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Inhibitor Report for: 5LZ9-7BR

General
Type Pyrrolidine, Cyanide, Sulfur Compound, Oxidanylidene
Chemical_Nomenclature 2-fluoro-5-[2-[(4S)-4-(4-methyl-1,1-dioxothian-4-yl)-2-oxopyrrolidin-1-yl]ethoxy]benzonitrile
Canonical SMILES CC1(CCS(=O)(=O)CC1)C2CC(=O)N(C2)CCOC3=CC(=C(C=C3)F)C#N
InChI InChI=1S/C19H23FN2O4S/c1-19(4-8-27(24,25)9-5-19)15-11-18(23)22(13-15)6-7-26-16-2-3-17(20)14(10-16)12-21/h2-3,10,15H,4-9,11,13H2,1H3/t15-/m1/s1
InChIKey SYEMWCXBADSSGE-OAHLLOKOSA-N
Other name(s) GTPL9796 ; CHEMBL3922315 ; J3.616.652E ; (S)-23 [PMID: 27933945] ; 2-Fluoranyl-5-[2-[(4~{s})-4-[4-Methyl-1,1-Bis(Oxidanylidene)thian-4-Yl]-2-Oxidanylidene-Pyrrolidin-1-Yl]ethoxy]benzenecarbonitrile
________________________________________________________________________________________________
MW|394.46
Formula|C19H23FN2O4S
CAS_number|
PubChem|122707120
UniChem|SYEMWCXBADSSGE-OAHLLOKOSA-N
IUPHAR|9796
Wikipedia|

Target
Families | 5LZ9-7BR ligand of proteins in family: PAF-Acetylhydrolase
Stucture | 1 structure: 5LZ9: Fragment-based inhibitors of Lipoprotein associated Phospholipase A2
Protein | human-PLA2G7

References:
Search PubMed for references concerning: 5LZ9-7BR
    Title: Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
    Woolford AJ, Day PJ, Beneton V, Berdini V, Coyle JE, Dudit Y, Grondin P, Huet P, Lee LY and Zhang X <11 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:10738, 2016 : PubMed