3-cyano-N-cyclopropylbenzenesulfonamide
General
Type : Cyanide,Sulfonamide,Cyclopropyl,Sulfur Compound,Benzenesulfonamide
Chemical_Nomenclature : 3-cyano-N-cyclopropylbenzenesulfonamide
Canonical SMILES : C1CC1NS(=O)(=O)C2=CC=CC(=C2)C#N
InChI : InChI=1S\/C10H10N2O2S\/c11-7-8-2-1-3-10(6-8)15(13,14)12-9-4-5-9\/h1-3,6,9,12H,4-5H2
InChIKey : IQBVFUJHLUVSIM-UHFFFAOYSA-N
Other name(s) : 3-Cyano-~{n}-Cyclopropyl-Benzenesulfonamide,HMS1774K04,ZINC7375423,AKOS000191900,MCULE-4290530860,7BX
MW : 222.27
Formula : C10H10N2O2S
CAS_number : 877227-35-5
PubChem : 8469252
UniChem : IQBVFUJHLUVSIM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : 3-cyano-N-cyclopropylbenzenesulfonamide ligand of proteins in family: PAF-Acetylhydrolase
Stucture : 5LZ2 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 3-cyano-N-cyclopropylbenzenesulfonamide
Protein : human-PLA2G7
References (1)
| Title : Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) - Woolford_2016_J.Med.Chem_59_10738 |
| Author(s) : Woolford AJ , Day PJ , Beneton V , Berdini V , Coyle JE , Dudit Y , Grondin P , Huet P , Lee LY , Manas ES , McMenamin RL , Murray CW , Page LW , Patel VK , Potvain F , Rich SJ , Sang Y , Somers DO , Trottet L , Wan Z , Zhang X |
| Ref : Journal of Medicinal Chemistry , 59 :10738 , 2016 |
| Abstract : Woolford_2016_J.Med.Chem_59_10738 |
| ESTHER : Woolford_2016_J.Med.Chem_59_10738 |
| PubMedSearch : Woolford_2016_J.Med.Chem_59_10738 |
| PubMedID: 27933945 |
| Gene_locus related to this paper: human-PLA2G7 |