Tetracyclic-carbamate-cp8
IC50 hAChE 3.6 microM; IC50 hBChE 5.2 nM
General
Type : PET probe,Carbamate,Natural_modified,Derivative of Evodiamine,Isoquinoline,Quinazoline
Chemical_Nomenclature : 13-Methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl (7-[18F]fluoroheptyl)carbamate
Canonical SMILES : C12=C(C=CC=C1)C4N(CC2)CC3=CC(=CC=C3N4C)OC(=O)NCCCCCCCF
InChI : InChI=1S\/C25H32FN3O2\/c1-28-23-12-11-21(31-25(30)27-15-8-4-2-3-7-14-26)17-20(23)18-29-16-13-19-9-5-6-10-22(19)24(28)29\/h5-6,9-12,17,24H,2-4,7-8,13-16,18H2,1H3,(H,27,30)
InChIKey : BRQIFYBESADBLA-UHFFFAOYSA-N
Other name(s) : [18F]-UW-MD-95,13-Methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl (7-[18F]fluoroheptyl)carbamate {[18F]8}
MW : 425.54
Formula : C25H32FN3O2
CAS_number :
PubChem :
UniChem : BRQIFYBESADBLA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Tetracyclic-carbamate-cp8 ligand of proteins in family: BCHE
Stucture :
Protein : human-BCHE
References (3)
| Title : Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model - Scheiner_2021_J.Med.Chem_64_9302 |
| Author(s) : Scheiner M , Hoffmann M , He F , Poeta E , Chatonnet A , Monti B , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 64(13): :9302 , 2021 |
| Abstract : Scheiner_2021_J.Med.Chem_64_9302 |
| ESTHER : Scheiner_2021_J.Med.Chem_64_9302 |
| PubMedSearch : Scheiner_2021_J.Med.Chem_64_9302 |
| PubMedID: 34152756 |
| Title : A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety - Sawatzky_2016_ChemMedChem_11_1540 |
| Author(s) : Sawatzky E , Al-Momani E , Kobayashi R , Higuchi T , Samnick S , Decker M |
| Ref : ChemMedChem , 11 :1540 , 2016 |
| Abstract : Sawatzky_2016_ChemMedChem_11_1540 |
| ESTHER : Sawatzky_2016_ChemMedChem_11_1540 |
| PubMedSearch : Sawatzky_2016_ChemMedChem_11_1540 |
| PubMedID: 27348083 |
| Title : Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer - Darras_2012_ACS.Med.Chem.Lett_3_914 |
| Author(s) : Darras FH , Kling B , Heilmann J , Decker M |
| Ref : ACS Med Chem Lett , 3 :914 , 2012 |
| Abstract : Darras_2012_ACS.Med.Chem.Lett_3_914 |
| ESTHER : Darras_2012_ACS.Med.Chem.Lett_3_914 |
| PubMedSearch : Darras_2012_ACS.Med.Chem.Lett_3_914 |
| PubMedID: 24900407 |