Cetilistat
Cetilistat is a pancreatic lipase inhibitor acting in the same way as the drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. rat pancreatic lipase and human pancreatic lipase IC50 of 54.8 nmol and 5.95 nmol respectively
General
Type : Lipase inhibitor
Chemical_Nomenclature : 2-hexadecoxy-6-methyl-3,1-benzoxazin-4-one
Canonical SMILES : CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C=C2)C)C(=O)O1
InChI : InChI=1S\/C25H39NO3\/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-28-25-26-23-18-17-21(2)20-22(23)24(27)29-25\/h17-18,20H,3-16,19H2,1-2H3
InChIKey : MVCQKIKWYUURMU-UHFFFAOYSA-N
Other name(s) : 282526-98-1,Citilistat,ATL-962,ATL 962,Cametor
MW : 401.59
Formula : C25H39NO3
CAS_number :
PubChem : 9952916
UniChem : MVCQKIKWYUURMU-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Cetilistat ligand of proteins in family: Pancreatic_lipase
Stucture :
Protein : human-PNLIP
References (6)
| Title : Overview of new antiobesity drugs - Hainer_2014_Expert.Opin.Pharmacother_15_1975 |
| Author(s) : Hainer V |
| Ref : Expert Opin Pharmacother , 15 :1975 , 2014 |
| Abstract : Hainer_2014_Expert.Opin.Pharmacother_15_1975 |
| ESTHER : Hainer_2014_Expert.Opin.Pharmacother_15_1975 |
| PubMedSearch : Hainer_2014_Expert.Opin.Pharmacother_15_1975 |
| PubMedID: 25100293 |
| Title : Cetilistat for the treatment of obesity - Gras_2013_Drugs.Today.(Barc)_49_755 |
| Author(s) : Gras J |
| Ref : Drugs Today (Barc) , 49 :755 , 2013 |
| Abstract : Gras_2013_Drugs.Today.(Barc)_49_755 |
| ESTHER : Gras_2013_Drugs.Today.(Barc)_49_755 |
| PubMedSearch : Gras_2013_Drugs.Today.(Barc)_49_755 |
| PubMedID: 24524093 |
| Title : Reduction of dietary fat absorption by the novel gastrointestinal lipase inhibitor cetilistat in healthy volunteers - Bryson_2009_Br.J.Clin.Pharmacol_67_309 |
| Author(s) : Bryson A , de la Motte S , Dunk C |
| Ref : British Journal of Clinical Pharmacology , 67 :309 , 2009 |
| Abstract : Bryson_2009_Br.J.Clin.Pharmacol_67_309 |
| ESTHER : Bryson_2009_Br.J.Clin.Pharmacol_67_309 |
| PubMedSearch : Bryson_2009_Br.J.Clin.Pharmacol_67_309 |
| PubMedID: 19220279 |
| Title : Cetilistat, a new lipase inhibitor for the treatment of obesity - Padwal_2008_Curr.Opin.Investig.Drugs_9_414 |
| Author(s) : Padwal R |
| Ref : Curr Opin Investig Drugs , 9 :414 , 2008 |
| Abstract : Padwal_2008_Curr.Opin.Investig.Drugs_9_414 |
| ESTHER : Padwal_2008_Curr.Opin.Investig.Drugs_9_414 |
| PubMedSearch : Padwal_2008_Curr.Opin.Investig.Drugs_9_414 |
| PubMedID: 18393108 |
| Title : Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats - Yamada_2008_Horm.Metab.Res_40_539 |
| Author(s) : Yamada Y , Kato T , Ogino H , Ashina S , Kato K |
| Ref : Hormone & Metabolic Research , 40 :539 , 2008 |
| Abstract : Yamada_2008_Horm.Metab.Res_40_539 |
| ESTHER : Yamada_2008_Horm.Metab.Res_40_539 |
| PubMedSearch : Yamada_2008_Horm.Metab.Res_40_539 |
| PubMedID: 18500680 |
| Title : Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients - Kopelman_2007_Int.J.Obes.(Lond)_31_494 |
| Author(s) : Kopelman P , Bryson A , Hickling R , Rissanen A , Rossner S , Toubro S , Valensi P |
| Ref : Int J Obes (Lond) , 31 :494 , 2007 |
| Abstract : Kopelman_2007_Int.J.Obes.(Lond)_31_494 |
| ESTHER : Kopelman_2007_Int.J.Obes.(Lond)_31_494 |
| PubMedSearch : Kopelman_2007_Int.J.Obes.(Lond)_31_494 |
| PubMedID: 16953261 |