTQTGDII-IIDLGSELNSYKRMAMLDTETTGANIGKWIVRMTSQLELPHETIHLIGQNVGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
anasu-vite1    	-----------------------------------------------------------------------PVEEGQQEIQKN-YHLSQINHALQPSFVPSPSNVPVVLMKPNGQPERTNLNNLAEAAKQ---QRNFGNQEVTIFITGLPQT-SQAVAKANKKLVQAYMQRYYGQQQPMDINSKEYDY--GSISG-NKISSSSEED----NDSSKNP-RPTRGDLV-IINLGATLTDMKRYALLDVDETGKMIGKAIVQLTNEVDVPEEIIHIVAQGIAAQVAGPAAREYKRLTGHKIRRITALDPSKIYAKNNEMITGLTRGDADFVDAIHTSTCGMGTHERVGDVDFYVNGPGSIAPGANNVVEASMRATRYFAETVRPGNEANFPALAANSLSQYENNEGTGKRAYMGIATDFDLEGDYVLKANAKSPFGKSSPAQQQNAYHRQHNTWKNSNPLNMK---     =====>
bacdo-1vite    	---MNPLKIFCFMAFVLAIANASPKH---GKNKDN----MNSLKPVDWLSASELESMPSVEDITLQQLENMSVEDAQRKIEKL-YHLSQINHALEPSFVPSPSNVPVILMKPNGQPERTNLNELVQTAKQ---QPNFGDEEVTIFITGLPQS-SPSVAKANKKLIQAYMQRYNGQRQPISN-NQDYDY--GNNKD-NQGATSSEEDY---SESWKNP-KPTKGNLV-VISLGSTLTNMKRLALIDVEQTGNMIGKALVELTNECGVPQEIIHIVGQGVGAQVAGAAGRQYKRLTGHQLRRITALDPAKLFAKDKDMLTGLARGDADFVDAIHTSTCGMGTRQRVGDVDFYVNGPASAAPGATNVIEATMRATRYFAESVRPGNERNFPAVAANSMDQYENNDGAGKRAYMGIATDFDLEGDYILKVNSKSPFGKSAPAQKQSTYHGQHQAWKSGKNQNNN---     =====>
bacdo-2vite    	---MKLVKTFGLLVLIVSAVSAGHKH---GNHGSGNTQVSSNLRPTSWLSVQELQSLPSGEDMNLQQLENMSVQEGERLIGKI-YHLFKINHNMSPSYVPSASNVPVVFVRPNGQSVETNLNELVTKAKQ---QPNFGNEEVTIFITGLPQT-SPAVAKANKKLVQAYMQRYYGQQQPVNANNQDYES--N---E-RQQATSSEEDY---SESWKQQ-KSNRGNLV-IIKLGAVLTNFKRYALLDVEQTGQMIGKTLVQLTDEADVPQEIIHLIGQGIGAQVAGAAGRQYKRWTGHQLRRITALDPAKIFASNKNVLSGLARGDADFVDAIHSSTCGMGTRQRVGDVDFYVNGPASAAPGADNVVEAAMRATRYYAESVRPGNERNFAAVPASSKQQYESNEGYGKRAYMGIAAQYDLKGDYVLNVNAKSPFGRSAPAQKQGSYHGLHQAWRSDKRNSQN---     =====>
caler-yolp2    	-------------------------------------------------------------------------------------HLSQAGRAIEPSFVPKASEIPAFLITPDNKKVNFKLSELPKIAKE---EKSFGDEEVTVYITGLPQK-TETVKKATRKLVQAYMQRYNGQAPERNS----VRYEDDSSE--KRNPSSSEE------DEWKSNSNKPSGNLV-VIELGNVLTNMKNYVFLDVEKTGMEIGDILVQCTDKADVPQEIVHVIGSNIAAHVAGAVGRQFTRETGHQLRRITGLDPSKIYAQTQKSLRGLARGDAEFVDVIHTSAYGWGTPTRCGDVDFYPNGPSRGVPGADNVVEASMRAIRYFAESVVPGNERNFPAVGATSLKQYKEQNGNGKRVYMGINTDYDVEGDFILQVNGKSPFGRSTPAQKQQNYHNVHKPWKMSSRDF-----     =====>
caler-yolp3    	---MNPLRIVCVAALLLAAGSA-NGN---L-------SGLNKLRPSQWLSSSQLDKLPRSMEISLQKLESMSVEKGAELMQKLCDHLSQINNDLKPSFLPSSSNVPCYIVKPNGKKVSTSLDKLASACKQ---QPNFGEEEVTILITGLPAT-TETVRKANRKLIDAYLQRYSTKRQQPS----KFDYS----GE-KM-ARTSSEED---SNEWQNQ-QASSGNLVVIIDLGNELNSFKRFSLLDVDETGAMIRSAIVEMTEKCDVADETIHVVAQGIAAHVAGAAGNEFTRKTGRQLRRITALDPSKILAKNPHSLTGLSRGDAEFVDAIHTNVYGMGTIQRVGDIDFYPNGPSAAVPGAQSIVEASMRATRYFAESVRPGNERNFPAVAANSLKEYKNNDGFGKRAYMGINVDYDLEGDYILEVNSKGPFGKRAPVQKQNSYHGVQQFLEKEGQ-------     =====>
