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Inhibitor Report for: 5-pyrid-3-yl-1,3,4-oxadiazole-5e

AChE (IC50 = 50.87 nM) and BuChE (IC50 = 4.77 nM) Reduces lipid peroxidation and glutathione (GSH), decreases beat-amyloid protein


General
Type Oxadiazol, Pyridine
Chemical_Nomenclature 2-(4-Chlorophenyl)-5-(5-Phenylpyridin)-3-yl-1,3,4-oxadiazole
Canonical SMILES [C]1=C([C]=N[C]=C1C2=[C][C]=[C][C]=[C]2)C3=NN=C(O3)C4=[C][C]=C([C]=[C]4)Cl
InChI InChI=1S/C19H12ClN3O/c20-17-8-6-14(7-9-17)18-22-23-19(24-18)16-10-15(11-21-12-16)13-4-2-1-3-5-13/h1-12H
InChIKey OLPJPJHZTDRYPB-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|333.77
Formula|C19H12ClN3O
CAS_number|
PubChem|
UniChem|OLPJPJHZTDRYPB-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | 5-pyrid-3-yl-1,3,4-oxadiazole-5e ligand of proteins in family: ACHE, BCHE
Protein | human-ACHE, human-BCHE

References:
Search PubMed for references concerning: 5-pyrid-3-yl-1,3,4-oxadiazole-5e
    Title: Discovery of New 1,3,4-Oxadiazoles with Dual Activity Targeting the Cholinergic Pathway as Effective Anti-Alzheimer Agents
    Elghazawy NH, Zaafar D, Hassan RR, Mahmoud MY, Bedda L, Bakr AF, Arafa RK
    Ref: ACS Chem Neurosci, :, 2022 : PubMed