Cpd8f-quinoline-carboxamide
LipY IC50 8.25 +/-0.43 microM (Orlistat <1.50). Highly selective towards the growth inhibition of hypoxic cultures of M. tuberculosis
General
Type : Quinoline,Carboxamide
Chemical_Nomenclature : 7-chloro-N-[(E)-(2,5-dimethoxyphenyl)methylideneamino]-6-fluoro-4-oxo-1H-quinoline-3-carboxamide
Canonical SMILES : C1(=C(C=C2C(=C1)C(=C(C=N2)C(=O)NN=CC3=C(C=CC(=C3)OC)OC)O)Cl)F
InChI : InChI=1S\/C19H15ClFN3O4\/c1-27-11-3-4-17(28-2)10(5-11)8-23-24-19(26)13-9-22-16-7-14(20)15(21)6-12(16)18(13)25\/h3-9H,1-2H3,(H,22,25)(H,24,26)\/b23-8+
InChIKey : PDBWRWOZXDSIPK-LIMNOBDPSA-N
Other name(s) :
MW : 403.79
Formula : C19H15ClFN3O4
CAS_number :
PubChem : 72793819
UniChem : PDBWRWOZXDSIPK-LIMNOBDPSA-N
IUPHAR :
Wikipedia :
Target
Families : Cpd8f-quinoline-carboxamide ligand of proteins in family: Hormone-sensitive_lipase_like
Stucture :
Protein : myctu-Rv3097c
References (1)
| Title : Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia - Saxena_2013_Int.J.Antimicrob.Agents_42_27 |
| Author(s) : Saxena AK , Roy KK , Singh S , Vishnoi SP , Kumar A , Kashyap VK , Kremer L , Srivastava R , Srivastava BS |
| Ref : Int J Antimicrob Agents , 42 :27 , 2013 |
| Abstract : Saxena_2013_Int.J.Antimicrob.Agents_42_27 |
| ESTHER : Saxena_2013_Int.J.Antimicrob.Agents_42_27 |
| PubMedSearch : Saxena_2013_Int.J.Antimicrob.Agents_42_27 |
| PubMedID: 23684389 |
| Gene_locus related to this paper: myctu-Rv3097c |