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Inhibitor Report for: Doxacurium

Interaction of doxacurium with cholinesterase not clinically relevent .neuromuscular non depolarising blocking drug, benzylisoquinolines resembling atracurium, benzylisoquinolinium diester. Bis quaternary


General
Type Neuromuscular Nondepolarizing Agents, Isoquinoline, Bisquaternary, Not A/B H target
Chemical_Nomenclature bis[3-[(1S)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] butanedioate dichloride
Canonical SMILES C[N+]1(CCC2=CC(=C(C(=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)OC)CCCOC(=O)CCC(=O)OCCC[N+]4(CCC5=CC(=C(C(=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]
InChI InChI=1S/C56H78N2O16.2ClH/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6;;/h29-34,39-40H,15-28H2,1-14H3;2*1H/q+2;;/p-2
InChIKey APADFLLAXHIMFU-UHFFFAOYSA-L
Other name(s) Nuromax ; BW A938U
________________________________________________________________________________________________
MW|1035.22
Formula|C56H78N2O16
CAS_number|106819-53-8
PubChem|5311076, 60168
UniChem|APADFLLAXHIMFU-UHFFFAOYSA-L
IUPHAR|
Wikipedia|Doxacurium_chloride

Target
Families | Doxacurium ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: Doxacurium
    Title: Clinical pharmacokinetics of the newer neuromuscular blocking drugs
    Atherton DP, Hunter JM
    Ref: Clinical Pharmacokinetics, 36:169, 1999 : PubMed

            

    Title: New neuromuscular blocking drugs [see comments]
    Hunter JM
    Ref: N Engl J Med, 332:1691, 1995 : PubMed

            

    Title: Newer neuromuscular blocking agents
    Bevan DR
    Ref: Pharmacol Toxicol, 74:3, 1994 : PubMed