ESTHER Database

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MSA from Cobalt (Ncbi) Cobalt
Color code	Main amino-acide (aa) at this position	Non majority aa at this position	50% conservation	Catalytic site	Catalytic site in alignement
Position       	....5....10...5....20...5....30...5....40...5....50...5....60...5....70...5....80...5....90...5....100..5....110..5....120..5....130..5....140..5....150..5....160..5....170..5....180..5....190..5....200..5....210..5....220..5....230..5....240..5....250..5....260..5....270..5....280..5....290..5....300..5....310..5....320..5....330..5....340..5....350..5....360..5....370..5....
9burk-q44ur6   	-------------------------------------------------------------------------------MILYLHGFRSSPESQKSRLLAARMAELGR------TGEWRCPSLS-VS--------PLEAIAVAEAE---VA-G------------ARDVTVIGSSLGGYYATWLAEKHG---------WKAVLLNPAIVPQRDLEQYLGEQS-------------LWHG-GGTIV-----------VERRHLHELD-ALRVP----AITR---ADRYYLFAATGDEVLDYREMLAHYPRAK----TRVI-DGSDH-GISEFADY-VDDVLAFCDGKTS----------------     =====>
9burk-q4b354   	---------------------------------------------------------------------------MPTTHLLYLHGFRSSPQSVKAKKMAAIVRLRHP------SVRWWCPQLP-PS--------PREALQAIMDG---IA-GWP------REAGFESLAVVGSSLGGFYATAVAERTG---------CRAVLLNPAVEPARDLSGYIGEQT-------------AWHNAGEHFF-----------FEPRFVDELR-ALQAG----PLKT---PENYLAVIAKGDEVLDWREMTARYAGAQ----IRLL-EGGDH-ALSDFDLH-LPAILDFLDLAP-----------------     =====>
9gamm-q1n2l6   	-------------------------------------------------------------------------MIPEQLRCLYLHGFKSGPQSSKAQQTQMFFEDHQN------QQNLHIPQLS-PA--------PQAAMDQAQFIYEQLLDE----------VGPASTLVIGSSLGGYFASYLVERFG---------GRCVLINPAVKPYELLRDYLGENE-------------NLYN-GERFV-----------VTEDYMDELK-ALDTP----ALAQ---PQRHFLMVQTHDETLDYRLACDKYRNGP----CIIE-YGGDH-SYSNFQQR-LPAVMNFMQMPY-----------------     =====>
9gamm-q1uet1   	------------------------------------------------------------------------------MKIIYIHGLDSRSNSVKGMLLQKYCNNHHA------DIQVIRPDLN-ES--------PDKVFARLCEL---VQQAKE---------ADDKVVVMGSSLGGYFATLVSNKTA---------CPAVLLNPSTQPHISLQRFVDDHVVDGIACDDGA-DTVIYRTTGGWA-----------MTLKDLDWFN-AHKLQ----QITH---PERLFVVIKQGDELLNPQVAADFYQAQG--VTVDLQ-SGGDH-RMTDFEQQ-LPMIMSHLQSLA-----------------     =====>
9gamm-q1yup3   	-----------------------------------------------------------------------------MPTLLYLHGFNSSPESAKAQQTQQWFGQNAP------GIEFICPSLP-PY--------ADQAMALLCEI---VEAR-----------LPEPVFVIGSSMGGFYASCLAERYV--EFD----VAAVLINPAVSPARGLDKWLGENS-------------NYHS-GETWL-----------FEPHHIDEYQ-RWDPS----AIKN---KNNYLVLLQSGDEVLDYRDAEQRYQGCK----IILE-SGGDH-SFIDYHRH-LETIYQFLLSTVPSNP-------------     =====>
9gamm-q1zd97   	-------------------------------------------------------------------------------MIIYLHGFDATSPGNHEKVMQLKFIDTDV----------RFV--------HYSTVHPKYDMSYILGEVHKHIQ----------SSDDQHPLICGVGLGGFWSERIGFLCG---------IKQVIFNPNLYPEDNMVGKIEWPEE-------------YLD-----------------IKSKCVADFR-----------KKN---THQCLCILSTVDNKTSIKLDDHELSAYY----PMILDTQQGH-KFKDISEH-LQSIKTFKLAKK-----------------     =====>
9gamm-q1zi25   	----------------------------------------------------------------------------MRKILLLLHGFHSSPKSKKSQQMQAYLSLHHP------EITFICPQLP-CL--------PEDVWQLLCDL---KEQY-----------KDAAIGVIGSSLGGYFATKLAQEFA---------LKTVLINPAVTPYHLLTTYIGDQI-------------QPYT-GEKYE-----------INSDYMGKLQ-ALDVE----SLRF---PENIWLLQQEGDEVLDHCHAKIKYAHCK----ITSE-KGGNH-SFSGFERF-IGEILTFLF--------------------     =====>
9gamm-q2br53   	---------------------------------------------------------------------------MNTPLYIYVHGFNSSPQSMKARLFVEYLQGKSL------GDQVMIPELS-HW--------PAEAMQQLRAL---VEQNQQ-----------RTVILLGSSLGGYYSTWLTEHYD----H----VRTVLINPSVRPFELLPQYLGPNV-------------NLYS-GKEYE-----------LTQEHLTQLL-ALNCQ----EIER---PEAYLLLTQTADETLDYREAVEKFSASP----QFVQ-PGGSH-GFEQFENL-IPAIMAFAEGRIDLPEAQPI---------     =====>
9gamm-q2byt3   	----------------------------------------------------------------------------MASLLIYLHGFNSSPQSLKAQQMAQYCAVHRP------DIKVVIPQLP-SY--------PEEAQTYLEEL---ILRF----------KDEYKIGLVGSSLGGYLCTWLSERFA---------LPAVLINPAVKPYELLVDYLGPQQ-------------NPYS-GENYV-----------LVPQHMAQLQ-QLDVV----TINA---PQHFWVLLQEGDEVLDYRQSELKYAESK----LTVE-PNGDH-SFVNFERF-PASIIQFLEL-------------------     =====>
9gamm-q2bz17   	-------------------------------------------------------------------------------MIIYLHGFDSTSPGNHEKVLQLQFIDSDI----------RFV--------NYSTLHPKHDMQHLLKEVHKLVD----------ENTDTTPMICGVGLGGYWAERIGFLCG---------IKQVILNPNLHPEKNMEGRIDRPEE-------------YTD-----------------IMTKCVEDFR-----------KKN---TGNCLCILSTNDEVLDNQSTKDELDQFY----DIVWDESETH-KFKKISQH-LQKIKAFKAQ-------------------     =====>
9gamm-q33pz4   	-------------------------------------------------------------------------------MILYFHGFDATSPGNHEKMRQLQFVDPDV----------RLI--------SYSTLHPKYDMQYLLNEVSRQLT----------QSDDPAPLAIGVGLGGYWAERIGFLNG---------LKTVMINPNLHPEDNMLGKIDRPEE-------------YAD-----------------IASKCVSQFR-----------EKH---KGRGMCILSRQDEVHDNQAVASILAPFY----PIVWDEEQRH-KFPSLAAH-LAEIKAFKEQQ------------------     =====>
9gamm-q33u67   	-------------------------------------------------------------------------------MLLYIHGFNSSPHSDKGVVTAQYIAKHFP------DINFVQPQLP-AT--------PKAAMALLTDL---VEQA---------LEMGESLSFIGSSLGGYFASYLAERYG---------GRAVLVNPAVKPFELFDEFLGPQY-------------NPYT-EEDYQ-----------ILPEHKLEVA-KYDTP----AISH---PDRFLVLLQSGDEVLDYRQAVNKYQCCQ----MLIE-AGGDH-SFVGYQQQ-MPGICDFLFLDK-----------------     =====>
9gamm-q3p1l9   	-------------------------------------------------------------------------------MLLYIHGFNSSPQSDKARVTAEYLRTHYP------QLAFFQPQLP-SS--------PIAAIALLEEI---CVEA---------IAEGESLAFIGSSLGGYYSSYLAERFG---------GLAVLVNPAIKPFELFEQFVGPQY-------------NPYT-DEHYH-----------LSINDKADIA-KYDTK----VINH---PERFLVLLQTGDEVLDYRQALHKYHHCA----LYCQ-PGGDH-SFVGYQQH-LTKICQFLKLD------------------     =====>
9gamm-q3qet3   	-------------------------------------------------------------------------------MLLYIHGFNSSPQSDKGLQSANFIAANHP------GVRLVQPQLP-TD--------IERAVALLCEI---TEEA---------KARGEPLRFIGSSLGGFFATYLAETYG---------GKAALINPAVSPYDLFEAFLGPQH-------------NPYT-GEDYL-----------VLPSHREALK-RYDVA----AIAN---PDRFFVLLQTGDEVLDYRLALGKYYCCR----MLIE-PGGDH-SFVGFERQ-LPDIAAFLELP------------------     =====>
9gamm-q3qg04   	-------------------------------------------------------------------------------MILYFHGFDSTSPGNHEKMRQLRFIDADV----------RLI--------SYSTEHPRYDMQQMLNDVARELA----------EVDKQQVIALGVGLGAFWAERIGFLNG---------IRAVLINPNLTPEHNMVGRIDRPEE-------------YAD-----------------IAAKCVTEFR-----------KKN---HGRCLCILSRHDEVLDSKVAQATLSPFY----PIVWDDEQPH-KFPELGSH-LATIKAFMTAS------------------     =====>
9vibr-q1zm49   	----------------------------------------------------------------------------MASLLIYLHGFNSSPQSLKAQQMAQYCADHRP------DIKVVMPQLP-SY--------PEEAQVYLEQL---ILRF----------KDEYKIGLVGSSLGGYLCTWLSERFA---------LPAVLINPAVKPYELLVDYLGPQQ-------------NPYS-GENYV-----------LVPQHMAQLQ-QLDVA----TIHA---PQHFWVLLQEGDEVLDYRQSMMKYAESK----LTVE-PNGDH-SFVNFERF-PASIIQFLEL-------------------     =====>
9vibr-q1zqp5   	-------------------------------------------------------------------------------MIIYLHGFDSTSPGNHEKVLQLQFIDSDI----------RFV--------NYSTLHPKHDMQHLLKEVHKLVD----------ENKDTKPLICGVGLGGYWAERIGFLCG---------IKQVIFNPNIHPENNMEGRIDRPEE-------------YTD-----------------IMTKCVEDFR-----------KKN---AGNCLCILSTNDEVLDNQATKDELDQFY----DIVWDENETH-KFKKISQH-LQKIKAFKAQ-------------------     =====>
aciad-q6f6x7   	---------------------------------------------------------------------------MPMMNLIYLHGFRSSSLSIKGQQLKHYCQAF-P------YIQVHLPDLN-LP--------PHEVIKKIENM---IQ-------------SMDQVALIGSSLGGFYATQLVAKYQ---------IPAVLINPAMRPWQLFRQLFSDQT-------------LPYTVCETWT-----------LDEQQLTEME-KIAVP----VVQA---ADKILVLLQQGDEVLDYREAERYYSQPAHPSLIFTD-AHGNH-AMEDFENK-LPLILAFLTYSLK----------------     =====>
acisp-O24848   	-------------------------------------------------------------------------MIKHPLKILFMHGLDSSRESTKFHAIESTNKFC-I------TIDYRNLSY-----------------NTVADF---YQNT---------IETIQPDLLIGHNLGGYWALKLSSQYH---------LAAIVANPSLAPL--FRDDYPSLTS-----------------------------------------K--ELDTD-----SP-------KIAYIELGDESLNMYDIQN---VLEDYMIVDSI-EGGHH-RLENPSKL-NILIDH-IQSEYFSHTI--R---------     =====>
