IDFP
IDFP is an organophosphorus compound that dually inhibits MGLL and FAAH(not an alpha/beta hydrolase) with IC50 values of 0.8 and 3 nM, respectively The compound used IDFPen in structure 4X96 human LCAT is slightly different
General
Type : Organophosphate,FAAH inhibitor,Multitarget
Chemical_Nomenclature : 1-[fluoro(propan-2-yloxy)phosphoryl]dodecane
Canonical SMILES : CCCCCCCCCCCCP(=O)(OC(C)C)F
InChI : InChI=1S\/C15H32FO2P\/c1-4-5-6-7-8-9-10-11-12-13-14-19(16,17)18-15(2)3\/h15H,4-14H2,1-3H3
InChIKey : SFRALHFBKRAJPW-UHFFFAOYSA-N
Other name(s) : Isopropyl dodecylfluorophosphonate,CHEMBL333149,Isopropyl Dodecylphosphonofluoridate,Isopropyl dodecylphosphonofluoridoate,615250-02-7
MW : 294.38
Formula : C15H32FO2P
CAS_number : 615250-02-7
PubChem : 24762154
UniChem : SFRALHFBKRAJPW-UHFFFAOYSA-N
IUPHAR :
Wikipedia : IDFP
Target
Families : IDFP ligand of proteins in family: PC-sterol_acyltransferase || Monoglyceridelipase_lysophospholip
Stucture :
Protein :
References (6)
| Title : Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase - Glukhova_2015_Nat.Commun_6_6250 |
| Author(s) : Glukhova A , Hinkovska-Galcheva V , Kelly R , Abe A , Shayman JA , Tesmer JJ |
| Ref : Nat Commun , 6 :6250 , 2015 |
| Abstract : Glukhova_2015_Nat.Commun_6_6250 |
| ESTHER : Glukhova_2015_Nat.Commun_6_6250 |
| PubMedSearch : Glukhova_2015_Nat.Commun_6_6250 |
| PubMedID: 25727495 |
| Gene_locus related to this paper: human-LCAT |
| Title : Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s) - Suzuki_2014_Toxicol.Lett_225_153 |
| Author(s) : Suzuki H , Ito Y , Noro Y , Koketsu M , Kamijima M , Tomizawa M |
| Ref : Toxicol Lett , 225 :153 , 2014 |
| Abstract : Suzuki_2014_Toxicol.Lett_225_153 |
| ESTHER : Suzuki_2014_Toxicol.Lett_225_153 |
| PubMedSearch : Suzuki_2014_Toxicol.Lett_225_153 |
| PubMedID: 24361246 |
| Title : Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes - Ruby_2011_PLoS.One_6_e26415 |
| Author(s) : Ruby MA , Nomura DK , Hudak CS , Barber A , Casida JE , Krauss RM |
| Ref : PLoS ONE , 6 :e26415 , 2011 |
| Abstract : Ruby_2011_PLoS.One_6_e26415 |
| ESTHER : Ruby_2011_PLoS.One_6_e26415 |
| PubMedSearch : Ruby_2011_PLoS.One_6_e26415 |
| PubMedID: 22073164 |
| Title : Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins - Ruby_2008_Proc.Natl.Acad.Sci.U.S.A_105_14561 |
| Author(s) : Ruby MA , Nomura DK , Hudak CS , Mangravite LM , Chiu S , Casida JE , Krauss RM |
| Ref : Proc Natl Acad Sci U S A , 105 :14561 , 2008 |
| Abstract : Ruby_2008_Proc.Natl.Acad.Sci.U.S.A_105_14561 |
| ESTHER : Ruby_2008_Proc.Natl.Acad.Sci.U.S.A_105_14561 |
| PubMedSearch : Ruby_2008_Proc.Natl.Acad.Sci.U.S.A_105_14561 |
| PubMedID: 18794527 |
| Title : Activation of the endocannabinoid system by organophosphorus nerve agents - Nomura_2008_Nat.Chem.Biol_4_373 |
| Author(s) : Nomura DK , Blankman JL , Simon GM , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE |
| Ref : Nat Chemical Biology , 4 :373 , 2008 |
| Abstract : Nomura_2008_Nat.Chem.Biol_4_373 |
| ESTHER : Nomura_2008_Nat.Chem.Biol_4_373 |
| PubMedSearch : Nomura_2008_Nat.Chem.Biol_4_373 |
| PubMedID: 18438404 |
| Title : Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids - Casida_2008_Chem.Biol.Interact_175_355 |
| Author(s) : Casida JE , Nomura DK , Vose SC , Fujioka K |
| Ref : Chemico-Biological Interactions , 175 :355 , 2008 |
| Abstract : Casida_2008_Chem.Biol.Interact_175_355 |
| ESTHER : Casida_2008_Chem.Biol.Interact_175_355 |
| PubMedSearch : Casida_2008_Chem.Biol.Interact_175_355 |
| PubMedID: 18495101 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |