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Diphenyl-chlorophosphate

Acetylcholinesterase is readily inhibited by 10-5 M diphenylphosphorochloridate even though the inhibitor hydrolyzes in a few seconds. Diphenyl phosphoryl enzyme spontaneously recovers only about 50% of its activity with a half time of about 17 min at pH 7.0 and 6 min at pH 8.0. The fact that only 50% of the original activity returns is due to aging.

General

Type : Organophosphate

Chemical_Nomenclature : [chloro(phenoxy)phosphoryl]oxybenzene

Canonical SMILES : C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl

InChI : InChI=1S\/C12H10ClO3P\/c13-17(14,15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12\/h1-10H

InChIKey : BHIIGRBMZRSDRI-UHFFFAOYSA-N

Other name(s) : Diphenyl chlorophosphate,Diphenyl phosphorochloridate,Diphenylchlorophosphate,Chlorodiphenyl Phosphate,Chlorodiphenoxyphosphine oxide

MW : 268.63

Formula : C12H10ClO3P

CAS_number : 2524-64-3

PubChem : 75654

UniChem : BHIIGRBMZRSDRI-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : Diphenyl-chlorophosphate ligand of proteins in family: ACHE

Stucture :

Protein :

References (1)

Title : Reactivation and aging of diphenyl phosphoryl acetylcholinesterase - Maglothin_1975_Biochim.Biophys.Acta_403_370
Author(s) : Maglothin JA , Wins P , Wilson IB
Ref : Biochimica & Biophysica Acta , 403 :370 , 1975
Abstract : Maglothin_1975_Biochim.Biophys.Acta_403_370
ESTHER : Maglothin_1975_Biochim.Biophys.Acta_403_370
PubMedSearch : Maglothin_1975_Biochim.Biophys.Acta_403_370
PubMedID: 241402