actsc-q3ef11   	-------------------------------------------------------------------------------MIIYLHGFSSSHANDYEKMTQLHYIDEDV----------RFI--------NYSTMHPRHDMQHLLQEVHKLIS----------RSEDKSPLICGLGLGGYWAERIGFLCG---------IKQVLFNPDLFPNETLQHKIDRPEE-------------FED-----------------IKTKCVSSFR-----------EKN---KGRCLVFLASLDERLNANRTADELAPYY----DIVWDDIATH-EFDKIAQY-VLTIRDFKNKA------------------     =====>
altat-q3cln7   	MGIFIKRAKHAAKIAYLCLRRLHAGSGQTAKNSPPVVKRRDIASLNWLITGK-STV------TLLEFNGIYMTDSKPEQVVIYLHGFLSSPQSVKAQQTKAFVDEHYP------DIVFYIPQLD-NH--------PKPAAKMLDEL---VARH-----------PNADFGFIGSSMGGYFSSYLLERYG---------GKAVLINPAVQPYNLLADYLGEHI-------------NPYT-KKRFS-----------LDESHTQDLT-TFDTK----TLAS---PQNYWVLLQTADETLDYRQAEQKYMGAK----LTIE-EGGDH-SFQGYERF-LADIFQFLLHD------------------     =====>
anade-q2inx3   	-------------------------------------------------------------------------------MLLYLHGFASGPSSTKATTLAARFAGIGV--------PVDVPDLT-PGEDGFERSSPSSMLAVAE---RRLAE------------AAPPHAVIGSSLGGYLAAVAASRDP--SI-----ERLVLMAPAFRLFERWSRRLGPAELEGWRARG-L-EVDHFASGRKRR-----------LGWQFFEDAQ-GWPAF----PE-V---RVPTLCIAGRRDETIPLEDVAAFVART--PGARLVE-VDDGHELTSSLDLI-FEEARAFLRPVT-GR--------------     =====>
anasp-ALL4967  	-----------------------------------------------------------------------------MTKYIYLHGFASSPLSAKAQDISKRFAQIHI--------QLTIPDLN-AG--EFSQLTITRQIQQVA---AIFP------------DNSEPITLIGSSLGGLTAAYLGQRYL--QV-----QRLVLLAPAFGFLSHWLPKMGEEAVQSWQQNGYY-PVYHYGEGKSLP-----------LSYNFVTDAA-QYQED----QIQR---PVPTLILHGKQDEVIPITASRDFAHFR--PWVELIE-LDSDHALGNVMEEI-WQAISLFCQLPESGRI-------------     =====>
aquae-AQ.1571  	--------------------------------------------------------------------MYFYDINNEKRLWLHLHGLATNVLGRKIEFLRNYFKEKKL--------YSF----F-ANDMDYEKHTTTNTLDFLEVLVRGFS------------QKFEEITLCGSSHGGYIAMNYVRKRPLFNV-----KRLVLLAPSYNTLSLIIKELGEDKVKPWLEGK-E-ELTILEEDREVTFIKDWAKDIIQNDYEIIKD---GRVDF----PEEP---PVEIVIMHGIRDDIVPIHYSETFAKSV--KVKKFLK-VDDDHQLNESLQKY-IEELL------------------------     =====>
azose-q5p6k3   	-------------------------------------------------------------------------------MIIYLHGFRSAPASIKAQALQRHMAAKGL------AHAFWCEQLP-VS--------PRAAIALVEAQ---IA-HCR------RERPELRPTLVGSSLGGFYATWLAEKHG---------LAAALVNPAVVAPLSLEAWVGPQT-------------NLYT-GERFD-----------FTARHIEELR-ALDIA----AITR---PERYWLLVETGDEVLDYRDAVAKYAGAR----QTVL-AGGDH-GFSRWNDY-LDALLAFAGLPS-----------------     =====>
azovi-q4iv51   	-------------------------------------------------------------------------MPSAVPSILYIHGFNSSSASLKARQLTCAMQALGL------ALRLRVPDLH-HH--------PRRAIAQLETL---LA-ELG------------RPTLVGSSLGGYYATHLAERHG---------LRAVLINPAVRPYRLFGGRLGTQH-------------NHYS-GETWE-----------LTVDHLAALA-ELEVP----PPRD---PARYRVWLQTGDETLDWRDAAAYYRHCA----PAVE-RGGDH-GFQGFAGR-LPELLAFAGFDAALWRDFDFSEL------     =====>
bora1-q2kuu7   	---------------------------------------------------------------------------MPEAKILYLHGFRSSPDSFKARLMAQAMADR--------PADWACPQLP-AS--------PKAAAELAREL---AQ-NLL------GDAPPRNLTVVGSSLGGYYATWLAQVLD---------CKAVLINPAVNAPRDLATQVGEHK-------------MYHS-AAPFV-----------FLPDYVQELH-ELHVP----VLTH---PERYFLIAATGDEVLDWREMRERFAGCR----QRII-PGSDH-GVSDFAQW-LPEVLDFALTGPH----------------     =====>
borpe-q7vus4   	------------------------------------------------------------------------------MPILYLHGFRSSPDSFKARLLAQAMHQRGL------AGQWQCPQLP-AS--------PQQAAELALAL---AREQLA------GQQDPRRLTVIGSSLGGYYATWLAERLG---------CQAVLLNPAVQAARDLATQVGEHR-------------MYHS-DAPFH-----------FLPEYVEELR-ALYAD----PLTH---PERYFLVAATGDEVLDWREMRDRYPGCR----QRIV-QGGDH-GLSDFPRW-MPEVLEFALGSPH----------------     =====>
burma-q62gx9   	-------------------------------------------------------------------------------MILYLHGFRSSPQSFKARALAARLDELGR------ADEWRCPVLS-VA--------PLAAIAAAEAE---VA-GVP----------AQRVTVIGSSLGGYYATWLAEKHG---------WRAVLLNPATQPQRDLRRHLGEQP-------------LWHG-GGTIV-----------VEPHHLDELN-ALHVA----AISR---PERYYLFAATGDEVLDYREMLARYPGAR----TRVI-EGSDH-GISEFADY-IDDVLAFCDAG------------------     =====>
burs3-q39js2   	-------------------------------------------------------------------------------MILYLHGFRSSPESQKSRQLAARMAELGR------TDEWRCPSLS-VS--------PLEAIAVAEAE---VA-G------------ARDVTVIGSSLGGYYATWLAEKHG---------WKAVLLNPAIVPQRDLEQHLGEQP-------------LYHG-GGTIV-----------VERRHLHELD-ALRVP----AITR---AERYYLFAATGDEVLDYREMLAHYPGAK----TRVI-EGSDH-GISEFADY-VDDVLAFCDGKTS----------------     =====>
burvi-q4bhm3   	-------------------------------------------------------------------------------MILYLHGFRSSPESQKSRLLAARMAALGR------TAEWRCPSLA-VS--------PLEAIAVAEAA---VA-G------------AQDVTVIGSSLGGYYATWLAECHG---------WKAVLLNPAIVPQRDLEQYLGEQP-------------LWHG-GGSIV-----------VERRHLQELD-ALRVP----AISR---PERYYLFAATGDEVLDYREMLAHYPGAK----TRVI-EGSDH-GISEFADY-VDDVLAFCDQKTS----------------     =====>
chrsd-q1qug6   	---------------------------------------------------------MYRFCGMLV---APVANMTPVTSILYLHGFNSGAASPKAQLIAATCERLAS--DGATPPRCVAPQLP-HR--------PDDALACAERE---LR-GLG------D-----DTLLIGSSMGGFLATCLAERAG---------LRAVLINPAVRPARLVAQWEGAAFE------------NPYT-HERFT-----------IDAQHGAALE-AMTPS----GIIA---PHRYRLLLGSADETLDCRDALAFYAGAP----TLVH-PGGDH-GFSALADY-LPAIFAHGGWTLPPRSPTRSDEST-----     =====>
chrvo-q7p1k1   	------------------------------------------------------------------------------MHIVYLHGFNSGPQSLKAGETASWLRQHAP------DIVLHCPRLS-PH--------PAEAARQADEL---IA-GLP------A-----DTLLIGSSLGGFYATLLAERHD---------RPAALINPAVRPDRDLERFRGEQT-------------NPYT-GEVYT-----------LGDDDLRALQ-EQRTA----A-PA---AGRYWLLLGSRDETLDWREAAVHYRHSR----QTVF-NGDDH-RLNNWPKV-LPEVVAWARRQLSSRA-------------     =====>
citk8-y1948    	-------------------------------------------------------------------------------MIIYLHGFDSNSPGNHEKVLQLQFIDSDV----------RLI--------SYSTRHPKHDMQHLLKEVDKMLQ----------LNVDDRPLICGVGLGGYWAERIGFLCD---------IRQVVFNPNLFPYENMEGKIDRPEE-------------YAD-----------------IATKCVTNFR-----------EKN---RDRCLVILSRHDEALDSHRSAKELHHFY----EIVWDEEQTH-KFKNISPH-LQRIKAFKTLG------------------     =====>
colp3-q47wj4   	----------------------------------------------------------------------------MKKNILHIHGFNSSPLSLKAEQTRKYMAKNFP------NVGFYCPQLA-TT--------PANAMSQLEQL---IETH----------DSNAKWYLIGSSLGGYFAHYLAKKYD---------CLAVLVNPAITPYELLHDYIGEQV-------------NPYT-EEVYQ-----------VTEDHMQQLK-ALEQTAPTIDCTE---KNNYLVMVQTGDEVLNYQQAVEKYQYCR----LIVQ-EGGDH-SFINFDNC-LPTISDFFQLDNTKRINSR----------     =====>
crowt-q4bwa5   	----------------------------------------------------MLQ-------SL--QLKYKCYMLNNQLNYIYLHGFASSSQSFKAQKFQELFATKNI--------PLIIPDLN-QN--DFYNLTLTRQIKQIS---SYIEN------------EPNSVVLVGSSLGALVSAFIAEKEE--KV-----KGLILIAPAFYFFSRWLENLDKDTLNTWKDEGEL-PIYHYGYEQELP-----------LSYQFIIDGK-NYNET----LLKR---PVPTLIFHGKNDEVIPIQSSHDYAQPR--EWVKLIE-LDSDHSLNDRISDI-WKQIQDYGKLRI-----------------     =====>
decar-q478u3   	---------------------------------------------------------------------------MGRGLIVYLHGFCSSPASWKSRLLGEEMARRGM------AAQFVCPQLS-PV--------PDEAVASVSRL---IE-QAS------G-----PVTLIGSSLGGHYANHLAEKHG---------LSAVLINPAVTDRLDLEKFVGTHA-------------NFHT-GEQFT-----------FTTAHAAQLK-AQ--V----SIPK---SERYWLLLEEGDEVLDYRQAQAFYAGCR----QTVL-PGGDH-SFTKFPDF-VPQIIEYAGL-------------------     =====>
ecoli-ycfp     	-------------------------------------------------------------------------------MIIYLHGFDSNSPGNHEKVLQLQFIDPDV----------RLI--------SYSTRHPKHDMQHLLKEVDKMLQ----------LNVDERPLICGVGLGGYWAERIGFLCD---------IRQVIFNPNLFPYENMEGKIDRPEE-------------YAD-----------------IATKCVTNFR-----------EKN---RDRCLVILSRNDEALNSQRTSEELHHYY----EIVWDEEQTH-KFKNISPH-LQRIKAFKTLG------------------     =====>
ecoli-yqia     	-----------------------------------------------------------------------------MSTLLYLHGFNSSPRSAKASLLKNWLAEHHP------DVEMIIPQLP-PY--------PSDAAELLESI---VLEH-----------GGDSLGIVGSSLGGYYATWLSQCFM---------LPAVVVNPAVRPFELLTDYLGQNE-------------NPYT-GQQYV-----------LESRHIYDLK-VMQID----PLEA---PDLIWLLQQTGDEVLDYRQAVAYYASCR----QTVI-EGGNH-AFTGFEDY-FNPIVDFLGLHHL----------------     =====>
