64D
Monoacylglycerol lipase (human-MGLL) inhibitor
General
Type : Piperidine,PET probe,Sulfonyl,Sulfur Compound
Chemical_Nomenclature : 4-[[(4-chlorophenyl)sulfonylamino]methyl]piperidine-1-carboxylic acid
Canonical SMILES : C1CN(CCC1CNS(=O)(=O)C2=CC=C(C=C2)Cl)C(=O)O
InChI : InChI=1S\/C13H17ClN2O4S\/c14-11-1-3-12(4-2-11)21(19,20)15-9-10-5-7-16(8-6-10)13(17)18\/h1-4,10,15H,5-9H2,(H,17,18)
InChIKey : CFNWARLITZSZQR-UHFFFAOYSA-N
Other name(s) : SAR127303,[11C]SAR127303,SCHEMBL14834137,4-({[(4-Chlorophenyl)sulfonyl]amino}methyl)piperidine-1-Carboxylic Acid
MW : 332.80
Formula : C13H17ClN2O4S
CAS_number :
PubChem : 86580387
UniChem : CFNWARLITZSZQR-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : 64D ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture : 4UUQ Crystal structure of human mono-glyceride lipase in complex with SAR127303
Protein : human-MGLL
References (3)
| Title : First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [(11)C]SAR127303 - Yamasaki_2018_Neuroimage_176_313 |
| Author(s) : Yamasaki T , Mori W , Zhang Y , Hatori A , Fujinaga M , Wakizaka H , Kurihara Y , Wang L , Nengaki N , Ohya T , Liang SH , Zhang MR |
| Ref : Neuroimage , 176 :313 , 2018 |
| Abstract : Yamasaki_2018_Neuroimage_176_313 |
| ESTHER : Yamasaki_2018_Neuroimage_176_313 |
| PubMedSearch : Yamasaki_2018_Neuroimage_176_313 |
| PubMedID: 29738910 |
| Title : Monoglyceride lipase: Structure and inhibitors - Scalvini_2016_Chem.Phys.Lipids_197_13 |
| Author(s) : Scalvini L , Piomelli D , Mor M |
| Ref : Chemistry & Physic of Lipids , 197 :13 , 2016 |
| Abstract : Scalvini_2016_Chem.Phys.Lipids_197_13 |
| ESTHER : Scalvini_2016_Chem.Phys.Lipids_197_13 |
| PubMedSearch : Scalvini_2016_Chem.Phys.Lipids_197_13 |
| PubMedID: 26216043 |
| Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642 |
| Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J |
| Ref : Sci Rep , 5 :7642 , 2015 |
| Abstract : Griebel_2015_Sci.Rep_5_7642 |
| ESTHER : Griebel_2015_Sci.Rep_5_7642 |
| PubMedSearch : Griebel_2015_Sci.Rep_5_7642 |
| PubMedID: 25560837 |
| Gene_locus related to this paper: mouse-ABHD6 |