cerca-1vite    	---MNPLKIFCFLALVIAVASA-NKH---GKNKDN--AGPNSLKPTDWLSVEELQSMTAIDDITLQQLENMSVEDAERKIEKI-YHLSQINHALEPSYVPSPSNVPVMLMKPNGQSQQTNHNELVEAAKQ---QPNFGDEEVTIFITGMPQT-SSAVLKANKKLVQAYMQRYNGQQQPING-NKDYDY--GSSQG-NQGATSSEEDY---SESWKNQ-KSTKGNLV-IINLGSTLTNMKRFALLDVEQTGNMIGKTLVQLTNEVDVPQEIIHIVAQCIGAQVAGAAGRQYKRLTGHQLRRITALDPSKIFAKNRNALTGLARGDADFVDAIHTSTCGMGTRQRVGDVDFYVNGPASTAPGTNNVVEASMRATRYFAESLRPGNERNFPAVAANSLNQYENNEGNGKRAYMGIATDFDLEGDYILKVNPKSPFGKSAPAQKQRRYHGLHQSWKSGKNQNQE---     =====>
cerca-2vite    	---MNPLTIFCLVAVLLSAATAH----------RGSNAIRNNLQPSGXLSPRELEDMPAINEITFEKLQEMPAEEAADLVNKI-YHLSQMSRNIEPSYAPSPNQIPAYTYTPTGQRVNFNLNQLVATAQQ---QPNFGKQEVTVFITGLPNK-SSAMLTANQKLVQAYLQAYNGRVQVQGEQGDD---------S-NQDTSSSEESS---NRPNGQQ-PKPNGNLV-VIDLGAVIRNFEDLVLLDINRVGAAIGNSLVQLTAQADVPQEVINIVAQGIAAHVAGAAARQYTRQTGNTLRRITAMDPSKIYARKPNTLVGLARGNADFVDAIHTSAYGLGTTTRAGDVDFYPNGPSVNMPGTDDIIEASLRATRYLAETVLPGNDRNFPAVAAESLQQYKNNNGNGRRAYMGIAADYDLEGDYILQVNAKSPFGKSAPAQKQNSYHGIHQGAGRPN--------     =====>
droad-YP1      	---------------MAVAAMASPSS---SRSDD--SSVNQALKPSQWLSP-------AVDDLTLDRLENMSLEKGAELLQQV-YHLSQINHD----------NVQVYVPKANGEKIVAPMNEMIQLLKQ---QQNFGKDEVTIIVTGLPKT-SETVKKANRKLVQAYLQRYNLQQQQQQGQKYNK---D-----SNRQRTSSEENY---SEQAKNA-NTQTGDII-V---GSELNTFKRIAMLD--------GKWIV----------ETIHLIGQNIGAHVAGAAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droae-q5i4x7   	---------------------------------D--NTVSQALKPSQWLSVQELQSIPAVDELTLERLENMSLEKGAELLQQV-YHLSQINHDVEPNFVP--SNIQVYVPKPNGDKIVAPISEMIQRLKQ---KQNFGQDEVTIIVTGLPQT-SETVKKATRKLVQAYMQRYNLQQQQQQAQKYNS---ES-EEDNKRQRTSSEEDY---SEQAKNA-NTNTGDII-VIDLGSTLTNYKRYAMLDIEKTGAKIGKWIVELTSELQLPHETIHMIGQNVGAHVAGAAANEFTRLTGHKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droae-q86fu1   	-------------------------------------------------------------------------------------HLSQINHDVEPNFVP--SNIQVYVPKPNGDKIVAPISEMIQRLKQ---KQNFGQDEVTIIVTGLPQT-SETVKKATRKLVQAYMQRYNLQQQQQQAQKYNS---ES-EEDNKRQRTSSEEDY---SEQAKNA-NTNTGDII-VIDLGSTLTNYKRYAMLDIEKTGAKIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droai-YP1      	---------------MAVAAMASPSS---SRMGD--NSVNQALKPSQWLSPQQLEGIQAVDDLTLDRLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKRNGDKIVAPLNEMIPLLKQ---QQNFGRDEVTIIVTGLPKT-CETVKKANRKLVQAYMQRYNLQQQQEQGQKYKK---DSS-E-ENRQRTSSEEDY---TEQAKNA-NTQTGDII-IIDLGSELNSYKRMAMLDTETTGANIGKWIVRMTSQLELPHETIHLIGQNVGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAMGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drobi-YP1      	