Reactivators of organophosphate-inhibited ChEs give rise to instable phosphorylated oximes that reinhibit the enzyme
Type : Organophosphate,Phosphonylated oxime
Chemical_Nomenclature : diethyl[(1-methylpyridin-1-ium-4-yl)methylideneamino] phosphate
Canonical SMILES : CCOP(=O)(OCC)ON=CC1=CC=[N+](C=C1)C
InChI : InChI=1S\/C11H18N2O4P\/c1-4-15-18(14,16-5-2)17-12-10-11-6-8-13(3)9-7-11\/h6-10H,4-5H2,1-3H3\/q+1
InChIKey : OABNVZQRFUXBEL-UHFFFAOYSA-N
Other name(s) : 1-methyl-4 pyridinium carboxaldehyde oxime,diethylphosphoryl-4PAM
MW : 273.25
Formula : C11H18N2O4P+
CAS_number :
PubChem : 85102394
UniChem : OABNVZQRFUXBEL-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Title : Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases - Leader_1999_Biochem.Pharmacol_58_503 |
Author(s) : Leader H , Vincze A , Manisterski B , Rothschild N , Dosoretz C , Ashani Y |
Ref : Biochemical Pharmacology , 58 :503 , 1999 |
Abstract : Leader_1999_Biochem.Pharmacol_58_503 |
ESTHER : Leader_1999_Biochem.Pharmacol_58_503 |
PubMedSearch : Leader_1999_Biochem.Pharmacol_58_503 |
PubMedID: 10424771 |