Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: LEI105

reversible dual DAGLA/DAGLB inhibitor


General
Type Pyridine
Chemical_Nomenclature 1-[6-(4-methylphenyl)-[1,3]oxazolo[4,5-b]pyridin-2-yl]-6-phenylhexan-1-one
Canonical SMILES CC1=CC=C(C=C1)C2=CC3=C(N=C2)N=C(O3)C(=O)CCCCCC4=CC=CC=C4
InChI InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3
InChIKey XDHONXIOZAUYDB-UHFFFAOYSA-N
Other name(s) LEI-105 ; SCHEMBL18240100 ; 6-phenyl-1-(6-(p-tolyl)oxazolo[4,5-b]pyridin-2-yl)hexan-1-one
________________________________________________________________________________________________
MW|384.47
Formula|C25H24N2O2
CAS_number|
PubChem|122390213
UniChem|XDHONXIOZAUYDB-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | LEI105 ligand of proteins in family: Lipase_3

References:
Search PubMed for references concerning: LEI105
    Title: Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta
    Berger N, van der Wel T, Hirschmugl B, Baernthaler T, Gindlhuber J, Fawzy N, Eichmann T, Birner-Gruenberger R, Zimmermann R and Wadsack C <1 more author(s)>
    Ref: Front Endocrinol (Lausanne), 14:1092024, 2023 : PubMed

            

    Title: Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons
    Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H and van der Stelt M <10 more author(s)>
    Ref: Journal of the American Chemical Society, 137:8851, 2015 : PubMed