---------------MAVAVMAKPN----GRM-D--NSVNQALKPSQWLSSSQLENIPAVDDLTMARLESMSLENGAELLQQV-YHLSQIHHNVEPNFVP--SNIQVYVPKPNGQKTVAPLNEMIQRLKQ---KQNFGNDEVTIIVTGLPQN-TETVQKATRKLVQAYMQRYNLQQQRQQAK-GDQDYEDS--NDKKNQRTSSEEDS---SEEAKNG-NTQSGDII-VIDLGSTLTTYKRYAMLDIEKTGAKIGKWIVQMVNELDMPFETIHLIGQNVGAHVAGAAAQEFTRLTGHKLRRVTGLDPSKIVAKSQ-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drobo-YP1      	---------------MAVAAMASPSS---GRTAG--NSVNQALKPSQWLSPEQLERIEAVDDLTLDRLESMSLEKGAELLQQV-YHLSQINHDIEPRYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPQN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPDFNSIAMLDIEKIGSIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drobu-YP1      	----------------MAVAMAGPTT----RMSD--SSVNQALKPSQWLSVQKLESIPAVDELTLERLESMPLNKGAELLQQV-YHLSQINHDVEPNFVP--SNVQVYVPKPNGEKIVAPINEMINLLKQ---KKNFGQDEVTIIVTGLPQT-SETVKKANRKLVEAYMQRYNLQQQQQQAQQYNS---NVD---QEQPRTSSEEDY---TEQAKNA-NANTGDII-VIDLGSTLTNYKRYAMLDIEKTGEKLGKWIAQLTSELELPYETIHMIGQNVGAHVAGAAANEFTRLTGHKLRRVTGLDPSHIVAKNR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drocr-YP1      	---------------MAVAAMASPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPRYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPQN-CDTVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKNA-NTKTGDII-VIDLGSELPDFNSIAMLDTEKIGGVYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drocy-YP1      	---------------MAVAAMASPSS---GRMGG--NSVNQMLKPSQWLSPQQLERIEAVDDLTLDRLESMSLEKGAELLQQV-YHLSQITHDIEPTYVP--SNVQVYVAKPNGEKIVAPLNEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYSK---DSS-EDNNRQRTSSEEDY---SEQARNA-NTKSGDII-VIDLGSELPTFSSIAMLDTETIGGIFGKWIVKLTHDLQLPYETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drodf-YP1      	---------------MAVAAMASPSS---GRTSG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTFVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQAKNA-NTKSGDII-VIDLGSELPTFNSVAMLDTEKIGGIFGKWIVKMTQDLQLRHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drodi-YP1      	---------------MAVAAMASPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLDRLESMSLEKGAELLQQV-YHLSQINHDIEPRYVP--SNVQVYVPKPNGEKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPQN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPDFNSIAMLDIEKIGSIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droen-YP1      	---------------MAVAAMASPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQVNHDIEPSFVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPDFNSIAMLDTEKIGGIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droez-q5i4x6   	---------------------------------D--NTVSQALKPSQWLSVQELQAIPAVDELTLERLENMSLEKGAELLQQV-YHLSQINHDVEPNFVP--NNIQVYVPKPNGDKIVAPINEMIQRLKQ---KQNFGQDEVTIIVTGLPQT-SETVKKATRKLVQAYMQRYNLQQQQQQAQKYNS---ES-DEDNKRQRTSSEEDY---SEQAKNA-NTNTGDII-VIDLGSTLTNYKRYAMLDIEKTGAKIGKWIVELTSELQLPHETIHMIGQNVGAHVAGAAANEFTRLTGHKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drofa-YP1      	---------------MAVAAMASPSS---GRMGG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLESMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGEKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNYQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPNFNRIAMLDTEKIGAIYGKWIVKMTHELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drogr-YP1      	---------------MAVAAMASPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPQN-CDTVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKNA-NTKTGDII-VIDLGSELPDFNSIAMLDTEKIGSIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drogr-q7jnc5   	------------------------------------NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPQN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKSA-NTQTGDII-VIDLGSELPDFNSIAMLDTEKIGSIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDP-------------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droha-YP1      	---------------MAVAAMASPSS---GRMAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENLSLEKGAELLQQV-YHLSQINHDVEPSYVP--SNVQVYVPKPNGDKIVAPLSEVTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYLQRYNMQQQQQHGMKHNK---DSA-EDDNRQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPDFNSIAMLDTEKIGGIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drohe-YP1      	---------------MAVAAMANPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENLSLEKGAELLQQV-YHLSQINHDVEPSYVP--SNVQVYVPKPNGDKIVAPLSEVTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVHAYMQRYNMQQQQQQGIKYNK---DSA-EDDNRQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPDFKSIAMLDTEKIGGIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drohn-YP1      	---------------MAVAAMASPSS---GRTSG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QHNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQAKNA-NTKSGDII-VIDLGSELPTFNSVAMLDTEKIGGIFGKWIVKMTQELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGH-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drohp-YP1      	---------------MAVAAMASPSS---GRTSG--NSVNQALKPSQWLSPQQLERIEAVDELTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVPKPNGDKIVAPLNEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQAKNA-NTKSGDII-VIDLGSELPSFNSIAMLDTEKIGGIFGKWIVKMTQDLQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droin-YP1      	---------------MAVAAMASPSS---SRSGD--SSVNQALKPSQWLSPQQLEGIQAVDDLTMDRLENMSLQKGAELLQQV-YHLSQINHDVEPSYVP--SNVQVYVPKPNGEKIVATMDEMIQRLKQ---QQNFGEDEVTIIVTGLPKT-SETVKKANRKLVHAYMQRYNLQQQQQQGQRYNK---GSS-EENNRQRSSSEEDY---NEQAKNA-NTQTGDII-VIDLGSKLDKYSRIAMLDTETTGCNMGKWIVELTQQLQLPHETIHLIGQNIGAHVAGAAAKEFTRLTGHKLRRVTGLDPSSIIAKAH-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droli-YP1      	---------------MAVAAMASPSS---GRMAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLESMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNYQRTSSEEDY---TEQAKNA-NTQTGDII-VIDLGSELPNFNRIAMLDTEKIGAIYGKWIVKMTHELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drome-1vite    	---MNPMRVLSLLACLAVAALAKPN----GRM-D--NSVNQALKPSQWLSGSQLEAIPALDDFTIERLENMNLERGAELLQQV-YHLSQIHHNVEPNYVP--SGIQVYVPKPNGDKTVAPLNEMIQRLKQ---KQNFGEDEVTIIVTGLPQT-SETVKKATRKLVQAYMQRYNLQQQRQHGKNGNQDYQDQSNEQRKNQRTSSEEDY---SEEVKNA-KTQSGDII-VIDLGSKLNTYERYAMLDIEKTGAKIGKWIVQMVNELDMPFDTIHLIGQNVGAHVAGAAAQEFTRLTGHKLRRVTGLDPSKIVAKSKNTLTGLARGDAEFVDAIHTSVYGMGTPIRSGDVDFYPNGPAAGVPGASNVVEAAMRATRYFAESVRPGNERSFPAVPANSLQQYKQNDGFGKRAYMGIDTAHDLEGDYILQVNPKSPFGRNAPAQKQSSYHGVHQAWNTNQDSKDYQ--     =====>
drome-2vite    	---MNPLRTLCVMACLLAVAMGNPQSGN--RSGRRSNSLDNVEQPSNWVNPREVEELPNLKEVTLKKLQEMSMEEGATLLDKL-YHLSQFNHVFKPDYTPEPSQIRGYIVGERGQKIEFNLNTLVEKVKR---QQKFGDDEVTIFIQGLPET-NTQVQKATRKLVQAYQQRYNLQPYETTD----YSNEEQSQR------SSSEEQQTQRRKQNGEQDDTKTGDLI-VIQLGNAIEDFEQYATLNIERLGEIIGNRLVELTNTVNVPQEIIHLIGSGPAAHVAGVAGRQFTRQTGHKLRRITALDPTKIYGKPEERLTGLARGDADFVDAIHTSAYGMGTSQRLANVDFFPNGPSTGVPGADNVVEATMRATRYFAESVRPGNERNFPSVAASSYQEYKQNKGYGKRGYMGIATDFDLQGDYILQVNSKSPFGRSTPAQKQTGYHQVHQPWRQSSSNQGSRRQ     =====>
drome-3vite    	---MMSLR-ICLLATCLLVAA----H---ASKDAS----NDRLKPTKWLTATELENVPSLNDITWERLENQPLEQGAKVIEKI-YHVGQIKHDLTPSFVPSPSNVPVWIIKSNGQKVECKLNNYVETAKA---QPGFGEDEVTIVLTGLPKT-SPAQQKAMRRLIQAYVQKYNLQQLQKNAQEQQQQL-----KS-SDYDYTSSEEA---ADQWKSA-KAASGDLI-IIDLGSTLTNFKRYAMLDVLNTGAMIGQTLIDLTNK-GVPQEIIHLIGQGISAHVAGAAGNKYTAQTGHKLRRITGLDPAKVLSKRPQILGGLSRGDADFVDAIHTSTFAMGTPIRCGDVDFYPNGPSTGVPGSENVIEAVARATRYFAESVRPGSERNFPAVPANSLKQYKEQDGFGKRAYMGLQIDYDLRGDYILEVNAKSPFGQRSPAHKQAAYHGMHHAQN-----------     =====>
droml-YP1      	---------------MAVAAMASPSS---GRTTG--NSVNQALKPSEWLSPQQLERIDAVDDLTLERLESMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVPKPNGDKIVAPLNEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYLQRYNLQQQQQEGQKYNK---DSA-EDTNRQRTSSEEDY---TEQAKHA-NTQTGDII-VIDLGSELPNFNSIAMLDTEKIGGIYGKWIVKLTHELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
dromm-YP1      	---------------MAVAAMASPSS---SRSGD--SSVNQALKPSQWLSPQQLEGIQAVDDLTIDRLENISLQKGAELLQQV-YHLSQINHDVEPSYVP--SNVQVYVPKPNGEKIVAPMNEMIQLLKQ---QQNFGEDEVTIIVTGLPKT-SETVKKANSKLVNAYMQRYNLKQQQQQGQKYNK---DSS-EENNRQRSSSEEDY---NEQAKNA-NTQTGDII-VIDLGSKLDKYSRIAMLDTEAIGCNMGKWIVELTQQLQMPHETIHLIGQNIGAHVAGAAAKEFTRLTGHKLRRVTGLDPSS-----------------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droni-YP1      	---------------MAVAAMASPSS---GRTGG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLESMSLEKGAELLQQV-YHLSQIKHDMEPTYVP--SNVKVYVPKPNGDKIVAPLNEITELLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNT---DSS-EDNNRQRTSSEEDY---SEQARNA-NTKSGDII-VIDLGSELPTFNSMAMLDTEAIGVIFGKWIVKMTHDLQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drooa-YP1      	---------------MAVAAMASPSS---GRTGG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SKVQVYVAKPNGEKIVAPLNEMTQLLKQ---QQDFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNVQQQQQQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQARNA-NTKSGDII-VIDLGSELPTFNSIAMLDTETIGGIFGKWIVKLTHDLQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droob-YP1      	---------------MAVAAMASPSS---GRMGG--NSVNQMLKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVAKPNGEKIVAPLNEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQARNA-NTKSGDII-VIDLGSELPTFSSIAMLDTETIGGIFGKWIVKLTHDLQLPYETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droor-YP1      	---------------MAVAAMASPSS---SRMGD--NSVNQALKPSQWLSPQQLESIQAVDDLTLDRLESMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNMQVYVPKPNGDKIVAPLNEIIPLLKQ---QQNFGQDEVTIIVTGLPKT-CETVKKANRKLVQAYMQRYNLQEQQQQGQKYNK---DSG-EENNRQRTSSEEDY---SEQAKNA-KTQTGDII-VIDLGSELNTYKRMAMLDTETTGANVGKWIVRMTRQLELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
dropi-YP1      	---------------MAVAAMASPSS---GRMAG--NSVNQALKPSQWLSPQQLEGIGAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVPKPNGDKIVAPLNEMTQLLKQ---EQNFGQDEVTIIVTGLPKN-CETVNKANRKLVQAYMQRYNLKEQQEQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQAKNA-KTQTGDII-VIDLGSKLPNYNSIAMLDTEAIGCIFGKWIVKMTNELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
dropl-YP1      	---------------MAVAAMASPSS---GRTSG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSS-EDNNRQRTSSEEDY---SEQAKNA-NTKSGDII-VIDLGSELPTFNSVAMLDTEKIGGIFGKWIVKMTQDLQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
dropn-YP1      	---------------MAVAAMASPSS---GRSAG--SSVNQALKPSQWLSPQQLERIEAVDELTLERLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SSVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKS-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNM---GSS-EDSNRQRTSSEEDY---TEQAKNA-KTQTGDII-VIDLGSELTNFNSMAMLDTEKIGSIYGKWIVKMTHELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
dropr-YP1      	---------------MAVAAMASPSS---SRMGG--NSVTQALKPSQWLSAQQLEGIQAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDVEPSYVP--SNMQVYVPKPNGDKIVAPLNEMIPLLKQ---QQNFGEDEVTIIVTGLPKT-SETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DS--EENNRQRTSSEEDY---SEQAKNA-NTQTGDII-VIDLGSEINNFKRMAMLDTETTGAKIGKWIVQMTYELQLPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drops-q29fw0   	---MNPMRVLSMLALLAVAVMAKPGS---SHM-D--NSVSQALKPSQWLSASALEAIPAADELTVERLENMSLEKGAELLQQI-YHLSQINHNVEPNFVP--SGIQVYVPKRNGEKIVAPLNEMIQRLKQ---KENFGDDEVTIIVTGLPST-TETVKKANRKLVQAYMQRYNLQQQRQHGNGR--DYDDS--NEKKGQRTSSEENS---SEESKNA-KTQSGDII-VIDLGATLTNYKRYAMLDIEKTGAKIGKWIVQMVSELDMPFDTIHLIGQGVGAHVAGASAQEFTRLTGHKLRRVTGLDPSKIVAKTRNTLTGLARGDAEFVDAIHTSVYGMGTPVRSADADFYPNGPAAGVPGAENVIEATMRATRYFAESVRPGNERSFPAVPANSLQQYKQNDGFGKRAYMGIDAAHDIEGDYILQVNAKSPFGRNAPAQKQSSYHGVHQAWKNDNK--DY---     =====>
drops-q29hv0   	----MSLR-LCLLLACLTAVA----Y---ANKDASSSTGMHELKPTKWLSASELESVPSLNDITWERLENEPLHKGANLIEKI-YHVSHIKHDLTPSFVPSPSNVPVWIIKSNGDRVEAKLNNYVEKAQA---QTGFGEDEVTIVLTGLPQT-SQTAKKAMRKLVQAYIQRYNLQQQQKNAQEQQQGYQQQTNKD-YDYTSTSSEEQ---ADQWKSA-KTASGDLI-IIDLGSTLTNFKRYAMLDVAGTGAMIGQTLIQLTNK-GVPQEIIHLIGQGIAAHVAGAAGNEFTAQTGHKLRRITGLDPAKLLSKRRNALVGLSRGDADFVDAIHTSAYGMGTFFRCGDVDFYPNGPSAGVPGAKNVIEAVARATRYFAESVRPGNERNFPAVPANSLEQYKEKDGFGKRAYMGLQTDFDLQGDYILEVNEKSPFGQRTPAQKQASYHGVHHYQN-----------     =====>
dropu-YP1      	---------------MAVVAMASPSS---GRTAG--NSVNQALKPSQWLSPQQLERIEAVDDLTLERLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPQN-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSA-EDNNRQRTSSEEDY---TEQAKSA-NTQTGDII-VIDLGSELPDFNSIAMLDTEKIGSIYGKWIVKMTHELELPHETIHLVGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
droqu-YP1      	---------------MAVAAMASPSS---GRMRG--NSVNQALKPSQWLSPQQLEAIEAVDDLTLERLESMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKPNGDKIVAPLSEMTQLLKQ---QQNFGQDEVTIIVTGLPKT-CETVKKANRKLVQAYMQRYNLQQQQQQGQRYNK---DSA-EDNNRQRTSSEEDY---SEQAKNA-NTQTGDII-VIDLGSELPDFNSIAMLDTEKIGSIYGKWIVKMTHELELPHETIHLIGQNIGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIIAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drosc-YP1      	---------------LAVAAMASPSS---SRMGD--NSVNQALKPSQWLSPQQLEGIQAVDDLTLDRLENMSLEKGAELLQQV-YHLSQINHDIEPSYVP--SNVQVYVPKRNGDKIVAPLNEMIPLLKQ---QQNFGRDEVTIIVTGLPKT-CETVKKANRKLVQAYMQRYNLQQQQQQGQKYNK---DSS-E-ENRQRTSSEEDY---TEQAKNA-NTQTGDII-IIDLGSELNSYKRMAMLDTETTGANIGKWIVRMTSQLELPHETIHLIGQNVGAHVAGAAANEFTRLTGHKLRRVTGLDPSSIVAKGR-----------------------------------------------------------------------------------------------------------------------------------------------------     =====>
drosf-YP1      	---------------MAVAAMASPSS---GRTGG--NSVNQALKPSQWLSPQQLEGIGSVDDLTLERLESMSLEKGAELLQQV-YHLSQINHDIEPTYVP--SNVQVYVPKANGDKIVASLDEMTQLLKQ---EQNFGQDEVTIIVTGLPKN-CETVNKANRKLVQAYMQRYNLKQQQ<