2-N-pyridin-2-ylbenzene-1,2-diamine
Not inhibitor of Notum. Compound 33 Fragment 648 IC50 500+/-64 microM
General
Type : Fragment inhibitor of Notum,Pyridine
Chemical_Nomenclature : 2-N-pyridin-2-ylbenzene-1,2-diamine
Canonical SMILES : C1=CC=C(C(=C1)N)NC2=CC=CC=N2
InChI : InChI=1S\/C11H11N3\/c12-9-5-1-2-6-10(9)14-11-7-3-4-8-13-11\/h1-8H,12H2,(H,13,14)
InChIKey : SMNUYINHUNGHMQ-UHFFFAOYSA-N
Other name(s) : (2-aminophenyl)-2-pyridylamine,SCHEMBL4943709,F1371-0170,Fragment 648,Fragment-648,Compound 33,S4V
MW : 185.22
Formula : C11H11N3
CAS_number : 26148-38-9
PubChem : 752150
UniChem : SMNUYINHUNGHMQ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : 2-N-pyridin-2-ylbenzene-1,2-diamine ligand of proteins in family: Pectinacetylesterase-Notum
Stucture : 7BAP Structure of the human Wnt deacylase Notum in complex with fragment 648
Protein : human-NOTUM
References (1)
| Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY |
| Ref : ACS Chem Neurosci , 13 :2060 , 2022 |
| Abstract : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| ESTHER : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedID: 35731924 |
| Gene_locus related to this paper: human-NOTUM |