Demecarium
Demecarium Bromide is the bromide salt form of demecarium, a quaternary ammonium compound and a long-acting cholinesterase inhibitor with parasympathomimetic activity. When used topically, demecarium inactivates both pseudocholinesterase and acetylcholinesterase, thereby preventing acetylcholine breakdown and increasing acetylcholine activity. This causes contraction of the iris sphincter muscle (producing miosis) and the ciliary muscle (affecting the accommodation reflex). In so doing, this agent increases the outflow of the aqueous humor, thereby reducing intraocular pressure.
General
Type : Trimethylammonium,Bisquaternary,Drug
Chemical_Nomenclature : trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium
Canonical SMILES : CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C
InChI : InChI=1S\/C32H52N4O4\/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8\/h17-22,25-26H,9-16,23-24H2,1-8H3\/q+2
InChIKey : RWZVPVOZTJJMNU-UHFFFAOYSA-N
Other name(s) : Humorsol,Frumtosnil,Tonilen,Tosmicil,Tosmilen,demarcarium,UNII-ILP8XJ8R5K,CHEBI:59719,ZINC3875376,DB00944
MW : 716.58
Formula : C32H52Br2N4O4
CAS_number : 56-94-0
UniChem : RWZVPVOZTJJMNU-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Demecarium_bromide
Target
References (2)
| Title : The effects of topical ocular application of 0.25\% demecarium bromide on serum acetylcholinesterase levels in normal dogs - Ward_2003_Vet.Ophthalmol_6_23 |
| Author(s) : Ward DA , Abney K , Oliver JW |
| Ref : Vet Ophthalmol , 6 :23 , 2003 |
| Abstract : Ward_2003_Vet.Ophthalmol_6_23 |
| ESTHER : Ward_2003_Vet.Ophthalmol_6_23 |
| PubMedSearch : Ward_2003_Vet.Ophthalmol_6_23 |
| PubMedID: 12641839 |
| Title : Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors - Brown_1982_J.Pharmacol.Exp.Ther_223_20 |
| Author(s) : Brown JH , Wetzel GT , Dunlap J |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 223 :20 , 1982 |
| Abstract : Brown_1982_J.Pharmacol.Exp.Ther_223_20 |
| ESTHER : Brown_1982_J.Pharmacol.Exp.Ther_223_20 |
| PubMedSearch : Brown_1982_J.Pharmacol.Exp.Ther_223_20 |
| PubMedID: 6288918 |