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Inhibitor Report for: AEBSF

serine protease inhibitor


General
Type Sulfur Compound, Sulfonyl
Chemical_Nomenclature 4-(2-aminoethyl)benzenesulfonyl fluoride
Canonical SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F
InChI InChI=1S/C8H10FNO2S/c9-13(11,12)8-3-1-7(2-4-8)5-6-10/h1-4H,5-6,10H2
InChIKey MGSKVZWGBWPBTF-UHFFFAOYSA-N
Other name(s) 4-(2-Aminoethyl)benzenesulfonyl fluoride ; Pefabloc ; 4-(2-Aminoethyl)benzenesulfonylfluoride ; Benzenesulfonyl fluoride, 4-(2-aminoethyl)-
________________________________________________________________________________________________
MW|203.23
Formula|C8H10FNO2S
CAS_number|34284-75-8
PubChem|1701
UniChem|MGSKVZWGBWPBTF-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | AEBSF ligand of proteins in family: S9N_PREPL_Peptidase_S9, 5_AlphaBeta_hydrolase, DPP4N_Peptidase_S9
Stucture | 3 structures: 6XYC, 4Q82, 2AJC
Protein | pig-dpp4, leima-OPB, halo1-d0lmj0, human-FAP

References:
Search PubMed for references concerning: AEBSF
    Title: Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor
    McLuskey K, Paterson NG, Bland ND, Isaacs NW, Mottram JC
    Ref: Journal of Biological Chemistry, 285:39249, 2010 : PubMed

            

    Title: Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase
    Legler PM, Kumaran D, Swaminathan S, Studier FW, Millard CB
    Ref: Biochemistry, 47:9592, 2008 : PubMed

            

    Title: Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV
    Engel M, Hoffmann T, Manhart S, Heiser U, Chambre S, Huber R, Demuth HU, Bode W
    Ref: Journal of Molecular Biology, 355:768, 2006 : PubMed