TerreulactoneA
Produced by Aspergillus terreus Fb000501. IC50 0.23 microM for ACHE IC50 >200 microM for BCHE
General
Type : Natural,Meroterpenoid
Chemical_Nomenclature : (1R,4R,13R,14R,16R)-13-hydroxy-16-methoxy-8-(4-methoxyphenyl)-4,14,19,19-tetramethyl-5,9,18-trioxapentacyclo[14.2.1.01,14.04,13.06,11]nonadeca-6(11),7-diene-10,15,17-trione
Canonical SMILES : CC1(C23CCC4(C(C2(C(=O)C1(C(=O)O3)OC)C)(CC5=C(O4)C=C(OC5=O)C6=CC=C(C=C6)OC)O)C)C
InChI : InChI=1S\/C28H30O9\/c1-23(2)27-12-11-24(3)26(32,25(27,4)21(30)28(23,34-6)22(31)37-27)14-17-19(36-24)13-18(35-20(17)29)15-7-9-16(33-5)10-8-15\/h7-10,13,32H,11-12,14H2,1-6H3\/t24-,25-,26+,27-,28-\/m1\/s1
InChIKey : AOFMVUCAUSHJLI-RKFAPSRVSA-N
Other name(s) : Terreulactone A,CHEMBL183507,BDBM50157912,Q15427889,13-hydroxy-16-methoxy-8-(4-methoxyphenyl)-4,14,19,19-tetramethyl-5,9,18-trioxapentacyclo[14.2.1.01,14.04,13.06,11]nonadeca-6(11),7-diene-10,15,17-trione
MW : 510.5
Formula : C28H30O9
CAS_number :
PubChem : 44391786
UniChem : AOFMVUCAUSHJLI-RKFAPSRVSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : Terreulactones A, B, C, and D: novel acetylcholinesterase inhibitors produced by Aspergillus terreus. I. Taxonomy, fermentation, isolation and biological activities - Cho_2003_J.Antibiot.(Tokyo)_56_344 |
| Author(s) : Cho KM , Kim WG , Lee CK , Yoo ID |
| Ref : J Antibiot (Tokyo) , 56 :344 , 2003 |
| Abstract : Cho_2003_J.Antibiot.(Tokyo)_56_344 |
| ESTHER : Cho_2003_J.Antibiot.(Tokyo)_56_344 |
| PubMedSearch : Cho_2003_J.Antibiot.(Tokyo)_56_344 |
| PubMedID: 12817807 |
| Title : Terreulactones A, B, C, and D: novel acetylcholinesterase inhibitors produced by Aspergillus terreus. II. Physico-chemical properties and structure determination - Kim_2003_J.Antibiot.(Tokyo)_56_351 |
| Author(s) : Kim WG , Cho KM , Lee CK , Yoo ID |
| Ref : J Antibiot (Tokyo) , 56 :351 , 2003 |
| Abstract : Kim_2003_J.Antibiot.(Tokyo)_56_351 |
| ESTHER : Kim_2003_J.Antibiot.(Tokyo)_56_351 |
| PubMedSearch : Kim_2003_J.Antibiot.(Tokyo)_56_351 |
| PubMedID: 12817808 |