Promethazine
Tricyclic amine-containing compound || Promethazine is a phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.Promethazine is a phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.
General
Type : Phenothiazine,Drug,Not A\/B H target,Sulfur Compound
Chemical_Nomenclature : 10-[2-(dimethylamino)propyl]phenothiazine
Canonical SMILES : CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
InChI : InChI=1S\/C17H20N2S\/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19\/h4-11,13H,12H2,1-3H3
InChIKey : PWWVAXIEGOYWEE-UHFFFAOYSA-N
Other name(s) : promethazine,Proazamine,Diphergan,Promethazin,Isophenergan,Phenargan,CHEMBL643,CHEBI:8461,SCHEMBL4700,RP-3277
MW : 320.90
Formula : C17H20N2S
CAS_number : 58-33-3 || 60-87-7
PubChem : 4927
UniChem : PWWVAXIEGOYWEE-UHFFFAOYSA-N
IUPHAR : 7282
Wikipedia : Promethazine
Target
References (1)
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : Radic_1993_Biochemistry_32_12074 |
| ESTHER : Radic_1993_Biochemistry_32_12074 |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |