Dehydroevodiamine

Isolated from Evodia rutaecarpa Bentham (CAS of chloride salt 75853-60-0) moderate AChE inhibition. Long-lasting facilitation of synaptic transmission due to activation of both muscarinic and NMDA receptors

General

Type : Natural,Pyridine,Indole,beta-carboline,Natural_modified,Derivative of Evodiamine

Chemical_Nomenclature : Indolo(2',3':3,4)pyrido(2,1-b)quinazolinium, 5,7,8,13-tetrahydro-14-methyl-5-oxo-, hydroxide, inner salt

Canonical SMILES : CN1C2=CC=CC=C2C(=O)[N+]3=C1C4=C(CC3)C5=CC=CC=C5N4.[Cl-]

InChI : InChI=1S\/C19H15N3O.ClH\/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22\;\/h2-9H,10-11H2,1H3\;1H

InChIKey : SVOMSEHNGXLQRU-UHFFFAOYSA-N

Other name(s) : DHED,Dehydroevodiamine chloride,Dehydroevodiamine,CCRIS 8946,AC1L4G2F

MW : 337.80

Formula : C19H16N3O.Cl

CAS_number : 67909-49-3 || 75853-60-0

PubChem : 156371

UniChem : SVOMSEHNGXLQRU-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : Dehydroevodiamine ligand of proteins in family: ACHE

Stucture :

Protein :

References (3)

Title : Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine - Decker_2005_Eur.J.Med.Chem_40_305

Author(s) : Decker M

Ref : Eur Journal of Medicinal Chemistry , 40 :305 , 2005

Abstract : Decker_2005_Eur.J.Med.Chem_40_305

ESTHER : Decker_2005_Eur.J.Med.Chem_40_305

PubMedSearch : Decker_2005_Eur.J.Med.Chem_40_305

PubMedID: 15725500

Title : Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice - Wang_2001_Eur.J.Pharmacol_413_221

Author(s) : Wang HH , Chou CJ , Liao JF , Chen CF

Ref : European Journal of Pharmacology , 413 :221 , 2001

Abstract : Wang_2001_Eur.J.Pharmacol_413_221

ESTHER : Wang_2001_Eur.J.Pharmacol_413_221

PubMedSearch : Wang_2001_Eur.J.Pharmacol_413_221