4-Oxo-beta-Lactam-A241-closed
In the structure the beta-lactam ring is described as open
General
Type : Piperazine,beta-Lactam
Chemical_Nomenclature :
Canonical SMILES : CN1CCN(CC1)CC2=CC(=CC=C2)N3C(C(C3=O)(CC)CC)=O
InChI : InChI=1S\/C19H27N3O2\/c1-4-19(5-2)17(23)22(18(19)24)16-8-6-7-15(13-16)14-21-11-9-20(3)10-12-21\/h6-8,13H,4-5,9-12,14H2,1-3H3
InChIKey : LMFQXNNEABURIM-UHFFFAOYSA-N
Other name(s) : Compound 11
MW : 329,44
Formula : C19H27N3O2
CAS_number :
PubChem :
UniChem : LMFQXNNEABURIM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : 4-Oxo-beta-Lactam-A241-closed ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 7A3L Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor A241
Protein : human-DPP8
References (1)
| Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R |
| Ref : Angew Chem Int Ed Engl , : , 2022 |
| Abstract : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| ESTHER : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| PubMedID: 36089535 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |