Tacrine-Donepezil-hybrid3
IC50=6.0 nM
General
Type : Derivative of Tacrine,Derivative of Donepezil
Chemical_Nomenclature : N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1,2,3,4-tetrahydroacridin-9-ylamino)acetamide
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCC(=O)NCCC4CCN(CC4)CC5=CC=CC=C5
InChI : InChI=1S\/C29H36N4O\/c34-28(30-17-14-22-15-18-33(19-16-22)21-23-8-2-1-3-9-23)20-31-29-24-10-4-6-12-26(24)32-27-13-7-5-11-25(27)29\/h1-4,6,8-10,12,22H,5,7,11,13-21H2,(H,30,34)(H,31,32)
InChIKey : AYESZVAJFBYQHK-UHFFFAOYSA-N
Other name(s) : CHEMBL486901,Tacrine-E2020 analog 3,BDBM8979,N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1,2,3,4-tetrahydroacridin-9-ylamino)acetamide
MW : 456.63
Formula : C29H36N4O
CAS_number :
PubChem : 10004239
UniChem : AYESZVAJFBYQHK-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease - Shao_2004_Bioorg.Med.Chem.Lett_14_4639 |
| Author(s) : Shao D , Zou C , Luo C , Tang X , Li Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :4639 , 2004 |
| Abstract : Shao_2004_Bioorg.Med.Chem.Lett_14_4639 |
| ESTHER : Shao_2004_Bioorg.Med.Chem.Lett_14_4639 |
| PubMedSearch : Shao_2004_Bioorg.Med.Chem.Lett_14_4639 |
| PubMedID: 15324879 |