edwi9-y1813    	-------------------------------------------------------------------------------MIIYLHGFDSTSPGNHEKVLQLQFIDTDV----------RLI--------SYSTRHPRHDMQYLLNEVSRVVR----------QGDDPGALICGVGLGGFWAERIGFLCG---------IRQVMVNPNLFPQETMPGLIDRPEE-------------YAD-----------------IATKCVENFR-----------SRN---RGRSLVLLSRHDEVLDSQRSAGLLAPYY----DVVWDEQQGH-KFSSLSPH-LQRIRAFKSVA------------------     =====>
ent38-y1623    	-------------------------------------------------------------------------------MIIYLHGFDSNSPGNHEKVLQLQFIDPDV----------RLI--------SYSTRHPKHDMQHLLKEVDKMLQ----------LNVDERPLICGVGLGGYWAERIGFLCD---------IRQVVFNPNLFPEENMEGKIDRPEE-------------YAD-----------------IATKCVSNFR-----------EKN---RDRCLAILSRQDEALNSHRAAEFLHHYY----EIVWDEEQTH-KFKNISPH-LQRIKAFKTLG------------------     =====>
erwct-q6d673   	-------------------------------------------------------------------------------MIIYLHGFDSTSPGNHEKVLQLQFIDEDV----------RLI--------SYSTLHPRHDMQHLLKQVDKMIQ----------HSDDDRSLICGVGLGGFWAERVGFLCD---------IRQVIVNPNLFPQENMSGKIDRPEE-------------YLD-----------------IATKCVANFR-----------EKN---RDRCMVMLSRQDEMLDSQRSAQTLGEYY----EIVWDDIQTH-KFKSISPH-LQRIKAFKTLG------------------     =====>
erwct-q6dac1   	-----------------------------------------------------------------------------MPTLLYLHGFNSTPQSSKATALKTWLAEQHP------EIDMVIPQLP-PY--------PTEAAEMMESL---IMER-----------AGRPVGIVGSSLGGYYATWLSQCFM---------LPAVVVNPAVKPFELLLDHLGEYQ-------------NPYT-GEQYV-----------LESRHVYDLK-VMQVD----RLES---PDLLWLLLQTGDEVLDYRQAVAYYTACR----QTVE-SGGNH-AFVGFEHF-FTPIVNFLGLTTD----------------     =====>
glovi-q7ndi8   	------------------------------------------------------------------------------MHLVYLHGFASGPNSTKGSFLKRRLAEFGY--------DLHQPDLN-AP--AFEAMTISSQLAVIA---RTLEG------------LTGPVTLLGSSMGGLLAVLQATRDP--RI-----ERLVLMAPAFGFARRWQERLGAAAVAEWRRSGKL-AVYHYAYRRECR-----------LGFEMLTDAL-GYDEV----QPRR---PVPTLILHGRRDEVVDFELSRAFAASR--PNVALRP-YDTDHAMIDVLEPM-WQEIRGFLKLERQGGYPAVRSS-------     =====>
hahch-q2s9n3   	---------------------------------------------------------------------------MSHSYILYLHGFNSSPQSFKAQCSQQWLAKYYP------NMDLAIPALH-YS--------PAVAMERLERE---YFAG-----------GDRPLGVIGSSLGGYYAAYLHHRYG---------VSSALINPAVRPYDLLEDYLGINK-------------NLYT-GEEYV-----------LEPRHMDELL-ALDSP----SPTI---GERIYTLVQTGDATLNYREAALKFAHCA----LWVQ-SGGSH-EFEDFERV-LPSIVNFFLSSTIQK--------------     =====>
helhp-q7vig4   	------------------------------------------------------------------------------MQYFYSHGFHSSRDSQAYKRLCCGLDIEPQQLVYDNGADFYTNLYS--------------CKSQLQNC---I-------------ESNMPFGFIGNSLGAFYLWQLTLFAP--TLSIPTPHTLILFNPVLEPLVQLKKYINQPQ-------------INTTTHQSFT-----------FSYDSWVSYAHSLRM-----PLAK---QIQCIVCLSLDDELIDVQVSKAYWQHYA----RIVM-IEGGH-IITDFSPF-KQTLAPFL---------------------     =====>
idilo-q5r0d5   	------------------------------------------------------------------------------MLVIFNHGKESGPWGSKIKVLAKTAEALGF--------SVTSVDYQ-GIDD------PDQRVEKLT---TYIE------------ALTENFLLVGSSMGGYVATVAAAK-T--KS-----RGLFLMAPAFYLGGQA-----------------------------------------------------NFD------ELTP---ACETQIVHGWKDDIVPVENSWRYAER---TRAELHL-VNDGHRLIDSLPQT-NALFKRFLETLLKG---------------     =====>
klep7-y1077    	-------------------------------------------------------------------------------MIIYLHGFDSNSPGNHEKVMQLQFIDPDV----------RLI--------SYSTRHPKHDMQHLLKEVDKMLQ----------LTADDRPLICGVGLGGYWAERIGFLCD---------IRQAVFNPNLFPHENMEGKIDRPEE-------------YAD-----------------IATKCVTNFR-----------EKN---RDRCLVVLSRQDEALDSQRSADLLHHYY----EIIWDEEQTH-KFKNISPH-LQRLKAFKTLG------------------     =====>
mansm-q65uj5   	-------------------------------------------------------------------------------MIIYLHGFSSSRPDDYENVMQLKMIDPDV----------RVI--------SYSTVHPRHDMTYILNETHKLVS----------ETQDDKPMICGVGLGGYWAERVGFLCG---------VKQIILNPNLFPEENMEGKIDRPEE-------------YLD-----------------IKTKCIEDFR-----------EKN---QSRCLVFLSKNDKVVDPKRSEALLSHYY----EVIWDDTDAH-QFKHIAPY-IQRLKEFKAA-------------------     =====>
metca-q605j8   	-------------------------------------------------------------------------------MIVYLHGFCSSPRSEKATLLGRRMAERAL------ADRFWCEQLP-PG--------PRQAIEFVEGV---LA-KCR------T-----RPALVGSSLGGYYATHLAEKHD---------LRAVLINPAAFAYRSLAPAVGRQR-------------NLHT-GEPFE-----------FTERHLAELA-RLEVP----RLSH---PERFWLLVETGDEVLDYREAVEKYSGAR----QTVI-EGGDH-SFRHFADY-LDAIIDFSLAP------------------     =====>
metfl-q3xct5   	-----------------------------------------------------------------------------------MPGFNSSPASEKSSLLRQHFPLVTI------------PEYNSWD--------PDIAYIQLEQA---ILPL-----------LNQGVLLTGSSLGGFWAYQFACRYR---------QPCLLINPCMHPELSLQRYIGKVE-------------NFYS-HEQGW-----------LTEAHLGKYA-AYRVN------GQ---PSRLTVLHEQGDELIPYMESVVNFSGKA----KLIL-PGGGHHRFARTDLI-AACIRDMLPPEDAGHQKA-----------     =====>
pasmu-y825     	-------------------------------------------------------------------------------MIIYLHGFDSSSPGNHEKVMQLKFIDEDV----------RFV--------NYSTLHPRHDMQFLLNEVHKLVS----------ESKDPAPLICGVGLGGYWSERIGFLCG---------IKQAIFNPNLFPYENMTGKIDRPEE-------------YKD-----------------IETKCVENFR-----------EKN---KGKCLVFLSKEDGILDSQRSAALLSPFY----EIVWDDVETH-KFKKISHH-LQRIKAFKQR-------------------     =====>
pholl-q7n0d9   	-----------------------------------------------------------------------------MSTLLYLHGFNSSPQSAKANALKAWLYQHHP------DIDMLVPQLP-PY--------PEEAAELLENL---VMEH-----------AGDDLGIVGSSLGGYLAIWLSQCFS---------LPAVVVNPAVRPFELLRDYLGENI-------------NPYT-NQRYT-----------LESRHIHDLK-SMWIE----PLES---PDLIWLLQQTGDEVLDYRQAVAYLVLCK----QTIE-SGGNH-AFIGFEHY-FPQIINFLGLSSDGEKKLAKNV-------     =====>
phopr-q6luz0   	--------------------------------------------------------------------------------MLYIHGFNSSPLSLKAQVMAEYCKQHRP------DIRVEIPQMP-CY--------PAQAATFIDDL---VSNF----------KQDYTIGLVGSSLGGYISTWLNSRHQ---------LPAVLVNPAVKPYELLQDYLGEQV-------------NPYT-NEKYW-----------LEPQHINELR-VMDVE----QLVD---PKQFWLLQQMGDEVLDYRQAVAKYAASK----QTVE-PNGDH-SFVDFERF-PADVIQFLNL-------------------     =====>
phopr-y2397    	-------------------------------------------------------------------------------MIIYLHGFDSNSPGNHEKVLQLQFIDPDV----------RFV--------NYSTLHPKHDMQHLIKEVHKLIE----------ESDDTKPLICGVGLGGYWAERIGFLCG---------IKQVIFNPNLNPSVNMEGRIDRPEE-------------YID-----------------IGTKCVADFR-----------EKN---AGNCLCVLSTNDEVLDNQLTSDALSDFY----KIIWDETQNH-KFKKISQH-LQAMKAFKE--------------------     =====>
pse14-q48p24   	-------------------------------------------------------------------------MTSDTPSLLYIHGLNSSALSRKACQLAALMKSLGL------ADRLQVPELH-HH--------PRQAVGQLETV---IK-ELG------------RPLLVGSSLGGYYATHLAQQHG---------LKAVLINPAVNPHQLFDGFLGVQQ-------------NLYT-GEQWQ-----------LTEDHIQALA-ELEVP----APQD---PQQFQVWLQTGDETLDYRRAEKFYRACA----LRIQ-AGGDH-SFQGFAEQ-MPALLSFAGFAPDLLQKIDLSAL------     =====>
pseae-PA4968   	-------------------------------------------------------------------------MTATSPSLLYIHGFNSSPESHKARQLQAAFGHLGL------AEGLRVPALH-HH--------PRQAIAQLERA---IA-ELG------------RPVLVGSSLGGYYATHLAERHG---------LAAILVNPAVAPHRSFDGYLGAQT-------------NHYS-GETWE-----------LTEDHVAALA-ELEVA----HLQR---PERYQVWLQTADETLDYRVAQAFYRACA----LRIQ-AGGDH-GFQGFARH-LPALLAFAGYPSALWRDTDFSTFD-----     =====>
psef5-q4kj95   	----------------------------------------------------------------------------MSGSILYIHGFNSAPASTKASQLHQVMEQLGL------AGQLRVPALH-HH--------PRQAIGQLEQA---IA-ELG------------RPLLVGSSLGGYYATHLAERYG---------LKALLINPAVSPHRMFDGYLGTQK-------------NLYT-DETWE-----------LTHDHVAALA-ALEVA----PPQD---PERYQVWLQTGDETLDYRSAERYYRACA----LRIQ-AGGDH-SFQGFAGQ-LPAMLNFAGITADQYQAIDFTAL------     =====>
pseht-q3ig70   	----------------------------------------------------------------------------MVKRVIYIHGFNSSEKSYKAVRFGELMA--HY------DVDYYVPRLN-HE--------PLQAIIELEQL---ITP---------------NTALLGSSLGGFFATYLSQRYH---------IPAVVINPAVAPGNLLQPLLGANY-------------NPYQ-DYNYE-----------LNNRHIDALK-VLTLS----ELKH---PELLYLLQQTGDEVLNFQHAVNYYSHCK----QLIE-FGGDH-SFIGFERT-IASIVDFLKLNKTS---------------     =====>
psepf-q3kj14   	----------------------------------------------------------------------------MSGSILYIHGFNSAPASKKACQLVEVMERLGL------SDQLRVPALH-HH--------PREAIGQLEQA---IA-ELG------------RPLLVGSSLGGYYATHLAERHG---------LKALLVNPAVSPHRMFDGYLGTQK-------------NLYT-DETWE-----------LTHDHVTALA-ELEVP----APQD---LQRYQVWLQTGDETLDYRLAQQYYRACA----LRIQ-AGGDH-SFQGFVTQ-LPALLSFAGIGADTYQAIDFTAL------     =====>
psepu-PP4916   	------------------MSRPRQPA-------------GNVLRNPWHCVKTRRTRYTARPCARITRREATDSGGSMSGSILYIHGFNSSPLSTKARQLEAVMQQLGL------ADQLRVPALH-HH--------PRQAMVQLEAA---IA-ELG------------APLLVGSSLGGYYATHLAERHG---------LKALLVNPAVTPHKHFDGYLGTQR-------------NHYS-GETWE-----------LTHDHVQALA-ELEVA----APAD---ADRYQVWLQTADETLDYRHAERYYRACA----LRIQ-AGGDH-SFQGFAER-LPALLAFAGIARGQYAALDFSVF------     =====>
psesy-PSPTO4964	-------------------------------------------------------------------------MTSDTPALLYIHGLNSSAQSKKACQLIALMKSLGL------ADRLQVPELH-HH--------PRQAMLQLESA---IG-ALG------------RPLLVGSSLGGYYATHLAQRHG---------LKAVLINPAVNPHQLFDGFLGMQQ-------------NLYT-GEQWQ-----------LTEDHIKALA-ELEVP----APQD---PQQFQVWLQTGDETLDYRRAEKFYRACA----LRIQ-AGGDH-SFQGFAER-LPALLSFAGFAPDLLQGIDLSVL------     =====>
pseu2-q4zz02   	-------------------------------------------------------------------------MTSDTPSLLYIHGLNSSNLSRKACQLSALMKSLGL------ADRLQVPELH-HH--------PRQAMLQLEAA---IT-ALG------------RPLLVGSSLGGYYATHLAQRHG---------LKAVLINPAVNPHQLFDGFLGVQQ-------------NLYT-GEQWQ-----------LTEDHIRALA-ELEVP----APQD---PQQFQVWLQTGDETLDYRRAEKFYRSCA----LRIQ-AGGDH-SFQGFAEH-MPALLTVAGFAPDLLQKIDLSAL------     =====>
psyar-q4fpw6   	------------------------------------------------------------------------------MNIIYIHGLDSDANSTKGMVLEHYCQQYHP------DINVVRLDFN-KT--------PDQVFSQILSF---IAGLKHNDNIEDEQFESSNTVLVGSSLGGYFSTLISNYTG---------CPALLLNPSTQPHVTLKRFANDLALKNDVKEEGLRSKIIHSTAGGWH-----------ISQADLQWFE-EHQLL----TVNY---PNKVSVLIKEGDELLNPELSKIFYQEQG--AMVTLQ-AGGDH-RFSDFGEQ-LPKVIDMLQQLL-----------------     =====>
psyck-q1q811   	------------------------------------------------------------------------------MNLIYIHGLDSDANSTKGRLLEDYCHQHHS------DINVYRPNLN-SA--------PEQVFEQLVKL---VTELN----------KGAKTVLIGSSLGGYFSTLISNHLG---------CPALLLNPSTQPHITLQRFYNASISNRDSSDGLPNNKVLHTTAGGWN-----------ITPSDLQWFA-EHQLL----AVNY---PDKVAVLLKKGDELLNSELSKAFYRSQG--ASVTVQ-AGGDH-RFSDFDKQ-LPMVIDMLQDLGRV---------------     =====>
psyck-q1qc79   	---------------------------------------------------------------------MMFPIENNDTFLLFFHGLDSSCETNKYTCIKREPKYC-Q------TVNYRDDFE--------------EIFNIYDIL---IQEK---------MKQYPRVVLAGHSLGGWFANHFAHKYN---------LRALLIAPCIYPSEVLADRIPQVAD-----------------------------------------M--KLSFP-----TSN---TEMVRVMIEVDDESLDVAVARRTLVNLPDSWEVEYF-ENGHH-RIARSEDI-WYHLVH-LCEDPIIWMD--EATYHGEE--     =====>
ralej-q46xb2   	-------------------------------------------------------------------------------MLLYLHGFRSSPQSFKARLVQERMREWGV------GRYYACPLLN-VS--------PVQAIAQAEAA---IH-AAR------A-GGDQEIAIVGSSLGGFYARWLGERHG---------CRTVLLNPAIHPWTDLMQYIGEQP-------------LWHG-GGTVT-----------VEPRHMQELL-DLRVD----TLSH---PERYYLLAATGDEVLDYREMVAACTGAH----IRVI-SGSDH-GISEFADY-VDDVLTFCGYGPGGVVPGRAA--------     =====>
ralme-q1liu5   	-------------------------------------------------------------------------------MLLYLHGFRSSPQSFKSRVVQDRMRAWGV------EKYFACPMLN-VS--------PSLAIAQAEAA---IR-GAR------A-GGETDIAIIGSSLGGFYARWLAEKHG---------CRAVLLNPAVHPWTDLERYLGEQP-------------LYHG-GGSVV-----------VERKHLQELL-DLRVD----AITR---PERYYLLAATGDEVLDYREMIAACPGAR----IRVI-EGSDH-GISEFEEY-VDDVLAFCGYTPNGKTVA-----------     =====>
ralso-RSC2781  	----------------------------------------------------------------------------MPASILYLHGFRSSPRSFKAQLLGQRMAAVGL------AHAYACPMLP-VS--------PRQAMAEIEAL---IA-DLS------S-RDGVAPALIGSSLGGYYATWLAERHG---------LRAAMLNPATRPDRDLAKYVGEQP-------------LWHG-GGTIR-----------VEPHHLDELH-ALAVT----AITQ---PERYYLLAATGDEVLDYREMLAHFPGAA----TRVI-DGGDH-GISDFARY-MDEVLVFCGVPAGLLAAHPFDRQAGA---     =====>
rhofd-q21t19   	---------------------------------------------------------------------MSTPQPTPVTHLLYLHGFRSSPQSAKARILAQHMASHQP------DVHWWCPQLP-PS--------PREAMALLLQG---SA-DWP------RE----SMAVVGSSLGGFYATWVAEQTG---------CKAVLLNPAVNPARDLEKYIGEQT-------------CWQDPQERFF-----------FQPEFVQELR-DLACA----SLTR---PERYLAVIAKGDELLDWRESHARYAGAQ----LRLL-EGSDH-GITDFDQQ-LPAVMAFLGLN------------------     =====>
sacd2-q21nu2   	-----------------------------------------------------------------------------MATVLYLHGFLSSPQSSKAKVTWRWLAKNHP------DVDFCCPQLS-SY--------PSQAIAQIEAE---LD-SLT------Q-----PVYVIGSSLGGFWATNLVERGL----V----AKAVLVNPAVDPHTRFDEFKNVPLQ------------SYYS-DETYC-----------LTEKDLQDLV-ALNYV----EPQQ---PNKYMLMVQTGDETLDYRMATKKYRHCK----QIVE-EGGSH-TFDGYENW-LPQIIEFFTQQSSDQ--------------     =====>
salty-STY3360  	-----------------------------------------------------------------------------MSTLLYLHGFNSSPRSAKACQLKNWLAERHP------HVEMIVPQLP-PY--------PADAAELLESL---VLEH-----------GGAPLGLVGSSLGGYYATWLSQCFM---------LPAVVVNPAVRPFELLTDYLGQNE-------------NPYT-GQQYV-----------LESRHIYDLK-VMQID----PLEA---PDLIWLLQQTGDEVLDYRQAVAYYASCR----QTVT-EGGNH-AFTGFEDY-FNQIVDFLGLHSC----------------     =====>
salty-YQIA     	-----------------------------------------------------------------------------MSTLLYLHGFNSSPRSAKACQLKNWLAERHP------HVEMIVPQLP-PY--------PADAAELLESL---VLEH-----------GGAPLGLVGSSLGGYYATWLSQCFM---------LPAVVVNPAVRPFELLTDYLGQNE-------------NPYT-GQQYV-----------LESRHIYDLK-VMQID----PLEA---PDLIWLLQQTGDEVLYYRQAVAYYASCR----QTVT-EGGNH-AFTGFEDY-FNQIVDFLGLHSC----------------     =====>
salty-ycfp     	-------------------------------------------------------------------------------MIIYLHGFDSNSPGNHEKVLQLQFIDPDV----------RLV--------SYSTRHPKHDMQHLLKEVDKMLQ----------LNVDERPLICGVGLGGYWAERIGFLCD---------IRQVVFNPNLFPYENMEGKIDRPEE-------------YAD-----------------IATKCVTNFR-----------EKN---RDRCLVILSRHDEALDSQRSAQALHPFY----EIVWDEEQTH-KFKNISPH-LQRIKAFKTLG------------------     =====>
serp5-y1925    	-------------------------------------------------------------------------------MIIYLHGFDSTSPGNHEKVLQLQFIDPDV----------RFI--------SYSTLHPRHDMQHLLKEVDKAVQ----------QGGDKHSLICGVGLGGFWAERIGFLCG---------IRQVIFNPNLSPEQHMQGKIDRPEE-------------YRD-----------------IATKCVEDFR-----------EKN---RDRCLVVLSRHDEVLDSQLSAELLHKYY----EIVWDEQQTH-KFKNLSPH-LQRIKAFKTLP------------------     =====>
sheb2-y1944    	-------------------------------------------------------------------------------MIFYLHGFDATSPGNHEKMRQLQFIDPDV----------RLV--------SYSTLHPKHDMQHLLKEVAKQMK----------HSDDPSPLMVGVGLGAYWAERIGFLNG---------LKSVLINPNLHPEENMQGKIDRPEE-------------YAD-----------------IANKCVSQFR-----------EKN---THKAMCIFSVNDEMFDNQQLASELSAYY----SIDWDDVQPH-KFPQLAAH-LPKIKAFKLA-------------------     =====>
shefr-q3nle4   	-------------------------------------------------------------------------------MLLYIHGFNSSPQSDKAVQTAHYIQQHYP------QVDFYQPQLP-SS--------PSVAMALLCNI---AEQA---------KQQGQTLRFIGSSLGGYFASYLTETYG---------GRAVLINPAVKPFELFEEFIGPQY-------------NPYT-NEHYQ-----------VLPQHQDDVA-LYNTH----VIRH---PDRFLVLLQTGDEVLDYRQALHKYHSCE----LHLE-PNGDH-SFVGYEQQ-LDKICKFIQL-------------------     =====>
sheon-SO3900   	-------------------------------------------------------------------------------MLLYIHGFNSSPFSDKAVITARYMAEYHP------SLTFHQPQLP-NT--------PKAAMALLQSY---VEAA---------QQANEPLNYIGSSLGGYFASYLAERYG---------GRAVLVNPAVKPFELFDEFMGPQF-------------NPYT-QEHYQ-----------VLPEHKREVA-EFNTP----VIRN---PERFLVLLQTGDEVLDYREALHKYHHCQ----LRIE-SGGDH-SFVGYERY-LQTVSQFLHLP------------------     =====>
sheon-ym51     	-------------------------------------------------------------------------------MIFYLHGFDATSPGNHEKMRQLQFIDPDV----------RLI--------SYSTLHPKHDMQYLLKEVAKQMQ----------HSDDPAPLMVGVGLGAYWAERIGFLNG---------LKSVLINPNLHPENTMQGKIDRPEE-------------YAD-----------------IANKCVSEFR-----------MKN---THKAMCILSRFDEVLESQLSADELSRYY----AIEWDETQPH-KFPQLAAH-LPKIKAFKLG-------------------     =====>
shesh-y2836    	-------------------------------------------------------------------------------MILYLHGFDATSPGNHEKMRQLQFIDKDV----------RLV--------SYSTLHPKHDMQHLLNEVSRQLQ----------QSDDSDPIIIGVGLGAYWAER