Hexamethonium
A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool
General
Type : Bisquaternary,Nicotinic antagonist,Trimethylammonium
Chemical_Nomenclature : 1,6-bis(trimethylammonium)hexane
Canonical SMILES : C[N+](C)(C)CCCCCC[N+](C)(C)C.[OH-].[OH-]
InChI : InChI=1S\/C12H30N2.2H2O\/c1-13(2,3)11-9-7-8-10-12-14(4,5)6\;\;\/h7-12H2,1-6H3\;2*1H2\/q+2\;\;\/p-2
InChIKey : GYLUMIIRFKDCKI-UHFFFAOYSA-L
Other name(s) : UNII-RVL393940Z,Hexamethonium hydroxide solution,Hexamethonum,Bistrium,Depressin,Hexanium
MW : 273.29
Formula : C12H30N2Cl2
CAS_number : 60-25-3
PubChem : 6059
UniChem : GYLUMIIRFKDCKI-UHFFFAOYSA-L
IUPHAR :
Wikipedia : Hexamethonium
Target
References (30)
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| Abstract : Jones_2000_J.Toxicol.Environ.Health.A_61_695 |
| ESTHER : Jones_2000_J.Toxicol.Environ.Health.A_61_695 |
| PubMedSearch : Jones_2000_J.Toxicol.Environ.Health.A_61_695 |
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| PubMedSearch : Alex_1999_Indian.J.Exp.Biol_37_455 |
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| Abstract : Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97 |
| ESTHER : Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97 |
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