BIGI-3h
Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
General
Type : Multitarget,Monoamine-oxidase-inhibitor,GSK-3 kinase inhibitor,Calcium Channel Antagonist,anti-Abeta-aggregation,Derivative of Donepezil
Chemical_Nomenclature :
Canonical SMILES : C15=C(OC=C(C1=O)C2NC(N(C(=C2C(OCC)=O)C)CCC3CCN(CC3)CC4=CC=CC=C4)=O)C(=CC(=C5)Cl)Cl
InChI : InChI=1S\/C31H33Cl2N3O5\/c1-3-40-30(38)26-19(2)36(14-11-20-9-12-35(13-10-20)17-21-7-5-4-6-8-21)31(39)34-27(26)24-18-41-29-23(28(24)37)15-22(32)16-25(29)33\/h4-8,15-16,18,20,27H,3,9-14,17H2,1-2H3,(H,34,39)
InChIKey : PCEFDTXXUQXRHF-UHFFFAOYSA-N
Other name(s) : (+\/-)-BIGI-3h
MW : 598.52
Formula : C31H33Cl2N3O5
CAS_number :
PubChem :
UniChem : PCEFDTXXUQXRHF-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Ismaili_2021_ACS.Chem.Neurosci__ |
| ESTHER : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |