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Inhibitor Report for: Fenoverine

Fenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome. Inactive on ACHE; IC50 0.09 +/- 0.01 microM BCHE. fenoverine does not act as a muscarinic or opiate-receptor antagonist, but modulates of the cellular calcium flow


General
Type Not A/B H target, Drug, Phenothiazine, Sulfur Compound, Piperazine, Benzodioxo
Chemical_Nomenclature 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone
Canonical SMILES C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
InChI InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2
InChIKey UBAJTZKNDCEGKL-UHFFFAOYSA-N
Other name(s) Spasmopriv ; UNII-N274ZQ6PZJ ; N274ZQ6PZJ ; SCHEMBL25003 ; CHEMBL1512949 ; CHEBI:135744 ; ZINC19899628 ; DB13042
________________________________________________________________________________________________
MW|459.6
Formula|C26H25N3O3S
CAS_number|37561-27-6
PubChem|72098
UniChem|UBAJTZKNDCEGKL-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Fenoverine ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: Fenoverine
    Title: Identification of Compounds for Butyrylcholinesterase Inhibition
    Li S, Li AJ, Travers J, Xu T, Sakamuru S, Klumpp-Thomas C, Huang R, Xia M
    Ref: SLAS Discov, :24725552211030897, 2021 : PubMed