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Inhibitor Report for: ABC47

potent dual inhibitor of ABHD3 and ABHD4 (IC50 values of 0.13 and 0.03 M, respectively)



General
Type: Carbamate, Piperidine, N-hydroxyhydantoin, Phenoxyphenyl
Chemical_Nomenclature: [1,3-dioxo-7-[(4-phenoxyphenyl)methyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] 4-phenylpiperidine-1-carboxylate
Canonical SMILES: C1CN(CCC1C2=CC=CC=C2)C(=O)ON3C(=O)C4CN(CCN4C3=O)CC5=CC=C(C=C5)OC6=CC=CC=C6
InChI: InChI=1S/C31H32N4O5/c36-29-28-22-32(21-23-11-13-27(14-12-23)39-26-9-5-2-6-10-26)19-20-34(28)30(37)35(29)40-31(38)33-17-15-25(16-18-33)24-7-3-1-4-8-24/h1-14,25,28H,15-22H2
InChIKey: RZRRRWRXKABFDO-UHFFFAOYSA-N
Other name(s): SCHEMBL17275314 ; ABC-47
MW: 540.6
Formula: C31H32N4O5
CAS_number:
PubChem: 118525585
IUPHAR:
Wikipedia:

Target families
ABC47 ligand of proteins in family: abh_upf0017, CGI-58_ABHD5_ABHD4
No structure

Protein target

References
Search PubMed for references concerning: ABC47
    Title: Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases
    Cognetta AB, 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF
    Ref: Chemical Biology, 22:928, 2015 : PubMed