EMP-Toxogonin

Reactivators of organophosphate-inhibited ChEs give rise to phosphorylated oximes that reinhibit the enzyme. Reactivation of AChE inhibited by MEPQ with Lu6(Toxogonin) will give EMP-Lu6(Toxogonin)

General

Type : Organophosphate,Phosphonylated oxime

Chemical_Nomenclature : ethoxyl methylphosphonyl-Toxogonin

Canonical SMILES : CCO[P](=O)(C)CN=CC1=CC=[N+](C=C1)COCN2C=CC(=C[N+]([H])=O)C=C2

InChI : InChI=1S\/C18H24N4O4P\/c1-3-26-27(2,24)14-19-12-17-4-8-21(9-5-17)15-25-16-22-10-6-18(7-11-22)13-20-23\/h4-13H,3,14-16H2,1-2H3\/q+1\/p+1

InChIKey : UOFGEYVWWJZAKO-UHFFFAOYSA-O

Other name(s) : EMP-Lu6,EMP-LuH6,ethoxy methyl phosphonyl toxogonin

MW : 463.29

Formula : C18H25Cl2N4O4P

CAS_number :

PubChem :

UniChem : UOFGEYVWWJZAKO-UHFFFAOYSA-O

IUPHAR :

Wikipedia :

Target

Families : EMP-Toxogonin ligand of proteins in family: ACHE

Stucture :

Protein :

References (1)

Title : Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium - Luo_1999_Biochemistry_38_9937

Author(s) : Luo C , Saxena A , Smith M , Garcia GE , Radic Z , Taylor P , Doctor BP

Ref : Biochemistry , 38 :9937 , 1999

Abstract : Luo_1999_Biochemistry_38_9937

ESTHER : Luo_1999_Biochemistry_38_9937

PubMedSearch : Luo_1999_Biochemistry_38_9937

PubMedID: 10433700

EMP-Toxogonin

General

Target

References (1)

1. Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium