LY2183240
Endocannabinoid Transport Blocker. Compound that inhibits MGLL ABHD6, PLA2G7 and strong inhibitor of FAAH (not an alpha/beta hydrolase)
General
Type : Cannabinoid-Receptor-ligand,Biphenyl,Urea derivative,FAAH inhibitor,Multitarget,Carboxamide,Tetrazol
Chemical_Nomenclature : N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
Canonical SMILES : CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3
InChI : InChI=1S\/C17H17N5O\/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14\/h3-11H,12H2,1-2H3
InChIKey : GZNIYOXWFCDBBJ-UHFFFAOYSA-N
Other name(s) : LY 2183240,UNII-2WBU91OKM7,2WBU91OKM7,CHEMBL509860
MW : 307.35
Formula : C17H17N5O
CAS_number : 874902-19-9
PubChem : 11507802
UniChem : GZNIYOXWFCDBBJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : LY2183240 ligand of proteins in family: Monoglyceridelipase_lysophospholip || Arylacetamide_deacetylase || ABHD6-Lip
Stucture :
Protein : human-MGLL || human-NCEH1 || human-ABHD6
References (1)
| Title : The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases - Alexander_2006_J.Am.Chem.Soc_128_9699 |
| Author(s) : Alexander JP , Cravatt BF |
| Ref : Journal of the American Chemical Society , 128 :9699 , 2006 |
| Abstract : Alexander_2006_J.Am.Chem.Soc_128_9699 |
| ESTHER : Alexander_2006_J.Am.Chem.Soc_128_9699 |
| PubMedSearch : Alexander_2006_J.Am.Chem.Soc_128_9699 |
| PubMedID: 16866524 |