CB2R-BCHE-x
Balanced dual acting butyrylcholinesterase inhibitor and human cannabinoid receptor 2 ligand IC50 hBCHE 0.76 microM Ki hCB2R 1.6microM
General
Type : Multitarget,Cannabinoid-Receptor-ligand,Piperidine,Imidazole,Carboxamide
Chemical_Nomenclature :
Canonical SMILES : C1(=CC=C2C(=C1)N=C([N]2CCC(C)C)CC3=CC=C(C=C3)OCC)C(=O)NCCC
InChI : 1S\/C25H33N3O2\/c1-5-14-26-25(29)20-9-12-23-22(17-20)27-24(28(23)15-13-18(3)4)16-19-7-10-21(11-8-19)30-6-2\/h7-12,17-18H,5-6,13-16H2,1-4H3,(H,26,29)
InChIKey : FLYKEYAVHVYDAL-UHFFFAOYSA-N
Other name(s) :
Target
References (1)
| Title : Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles - Dolles_2018_J.Med.Chem_61_1646 |
| Author(s) : Dolles D , Hoffmann M , Gunesch S , Marinelli O , Moller J , Santoni G , Chatonnet A , Lohse MJ , Wittmann HJ , Strasser A , Nabissi M , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 61 :1646 , 2018 |
| Abstract : Dolles_2018_J.Med.Chem_61_1646 |
| ESTHER : Dolles_2018_J.Med.Chem_61_1646 |
| PubMedSearch : Dolles_2018_J.Med.Chem_61_1646 |
| PubMedID: 29400965 |