Inhibitor Report for: 3-amino-4-phenyl-pyrrolidine-15B General
Type Trifluoro , Pyrrolidine , Pyridine , Pyrimidine Chemical_Nomenclature (3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine Canonical SMILES COC1=NC=C(C=C1)C2=CC(=NC=N2)N3CC(C(C3)N)C4=CC(=C(C=C4F)F)F InChI InChI=1S/C20H18F3N5O/c1-29-20-3-2-11(7-25-20)18-6-19(27-10-26-18)28-8-13(17(24)9-28)12-4-15(22)16(23)5-14(12)21/h2-7,10,13,17H,8-9,24H2,1H3/t13-,17+/m1/s1 InChIKey IFKWHPAWYJARQJ-DYVFJYSZSA-N Other name(s) PZF ; CHEMBL237786 ; (3R,4S)-1-(6-(6-methoxypyridin-3-yl)pyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine ; BDBM50221073 ; DB08445
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Target
Families | 3-amino-4-phenyl-pyrrolidine-15B ligand of proteins in family: DPP4N_Peptidase_S9 Stucture | 1 structure : 2QJR : Dipepdyl peptidase IV in complex with inhibitor PZF Protein | human-DPP4
References:
Title: (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterizationWright SW , Ammirati MJ , Andrews KM , Brodeur AM , Danley DE , Doran SD , Lillquist JS , Liu S , McClure LD and Cox ED <10 more author(s)> Wright SW , Ammirati MJ , Andrews KM , Brodeur AM , Danley DE , Doran SD , Lillquist JS , Liu S , McClure LD , McPherson RK , Olson TV , Orena SJ , Parker JC , Rocke BN , Soeller WC , Soglia CB , Treadway JL , VanVolkenburg MA , Zhao Z , Cox ED (- 10) Ref: Bioorganic & Medicinal Chemistry Lett, 17 :5638, 2007 : PubMed Abstract
